Ligand-controlled NiH-catalyzed regiodivergent hydroalkylation of 2-alkenylazaarenes
作者机构:State Key Laboratory of Applied Organic ChemistrySchool of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou730000China
出 版 物:《Science China Chemistry》 (中国科学(化学英文版))
年 卷 期:2024年第67卷第6期
页 面:1935-1940页
核心收录:
学科分类:081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金:supported by the Dalian Institute of Chemical Physics,the Chinese Academy of Sciences the National Natural Science Foundation of China(21472186,21272231)
主 题:NiH regiodivergent hydroalkylation azaarenes interrupted chain-walking
摘 要:A nickel-hydride(Ni H)-catalyzed migratory and nonmigratory hydroalkylation reaction of 2-alkenyl azaarenes with alkyl iodines has been established through strategic modulation of N-or P-donor *** method enables the synthesis of diverseβ-orγ-branched aromatic *** mild regiodivergent protocols exhibit wide substrate scope,excellent functional tolerance,and great reaction yield with remarkable ***,deuterium labeling studies reveal Ni H-catalyzed interrupted chain-walking mode as the mechanism behind remotedβ-selective hydroalkylation reaction—an interesting phenomenon mediated through aromatic imine directing groups.