Multi‑Functional Fibrous Dressings for Burn Injury Treatment with Pain and Swelling Relief and Scarless Wound Healing
作者机构：State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsShanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620People’s Republic of China Department of Chemical EngineeringFaculty of EngineeringGraduate SchoolKyushu UniversityFukuoka 819‑0395Japan United Graduate School of Drug Discovery and Medical Information SciencesGifu University1‑1 YanagidoGifu 501‑1193Japan Department of OrthopedicsShandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021People’s Republic of China Department of ChemistryCollege of ScienceKing Saud UniversityP.O.Box 245511451 RiyadhSaudi Arabia Faculty of Engineering and Industrial SciencesSwinburne University of TechnologyBoroondaraVIC 3122Australia Medical Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250117People’s Republic of China Department of Thoracic SurgeryShanghai Pulmonary HospitalTongji University School of MedicineShanghai 200443People’s Republic of China
出 版 物：《Advanced Fiber Materials》 (先进纤维材料（英文）)
年 卷 期：2023年第5卷第6期
页 面：1963-1985页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：Science and Technology Commission of Shanghai Municipality(No.20S31900900,20DZ2254900) Sino German Science Foundation Research Exchange Center(M-0263) Taishan Scholars Program of Shandong Province(tsqn201812141) Shandong Provincial Natural Science Foundation(ZR2021MH004) Academic promotion program of Shandong First Medical University(2019RC016) Researchers Supporting Project Number(RSP2023R65) King Saud University,Riyadh,Saudi Arabia,China Education Association for International Exchange(2022181) Donghua University Postgraduate Innovation and Entrepreneurship Ability Training Program(yjssc2023002) Grant-in-Aid for JSPS Research Fellows(JP21F21353) M.S.is an International Research Fellow of the Japan Society for the Promotion of Science(Postdoctoral Fellowships for Research in Japan(Standard)) M.S.is keenly grateful to the Gifu University,Japan for Special Cooperative Research Program and College of Biological Science and Medical Engineering,Donghua University,Shanghai,China for cooperative research
主 题：Burn injury Wound healing Skin regeneration Pain and swelling relief Nanofiber membrane
摘 要：As one of the most common forms of skin injuries,skin burns are often accompanied by edema pain,suppuration of infection,slow tissue regeneration,and severe scar formation,which significantly delay wound healing as well as affect the quality of *** prepared multifunctional electrospun poly(L-lactide-co-glycolide)/gelatin(P/G)-based dressings to synergistically harness the therapeutic benefits of peppermint essential oil(T),burn ointment(B),and Oregano essential oil(O)(P/G@TBO)for skin regeneration in punch and burn injury *** P/G@TBO can afford the sustained release of bioactive cues for up to 72 h as well as remarkably promote cell migration(ca.P/G@TBO,89%*** group,51%)at 24 *** P/G@TBO membranes also showed significant angiogenic effect as well as antibacterial and anti-inflammatory properties than that of the control group in ***,P/G@TBO dressings enabled fast wound healing(ca.P/G@TBO,100%wound closure *** group,95%)in a full-thickness excisional defect model up to 14 days in *** evaluation of membranes in different animal models,including tail wagging model,facial itch model,and hot burn injury model showed significant pain relieve effect as well as itching and swelling relief functions during earlier stages of wound *** were next transplanted into a scalded wound model in rats and an ear punch wound model in rabbits,which manifested antibacterial and anti-inflammatory properties and promoted re-epithelialization to achieve scarless wound healing percentage wound closure at day 28:P/G@TBO,96%*** group 66%.Taken together our approach of simultaneously harnessing T,B,and O to enable multifunctionality to fibrous dressings may hold great promise for burn wound healing applications and other related disciplines.
维普期刊数据库
