Impact of propofol and sevoflurane anesthesia on cognition and emotion in gastric cancer patients undergoing radical resection

作     者：Ao-Han Li Su Bu Ling Wang Ai-Min Liang Hui-Yu Luo 

作者机构：Department of AnesthesiologyXiangyang No.1 People's HospitalHubei University of MedicineXiangyang 441000Hubei ProvinceChina Department of Cardiothoracic SurgeryXiangyang No.1 People's HospitalHubei University of MedicineXiangyang 441000Hubei ProvinceChina Department of RehabilitationXiangyang No.1 People's HospitalHubei University of MedicineXiangyang 441000Hubei ProvinceChina Department of Internal Medicine-CardiovascularXiangyang No.1 People's HospitalHubei University of MedicineXiangyang 441000Hubei ProvinceChina 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2024年第16卷第1期

页      面：79-89页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Propofol Sevoflurane Radical resection of gastric cancer Anesthetic effect Cognitive function Negative emotion 

摘      要：BACKGROUND Propofol and sevoflurane are commonly used anesthetic agents for maintenance anesthesia during radical resection of gastric ***,there is a debate concerning their differential effects on cognitive function,anxiety,and depression in patients undergoing this *** To compare the effects of propofol and sevoflurane anesthesia on postoperative cognitive function,anxiety,depression,and organ function in patients undergoing radical resection of gastric *** A total of 80 patients were involved in this *** subjects were divided into two groups:Propofol group and sevoflurane *** evaluation scale for cognitive function was the Loewenstein occupational therapy cognitive assessment(LOTCA),and anxiety and depression were assessed with the aid of the self-rating anxiety scale(SAS)and self-rating depression scale(SDS).Hemodynamic indicators,oxidative stress levels,and pulmonary function were also *** The LOTCA score at 1 d after surgery was significantly lower in the propofol group than in the sevoflurane ***,the SAS and SDS scores of the sevoflurane group were significantly lower than those of the propofol *** sevoflurane group showed greater stability in heart rate as well as the mean arterial pressure compared to the propofol ***,the sevoflurane group displayed better pulmonary function and less lung injury than the propofol *** Both propofol and sevoflurane could be utilized as maintenance anesthesia during radical resection of gastric *** anesthesia has a minimal effect on patients pulmonary function,consequently enhancing their postoperative *** anesthesia causes less impairment on patients cognitive function and mitigates negative emotions,leading to an improved postoperative mental ***,the selection of anesthetic agents should be based on the individual patient s specific circumstances.