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Correlation of ARNTL2 with Immune Infiltration and Its Role as a Potential Prognostic Biomarker in Lung Adenocarcinoma

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Clinical Complementary Medicine and Pharmacology 2021年第1期1卷 32-40页

作者： Junjie Pan Hongkuan Yang lihong Zhu Yafang Lou Department of Pulmonary and Critical Care Medicine Hangzhou Hospital of Traditional Chinese Medicine(Dingqiao District)Hangzhou 310021China Respiratory Intensive Care Unit The People’s Hospital of GaozhouMaoming 525200China Department of Pulmonary and Critical Care Medicine Hangzhou Hospital of Traditional Chinese MedicineHangzhou 310007China

Background:ARNTL2 is a core component of the circadian clock genes and plays regulatory roles in the cell cycle and immune infiltration,but its mechanism in lung cancer(LC)remains ***:To investigate the clinical and therapeutic value of ARNTL2 in ***:The Oncomine and Cancer Cell Line Encyclopedia(CCLE)databases were adopted for assessing the ARNTL2 expression,after which the Kaplan-Meier plotter and Gene Expression Profiling Interactive Analysis 2(GEPIA2)databases were used to assess the correlation of ARNTL2 with *** univariate and multi-variate Cox regression analyses were utilized to identify independent prognostic ***,we explored how ARNTL2 expression is related to immune infiltration,and immunomodulators in non-small lung cancer(NSCLC)using the Tumor Immune Estimation Resource(TIMER)database,TISIDB database and Gene Set Enrichment Analysis(GSEA).Finally,coexpression of ARNTL2 and PD-L1 in lung adenocarcinoma(LUAD)was verified via immunofluorescence staining and COXPRESdb v7 ***:Our study demonstrated a remarkable upregulated expression of ARNTL2 in multiple cell lines and can-cers,including *** analysis displayed a remarkable correlation between high ARNTL2 expression and unfavorable overall survival(OS)and first progressive(FP)survival among patients ailing from LUAD,and ARNTL2 was an independent predictor of prognosis for LUAD *** analysis showed that overexpres-sion of ARNTL2 was significantly linked with cell cycle and ***,we reported a correlation of ARNTL2 expression with immunomodulators and *** staining revealed that ARNTL2 and PD-L1 were elevated relative to normal tissue for LUAD,and colocalization of them was ***:Elevated ARNTL2 expression in LUAD revealed the prognostic values and its prospective role as a target for cell cycle and immune therapy.

关键词： ARNTL2 Lung adenocarcinoma Prognosis Cell cycle Immune infiltration

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Influence of Ren and Du meridian electro-acupuncture on neural stem cell proliferation and extracellular signal-regulated kinase pathway in a rat model of focal cerebral ischemia injury

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Neural Regeneration Research 2010年第6期5卷 433-438页

作者： Wenshu Luo Haibo Yu Zhuoxin Yang Min Pi lihong Diao Xiaodan Rao Department of Acupuncture and Moxibustion Shenzhen Municipal Hospital of Traditional Chinese Medicine Shenzhen 518033 Guangdong Province China Department of Rehabilitation Shekou People's Hospital Shenzhen 518000 Guangdong Province China

BACKGROUND： Studies have shown that electro-acupuncture at the Ren meridian could improve proliferation of subventricular zone neural stem cells in cerebral-ischemic rats. However, there are few reports on the influence of electro-acupuncture at the Du meridian on neural stem cell proliferation. OBJECTIvE： To observe the influence of electro-acupuncture at Ren and Du meridians on neural stem cell proliferation in the subventricular zone and altered signal transduction in cerebral ischemia rats. DESIGN, TIME AND SETTING： A randomized, controlled, animal experiment was performed at the Laboratory of Human Anatomy, Medical College of Sun Yat-sen University from May 2006 to February 2008. MATERIALS： Mouse anti-rat bromodeoxyuridine （BrdU） monoclonal antibody was provided by Sigma, USA; mouse anti-rat nestin monoclonal antibody and extracellular signal-regulated protein kinase （ERK） specific inhibitor PD98059 were provided by Calbiochem, Germany; acupuncture needle was provided by Suzhou Acupuncture Supplies, China. METHODS： A total of 126 rats were randomly assigned to four groups： model （n = 36）, Du meridian （n = 36）, Ren/Du meridian （n = 36）, and Ren/Du meridian ＋ PD98059 （n = 18）. Rats in the Ren/Du meridian ＋ PD98059 group were observed on days 7 （n = 6） and 14 （n = 12） after cerebral ischemia injury. Rats in the model, Du meridian, and Ren/Du meridian groups were observed on days 7, 14, and 28 after cerebral ischemia injury, with 12 rats per group at each time point. Thread occlusion was used to establish middle cerebral artery occlusion models. Electro-acupuncture was performed at Renzhong （DU 26） and Baihui （DU 20） acupoints in the Du meridian group, as well as Chengjiang （RN 24）, Guanyuan （RN 4）, Renzhong, and Baihuiacupoints in the Ren/Du meridian and Ren/Du meridian ＋ PD98059 groups 2 days after model establishment. In addition, electro-acupuncture stimulation with disperse-dense waves was performed, with 30 Hz disperse wave, 100 Hz dense wave, and 5 v intensi

关键词： cerebral ischemia electro-acupuncture extracellular signal-regulated protein kinase middle cerebral artery occlusion brain injury neural regeneration cerebral infarction

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第一性原理研究掺杂过渡元素对碳化钨性能的影响

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稀有金属材料与工程 2021年第3期50卷 887-893页

作者：王旭飞崔红刘菊蓉熊丽红陕西理工大学机械工程学院陕西汉中723000 陕西省工业自动化重点实验室陕西汉中723000 秦川集团汉江工具有限责任公司陕西汉中723002

碳化钨(WC)在高温动力装备上应用越来越多,WC的脆性和高密度限制了其更广泛的使用,金属原子掺杂是提高WC性能的一种方法。采用基于第一原理的广义梯度作为近似交换相关函数,研究了A_(0.25)W_(0.75)C(A为Ti、v、Cr、Mn、Co和Ni)的弹性、... 详细信息

碳化钨(WC)在高温动力装备上应用越来越多,WC的脆性和高密度限制了其更广泛的使用,金属原子掺杂是提高WC性能的一种方法。采用基于第一原理的广义梯度作为近似交换相关函数,研究了A_(0.25)W_(0.75)C(A为Ti、v、Cr、Mn、Co和Ni)的弹性、电子和X射线吸收特性。数值分析结果显示,Ti_(0.25)W_(0.75)C的B/G值(B为体模量,G为剪切模量)为1.869,改性为延性材料,其它均为脆性材料。掺杂25%的v、Co、Ni原子可使WC的脆性降低,掺杂25%的Cr、Mn原子可使WC脆性增大。掺杂后化合物的态密度分布范围减小,费米能级处数值增大,金属性增强,其中Mn_(0.25)W_(0.75)C金属性最强。参杂后X射线吸收谱蓝移,在软X射线波段存在吸收波段,其中Cr、v、Ti在15.74~22.25nm波段出现强吸收峰。研究结果有助于塑性低密度WC类化合物的实验和应用研究。

关键词：碳化钨掺杂过渡元素第一性原理

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经食管超声心动图对非瓣膜性房颤患者血栓形成危险因素的研究

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中国超声医学杂志 2021年第3期37卷 271-274页

作者：宋群霞王丽红青岛大学附属烟台毓璜顶医院超声科

目的对非瓣膜性房颤患者左心房/左心耳形成血栓的危险因素进行分析和预测。方法选取行左心耳封堵术的非瓣膜性房颤患者109例,将既往左心房或左心耳出现自发显影、泥浆样改变或血栓者分为血栓组39例,其余为非血栓组70例,比较两组患者基... 详细信息

目的对非瓣膜性房颤患者左心房/左心耳形成血栓的危险因素进行分析和预测。方法选取行左心耳封堵术的非瓣膜性房颤患者109例,将既往左心房或左心耳出现自发显影、泥浆样改变或血栓者分为血栓组39例,其余为非血栓组70例,比较两组患者基本临床资料,分析经胸、经食管超声及实时三维超声心动图检查获取的参数,评估血栓形成的危险因素。结果与非血栓组比较,血栓组患者PeAF,BNP增高,LAD增大,E增高,左心耳分叶增多,LAA-v减低（PvASc评分、年龄、性别、有吸烟史、血管栓塞、高血压、脑梗死病史比较差异无统计学意义（P>0.05）。多因素Logistic回归分析LAA-v减低是非瓣膜性房颤患者左心房或左心耳血栓形成的独立危险因表（Pv对血栓形成有良好的辨别能力（AUC 0.782,95%CI:0.692～0.872,Pv≤43.50 cm/s预测血栓形成的灵敏度为87.20%、特异度为62.90%。结论 PeAF、BNP增高,LAD增大,左心耳分叶较多均增加NvAF患者的血栓风险。尤其LAA-v减低对左心房或左心耳血栓形成有预测作用,经食管超声心动图可以为NvAF患者的临床预防、治疗提供更多依据。

关键词：左心耳血栓经食道超声心动图非瓣膜性房颤实时三维超声心动图

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Single-shot compressed ultrafast photography: a review

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Advanced Photonics 2020年第1期2卷 41-56页

作者： Dalong Qi Shian Zhang Chengshuai Yang Yilin He Fengyan Cao Jiali Yao Pengpeng Ding Liang Gao Tianqing Jia Jinyang Liang Zhenrong Sun lihong v.wange East China Normal University School of Physics and Electric ScienceState Key Laboratory of Precision SpectroscopyShanghaiChina Shanxi University Collaborative Innovation Center of Extreme OpticsTaiyuanChina University of Illinois at Urbana-Champaign Department of Electrical and Computer EngineeringUrbanaIllinoisUnited States Institut National de la Recherche Scientifique CentreÉnergie Matériaux TélécommunicationsLaboratory of Applied Computational ImagingVarennesQuébecCanada

Compressed ultrafast photography(CUP)is a burgeoning single-shot computational imaging technique that provides an imaging speed as high as 10 trillion frames per second and a sequence depth of up to a few hundred *** technique synergizes compressed sensing and the streak camera technique to capture nonrepeatable ultrafast transient events with a single *** recent unprecedented technical developments and extensions of this methodology,it has been widely used in ultrafast optical imaging and metrology,ultrafast electron diffraction and microscopy,and information security *** review the basic principles of CUP,its recent advances in data acquisition and image reconstruction,its fusions with other modalities,and its unique applications in multiple research fields.

关键词： ultrafast optical imaging compressed sensing computational imaging single-shot measurement

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Changes of evoked potential in different hippocampal regions induced by electrostimulation at medial mamillary nucleus of rats

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Neural Regeneration Research 2006年第1期1卷 87-89页

作者： Xinxin Li lihong Shang Liang Zhang Fengzhi Cui Department of Physiology Shenyang Medical College Shenyang 110034 Liaoning Province China Department of Physiology. Sujiatun Distdct Health School Shenyang 110101. Liaoning Province China

BACKGROUND： Morphological data have shown that the most important afferent fibers of papillary body come from hippocampal structure.OBJECTIvE： To observe the changes of evoked potential in hippocampus and the significance after electrostimulation at medial mamillary nucleus. DESIGN： An observational control experiment.SETTING： Department of Physiology, Shenyang Medical College.MATERIALS ： Twenty-three male or female Wistar rats, 3-4 months old, weighing 270-350 g, were provided by bhe animal room of Shenyang Medical College [the license number was scxk（Liao）2003-0016]. METHODS： The Wistar rats were anaesthetized by intraperintoneal injection of 20% urethane （1 g/kg）, tracheal intubation was also given. The self-made double-pole metal stimulating electrode with the point diameter of 1 mm was inserted into medial mamillary nucleus, the wanted hippocampal guidance spot was found within the rang of the hippocampal region at the same side of tee mamillary body range （CA1-CA4）, inserted with same-core guidance electrode, a sole square-wave stimulation of wave wide 0.2 ms stimulated with electrodes at the applied intensity of 7-9 v, the evoked potential was induced through guidance electrodes, and then input to the ATAC-350 data-processing machine for memory showing wave processing, the memory recorded wave recording graph was separately drawn up by the X-Y recording instrument to observe the latency, time procedure and amplitude of the evoked potential in each hippocampal region of the rats and calculate the percentage of the evoked potential in each hippocampal region. Totally 78 guidance spots in hippocampus were recorded, including 30 positive reaction spots and 48 negative ones. MAIN OUTCOME MEASURES： ① Latency, time procedure and amplitude of the evoked potentials in each hippocampal region of rats; ②percentage of the evoked potentials in each hippocampal region; ③ the wave shapes of the evoked potentials in each hippocampal region from different arrangem

关键词： Changes of evoked potential in different hippocampal regions induced by electrostimulation at medial mamillary nucleus of rats body

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Reduced clinical severity during 2022 Shanghai Spring epidemic of SARS-Cov-2 omicron BA.2 variant infection——an integrated account of virus pathogenicity and vaccination effectiveness

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National Science Review 2024年第4期11卷 24-27页

作者： Xingyue Wu Yao Chen Kangli Cao Yao Shen Xueling Wu Yilin Yang Zhongshu Kuang Qingrun Li Zhenzhen Lu Yichen Jia Mian Shao Guorong Gu Xiangwei wang Ye Yao Ying wang Shaodie Chen Zhigao Yu Wei Wei Longfei Ding Lulu Lan Tianwen Gu Xiangyu Long Jian Sun Lingyu Xing Jiayuan Shen Yi Han Yue Luo Sucheng Mu Mengna Lin Xiaoyan Zhang Rong Zeng Jianqing Xu Guoping Zhao lihong Huang Zhenju Song Department of Emergency Medicine Clinical Center for Bio-Therapy Department of Biostatistics and Department of UrologyShanghai Key Laboratory of Lung Inflammation and Injury Zhongshan Hospital Fudan University Department of Respiratory and Critical Care Medicine Shanghai Pudong Hospital Fudan University Department of Pulmonology Renji Hospital Shanghai Jiao Tong University School of Medicine Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai Public Health Clinical Center Fudan University Department of Biostatistics School of Public Health Key Laboratory of Public Health Safety of Ministry of Education and Shanghai Institute of Infectious Disease and Biosecurity School of Public Health Fudan University Shanghai Institute of Immunology Department of Immunology and Microbiology Shanghai Institute of Virology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationSchool of Medicine Shanghai Jiao Tong University State Key Laboratory of Genetic Engineering Fudan Microbiome CenterSchool of Life Sciences Fudan University Bio-Med Big Data Center Shanghai Institute of Nutrition and Health Chinese Academy of Sciences

The emergence of SARS-Co v-2 variant of concern omicron BA.2 led to high infection incidence rates as well as reduced severity of COvID-19 during the Shanghai Spring epidemic of 2022 [1]. We assessed the role of viral pathogenicity and the effectiveness of inactivated vaccines in a retrospective observational study including 10 258 confirmed COvID-19cases identified between April and June of 2022, from four COvID-19 designated hospitals located in two areas of Shanghai, namely the West Bund and the East Bund, where the populations’ demographic characteristics varied significantly (Table S1, Fig. S1).

关键词： sars-cov-2 effectiveness epidemic shanghai integrated spring clinical variant virus account

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两相钛合金TC16衍射峰形分析与织构测定

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稀有金属材料与工程 2021年第4期50卷 1433-1440页

作者：杨梦瑶袁利红王文睿张晖张旺峰西安交通大学物理学院材料物理系陕西西安710049 北京航空材料研究院钛合金研究所北京100095

TC16(Ti-3Al-5Mo-4.5v)钛合金的α相(0002)和β相(110)衍射峰位差小于0.1°,由于β相含量增多,在传统的X衍射织构测试光路中两峰重叠严重,目前α+β两相TC16钛合金织构无法测量。本研究对热轧退火态TC16钛合金棒材进行重叠衍射峰分离操... 详细信息

TC16(Ti-3Al-5Mo-4.5v)钛合金的α相(0002)和β相(110)衍射峰位差小于0.1°,由于β相含量增多,在传统的X衍射织构测试光路中两峰重叠严重,目前α+β两相TC16钛合金织构无法测量。本研究对热轧退火态TC16钛合金棒材进行重叠衍射峰分离操作,通过光学显微镜、X射线衍射仪、维氏硬度计对TC16合金的显微组织、织构和力学性能进行研究。在Matlab平台上借助柯西平方函数拟合衍射峰形,依据α相衍射峰和β相衍射峰的展宽和重叠影响程度,考察衍射光路参数改变对其产生的影响。结果表明:利用多导毛细管和平行长索拉狭缝的X射线衍射光路配置,解决了衍射峰重叠问题,提高了织构测定的准确性;测试发现,热轧退火态TC16棒材中主要存在2种织构组分,为和双重丝织构;织构的存在使TC16横向抗拉强度小于纵向抗拉强度,讨论了织构对钛合金机械性能的影响。本研究对于提高钛合金紧固件的性能和加工工艺具有重要理论和工程意义,同时,也为两相钛合金织构的准确测定提供了一种解决方案。

关键词：两相钛合金 TC16 衍射峰峰形分析织构

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乙烯路线制备甲基丙烯酸甲酯研究进展

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化工进展 2019年第4期38卷 1739-1745页

作者：李斌解铭齐翔张乐王光远申利红王博邯郸学院化学化工与材料学院河北邯郸056005

甲基丙烯酸甲酯(MMA)是一种重要的基础有机化工原料,主要用于生产有机玻璃、塑料改性剂及表面涂料等诸多行业,具有非常广阔的发展前景,MMA合成路线众多。本文综述了以乙烯为起始原料,经过羰基化反应制备丙醛、丙酸和丙酸甲酯等中间产物... 详细信息

甲基丙烯酸甲酯(MMA)是一种重要的基础有机化工原料,主要用于生产有机玻璃、塑料改性剂及表面涂料等诸多行业,具有非常广阔的发展前景,MMA合成路线众多。本文综述了以乙烯为起始原料,经过羰基化反应制备丙醛、丙酸和丙酸甲酯等中间产物,然后经羟醛缩合反应制备MMA的研究进展。概述了乙烯制备MMA的3条工艺路线及其发展趋势,指出中间产物与甲醛的缩合反应是乙烯路线的关键步骤,重点介绍了羟醛缩合反应及其催化剂的研究现状。目前用于气相催化羟醛缩合反应的催化剂主要有v、Si、P酸性催化剂和K、Cs碱性催化剂,其中以Cs为主活性组分的碱性催化剂研究最为广泛,载体种类、助剂、制备方法、反应条件等对催化剂的活性、选择性和寿命等具有较大影响。为进一步改善催化剂的性能,需加强对羟醛缩合反应催化机理的研究,具有酸碱两性的复合催化剂是今后重点研究方向。

关键词：甲基丙烯酸甲酯乙烯羟醛缩合催化剂

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鄂北地区水稻适宜节水模式与节水潜力

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农业工程学报 2017年第4期33卷 169-177页

作者：刘路广谭君位吴瑕王丽红曹俊龙湖北省水利水电科学研究院武汉430070 武汉大学水资源与水电工程科学国家重点实验室武汉430072 湖北水利水电职业技术学院武汉430070 长渠灌溉试验站襄阳441000

研究作物需水规律、探寻适宜节水模式对缓解农业用水短缺十分重要。该文基于长渠灌溉试验站2009-2013年的水稻灌溉试验数据,分析了浅灌、中蓄、湿润3种传统灌溉模式下水稻的需水规律;运用率定后的ORYZA_v3模型模拟了30 a(1981-2010年)... 详细信息

研究作物需水规律、探寻适宜节水模式对缓解农业用水短缺十分重要。该文基于长渠灌溉试验站2009-2013年的水稻灌溉试验数据,分析了浅灌、中蓄、湿润3种传统灌溉模式下水稻的需水规律;运用率定后的ORYZA_v3模型模拟了30 a(1981-2010年)不同灌溉模式、不同灌溉下限以及不同灌水定额等多种情景下的水稻生长,对比分析了水稻各生育阶段腾发量、耗水量、灌溉定额、灌水次数、产量以及水分生产率在不同情景下的差异;通过模拟典型年不同受旱情景下的水稻生长,对比分析了各生育阶段不同受旱程度对水稻腾发量和产量的影响。结果表明:与浅灌模式相比,湿润模式下水稻年均产量增加2.7%、灌溉用水量减少4.2%;中蓄模式下水稻产量减少2.3%、灌溉用水量减少1.1%;湿润模式优于浅灌、中蓄模式。分蘖期的灌溉下限低于90%能减少水稻腾发量47%以上,其他阶段的灌溉下限低于70%时能减少水稻腾发量10%以上;拔节孕穗期和抽穗开花期受旱对产量的影响最大;综合考虑节水、降低田间管理难度、确保粮食产量等因素,提出了鄂北地区的适宜灌溉模式:蓄水深度为60 mm,返青期保持薄水层,黄熟期水层自然落干,拔节孕穗期、乳熟期可中度受旱(灌溉下限为饱和含水率的70%~80%),分蘖、抽穗开花期可轻度受旱(灌溉下限不能低于饱和含水率的80%);灌水定额为30~40 mm。该适宜灌溉模式可为鄂北地区至少可节水1.68亿m^3,具有巨大的节水潜力。研究结果对指导鄂北地区水稻灌溉用水和明晰节水重点具有重要意义。

关键词：灌溉腾发量模型 ORYZA_v3模型节水潜力

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