Imiquimod:A potential option for inhibition of repigmentation of congenital melanocytic nevus after laser ablation

作     者：Yifei Zhao Yun Zou Xiangyu Chen Hanlin Zeng Hanru Ying Xiaoxi Lin Hui Chen Yifei Zhao;Yun Zou;Xiangyu Chen;Hanlin Zeng;Hanru Ying;Xiaoxi Lin;Hui Chen

作者机构：Department of Plastic and Reconstructive SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Shanghai Institute of Precision MedicineShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Department of OncologyShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai201900China 

出 版 物：《Chinese Journal of Plastic and Reconstructive Surgery》 (Chinese Journal of Plastic and Reconstructive Surgery)

年 卷 期：2024年第6卷第2期

页      面：76-78页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by Shanghai Municipal Key Clinical Specialty (grant no. shslczdzk00901) Clinical Research Project of Multi-Disciplinary Team, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine 

主　　题：Imiquimod Congenital melanocytic nevus Recurrence Laser 

摘      要：Congenital melanocytic nevi(CMN) are common skin tumors. Large and specially located nevi cannot be completely removed by surgery, posing the risks of both cosmetic deformities and potential *** treatments, such as laser therapy and physical dermabrasion, can overcome the limitations of surgery;however, the high rate of repigmentation remains an unresolved global challenge. We conducted a self-controlled observational study of a patient with a nevus on the chest. Two areas of the lesion were treated with an Er:YAG laser and 5% imiquimod cream was applied to one of these areas. After nearly 7-months of follow-up, we observed a significant difference in color between the two areas, suggesting that topical imiquimod may inhibit repigmentation and significantly enhance the effectiveness of laser treatment.