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Porous photothermal antibacterial antioxidant dual–crosslinked cryogel based on hyaluronic acid/polydopamine for non-compressible hemostasis and infectious wound repair

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Journal of Materials Science & Technology 2022年第26期121卷 207-219页

作者： Chunbo Wang yuqing liang Ying Huang Meng Li Baolin Guo Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China

Cryogel dressings with good absorption ability and photothermal antibacterial properties for preventing wound infections and treating infected wounds have attracted widespread *** this work,a series of cryogels with macroporous structure,antioxidant and photothermal properties were prepared based on adipic dihydrazide modified hyaluronic acid(HA-ADH),and dopamine(DA).The antioxidant properties,hemostatic properties,near infrared(NIR)assisted photothermal antibacterial ability provided by polydopamine,recyclable compression mechanical properties,and cytocompatibility were *** results demonstrated that the HA-ADH/DA cryogels have stable mechanical properties,great antibacterial properties against ***(EC)and methicillin-resistant ***(MRSA).The high swelling ratio due to the high water retention of HA equipped the cryogels with the capability of absorbing exuded blood and excessive tissue fluid in the infected full-thickness skin defect model of *** cryogels demonstrated good cytocompatibility and antioxidant performance through cell tests and 1,1-diphenyl-2-methylbenzohydrazino(DPPH)scavenging efficiency *** cryogels showed enhanced blood-clotting index(BCI)and better hemostatic ability in the mouse liver trauma model and the rat deep noncompressible liver defect model compared with gauze and gelatin ***,compared with commercial TegadermTMdressing in vivo,the HA-ADH/DA cryogels could greatly promote infected skin wound healing in a full-thickness infected skin defect wound *** summary,the macroporous HAADH/DA cryogels with good antioxidant,high swelling ratio,photothermal antibacterial property,and biocompatibility are a promising hemostatic material and wound healing dressing.

关键词： Dopamine-hyaluronic acid-based cryogels Antioxidant Photothermal antibacterial Wound healing Hemostasis

Bioinspired Injectable Self-Healing Hydrogel Sealant with Fault-Tolerant and Repeated Thermo-Responsive Adhesion for Sutureless Post-Wound-Closure and Wound Healing

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Nano-Micro Letters 2022年第11期14卷 256-274页

作者： yuqing liang Huiru Xu Zhenlong Li Aodi Zhangji Baolin Guo State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049People’s Republic of China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710049People’s Republic of China

Hydrogels with multifunctionalities,including sufficient bonding strength,injectability and self-healing capacity,responsive-adhesive ability,fault-tolerant and repeated tissue adhesion,are urgently demanded for invasive wound closure and wound *** by the adhesive mechanism of mussel and brown algae,bioinspired dynamic bonds cross-linked multifunctional hydrogel adhesive is designed based on sodium alginate(SA),gelatin(GT)and protocatechualdehyde,with ferric ions added,for sutureless *** dynamic hydrogel cross-linked through Schiff base bond,catechol-Fe coordinate bond and the strong interaction between GT with temperature-dependent phase transition and SA,endows the resulting hydrogel with sufficient mechanical and adhesive strength for efficient wound closure,injectability and self-healing capacity,and repeated closure of reopened ***,the temperature-dependent adhesive properties endowed mispositioning hydrogel to be removed/repositioned,which is conducive for the fault-tolerant adhesion of the hydrogel adhesives during ***,the hydrogels present good biocompatibility,near-infrared-assisted photothermal antibacterial activity,antioxidation and repeated thermo-responsive reversible adhesion and good hemostatic *** in vivo incision closure evaluation demonstrated their capability to promote the post-wound-closure and wound healing of the incisions,indicating that the developed reversible adhesive hydrogel dressing could serve as versatile tissue sealant.

关键词： Bioinspired injectable hydrogel Tissue sealant Temperature-dependent adhesion Reversible adhesion Wound healing

Small molecule SMU-CX24 targeting toll-like receptor 3 counteracts inflammation:A novel approach to atherosclerosis therapy

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Acta Pharmaceutica Sinica B 2022年第9期12卷 3667-3681页

作者： Xiaohong Cen Baoqu Wang yuqing liang Yanlin Chen Yu Xiao Shaohua Du Kutty Selva Nandakumar Hang Yin Shuwen Liu Kui Cheng Guangdong Provincial Key Laboratory of New Drug Screening and State Key Laboratory of Organ Failure Research School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Musculoskeletal Oncology the Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510642China School of Pharmaceutical Sciences Beijing Advanced Innovation Center for Structural BiologyTsinghua-Peking Joint Center for Life SciencesTsinghua UniversityBeijing 100084China

Toll-like receptor 3(TLR3),as an important pattern recognition receptor(PRR),dominates the innate and adaptive immunity regulating many acute and chronic inflammatory *** is proved as an inflammatory disease,and inflammatory events involved in the entire process of initiation and ***,the contribution of TLR3 to atherosclerosis remains ***,we identified the clinical relevance of TLR3 upregulation and disease processes in human ***,activation of TLR3 also directly led to significant expression of atherogenic chemokines and adhesion ***,silencing TLR3 inhibited the uptake of oxLDL by macrophages and significantly reduced foam cell *** the aberrance in TLR3 functions on atherosclerosis progression,we hypothesized that TLR3 could serve as novel target for clinical atherosclerosis ***,we developed the novel ellipticine derivative SMU-CX24,which specifically inhibited TLR3(IC_(50)=18.87±2.21 nmol/L).In vivo,atherosclerotic burden was alleviated in Western diet fed ApoE^(−/−)mice in response to SMU-CX24 treatment,accompanying notable reductions in TLR3 expression and inflammation infiltration within atherosclerotic ***,for the first time,we revealed that pharmacological downregulation of TLR3 with specific inhibitor regenerated inflammatory environment to counteract atherosclerosis progression,thereby proposing a new strategy and probe for atherosclerosis therapy.

关键词： Toll-like receptor 3 Atherosclerosis Small molecule Inflammation Macrophage

Desiccation tolerance in bryophytes： the rehydration proteomes of Bryum argenteum provide insights into the resuscitation mechanism

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Journal of Arid Land 2018年第1期10卷 152-167页

作者： GAO Bei ZHANG Daoyuan LI Xiaoshuang YANG Honglan liang yuqing CHEN Moxian ZHANG Yuanming ZHANG Jianhua Andrew WOOD Key Laboratory of Biogeography and Bioresource in Arid Land Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China School of Life Sciences and State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongHong KongChina Department of Biology Faculty of ScienceHong Kong Baptist UniversityHong KongChina Department of Plant Biology Southern Illinois University-CarbondaleCarbondaleIL 62901-6509USA

Bryum argenteum Hedw. is a desiccation tolerant bryophyte and belongs to one of the most important components of the biological soil crusts （BSCs） found in the deserts of Central Asia. Limited information is available on rehydration-responsive proteins in desiccation tolerant plants. As a complement to our previous research analyzing the rehydration transcriptome, we present a parallel quantitative proteomic effort to study rehydration-responsive proteins. Bryophyte gametophores were desiccated （Dry） and rehydrated for 2 h （R2） and 24 h （R24）. Proteins from Dry, R2 and R24 gametophores were labeled by isobaric tags for relative and absolute quantitation （iTRAQ） to determine the relative abundance of rehydration-responsive proteins. A total of 5503 non-redundant protein sequences were identified and 4772 （86.7%） protein sequences were annotated using Gene Ontology （GO） terms and Pfam classifications. Upon rehydration 239 proteins were elevated and 461 proteins were reduced as compared to the desiccated protein sample. Differentially up-regulated proteins were classified into a number of categories including reactive oxygen species scavenging enzymes, detoxifying enzymes, Late Embryogenesis Abundant （LEA） proteins, heat shock proteins, proteasome components and proteases, and photosynthesis and translation related proteins. Furthermore, the results of the correlation between transcriptome and proteome revealed the discordant changes in the expression between protein and mRNA.

关键词： desiccation tolerance B*Tum Physcomitrellapatens proteome iTRAQ rehydration

Application Status of Enhanced Recovery After Surgery in Perioperative Nursing of Neurosurgery

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Journal of Clinical and Nursing Research 2022年第6期6卷 1-6页

作者： Ying Wu yuqing liang Hao Chen Lixia Xue Department of Neurosurgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

Enhanced recovery after surgery(ERAS)is a strategy of perioperative management aimed to accelerate the rehabilitation of patients through various optimized perioperative managements as well as ongoing adherence to a patient-focused,multidisciplinary,and multimodal *** is a good reflection of the perioperative value-based care,which has been widely applied in many surgical fields and shown quick recovery and low morbidity when applied on ***,there is a lack of attention on ERAS in *** review aims to describe the current application status of ERAS in neurosurgery and to provide readers with the commonly accepted principles in the perioperative nursing of neurosurgery.

关键词： Application status Enhanced recovery after surgery Neurosurgery Nursing

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抗偏移混合拓扑恒流无线充电系统研究

电力系统保护与控制 2024年第15期52卷 105-114页

作者：梁雨晴唐忠上海电力大学电气工程学院上海200090

针对电动汽车无线充电系统因偏移导致充电效率降低的实际问题,提出一种新型强抗偏移的恒流无线充电系统。首先,在磁耦合设计上,引入DDQD大解耦线圈有效减缓X、Y两方向偏移耦合系数衰减,通过与DDQ线圈的对比体现所提出的DDQD线圈在抗偏... 详细信息

针对电动汽车无线充电系统因偏移导致充电效率降低的实际问题,提出一种新型强抗偏移的恒流无线充电系统。首先,在磁耦合设计上,引入DDQD大解耦线圈有效减缓X、Y两方向偏移耦合系数衰减,通过与DDQ线圈的对比体现所提出的DDQD线圈在抗偏移方面的优越性。然后,在补偿拓扑设计上,通过DDQD线圈将随耦合系数呈不同变化趋势的LCC拓扑和LC拓扑进行串联,使输出功率变化平缓,进一步提高了系统的抗偏移能力,并且使系统具有恒流输出特性。最后,通过仿真实验验证了该方案的有效性,在磁耦合机构发生偏移时,减缓了无线充电系统的线圈耦合系数和传输效率的下降程度,具有一定的现实意义。

关键词：电动汽车无线电能传输恒流输出抗偏移串联混合型

Multi‑Functional Fibrous Dressings for Burn Injury Treatment with Pain and Swelling Relief and Scarless Wound Healing

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Advanced Fiber Materials 2023年第6期5卷 1963-1985页

作者： Zhengchao Yuan Yue Zhao Muhammad Shafiq Jiahui Song Jing Hou yuqing liang Xiao Yu Yujie Chen Fan Yu Mohamed EL‑Newehy Hany EL‑Hamshary Yosry Morsi Shichao Jiang Hui Zheng Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620People’s Republic of China Department of Chemical Engineering Faculty of EngineeringGraduate SchoolKyushu UniversityFukuoka 819‑0395Japan United Graduate School of Drug Discovery and Medical Information Sciences Gifu University1‑1 YanagidoGifu 501‑1193Japan Department of Orthopedics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021People’s Republic of China Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 245511451 RiyadhSaudi Arabia Faculty of Engineering and Industrial Sciences Swinburne University of TechnologyBoroondaraVIC 3122Australia Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117People’s Republic of China Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji University School of MedicineShanghai 200443People’s Republic of China

As one of the most common forms of skin injuries,skin burns are often accompanied by edema pain,suppuration of infection,slow tissue regeneration,and severe scar formation,which significantly delay wound healing as well as affect the quality of *** prepared multifunctional electrospun poly(L-lactide-co-glycolide)/gelatin(P/G)-based dressings to synergistically harness the therapeutic benefits of peppermint essential oil(T),burn ointment(B),and Oregano essential oil(O)(P/G@TBO)for skin regeneration in punch and burn injury *** P/G@TBO can afford the sustained release of bioactive cues for up to 72 h as well as remarkably promote cell migration(ca.P/G@TBO,89%*** group,51%)at 24 *** P/G@TBO membranes also showed significant angiogenic effect as well as antibacterial and anti-inflammatory properties than that of the control group in ***,P/G@TBO dressings enabled fast wound healing(ca.P/G@TBO,100%wound closure *** group,95%)in a full-thickness excisional defect model up to 14 days in *** evaluation of membranes in different animal models,including tail wagging model,facial itch model,and hot burn injury model showed significant pain relieve effect as well as itching and swelling relief functions during earlier stages of wound *** were next transplanted into a scalded wound model in rats and an ear punch wound model in rabbits,which manifested antibacterial and anti-inflammatory properties and promoted re-epithelialization to achieve scarless wound healing percentage wound closure at day 28:P/G@TBO,96%*** group 66%.Taken together our approach of simultaneously harnessing T,B,and O to enable multifunctionality to fibrous dressings may hold great promise for burn wound healing applications and other related disciplines.

关键词： Burn injury Wound healing Skin regeneration Pain and swelling relief Nanofiber membrane

Prevalence of Metabolic Obese Normal Weight and Related Risk Factors in South China

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Medicinal Plant 2021年第2期12卷 74-78页

作者： Xuehua LUO Zien liang Yan LI Qingbin WU Zhiqiang PAN yuqing liang Lingyu LI Juanjuan MAI Huijun XIE Li HAN Department of Traditional Chinese Medicine The First Affiliated Hospital of Jinan University Guangzhou 510630 China College of Traditional Chinese Medicine Jinan University Guangzhou 510632 China Information Section The First Affiliated Hospital of Jinan University Guangzhou 510630 China

[Objectives]Metabolic obese normal weight(MONW)is becoming one of the pubic problems which are threatening human ***,MONW was facing a great challenge for limited attention,especially for the female in *** aim of this research was to estimate the prevalence of MONW and its related risk components in South China.[Methods]A community-based cross-sectional study was performed on 3349 residents aged 18-93 years in The First Affiliated Hospital of Jinan University,Guangzhou,China,in *** was collected by physical examination data which included physical measurements and laboratory examinations.[Results]In all subjects,55%were females(M/F=1509/1840).The prevalence of MONW was 16.09%(0.04%for male,16.05%for female,P<0.001).The prevalence increased significantly with increasing age in both genders(P<0.001).The binary logistic regression analysis shows that among the risk factors with MONW,age,BMI,gender,systolic pressure,hypertension[Male:ORs=2.56,95%CI(1.23,5.32);Female:ORs=2.88,95%CI(1.76,4.71)]and hypertriglyceridemia[Male:ORs=3.23,95%CI(1.67,6.19);Female:ORs=2.57,95%CI(1.64,4.03)]were found to be statistically *** level of ALT in MONW group was(27.88±15.85)in male and(24.33±15.75)in female,which were significantly higher than those in the non-MetS group.[Conclusions]The prevalence of MONW was pretty *** considered MONW be significantly associated with the increase of *** gender,advanced age,and elevated ALT were independent risk factors for *** was high time that the government should raise the public attention toward metabolic function in normal weight *** prevention and treatment strategies for MONW and its risk factors should be developed targeting different ages and genders.

关键词： Metabolic Obese Normal Weight Prevalence Related risk factor

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某大跨度悬挂板MTMD减振控制

安徽建筑大学学报 2018年第6期26卷 1-7页

作者：梁玉青湖北工业大学土木建筑与环境学院湖北武汉430068

大跨度悬挂楼板动力特性复杂,在行人荷载下容产生较大的竖向振动,不能满足舒适度的要求。针对某大跨悬挂板舒适度问题,根据大跨悬挂板的模态特性,设计了多调谐质量阻尼器减振系统的加装位置及参数,并综合考虑了连续行走、连续跑动、连... 详细信息

大跨度悬挂楼板动力特性复杂,在行人荷载下容产生较大的竖向振动,不能满足舒适度的要求。针对某大跨悬挂板舒适度问题,根据大跨悬挂板的模态特性,设计了多调谐质量阻尼器减振系统的加装位置及参数,并综合考虑了连续行走、连续跑动、连续跳跃和小组结伴行走等不同行人荷载工况。分析结果表明,大跨悬挂板在无控状况下产生了较大的竖向振动响应,其竖向加速度响应超过了舒适度设计限值要求,而在悬挂板1阶竖向振型最大加速度响应节点1311位置附近加装MTMD后,在共振工况下楼板振动最激烈位置减振效果达到43.8%以上,确保了大跨悬挂板在共振状态下也满足舒适度要求。

关键词：多调谐质量阻尼器减振系统(MTMDS) 大跨悬挂板舒适度振动共振