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Chinese Physics B 2022年第10期31卷 120-125页

作者： Wang lin Ting-Ting Wang Qi-Liang Wang Xian-Yi Lv Gen-Zhuang Li Liu-An Li Jin-ping Ao Guang-Tian Zou State Key Laboratory of Superhard Material College of PhysicsJilin UniversityChangchun 130012China Shenzhen Research institute Jilin UniversityShenzhen 518057China National Key Discipline Laboratory of Wide Bandgap Semiconductor Xidian UniversityXi’an 710071China

A novel junction terminal extension structure is proposed for vertical diamond Schottky barrier diodes(SBDs) by using an n-Ga_(2)O_(3)/p-diamond heterojunction. The depletion region of the heterojunction suppresses part of the forward current conduction path, which slightly increases the on-resistance. On the other hand, the reverse breakdown voltage is enhanced obviously because of attenuated electric field crowding. By optimizing the doping concentration, length, and depth of n-Ga_(2)O_(3), the trade-off between on-resistance and breakdown voltage with a high Baliga figure of merit(FOM)value is realized through Silvaco technology computer-aided design simulation. In addition, the effect of the work functions of the Schottky electrodes is evaluated. The results are beneficial to realizing a high-performance vertical diamond SBD.

关键词： diamond Schottky barrier diode junction terminal extension simulation

Generation of high-energy dual-wavelength domain wall pulse with low repetition rate in an HNLF-based fiber ring laser

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Chinese Physics B 2014年第6期23卷 217-220页

作者：罗智超林振彬李金玉朱鹏飞宁秋奕邢晓波罗爱平徐文成 Laboratory of Nanophotonic Functional Materials and Devices School of Information and Optoelectronic Science and Engineering South China Normal University Department of Environmental Engineering Guangdong Industry Technical College MOE Key Laboratory of Laser Life Science and institute of Laser Life Science College of BiophotonicsSouth China Normal University

The generation of high-energy dual-wavelength domain wall pulse with a low repetition rate is demonstrated in a highly nonlinear fiber （HNLF）-based fiber ring laser. By introducing the intracavity birefringence-induced spectral filtering effect, the dual-wavelength lasing operation can be achieved. In order to enhance the cross coupling effect between the two lasing beams for domain wall pulse formation, a 215-m HNLF is incorporated into the laser cavity. Experimentally, it is found that the dual-wavelength domain wall pulse with a repetition rate of 77.67 kHz could be efficiently obtained through simply rotating the polarization controller （PC）. At a maximum pump power of 322 mW, the 655-nJ single pulse energy in cavity is obtained. The proposed configuration provides a simpler and more efficient way to generate high energy pulse with a low repetition rate.

关键词： fiber lasers high-energy pulse domain wall low repetition rate

Genetic lineage tracing identifies cardiac mesenchymal-to-adipose transition in an arrhythmogenic cardiomyopathy model

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Science China(Life Sciences) 2023年第1期66卷 51-66页

作者： Xinyan Huang Lei Yan Jufeng Meng Nanbo Liu Shuoji Zhu Zhen Jiang Shan Kou Teng Feng Chao-Po lin Bin Zhou Juan Tang ping Zhu Hui Zhang School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China guangdong Cardiovascular institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510100China guangdong Provincial Key Laboratory of Pathogenesis Targeted Prevention and Treatment of Heart DiseaseGuangzhou 510100China institute for Regenerative Medicine Shanghai East HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Science and TechnologyTongji UniversityShanghai 200092China State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceInstitute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China

Arrhythmogenic cardiomyopathy(ACM)is one of the most common inherited cardiomyopathies,characterized by progressive fibrofatty replacement in the ***,the cellular origin of cardiac adipocytes in ACM remains largely *** the cellular source of cardiac adipocytes in ACM would elucidate the underlying pathological process and provide a potential target for ***,we generated an ACM mouse model by inactivating desmosomal gene desmoplakin in cardiomyocytes;and examined the adipogenic fates of several cell types in the disease *** results showed that SOX9^(+),PDGFRa^(+),and PDGFRb^(+)mesenchymal cells,but not cardiomyocytes or smooth muscle cells,contribute to the intramyocardial adipocytes in the ACM ***,Bmp4 was highly expressed in the ACM mouse heart and functionally promoted cardiac mesenchymal-to-adipose transition in vitro.

关键词： adipocyte heart genetic lineage tracing cardiomyocyte mesenchymal cell

Perioperative extracorporeal membrane oxygenation in pediatric congenital heart disease:Chinese expert consensus

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World Journal of Pediatrics 2023年第1期19卷 7-19页

作者： Ru lin Wei Wang Xu Wang Zhuo-Ming Xu Jin-ping Liu Cheng-Bin Zhou Xiao-Yang Hong Xu-Ming Mo Shan-Shan Shi Li-Fen Ye Qiang Shu Department of Extracorporeal Life Support Heart InstituteNational Clinical Research Center for Child HealthChildren's HospitalZhejiang University School of MedicineHangzhouChina Department of Thoracic and Cardiovascular Surgery Shanghai Children's Medical CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Pediatric Intensive Care Unit National Center for Cardiovascular Disease and Fuwai HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijingChina Department of Cardiopulmonary Bypass National Center for Cardiovascular Disease and Fuwai HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijingChina Department of Cardiovascular Surgery Guangdong Provincial Cardiovascular InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouChina Pediatric Intensive Care Unit Faculty of PediatricsChinese PLA General HospitalBeijingChina Department of Cardiothoracic Children's Hospital of Nanjing Medical UniversityNanjingChina Department of CICU Heart InstituteNational Clinical Research Center for Child HealthChildren's HospitalZhejiang University School of MedicineHangzhouChina Department of Cardiac Surgery National Clinical Research Center for Child HealthChildren's HospitalZhejiang University School of MedicineBinsheng Road 3333Hangzhou 310052China

Background Congenital heart disease(CHD)is one of the main supportive diseases of extracorporeal membrane oxygena-tion in *** management of extracorporeal membrane oxygenation(ECMO)for pediatric CHD faces more severe challenges due to the complex anatomical structure of the heart,special pathophysiology,perioperative complications and various concomitant *** survival rate of ECMO for CHD was significantly lower than other classifica-tions of diseases according to the Extracorporeal Life Support Organization *** expert consensus aims to improve the survival rate and reduce the morbidity of this patient population by standardizing the clinical *** The editing group of this consensus gathered 11 well-known experts in pediatric cardiac surgery and ECMO field in China to develop clinical recommendations formulated on the basis of existing evidences and expert *** The primary concern of ECMO management in the perioperative period of CHD are patient selection,cannulation strategy,pump flow/ventilator parameters/vasoactive drug dosage setting,anticoagulation management,residual lesion screening,fluid and wound management and weaning or transition *** and treatment of complications of bleeding,thromboembolism and brain injury are emphatically discussed *** conditions of ECMO management related to the cardiovascular anatomy,haemodynamics and the surgical procedures of common complex CHD should be *** The consensus could provide a reference for patient selection,management and risk identification of periop-erative ECMO in children with CHD.

关键词： Circulatory support Congenital heart disease Extracorporeal membrane oxygenation Pediatric Respiratory support

A genome-wide association study identifies novel genetic loci that modify pharmacokinetic-pharmacodynamic responses to clopidogrel

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中国药理学与毒理学杂志 2016年第10期30卷 1047-1048页

作者： ZHONG Wan-ping WU Hong CHEN Ji-yan Li Xin-xin lin Hao-ming ZHANG Bin ZHANG Zhi-wei MA Dun-liang SUN Shuo LI Han-ping MAI Li-ping HE Gou-dong WANG Xi-pei LEI He-ping TANG Lan LIU Shu-wen ZHONG Shi-long guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention Guangdong Cardiovascular Institute Medical Research Center of guangdong General Hospital Guangdong Academy of Medical Sciences Sun Yatsen Memorial Hospital Sun Yat-sen University Department of Pharmaceutics School of Pharmaceutical SciencesSouthern Medical University

OBJECTIVE Genetic variants in the pharmacokinetic(PK)mechanism are the main underlying factors that modify the antiplatelet efficacy of ***,joint analysis of genetic variants that modify pharmacodynamic(PD)and PK responses to clopidogrel should be effective for identifying the genetic variants affecting the antiplatelet response to the *** A genome-wide association study was conducted to identify new genetic loci that modify PD responses to clopidogrel and its active metabolite H4 in 115 Chinese patients with coronary heart disease(CHD).RESULTS We identified novel variants in two transporter genes(rs12456693 in SLC14A2 and rs2487032 in ABCA1)and in N6AMT1(rs2254638)associated with clopidogrel-treated P2Y12reaction unit(PRU)and plasma H4 *** associations between these single nucleotide polymorphisms(SNPs)and PK parameters of clopidogrel and H4 were observed in 31 additional CHD patients(Plinical factors,dramatically improved the predictability of PRU variability to 37.7%compared with the published value of approximately 20%.The function of these SNPs on the activation of clopidogrel was validated in 32 liver S9 fractions,and the N6AMT1 rs2254638 T variant was found to be associated with decreased formation of H4(P=0.0386).Meanwhile,N6AMT1 rs2254638 was further identified to exert a marginal risk effect for MACE in an independent CHD patient cohort(OR:1.428,95%CI:0.978-2.086,P=0.0653,FDR=0.4726).In conclusion,we systematically identified new genetic variants as risk factors for the reduced efficacy of *** Our study findings enhanced the understanding of the absorption and metabolic mechanisms that influence PD responses to clopidogrel treatment.

关键词： clopidogrel pharmacokinetics pharmacodynamics genome-wide association study N6AMT1

Heart rate-adjusted PR as a prognostic marker of long-term ventricular arrhythmias and cardiac death in ICD/CRT-D recipients

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Journal of Geriatric Cardiology 2019年第3期16卷 259-264页

作者： Yu-Qiu LI Shuang ZHAO Ke-ping CHEN Yang-Gang SU Wei HUA Si-lin CHEN Zhao-Guang LIANG Wei XU Yan DAI Xiao-Han FAN Shu ZHANG State Key Laboratory of Cardiovascular Disease Arrhythmia CenterFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Shanghai Institute of Cardiovascular DiseasesZhongshan HospitalFudan UniversityShanghaiChina Department of Cardiology Guangdong Cardiovascular InstituteGuangdong General HospitalGuangzhouChina Department of Cardiology First Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Cardiology Nanjing Drum Tower HospitalNanjingChina

Objective To evaluate the PR to RR interval ratio (PR/RR,heart rate-adjusted PR) as a prognostic marker for long-term ventricular arrhythmias and cardiac death in patients with implantable cardioverter defibrillator (ICDs) and cardiac resynchronization therapy with defibrillators (CRT-D).Methods We retrospectively analyzed data from 428 patients who had an ICD/CRT-D equipped with home *** PR and RR interval data prior to ICD/CRT-D implantation were collected from standard 12-lead electrocardiograph,and the PR/RR was *** primary endpoint was appropriate ICD/CRT-D treatment of ventricular arrhythmias (VAs),and the secondary endpoint was cardiac *** During a mean follow-up period of 38.8 ± 10.6 months,197 patients (46%) experienced VAs,and 47 patients (11%) experienced cardiac *** overall PR interval was 160 ± 40 ms,and the RR interval was 866 ± 124 *** on the receiver operating characteristic curve,a cut-off value of 18.5% for the PR/RR was identified to predict VAs.A PR/RR ≥ 18.5% was associated with an increased risk of VAs [hazard ratio (HR)= 2.243,95% confidence interval (CI)= 1.665–3.022,P line can serve as a predictor of future VAs and cardiac death in ICD/CRT-D recipients.

关键词： Implantable cardioverter defibrillator PR interval RR interval Ventricular arrhythmias

Laboratory studies on the infectivity of human respiratory viruses:Experimental conditions,detections,and resistance to the atmospheric environment

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Fundamental Research 2024年第3期4卷 471-483页

作者： Yaohao Hu Shuyi Peng Bojiang Su Tao Wang Juying lin Wei Sun Xiaodong Hu Guohua Zhang Xinming Wang ping'an Peng Xinhui Bi State Key Laboratory of Organic Geochemistry and guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China guangdong-Hong Kong-Macao Joint Laboratory for Environmental Pollution and Control Guangzhou 510640China

The environmental stability of infectious viruses in the laboratory setting is crucial to the transmission potential of human respiratory *** experimental techniques or conditions used in studies over the past decades have led to diverse understandings and predictions for the stability of viral infectivity in the atmospheric *** this paper,we review the current knowledge on the effect of simulated atmospheric conditions on the infectivity of respiratory viruses,mainly focusing on influenza viruses and coronaviruses,including severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome ***,we summarize the impact of the experimental conditions on viral stability;these involve the methods of viral aerosol generation,storage during aging and collection,the virus types and strains,the suspension matrixes,the initial inoculum volumes and concentrations,and the drying ***,we summarize and discuss the detection methods of viral infectivity and their ***,we integrate the results from the reviewed studies to obtain an overall understanding of the effects of atmospheric environmental conditions on the decay of infectious viruses,especially aerosolized ***,this review highlights the knowledge gaps in predicting the ability of viruses to maintain infectivity during airborne transmission.

关键词： Respiratory viruses Viral infectivity Laboratory simulation Atmospheric environmental condition Airborne transmission

双氢青蒿素哌喹片治疗无并发症恶性疟的临床随机对照试验

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中国新药与临床杂志 2004年第11期23卷 783-785页

作者：宋建平符林春谈博李国桥广州中医药大学热带医学研究所广东广州510405

目的 :探讨双氢青蒿素哌喹片在柬埔寨马德望省治疗无并发症恶性疟的有效性和安全性。方法 :无并发症恶性疟疾病人 5 0例 ,按随机数字表随机分成 2组 ,每组 2 5例 ,一组用双氢青蒿素哌喹片 ,一组用复方双氢青蒿素片 ,采用 2d内 4次给药 ... 详细信息

目的 :探讨双氢青蒿素哌喹片在柬埔寨马德望省治疗无并发症恶性疟的有效性和安全性。方法 :无并发症恶性疟疾病人 5 0例 ,按随机数字表随机分成 2组 ,每组 2 5例 ,一组用双氢青蒿素哌喹片 ,一组用复方双氢青蒿素片 ,采用 2d内 4次给药 ,成人总量 8片的给药方案 ,观察治愈率、复燃率、平均原虫转阴时间、退热时间和不良反应。结果 :双氢青蒿素哌喹片组的原虫转阴时间为 (36±s 2 0 )h ,复方双氢青蒿素片组为 (36± 17)h ;退热时间双氢青蒿素哌喹片组为 (4 2± 2 5 )h ,复方双氢青蒿素片为(31± 2 1)h ;随访 2 8d ,双氢青蒿素哌喹片组治愈率为 10 0 % ,复方双氢青蒿素片组有 1例于d 2 1复燃 ,治愈率为 96 %。病人对两药均有较好的耐受性 ,个别病人在服药过程中出现恶心、腹痛等症状 ,均轻微而且是自限性的。结论 :双氢青蒿素复方具有高效、速效、低毒、病人顺应好等优点。

关键词：疟原虫恶性疟疾恶性随机对照试验双氢青蒿素哌喹甲氧苄啶

Total Ginsenoside Extract from Panax ginseng Enhances Neural Stem Cell Proliferation and Neuronal Differentiation by Inactivating GSK-3β

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Chinese Journal of Integrative Medicine 2022年第3期28卷 229-235页

作者： lin Kai-li ZHANG Ji CHUNG Hau-lam WU Xin-yi LIU Bin ZHAO Bo-xin SZE Stephen Cho-wing ZHOU ping-zheng YUNG Ken Kin-lam ZHANG Shi-qing School of Public Health Guangzhou Medical UniversityGuangzhou(511436)China Department of Biology Hong Kong Baptist University(HKBU)Hong Kong Special Administrative Region(999077)China HKBU Shenzhen Research institute and Continuing Education ShenzhenGuangdong Provinee(518057)China Department of Plastic Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhou(510515)China Guangzhou institute of Cardiovascular Disease the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou(510260)China Department of Pharmacy Nan fang HospitalSouther n Medical Un iversityGuan gzhou(510515)China guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou(510515)China

Objective:To study the effects of total ginsenosides(TG)extract from Panax ginseng on neural stem cell(NSC)proliferation and differentiation and their underlying ***:The migration of NSCs after treatment with various concentrations of TG extract(50,100,or 200μg/mL)were *** proliferation of NSCs was examined by a combination of cell counting kit-8 and neurosphere *** differentiation mediated by TG extract was evaluated by Western blotting and immunofluorescence staining to monitor the expression of nestin and microtubule associated protein 2(MAP2).The GSK-3β/β-catenin pathway in TG-treated NSCs was examined by Western blot *** NSCs with constitutively active GSK-3βmutant were made by adenovirus-mediated gene transfection,then the proliferation and differentiation of NSCs mediated by TG were further ***:TG treatment significantly enhanced NSC migration(P<0.01 or P<0.05)and increased the proliferation of NSCs(P<0.01 or P<0.05).TG mediation also significantly upregulated MAP2 expression but downregulated nestin expression(P<0.01 or P<0.05).TG extract also significantly induced GSK-3βphosphorylation at Ser9,leading to GSK-3βinactivation and,consequently,the activation of the GSK-3β/β-catenin pathway(P<0.01 or P<0.05).In addition,constitutive activation of GSK-3βin NSCs by the transfection of GSK-3βS9 A mutant was found to significantly suppress TG-mediated NSC proliferation and differentiation(P<0.01 or P<0.05).Conclusion:TG promoted NSC proliferation and neuronal differentiation by inactivating GSK-3β.

关键词： ginsenoside neural stem cell proliferation neuronal differentiation GSK-3β

Role of juvenile hormone receptor Methoprene-tolerant 1 in silkworm larval brain development and domestication

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Zoological Research 2021年第5期42卷 637-649页

作者： Yong Cui Zu-Lian Liu Cen-Cen Li Xiang-Min Wei Yong-Jian lin Lang You Zi-Dan Zhu Hui-Min Deng Qi-Li Feng Yong-ping Huang Hui Xiang guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Guangzhou Key Laboratory of Insect Development Regulation and Application ResearchInstitute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouGuangdong 510631China Key Laboratory of Insect Developmental and Evolutionary Biology Institute of Plant Physiology and EcologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200032China College of Life Sciences Xinyang Normal UniversityXinyangHenan 464000China

The insect brain is the central part of the neurosecretory system,which controls morphology,physiology,and behavior during the insect’s *** are holometabolous insects,and their brains develop during the larval period and metamorphosis into the adult *** the only fully domesticated insect,the Lepidoptera silkworm Bombyx mori experienced changes in larval brain morphology and certain behaviors during the domestication *** regulation in insects is a key factor in multiple ***,how juvenile hormone(JH)signals regulate brain development in Lepidoptera species,especially in the larval stage,remains *** recently identified the JH receptor Methoprene tolerant 1(Met1)as a putative domestication *** artificial selection on Met1 impacts brain and behavioral domestication is another important issue addressing Darwin’s theory on ***,CRISPR/Cas9-mediated knockout of Bombyx Met1 caused developmental retardation in the brain,unlike precocious pupation of the *** the whole transcriptomelevel,theecdysteroid(20-hydroxyecdysone,20 E)signaling and downstream pathways were overactivated in the mutant cuticle but not in the *** related to cell proliferation and specialization processes,such as extracellular matrix(ECM)-receptor interaction and tyrosine metabolism pathways,were suppressed in the *** evolutionary analysis and in vitro assay identified an amino acid replacement located in a novel motif under positive selection in ***,which decreased transcriptional binding *** *** MET1 protein showed a changed structure and dynamic features,as well as a weakened co-expression gene network,compared with *** on comparative transcriptomic analyses,we proposed a pathway downstream of JH signaling(i.e.,tyrosine metabolism pathway)that likely contributed to silkworm larval brain development and domestication and highlighted the importance of the biogenic amine syste

关键词： Met1 Brain Artificial selection Tyrosine metabolism pathway Silkworm