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早产小于胎龄儿校正0~24月龄追赶生长的纵向研究

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中国当代儿科杂志 2024年第1期26卷 72-80页

作者：李佳美谢群英文羽祺宋燕燕梁会营胡艳广州市妇女儿童医疗中心儿童保健部广东广州510623 中国医科大学公共卫生学院辽宁沈阳110122

目的了解早产小于胎龄儿(small for gestational age,SGA)和适于胎龄儿(appropriate for gestational age,AGA)校正0~24月龄期间生长发育状况和差异,为早产儿早期健康干预提供依据。方法回顾性选取2019年7月—2022年7月在广州市妇女儿... 详细信息

目的了解早产小于胎龄儿(small for gestational age,SGA)和适于胎龄儿(appropriate for gestational age,AGA)校正0~24月龄期间生长发育状况和差异,为早产儿早期健康干预提供依据。方法回顾性选取2019年7月—2022年7月在广州市妇女儿童医疗中心定期保健的824例早产儿作为研究对象,其中SGA 144例,AGA 680例。分析和比较SGA组和AGA组出生及校正0~24月龄的体格发育数据。结果SGA组在校正0~18月龄期间的体重和身长均落后于同月龄AGA组(P0.05)。校正24月龄时,85%(34/40)SGA早产儿和79%(74/94)AGA早产儿完成追赶生长。按胎龄分层分析的结果显示:胎龄<34周SGA亚组体重、身长在校正0~9月龄与胎龄<34周和≥34周AGA亚组比较差异有统计学意义(P<0.05);胎龄≥34周SGA亚组体重、身长分别在校正0~18月龄和校正0~12月龄与胎龄<34周和≥34周AGA亚组比较差异有统计学意义(P<0.05)。胎龄<34周和≥34周SGA早产儿追赶生长分别主要发生在校正0~12月龄、校正0~18月龄。结论SGA早产儿生命早期体格发育落后于AGA早产儿,但在校正24月龄时实现追赶生长的比例高于AGA早产儿。胎龄<34周SGA早产儿实现追赶生长的时间早于胎龄≥34周SGA早产儿。

关键词：小于胎龄儿适于胎龄儿体格发育追赶生长早产儿

Computed tomography perfusion imaging evaluation of angiogenesis in patients with pancreatic adenocarcinoma

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World Journal of Clinical Cases 2022年第8期10卷 2393-2403页

作者： Wen Liu Bo Yin Zong-hui liang Yang Yu Na Lu Department of Radiology Jinshan HospitalFudan UniversityShanghai 201508China Department of Radiology Huashan HospitalFudan UniversityShanghai 200000China Department of Radiology Huashan Hospital NorthFudan UniversityShanghai 200000China Department of Radiology Shanghai Jing’an District Central HospitalHuashan Hospital Jing’an BranchFudan UniversityShanghai 200000China

BACKGROUND Pancreatic adenocarcinoma is one of the most common malignant tumors of the digestive *** than 80%of patients with pancreatic adenocarcinoma are not diagnosed until late stage and have distant or local *** To investigate the value of computed tomography(CT)perfusion imaging in the evaluation of angiogenesis in pancreatic adenocarcinoma *** This is a retrospective cohort *** with pancreatic adenocarcinoma and volunteers without pancreatic diseases underwent CT perfusion imaging from December 2014 to August 2017 in Huashan Hospital,Fudan University Shanghai,*** A total number of 35 pancreatic adenocarcinoma patients and 33 volunteers were *** relative blood flow(r BF),and relative blood volume(r BV)were significantly lower in patients with pancreatic adenocarcinoma than in the control group(P<0.05).Conversely,the relative permeability in patients with pancreatic adenocarcinoma was significantly higher than that in controls(P<0.05).In addition,r BF,r BV,and the vascular maturity index(VMI)were significantly lower in gradeⅢ-Ⅳpancreatic adenocarcinoma than in gradeⅠ-Ⅱpancreatic adenocarcinoma(P<0.05).Vascular endothelial growth factor(VEGF),CD105-MVD,CD34-MVD,and angiogenesis rate(AR)were significantly higher in gradeⅢ-Ⅳpancreatic adenocarcinoma than in gradeⅠ-Ⅱpancreatic adenocarcinoma(P<0.05).Significant correlations between r BF and VEGF,CD105-MVD,AR,and VMI(P<0.01)were ***,the levels of r BV were statistically significantly correlated with those of VEGF,CD105-MVD,CD34-MVD,and VMI(P<0.01).CONCLUSION Perfusion CT imaging may be an appropriate approach for quantitative assessment of tumor angiogenesis in pancreatic adenocarcinoma.

关键词： Pancreatic adenocarcinoma Perfusion computed tomography Angiogenesis Evaluation Imaging Quantitative assessment

Biodegradable Poly(butylene adipate-co-terephthalate)/Poly(glycolic acid) Films: Effect of Poly(glycolic acid) Crystal on Mechanical and Barrier Properties

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Chinese Journal of Polymer Science 2023年第7期41卷 1123-1132页

作者： Hong-Wei Pan Ye Wang Shi-Ling Jia Yan Zhao Jun-Jia Bian hui-Li Yang Yan-Ping Hao Li-Jing Han hui-liang Zhang Key Laboratory of Polymer Ecomaterials Chinese Academy of SciencesChangchun Institute of Applied ChemistryChangchun130022China School of Pharmaceutical Sciences Changchun University of Chinese MedicineChangchun130117China Changchun University of Technology Changchun130012China Shandong Dawn Polymer Co. Ltd.Longkou265700China

Binary biodegradable polymers films, poly(butylene adipate-co-terephthalate)(PBAT) and poly(glycolic acid)(PGA), were prepared through batch melt mixing to obtain Film Ⅰ and Film Ⅱ under two different processing conditions. PGA crystals played a major role in enhancing the mechanical and barrier properties of the films. For Film Ⅰ, there were initial PGA crystals before the film blowing process, the PGA molecular chain further crystallized, forming the oriented crystallization of PGA. Moreover, the Xcand crystalline size in Film Ⅰ were higher than those in Film Ⅱ. Compared with the different processing methods, Film Ⅰ has excellent mechanical and oxygen barrier properties due to the crystallization and orientation. The tensile strength reached 45.0 MPa, and tear strength exceeded 138.2 kN/m, while the elongation at break was as high as 750% for PBAT/PGA 85/15 in Film Ⅰ. The WVTR, WVP coefficients, and OP coefficients of PBAT/PGA films were decreased obviously with increasing the PGA content both in Film Ⅰ and Film Ⅱ. Moreover, the barrier properties of oxygen in Film Ⅰ were better than that in Film Ⅱ. This work reveals a feasible processing technique by introducing of initial crystallization of PGA to blow PBAT/PGA films with excellent mechanical and barrier properties.

关键词： Poly(butylene adipate-co-terephthalate) Poly(glycolic acid)(PGA) Biodegradable polymers Films

Uniqueness on Difference Operators of Meromorphic Functions of Infinite Order

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Acta Mathematica Sinica,English Series 2024年第2期40卷 511-527页

作者： hui LI Ming liang FANG Xiao YAO School of Science China University of Mining and TechnologyBeijing 100083P.R.China Institute of Mathematics Academy of Mathematics and System SciencesChinese Academy of SciencesBeijing 100190P.R.China School of Sciences Hangzhou Dianzi UniversityHangzhou 310012P.R.China School of Mathematical sciences and LPMC Nankai UniversityTianjin 300071P.R.China

We investigate the uniqueness problems of meromorphic functions and their difference operators by using a new *** is proved that if a non-constant meromorphic function f shares a non-zero constant and ∞ counting multiplicities with its difference operators Δcf(z) and Δ_(c)^(2)f(z), thenΔcf(z)≡Δ_(c)^(2)f(z).In particular,we give a difference analogue of a result of *** method has two distinct features:(ⅰ) It converts the relations between functions into the corresponding *** makes it possible to deal with the uniqueness problem by linear algebra and combinatorics.(ⅱ) It circumvents the obstacle of the difference logarithmic derivative lemma for meromorphic functions of infinite order,since this method does not depend on the growth of the ***,the idea in this paper can also be applied to the case for several variables.

关键词： Uniqueness meromorphic functions difference operators infinite order

Microstructure and wear resistance of AlCrFeNiMo_(0.5)Si_(x) high-entropy alloy coatings prepared by laser cladding

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China Foundry 2022年第6期19卷 473-480页

作者： Xiao-cong Li hui liang Yan-zhou Zhao Li Gao Li Jiang Zhi-qiang Cao Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024LiaoningChina School of Physics and Electronic Technology Liaoning Normal UniversityDalian 116029LiaoningChina

In recent years,the coating prepared by laser cladding has attracted much attention in the field of wear *** this work,AlCrFeNiMo_(0.5)Si_(x)(x=0,0.5,1.0,1.5,2.0)high-entropy alloy coatings were designed and prepared on Q235 steel by laser *** effect of Si content on microstructure,microhardness and wear resistance of the coatings was studied in *** results indicate that the AlCrFeNiMo_(0.5)Si_(x) highentropy alloy coatings show an excellent bonding between substrate and the cladding *** AlCrFeNiMo_(0.5)Si_(x) coatings are composed of nano-precipitated phase with BCC structure and matrix with ordered B2 *** the addition of Si,the white phase(Cr,Mo)_(3)Si with cubic structure appears in the interdendritic,and the morphology of the coating(x=2.0)transforms into lamellar eutectic-like *** addition of Si enhances the microhardness and significantly improves the wear resistance of the *** x increases from 0 to 2.0,the average hardness of the cladding zone increases from 632 HV to 835 HV,and the wear rate decreases from 1.64×10^(-5) mm^(3)·(N·m)^(-1) to 5.13×10^(-6) mm^(3)·(N·m)^(-1).When x≥1.5,the decreasing trend of the wear rate gradually slows *** wear rates of Si1.5 and Si2.0 coatings are 5.85×10^(-6) mm^(3)·(N·m)^(-1) and 5.13×10^(-6) mm^(3)·(N·m)^(-1),respectively,which is an order of magnitude lower than that of Q235 steel.

关键词： high-entropy alloy coatings laser cladding microstructure wear resistance

一种(2SPU-1U)&1R少自由度帆船运动模拟平台的研究

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舰船电子工程 2024年第5期44卷 88-93页

作者：陈龙梁辉盛尉航杨琳邓芳汪传生青岛科技大学机电工程学院青岛266061 青岛科技大学轮胎先进装备与关键材料国家工程研究中心青岛266061 青岛科技大学体育学院青岛266061

针对现存多数单一自由度的帆船模拟运动平台,提出一种新型3-DOF的(2SPU-1U)&1R少自由度混联帆船运动模拟平台,该运动平台由一个2SPU-1U的并联机构和一个旋转副R串联构成,能够实现帆船的横摇、纵摇、艏摇三个自由度的运动模拟,同时该平... 详细信息

针对现存多数单一自由度的帆船模拟运动平台,提出一种新型3-DOF的(2SPU-1U)&1R少自由度混联帆船运动模拟平台,该运动平台由一个2SPU-1U的并联机构和一个旋转副R串联构成,能够实现帆船的横摇、纵摇、艏摇三个自由度的运动模拟,同时该平台还可以应用到驾驶、飞行等模拟器场合。采用Grübler-Kutzbach公式计算出机构的自由度数目,建立了2SPU-1U并联机构的约束方程,并通过数值法求解出并联机构的位姿逆解,利用粒子群优化(PSO)算法分析并联机构的位姿正解。最后运用Solidworks和Adams软件进行联合建模仿真分析,验证了机构运行平稳,能够实现帆船横摇、纵摇和艏摇的运动模拟。

关键词： 2SPU-1U 少自由度混联机构 Adams仿真

基于蛋白质泛素化探讨栀子苷干预非酒精性脂肪性肝炎大鼠作用机制

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中国中西医结合杂志 2024年第4期44卷 448-452页

作者：梁惠卿郑晓婷赖鹏华许玲夏刘垚昱张绍良周志佳黄稚真陈少东厦门大学医学院福建361102 厦门市中医院肝病中心福建361009 福建中医药大学中西医结合学院福建351012 上海中医药大学附属曙光医院肝病科上海201203

目的观察栀子苷对非酒精性脂肪性肝炎(NASH)大鼠的影响,基于蛋白质泛素化理论进一步探讨其可能机制。方法运用高脂饮食16周建立大鼠NASH模型。将32只大鼠随机分为正常组、模型组、栀子苷组和盐酸吡格列酮组,每组8只。第9周起,正常组和... 详细信息

目的观察栀子苷对非酒精性脂肪性肝炎(NASH)大鼠的影响,基于蛋白质泛素化理论进一步探讨其可能机制。方法运用高脂饮食16周建立大鼠NASH模型。将32只大鼠随机分为正常组、模型组、栀子苷组和盐酸吡格列酮组,每组8只。第9周起,正常组和模型组大鼠分别给予双蒸水10 mL/(kg·d)灌胃,栀子苷组和盐酸吡格列酮组分别给予60 mg/(kg·d)栀子苷溶液和10 mg/(kg·d)盐酸吡格列酮溶液,共干预8周。生化法检测肝组织甘油三酯(TG)含量、血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)的含量;HE染色观察肝组织病理学变化;ELISA法检测肝组织泛素特异性蛋白酶18(USP18)、去泛素化酶活性抑制转化生长因子-β激活激酶1(TAK1)、转化生长因子β活化激酶结合蛋白1(TAB1)表达水平。结果与正常组比较,模型组大鼠显示出典型的NASH组织学特征,经过栀子苷干预后,肝细胞脂肪变性、炎症浸润减轻。与正常组比较,模型组大鼠体重、脂肪重量、肝湿重、肝指数、肝组织TG含量、血清TC、LDL-C含量均升高(P<0.05),肝组织USP18、TAK1、TAB1表达降低(P<0.05)。与模型组比较,栀子苷组大鼠脂肪重量、肝湿重、肝指数、肝组织TG含量、血清TC、LDL-C含量降低,肝组织USP18、TAK1、TAB1水平明显升高(P<0.05);盐酸吡格列酮组大鼠脂肪重量、肝指数、肝组织TG与血清TC、LDL-C含量均降低(P<0.05)。结论栀子苷能明显改善大鼠肝组织脂肪变性与炎症状态,升高肝组织USP18、TAK1、TAB1水平,其作用机制可能与调节蛋白质泛素化有关。

关键词：栀子苷非酒精性脂肪性肝炎蛋白质泛素化中药单体

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安徽省紧密型城市医联体核心医院医务人员对双向转诊运行现状的认知及满意度研究

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安徽医学 2024年第1期45卷 100-105页

作者：董海燕黄晓磊梁辉纪凯陈任皖西卫生职业学院附属医院门诊部安徽六安237000 中国科学技术大学附属第一医院医务处安徽合肥230001 中国科学技术大学附属第一医院人力资源部安徽合肥230001 安徽医科大学卫生管理学院安徽合肥230032

目的探讨安徽省紧密型城市医联体核心医院医务人员对双向转诊运行现状的认知、满意度及影响因素,为提升医疗卫生服务的连续性,推进分级诊疗制度落地做实。方法采用多阶段分层随机抽样抽取皖中合肥市第二人民医院紧密型城市医联体、皖北... 详细信息

目的探讨安徽省紧密型城市医联体核心医院医务人员对双向转诊运行现状的认知、满意度及影响因素,为提升医疗卫生服务的连续性,推进分级诊疗制度落地做实。方法采用多阶段分层随机抽样抽取皖中合肥市第二人民医院紧密型城市医联体、皖北宿州市立医院紧密型城市医联体和皖南池州市人民医院紧密型城市医联体核心医院的511名医务人员为调查对象。采用自制问卷调查医务人员对双向转诊运行现状的认知和满意度情况,并采用二元回归模型分析影响医务人员满意度的因素。结果139名(27.20%)医务人员对双向转诊运行现状表示满意。二元回归分析结果显示,性别、职称、是否了解双向转诊、所在单位对双向转诊宣传力度、双向转诊制度必要性认知是影响其满意度的因素(P均<0.05)。调查的511名核心医院医务人员中有397人(77.69%)认为患者不信任基层医疗机构的服务能力、338人(66.14%)认为基层医疗机构的服务水平有限、222人(43.44%)认为医疗机构间经济利益分配不均衡、341人(66.73%)认为没有统一的双向转诊标准和指南、323人(63.21%)配套的政策支持不到位、301人(58.90%)认为医疗机构间缺乏信息沟通是当前安徽省紧密型医联体运行的主要障碍。结论完善安徽省紧密型城市医联体双向转诊工作、提升医务人员满意度,需要进一步加大对双向转诊制度的宣传力度、提高基层医疗机构服务能力、明确双向转诊标准和指南、平衡医疗机构间经济利益、加大政策支持力度和完善信息系统建设。

关键词：城市医联体医务人员双向转诊认知满意度

Metaverse virtual social center for elderly communication in time of social distancing

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Virtual Reality & Intelligent Hardware 2023年第1期5卷 68-80页

作者： hui liang Jiupeng LI Yi WANG Junjun PAN Yazhou ZHANG Xiaohang DONG Department of Software Engineering Zhengzhou University of Light IndustryZhengzhou 450002China General Hospital of Pingmei Shenma Group Pingdingshan 467000China Department of Computer Science and Technology Beihang UniversityBeijing 100191China

Background The lack of social activities among the elderly due to physical limitations can result in loneliness and depression. The spread of COVID-19 has made it difficult for the elderly to conduct stable social activities, increasing feelings of loneliness. The metaverse is a virtual world that mirrors reality. This allows the elderly to overcome the constraints of reality and perform social activities stably and continuously, providing new ideas for alleviating loneliness. Methods By analyzing their needs, a virtual social center framework for the elderly was proposed in this study. In addition, a prototype system was designed according to this framework. The elderly can socialize in virtual reality with metaverse-related technologies and human–computer interaction tools. Additionally, a test was conducted jointly with the chief physician of the geriatric rehabilitation department of a tertiary hospital. Results The results demonstrated that the mental state of the elderly who had used the virtual social center was significantly better than that of those who had not used it. Conclusions Thus, virtual social centers can help relieve loneliness and depression among the elderly with increasing global epidemics and an aging society. Hence,they have promotional value.

关键词： Elderly Loneliness and depression Metaverse Virtual social center HCI