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Bovine Serum Albumin Loaded Solid Lipid Nanoparticles Prepared by Double Emulsion Method

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Chemical Research in Chinese Universities 2010年第1期26卷 136-141页

作者： LI Zhen LI Xin-wei ZHENG Li-qiang lin Xiao-hong GENG Fei YU Li Key Laboratory of Colloid and Interface Chemistry Ministry of Education Shandong University Jinan 250100 P. R. China

Solid lipid nanoparticles loaded with bovine serum albumin（BSA） were prepared by a double emulsion method. As the mass fraction of the model drug BSA increased from 0 to 15%, the particle size gradually increased. The physical stability of the nanoparticles was investigated by zeta potential measurement and they were shown to be quite stable. Fluorescence spectroscopy confirmed that the loaded position of BSA was on the interface between the inner aqueous phase and the solid lipid phase. Both Fourier-transform infrared spectroscopy and circular dichroism spectra indicate that BSA in the nanoparticles was not destroyed, but the secondary structure was disrupted slightly.

关键词： Solid lipid nanoparticle Double emulsion Bovine serum albumin Drug model

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聚异戊二烯的紫外光老化机理研究

橡胶工业 2024年第6期71卷 411-414页

作者：刘金瑞李邦森林晓雪张妍张大帅李晨石建军孙天一史载锋林强海南师范大学化学与化工学院/海南省水污染治理与资源化重点实验室海南海口571158

通过傅立叶红外光谱、凝胶渗透色谱、差示扫描量热曲线、核磁共振波谱和紫外-可见吸收光谱分析顺式-1,4-聚异戊二烯(以下简称聚异戊二烯)的紫外光老化机理。结果表明:聚异戊二烯的耐紫外光老化性能较差,紫外光照后其表面出现波纹;在紫... 详细信息

通过傅立叶红外光谱、凝胶渗透色谱、差示扫描量热曲线、核磁共振波谱和紫外-可见吸收光谱分析顺式-1,4-聚异戊二烯(以下简称聚异戊二烯)的紫外光老化机理。结果表明:聚异戊二烯的耐紫外光老化性能较差,紫外光照后其表面出现波纹;在紫外光照过程中,聚异戊二烯主要发生支链取代、氢和自由基转移反应,其玻璃化温度升高。

关键词：聚异戊二烯紫外光老化机理

基于国际物品编码组织标准的出口疫苗追溯标识系统的应用进展

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中国生物制品学杂志 2024年第5期37卷 627-633页

作者：刘睿智刘一漩(综述) 林强李志敏(审校) 中国物品编码中心国家条码质量检验检测中心北京100011

COVID-19是由SARS-CoV-2感染引起的一种呼吸道疾病,具有较强的传染力,严重威胁人类健康,接种疫苗是预防SARS-CoV-2感染最有效的手段。世界卫生组织(World Health Organization,WHO)要求使用国际物品编码组织(Global Standard 1,GS1)标... 详细信息

COVID-19是由SARS-CoV-2感染引起的一种呼吸道疾病,具有较强的传染力,严重威胁人类健康,接种疫苗是预防SARS-CoV-2感染最有效的手段。世界卫生组织(World Health Organization,WHO)要求使用国际物品编码组织(Global Standard 1,GS1)标准实现对新型冠状病毒疫苗(简称新冠疫苗)和治疗制剂的跟踪与追溯。追溯标识系统是追溯系统的基础和核心,是实施追溯的前提,贯穿于整个产品追溯过程中。通过对出口疫苗产品各级包装及物流单元进行全球唯一性编码、建立疫苗追溯码和物流单元追溯码标识,帮助出口疫苗生产企业建立追溯制度,实现产品生产、流通、使用等环节信息的追溯,可强化出口疫苗产品质量安全监管、风险监测预警和有效处置、问题产品召回及原因分析,增强国际市场对中国疫苗安全的信任与认可。本文对出口疫苗产品建立追溯制度的重要性、GS1系统在国内外医疗领域的应用、出口疫苗产品追溯标识编码、条码表示及质量要求作一综述,以期为我国出口疫苗产品建立追溯标识制度,满足国际标准法规要求提供参考。

关键词：国际物品编码组织标准疫苗追溯标识系统

Dynamic biomechanical effect of lower body positive pressure treadmill training for hemiplegic gait rehabilitation after stroke: A case report

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World Journal of Clinical Cases 2021年第3期9卷 632-638页

作者： Hui-Fang Tang Bing Yang qiang lin Jun-Jie Liang Zhi-Wei Mou Department of Rehabilitation Medicine The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Neurology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510070Guangdong ProvinceChina

BACKGROUND Lower body positive pressure(LBPP)treadmill has potential applications for improving the gait of patients after stroke,but the related mechanism remains *** SUMMARY A 62-year-old male patient suffered from ischemic stroke with hemiplegic *** was referred to our hospital because of a complaint of left limb weakness for 2 *** LBPP training was performed one session per day and six times per week for 2 *** dynamic plantar pressure analysis was taken every 2 ***,three-digital gait analysis and synchronous electromyography as well as clinical assessments were taken before and after LBPP intervention and at the 4-wk *** LBPP training,our patient not only improved his lower limb muscle strength and walking speed,but more importantly,the symmetry index of various biomechanical indicators ***,the patient’s planter pressure transferring from the heel area to toe area among the LBPP training process and the symmetry of lower body biomechanical parameters *** In this study,we documented a dynamic improvement of gait performance in a stroke patient under LBPP training,which included lower limb muscle strength,walking speed,and symmetry of lower limb *** study provides some crucial clues about the potential dynamic mechanism for LBPP training on gait and balance improvement,which is related to rebuilding foot pressure distribution and remodeling symmetry of biomechanics of the lower limb.

关键词： Lower body positive pressure treadmill Dynamic plantar pressure Stroke Gait analysis Electromyography Case report Rehabilitation

基于数字化肌理演绎的建筑表皮空间优化研究——以某商业综合体项目为例

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智能建筑与智慧城市 2024年第1期 121-124页

作者：鞠瑞馨丛阳刘鹏飞孙阳林强中国建筑东北设计研究院有限公司

高质量建造的实现始于精细的数字优化设计,在参数化设计的全生命周期中建筑立面的建造完成度问题逐渐成为核心关键,以某商业综合体为实例进行肌理式立面优化设计的方法研究。文章运用“像素化网格2D法向投影3D曲面空间的格栅几何细分”... 详细信息

高质量建造的实现始于精细的数字优化设计,在参数化设计的全生命周期中建筑立面的建造完成度问题逐渐成为核心关键,以某商业综合体为实例进行肌理式立面优化设计的方法研究。文章运用“像素化网格2D法向投影3D曲面空间的格栅几何细分”的立面优化方法,对参数化肌理式立面表皮系统进行工业优化,完成了建筑方案与工业化数字建造设计的无缝衔接,并实现设计施工一体化。研究中获得了最优幕墙结构系统的数字建造方案,包括参数化优化设计流程、方法及其工艺逻辑流程图和具有源代码的可视化脚本逻辑图,以此增强肌理式表皮幕墙在实践工业建造方面的适应性,并在整体工期和工程成本方面合理化的大幅降低。

关键词：商业综合体高质量建造参数化优化设计系统表皮空间优化方法肌理式幕墙体系

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突出“四个精准”举措全力推进汽修人才教育培养

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时代汽车 2024年第5期 61-63页

作者：曾学鹏曾兵孙建文刘畅林强内江市高级技工学校四川省内江市641000 内江师范学院四川省内江市641100

随着汽车产业的迅猛发展,对成渝地区经济形成了极大的促进,高质量高素质的技能型汽修人才的需求量不断增加,成为中职汽车专业现阶段人才培养的主要方向。中职院校需要围绕“四个精准”教育目标开展教育教学活动,力求通过校企合作等方式... 详细信息

随着汽车产业的迅猛发展,对成渝地区经济形成了极大的促进,高质量高素质的技能型汽修人才的需求量不断增加,成为中职汽车专业现阶段人才培养的主要方向。中职院校需要围绕“四个精准”教育目标开展教育教学活动,力求通过校企合作等方式,调整学校的课程结构设置,培养专业的理想人才。本文以汽修人才培养为研究方向,围绕“四个精准”目标开展论述,重点阐述汽修人才培养路径,以期能够实现成渝地区汽车产业的协同发展。

关键词：汽修人才教育培训四个精准中职

人工塑造生境条件下中华倒刺鲃的栖息偏好研究

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水生态学杂志 2024年第1期45卷 134-142页

作者：刘瀚林俊强王先政班学君王东胜张迪彭期冬靳甜甜中国水利水电科学研究院北京100038 四川圣达水电开发有限公司四川乐山614000 河海大学农业与科学工程学院江苏南京211100 水电水利规划设计总院北京100120

为了促进受水电工程影响河段鱼类资源的恢复,选择中华倒刺鲃(Spinibarbus sinensis),依托大型生态试验场,人工塑造多种近自然微地形生境,营造适宜鱼类栖息的水文水动力环境,研究其栖息行为偏好特性。设置0.3、0.6、1.0、1.5、2.0、3.0 m... 详细信息

为了促进受水电工程影响河段鱼类资源的恢复,选择中华倒刺鲃(Spinibarbus sinensis),依托大型生态试验场,人工塑造多种近自然微地形生境,营造适宜鱼类栖息的水文水动力环境,研究其栖息行为偏好特性。设置0.3、0.6、1.0、1.5、2.0、3.0 m^(3)/s共6种流量工况,分别进行多地形组合、沙洲地形局部偏好、深潭浅滩地形局部偏好鱼类栖息生境选择试验。采用PIT射频识别系统实时监测鱼类栖息行为,选取流速、涡量、湍流动能和床体切应力4个水动力指标,计算对应流场条件下的中华倒刺鲃栖息适宜度,并基于随机森林和CART算法筛选影响中华倒刺鲃栖息选择的主要水动力指标,探究其栖息行为的水动力选择机制。结果表明,深潭浅滩及沙洲河段的进出口是中华倒刺鲃喜好栖息场所,涡量和流速是影响其栖息的主要水动力指标。流速高于0.545 m/s、低于2.3 m/s,涡量高于0.72/m、低于15.7/m时的流场条件,为试验工况下中华倒刺鲃的最适宜栖息环境。研究结果为鱼类栖息地生态修复及生态调度提供了理论依据和技术支撑。

关键词：中华倒刺鲃微地形水文水动力鱼类行为流速涡量

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Environmental Characteristics of Groundwater:an Application of PCA to Water Chemistry Analysis in Yulin

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Journal of China University of Mining and Technology 2007年第1期17卷 73-77页

作者： DONG Dong-lin WU qiang ZHANG Rui SONG Ying-xia CHEN Shu-ke LI Pei LIU Shou-qiang BI Cen-cen LV Zhen-qi HUANG Song-lin State Key Lab of Coal Resources and Safe Mining China University of Mining ＆ Technology Beijing 100083 China

For our investigation into the water quality in Yulin city, we collected 76 typical water samples to be tested for particle quality. By applying a Romani type classification method the groundwater of Yulin city was classified into nine categories by type, i.e., Ca-HCO3, Na-HCO3, Na-HCO3-SO4-Cl, Na-HCO3-SO4, Na-Cl, Na-Cl-HCO3, Na-Ca- HCO3, Ca-Cl-HCO3 and Ca-HCO3-SO4-Cl. A principal component analysis was carried out in order to analyze the groundwater environment. From this analysis we considered that the information collected could be represented by 21 indices from which we extracted seven principal components, which, respectively, accounted for 37.4%, 13.0%, 8.1%, 7.2%, 6.3%, 5.9% and 4.6% of the total variation. The results show that the groundwater environment of this region is largely determined by characteristic components of the natural groundwater background. One part of the water was polluted by leaching/eluviation of solid waste generated from coal mining. Another part of the ground water was contaminated by acid mine water from the coal layer and from improper irrigation. In addition, geological and hydrogeological conditions also cause changes in the water environment.

关键词： water environment principal component analysis component loading groundwater type Yulin city

Photocatalytic activity of Lu^(3+)/TiO_2 prepared by ball milling method

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Journal of Rare Earths 2018年第8期36卷 819-825页

作者： Di Wu Chen Li Qiushi Kong Zaifeng Shi Dashuai Zhang Lili Wang Lizhi Han Xiaopeng Zhang qiang lin Key Laboratory of Water Pollution Treatment & Resource Reuse Hainan Normal University College of Chemistry and Chemical Engineering Hainan Normal University

Ball milling method was applied to prepare Lu^3＋/TiO2 photocatalysts. The catalysts were characterized with X-ray powder diffraction（XRD）, X-ray photoelectron spectroscopy（XPS）, UV-visible diffuse reflectance spectra（UV-vis DRS）, energy dispersive X-ray spectrometer（EDS）, transmission electron microscopy（TEM） and Brunauer-Emmett-Teller（BET） method. The photocatalytic activities were determined by the degradation of methylene blue（MB） equipped with a 300 W medium pressure mercury lamp. Results show that the first order reaction rate constants of Lu^3＋/TiO2 and pure TiO2 are0.0565 and 0.0263 min-1, respectively, which both were evaluated under the condition of catalysts loading of 0.2 g/L,initial concentration of 25 mg/L for MB, mole ratio of Lu^3＋/TiO2 of 1.5% and milling time of 4 h. The average crystal sizes of 1.5 mol% Lu^3＋/TiO2 and pure TiO2 are 18.7 and 19.3 nm, respectively.

关键词： Ball milling method Rare earth Lutetium Titanium dioxide Methylene blue