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Exploring the Novel Genetic Variant of PITX1 Gene and Its Effect on Milk Performance in Dairy Goats

Journal of Integrative Agriculture 2013年第1期12卷 118-126页

作者： LAN Xian-yong ZHAO Hai-yu li zhuan-jian ZHOU Rui PAN Chuan-ying LEI Chu-zhao CHEN Hong College of Animal Science and Technology Northwest A&F University/Shaanxi Key Laboratory of Molecular Biology for Agriculture College of life Sciences Northwest A&F University

Paired-like homeodomain transcription factor 1 （PITX1） plays an important role in pituitary development by indirectly regulating the expression of the GH and PRL genes, and therefore PITX1 gene is regarded as a potential candidate gene for building the relationship between the gene polymorphism and milk traits. The aim of this study was to explore the novel genetic variant in PITX1 gene and its effect on milk performance in dairy goats. Herein, a novel genetic variation （NW_00314033： g.201GA or IVS1＋41GA） located at nt41 position of the first intron of the goat PITX1 gene was reported at the P1 locus, which can be genotyped by the Msp I PCR-RFLP. In the Msp I PCR-RFLP analyis, the GG variant was a major genotype, and the A variant was a minor allele in Guanzhong dairy goats which was at Hardy-Weinberg disequilibrium （chi-square χ2=140, P0.01）. The establishment of associations between different genotypes and milk performance was performed in the analyzed population. A total of three significant associations of the polymorphism with average milk fat content （%）（P=0.045）, morning milk fat content （%）（P=0.049）, and afternoon milk fat content （%）（P=0.050）, were found, respectively. A significant relationship between the polymorphism and average total solid content （P=0.029） was also detected. This novel single nucleotide polymorphism （SNP） extended the spectrum of genetic variation of the goat PITX1 gene, and its significant association with milk performance would benefit from the application of DNA markers related to improving milk performance through marker-assisted selection （MAS） in dairy goats.

关键词： dairy goat PITX1 gene genetic variant association milk performance

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Integrative analysis of hypothalamic transcriptome and genetic association study reveals key genes involved in the regulation of egg production in indigenous chickens

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Journal of Integrative Agriculture 2022年第5期21卷 1457-1474页

作者： WANG Dan-dan ZHANG Yan-yan TENG Meng-lin WANG Zhang XU Chun-lin jianG Ke-ren MA Zheng li zhuan-jian TIAN Ya-dong KANG Xiang-tao li Hong liU Xiao-jun College of Animal Science and Technology Henan Agricultural UniversityZhengzhou 450046P.R.China Henan Key Laboratory for Innovation and Utilization of Chicken Germ plasm Resources Zhengzhou 450046P.R.China International Joint Research Laboratory for Poultry Breeding of Henan Zhengzhou 450046P.R.China School of life Science and Engineering Foshan UniversityFoshan 528225P.R.China

Indigenous chicken products are increasingly favored by consumers due to their unique meat and egg ***,the relatively poor egg-laying performance largely impacts the economic benefits and hinders sustainable development of the local chicken ***,excavating key genes and effective molecular markers associated with egg-laying performance is necessary to improve egg production via genetic selection in indigenous *** the present study,comparative hypothalamic transcriptome between pre-laying(15 weeks old)and peak-laying(30 weeks old)Lushi blueshelled-egg(LBS)chicken was performed.A total of 518 differentially expressed genes(DEGs)were *** the DEGs,64 genes were enriched in 10 Gene Ontology(GO)terms associated with reproductive regulation via GO analysis and considered as potential candidate genes regulating egg-laying *** the 64 genes,16 showed high connectivity(degree≥12)by protein–protein interaction(PPI)network analysis and were considered as potential core candidate genes(PCCGs).To further look for key candidate genes from the PCCGs,firstly,the expression patterns of the 16 genes were examined in the hypothalamus of two indigenous breeds(LBS and Gushi(GS)chickens)between the pre-laying and peak-laying stages using quantitative real-time PCR(qRT-PCR).Eleven out of the 16 genes showed significantly differential expression(P<0.05)with the same changing trends in the two ***,correlations between the expression levels of the above 11 genes and egg numbers and reproductive hormone concentrations in serum were investigated in high-yielding and low-yielding GS *** the 11 genes,eight showed significant correlations(P<0.05)between their expression levels and egg numbers,and between expression levels and reproductive hormone concentration in ***,an association study on single nucleotide polymorphisms(SNPs)identified in these eight genes and egg production traits was carried out in 640 GS hens,and

关键词： hypothalamus RNA-seq egg production SNP indigenous chicken

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Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 2005-2007页

作者： Bryan Sun Lulin li jian Luo Palo Alto Veterans Institute for Research VA Palo Alto Health Care SystemPalo AltoCAUSA Polytrauma System of Care VA Palo Alto Health Care SystemPalo AltoCAUSA

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of *** current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial ***,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic ***,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.

关键词： stimulator interferon inflammation

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Prussian Blue Analogue‑Templated Nanocomposites for Alkali‑Ion Batteries:Progress and Perspective

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Nano-Micro Letters 2025年第1期17卷 216-261页

作者： jian‑En Zhou Yilin li Xiaoming lin Jiaye Ye Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China School of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

lithium-ion batteries(liBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium *** enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal *** review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(liBs,SIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these *** on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.

关键词： Prussian blue analogues Self-sacrificial template lithium-ion batteries Sodium-ion batteries Potassium-ion batteries

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The Mechanism of Heating Rate on the Secondary Recrystallization Evolution in Grain Oriented Silicon Steel

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 275-282页

作者： GAO Qian li Jun WANG Xianhui CAO Laifu GONG jian li Bo Central Iron and Steel Research Institute Group Beijing 100081China Shougang Zhixin Electromagnetic Material R&D(Beijing)Co. Ltd.Beijing 101300China Beijing Shougang Co. Ltd.Qian’an 064404China

Grain-oriented silicon steels were prepared at different heating rates during high temperature annealing,in which the evolution of magnetic properties,grain orientations and precipitates were *** illustrate the Zener factor,the diameter and number density of precipitates of interrupted testing samples were statistically *** effect of precipitate ripening on the Goss texture and magnetic property was *** indicated that the trend of Zener factor was similar under different heating rates,first increasing and then decreasing,and that the precipitate maturing was greatly inhibited as the heating rate *** recrystallization was developed at the temperature of 1010℃when a heating rate of 5℃/h was used,resulting in Goss,Brass and{110}oriented grains growing abnormally and a magnetic induction intensity of ***,increasing the heating rate to 20℃/h would inhibit the development of undesirable oriented grains and obtain a sharp Goss ***,when the heating rate was extremely fast,such as 40℃/h,poor secondary recrystallization was developed with many island grains,corresponding to a decrease in magnetic induction intensity to 1.87 *** a suitable heating rate of 20℃/h,the sharpest Goss texture and the highest magnetic induction of 1.94 T with an onset secondary recrystallization temperature of 1020℃were found among the experimental variables in this *** heating rate affected the initial temperature of secondary recrystallization by controlling the maturation of precipitates,leading to the deviation and dispersion of Goss texture,thereby reducing the magnetic properties.

关键词： high temperature annealing heating rate secondary recrystallization grain oriented silicon steel

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Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-Wei li jian-Hong Shi Tan li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

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西部农村养老保障问题及对策研究

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特区经济 2011年第3期 172-174页

作者：于转利罗剑朝陈菁西藏民族学院陕西咸阳712082 西北农林科技大学陕西杨陵712100 兰州商学院甘肃兰州730000

随着农村老龄化问题的突出及传统养老模式保障功能的弱化,我国农村养老面临着严峻的挑战。本文通过对西部农村养老保障现状的调查及相关统计数据的分析,发现当前我国西部农村在养老保障方面存在政府缺位严重、农民养老支出少、保障水平... 详细信息

随着农村老龄化问题的突出及传统养老模式保障功能的弱化,我国农村养老面临着严峻的挑战。本文通过对西部农村养老保障现状的调查及相关统计数据的分析,发现当前我国西部农村在养老保障方面存在政府缺位严重、农民养老支出少、保障水平差等问题,建议国家与当地政府应加大对西部农村养老保障的支持力度,积极探索适合当地农民需求有效的养老保障模式,切实保障西部农村老年人的合法权益。

关键词：西部农村养老保障存在问题对策研究

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Resistance of Cement-based Grouting Materials with Nano- SiO_(2) Emulsion to Chloride Ion Penetration

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 114-119页

作者： li Shuiping CHENG jian WEI Chao YUAN Bin YU Chengxiao College of Architectural Science and Engineering Yangzhou UniversityYangzhou 225127China

The chloride penetration resistance of cement-based grout materials was improved by nano-silica *** of mixtures containing different nano-silica particles or emulsions were exposed in sodium chloride solutions of specific concentrations with different test *** properties of the mixes were assessed in terms of weight loss and compressive strength.X-ray diffraction(XRD)and scanning electron microscopy(SEM)of mixes were performed to analysis the phase evolution and *** results demonstrated that the introduction of nano-SiO_(2) emulsion significantly decreased the compressive strength loss and calcium hydroxide(CH)crystal content of hydration production,and then enhanced the resistance of cement-based grouting materials to chloride ion *** improvement derives from the filling and pozzolanic effects of nano-SiO_(2) particles,which were incorporated via an emulsion and attributed to a well dispersion in grouting matrix.

关键词： grouting materials nano-SiO_(2)emulsion chloride ion penetration,weight loss strength loss

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山羊miRNA研究进展

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家畜生态学报 2013年第8期34卷 6-10,20页

作者：李转见韩瑞丽蓝贤勇陈宏河南农业大学牧医工程学院/河南省家禽种质资源创新工程研究中心河南郑州450002 西北农林科技大学动物科技学院陕西杨凌712100

miRNA作为一类内源性的,小型非编码RNA,通过其种子序列与靶基因互作,以序列特异性方式调控靶基因的表达,参与多种生理、生化和病理的过程。本文综述了近年来miRNA在山羊泌乳生理、肌肉生长和发育、毛囊皮肤发育和繁殖生理等方面的研究,... 详细信息

miRNA作为一类内源性的,小型非编码RNA,通过其种子序列与靶基因互作,以序列特异性方式调控靶基因的表达,参与多种生理、生化和病理的过程。本文综述了近年来miRNA在山羊泌乳生理、肌肉生长和发育、毛囊皮肤发育和繁殖生理等方面的研究,为相关研究提供参考。

关键词：山羊 miRNA 泌乳生理肌肉生长和发育毛囊发育繁殖生理

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Energy management strategy that optimizes battery degradation for electric vehicles with hybrid energy storage system

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Science China Technological Sciences 2025年

作者： jian WANG Chaofeng PAN Zhongxing li School of Automotive and Traffic Engineering Jiangsu University Automotive Engineering Research Institute Jiangsu University

The short life of electric vehicle (EV) batteries is an important factor limiting the popularization of EVs. A hybrid energy storage system (HESS) for EVs combines li-ion batteries with supercapacitors, so that the supercapacitor shares the peak power during the starting and braking, effectively solving the problem of irreversible capacity degradation of li-ion batteries. Herein, an energy management strategy for HESS was designed based on battery degradation to extend the service life of the EV battery. First, to obtain accurate battery degradation characteristics, a cycling charge–discharge test was *** this test, the effects of discharge rate and state of charge on battery degradation rate were determined, and the battery degradation model was constructed. Based on the working map of the motor obtained through the bench test, a data-based model of the power system was constructed to accurately characterize the energy consumption of the EV under different operating conditions. Second, rule-based and optimization-based energy management strategies that consider battery degradation were designed using the fuzzy algorithm and dynamic programming (DP) algorithm. The effectiveness of the devised control strategies was assessed using the model-in-the-loop and hardware-in-the-loop test platforms. The fuzzy control strategy had a simple structure and could be rapidly calculated but showed worse performance than the DP-based strategy in terms of battery degradation. The DP-based energy management strategy resulted in 16.68%lower capacity degradation than the fuzzy strategy.

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