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Chinese Physics Letters 2011年第1期28卷 205-207页

作者： liang hui-min WANG Jing-Quan College of Science Hebei University of Engineering Handan 056038 Department of Physics Sichuan University Chengdu 610064

Second-exciting surface-polasmon-polariton （SPP） interference lithography （SE-SPPIL） designed by an improving attenuated total reflection （ATR） mode is suggested for fabricating metal nanograting. A metal film coated under a prism excites SPP first, and then the SPP energy transmits into another metal film and launches SPP again. An interlayer between two metal films is a thin resist coated on the second metal film. An interference nanopattern is formed in the resist when two SPP waves are launched symmetrically. After development, chemical or physical etching, the nanopattern is transferred into the metal film. A random thickness metal grating can be achieved as the thickness of the second metal film does not influence the interference pattern intensity. This scheme is promising for fabricating metal nanograting at low cost.

关键词： Condensed matter: electrical, magnetic and optical Optics, quantum optics and lasers Nanoscale science and low-D systems

香豆素类化合物的生物合成关键酶及活性研究进展

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中国中药杂志 2024年第14期49卷 3693-3705页

作者：吕华伟梁慧敏朱梦迪王鸿李行诺浙江工业大学药学院浙江省中药大健康产品创新研发与数智化制造中医药重点实验室浙江湖州313000 浙江工业大学分析测试中心浙江杭州310014

香豆素是一类以苯骈α-吡喃环为母核的天然产物,许多香豆素衍生物具有多种药理活性,如抗菌、抗炎、抗肿瘤、抗凝血、抗骨质疏松、杀虫等,在医药、农业领域发挥了重要作用。香豆素衍生物的开发利用一直备受关注。随着基因测序技术的成熟... 详细信息

香豆素是一类以苯骈α-吡喃环为母核的天然产物,许多香豆素衍生物具有多种药理活性,如抗菌、抗炎、抗肿瘤、抗凝血、抗骨质疏松、杀虫等,在医药、农业领域发挥了重要作用。香豆素衍生物的开发利用一直备受关注。随着基因测序技术的成熟以及合成生物学的快速发展,香豆素衍生物的生物合成研究已取得许多重要进展,也日益受到国内外学者的关注。该文综述了目前已报道的香豆素衍生物的生物合成关键酶,如细胞色素P450酶(cytochrome P450 enzyme,CYP450)、异戊烯基转移酶(prenyltransferase,PT)、UDP-葡萄糖基转移酶(UDP-glucosyltransferase,UGT)等,并对其在抗肿瘤、抗炎、抗氧化、抗菌等方面的药理活性进行系统总结,期望为香豆素衍生物的生物合成研究及其药用潜力的进一步挖掘提供参考价值。

关键词：香豆素细胞色素P450酶异戊烯基转移酶葡萄糖基转移酶生物活性

Discussion on dynamic reliability tolerance design technology of electromagnetic relay

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第3期8卷 439-443页

作者： YE Xue-rong liang hui-min ZHAI Guo-fu School of Electrical Engineering and Automation Harbin Institute of Technology Harbin 150001 China

Reliability tolerance design of electromagnetic relay during its design period plays an essential role in guaranteeing the consistencies of reliability and output characteristic. The reliability tolerance design can ensure that the products would work well under the influence of disturbing factors (including internal interference, external interference, and machining dispersion). Com- pared with static characteristic, dynamic characteristic of electromagnetic relay can describe its operating process better. This article researches influence of the three kinds of disturbing factors on the dynamic characteristic of electromagnetic relay based on calculating dynamic characteristic. Then, the dynamic reliability tolerance design method of electromagnetic relay is discussed considering three kinds of disturbing factors. Conclusions reached can help to assure the reliability of electromagnetic relay from the beginning of design.

关键词： Electromagnetic relay Tolerance design Reliability Dynamic characteristic

Rapid detection of nanoplastic particles by a luminescent Tb-based coordination polymer

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Chinese Chemical Letters 2024年第5期35卷 529-533页

作者： Tiankai Sun hui min Zongsu Han liang Wang Peng Cheng Wei Shi Department of Chemistry College of ChemistryNankai UniversityTianjin 300071China State Key Laboratory of Separation Membranes and Membrane Processes School of Environmental Science and EngineeringTiangong UniversityTianjin 300387China Key Laboratory of Advanced Energy Materials Chemistry(MOE) Frontiers Science Center for New Organic Matter and Renewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

Nanoplastics(NPs)in aqueous environment have become a category of emerging pollutants on account of their potential risks to both human health and *** detection of NPs is a great challenge due to the lack of sensitive and selective sensing materials with fast response time and wide sensing range of particle ***,a Tb-based coordination polymer has been synthesized for luminescent detection of nanopolystyrene with different particle sizes in aqueous solutions,showing a low limit of detection,fast response time within 10 s and high selectivity in the presence of other ***“turn-on”sensing mechanism is studied in *** work provides a facile method for the fast detection of NPs.

关键词： Coordination polymer Nano polystyrene Luminescent detection Sensing mechanism Water safety

The low Mach number limit of non-isentropic magnetohydrodynamic equations with large temperature variations in bounded domains

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Science China Mathematics 2024年第4期67卷 787-818页

作者： min liang Yaobin Ou School of Mathematics Renmin University of ChinaBeijing 100872China

This paper verifies the low Mach number limit of the non-isentropic compressible magnetohydrodynamic(MHD)equations with or without the magnetic diffusion in a three-dimensional bounded domain when the temperature variation is large but *** uniform estimates of strong solutions are established in a short time interval independent of the Mach number,provided that the slip boundary condition for the velocity and the Neumann boundary condition for the temperature are imposed and the initial data is well-prepared.

关键词： low Mach number limit non-isentropic compressible magnetohydrodynamic equations large temperature variations bounded domains

Hepatic　arterial　infusion　chemotherapy　and　embolization　in　the　treatment　of　primary　hepatic　carcinoma

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World Journal of Gastroenterology 1997年第2期3卷 47-50页

作者： ZHENG Chuan Sheng, FENG Gan Sheng, ZHOU Ru ming, liang Bo, liang hui min, ZHEN Jun, YU Jian ming and LIU hui

AIM To study the effects of hepatic arterial infusion chemotherapy (HAI) or embolization (HAE) in the treatment of primary hepatic carcinoma (PHC) and the factors influencing the effects. METHODS Follow up information in 188 patients (166 males and 22 females) with PHC treated with HAI ( n =82) or HAE ( n =106) were analyzed retrospectively. RESULTS The overall therapeutic effects were as follows: symptomatic relief in 59 6%; tumor shrinkage in 55%, blood AFP decrease in 37 8% and the overall survival rates of 1/2, 1, 2 and 3 years after treatment being 75 4%, 46%, 23 5% and 14 7%, respectively. The mean survival time was 12 2 months and the longest survival period was 50 months after treatment. In the HAI group the 1/2, 1, 2 and 3 years survival rates were 61 0%, 25 4%, 4 5% and 0%, respectively, the mean survival time being 7 7 months; in the HAE group the survival rates were 86 8%, 61 7%, 37 8% and 26 1%, respectively, the mean survival time being 15 7 months. Eighteen patients received secondary surgery. Seven factors influencing the therapeutic effects were analyzed. CONCLUSION Those cases of PHC with or without mild liver cirrhosis, stages Ⅰ and Ⅱ, single tumor, tumor size less than 10cm in diameter, no cancerous thrombus within the portal vein or hepatic arterio venous fistula, and HAE treatment time more than 3 times had better therapeutic effects than the contrast cases. To overcome these influencing factors and to adopt the comprehensive therapy would improve the effects of HAI or HAE in the treatment of PHC.

关键词： liver neoplasms/therapy chemoembolization, therapeutic

Ligand-controlled NiH-catalyzed regiodivergent hydroalkylation of 2-alkenylazaarenes

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Science China Chemistry 2024年第6期67卷 1935-1940页

作者： Ya-Ping Shao Zhuo-min Chi Yong-min liang State Key Laboratory of Applied Organic Chemistry School of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou730000China

A nickel-hydride(Ni H)-catalyzed migratory and nonmigratory hydroalkylation reaction of 2-alkenyl azaarenes with alkyl iodines has been established through strategic modulation of N-or P-donor *** method enables the synthesis of diverseβ-orγ-branched aromatic *** mild regiodivergent protocols exhibit wide substrate scope,excellent functional tolerance,and great reaction yield with remarkable ***,deuterium labeling studies reveal Ni H-catalyzed interrupted chain-walking mode as the mechanism behind remotedβ-selective hydroalkylation reaction—an interesting phenomenon mediated through aromatic imine directing groups.

关键词： NiH regiodivergent hydroalkylation azaarenes interrupted chain-walking

Impact of propofol and sevoflurane anesthesia on cognition and emotion in gastric cancer patients undergoing radical resection

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 79-89页

作者： Ao-Han Li Su Bu Ling Wang Ai-min liang hui-Yu Luo Department of Anesthesiology Xiangyang No.1 People's HospitalHubei University of MedicineXiangyang 441000Hubei ProvinceChina Department of Cardiothoracic Surgery Xiangyang No.1 People's HospitalHubei University of MedicineXiangyang 441000Hubei ProvinceChina Department of Rehabilitation Xiangyang No.1 People's HospitalHubei University of MedicineXiangyang 441000Hubei ProvinceChina Department of Internal Medicine-Cardiovascular Xiangyang No.1 People's HospitalHubei University of MedicineXiangyang 441000Hubei ProvinceChina

BACKGROUND Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric ***,there is a debate concerning their differential effects on cognitive function,anxiety,and depression in patients undergoing this *** To compare the effects of propofol and sevoflurane anesthesia on postoperative cognitive function,anxiety,depression,and organ function in patients undergoing radical resection of gastric *** A total of 80 patients were involved in this *** subjects were divided into two groups:Propofol group and sevoflurane *** evaluation scale for cognitive function was the Loewenstein occupational therapy cognitive assessment(LOTCA),and anxiety and depression were assessed with the aid of the self-rating anxiety scale(SAS)and self-rating depression scale(SDS).Hemodynamic indicators,oxidative stress levels,and pulmonary function were also *** The LOTCA score at 1 d after surgery was significantly lower in the propofol group than in the sevoflurane ***,the SAS and SDS scores of the sevoflurane group were significantly lower than those of the propofol *** sevoflurane group showed greater stability in heart rate as well as the mean arterial pressure compared to the propofol ***,the sevoflurane group displayed better pulmonary function and less lung injury than the propofol *** Both propofol and sevoflurane could be utilized as maintenance anesthesia during radical resection of gastric *** anesthesia has a minimal effect on patients'pulmonary function,consequently enhancing their postoperative *** anesthesia causes less impairment on patients'cognitive function and mitigates negative emotions,leading to an improved postoperative mental ***,the selection of anesthetic agents should be based on the individual patient's specific circumstances.

关键词： Propofol Sevoflurane Radical resection of gastric cancer Anesthetic effect Cognitive function Negative emotion

Review and comparison of methods and benchmarks for automatic modal identification based on stabilization diagram

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第2期11卷 209-224页

作者： min He Peng liang Jiuxian Liu Zhiqiang liang School of Architecture and Civil Engineering Xi'an University of Science and TechnologyXi'an 710064China School of Highway Chang'an UniversityXi'an 710064China

Automatic modal identification via automatically interpreting the stabilization diagram provides key technique in bridge structural health *** paper reviews the progress in the area of automatic modal identification based on interpreting the stabilization *** whole identification process is divided into four steps from establishing the stabilization diagram to removing the outliers in the identification *** criteria and algorithms used in each step in the existing studies are carefully summarized and *** between typical methods in cleaning and interpreting the stabilization diagram are also *** structure benchmarks used in the existing studies to validate the proposed automatic modal identification methods are also *** on the review and comparison,the specific ratio method for cleaning the stabilization diagram,the hierarchical clustering method for interpreting the stabilization diagram and the adjusted boxplot for removing the outliers in the identification results are the most suitable methods for each *** key point of automatic modal identification based on interpreting the stabilization diagram has also discussed,and it is recommended to pay more attention to cleaning the stabilization *** study about automatic modal identification under situation with very few sensors deployed should be more *** review aims to help researchers and practitioners in implementing existing automatic modal identification algorithms effectively and developing more suitable and practical methods for civil engineering structures in the future.

关键词： Bridge structural health monitoring Automatic modal identification Stabilization diagram Eriteria and methods Real structure benchmarks

Rheum palmatum L. and Salvia miltiorrhiza Bge. Alleviates Acute Pancreatitis by Regulating Th17 Cell Differentiation: An Integrated Network Pharmacology Analysis, Molecular Dynamics Simulation and Experimental Validation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 408-420页

作者： FENG min-chao LUO Fang HUANG liang-jiang LI Kai CHEN Zu-min LI hui YAO Chun QIN Bai-jun CHEN Guo-zhong The First Clinical Medical College Guangxi University of Traditional Chinese MedicineNanning 530000China Guangxi Key Laboratory of Molecular Biology of Traditional Chinese Medicine and Preventive Medicine Nanning 530000China Graduate School Guangxi University of Traditional Chinese MedicineNanning 530000China Department of Gastroenterology the First Affiliated Hospital of Guangxi University of Traditional Chinese MedicineNanning 530023China

Objective: To identify the core targets of Rheum palmatum L. and Salvia miltiorrhiza Bge.,(Dahuang-Danshen, DH-DS) and the mechanism underlying its therapeutic efficacy in acute pancreatitis(AP)using a network pharmacology approach and validate the findings in animal experiments. Methods: Network pharmacology analysis was used to elucidate the mechanisms underlying the therapeutic effects of DH-DS in AP. The reliability of the results was verified by molecular docking simulation and molecular dynamics ***, the results of network pharmacology enrichment analysis were verified by immunohistochemistry,Western blot analysis and real-time quantitative PCR, respectively. Results: Sixty-seven common targets of DH-DS in AP were identified and mitogen-activated protein kinase 3(MAPK3), Janus kinase 2(JAK2), signal transducer and activator of transcription 3(STAT3), protein c-Fos(FOS) were identified as core targets in the protein interaction(PPI) network analysis. Gene ontology analysis showed that cellular response to organic substance was the main functions of DH-DS in AP, and Kyoto Encyclopedia of Genes and Genomes analysis showed that the main pathway included Th17 cell differentiation. Molecular docking simulation confirmed that DH-DS binds with strong affinity to MAPK3, STAT3 and FOS. Molecular dynamics simulation revealed that FOS-isotanshinone Ⅱ and STAT3-dan-shexinkum d had good binding capacity. Animal experiments indicated that compared with the AP model group, DH-DS treatment effectively alleviated AP by inhibiting the expression of interleukin-1β, interleukin-6 and tumor necrosis factor-α, and blocking the activation of Th17 cell differentiation(P<0.01). Conclusion: DH-DS could inhibit the expression of inflammatory factors and protect pancreatic tissues,which would be functioned by regulating Th17 cell differentiation-related m RNA and protein expressions.

关键词： Rheum palmatum L. Salvia miltiorrhiza Bge. molecular docking simulation network pharmacology acute pancreatitis Th17 cell differentiation