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How Well does BCC_CSM1.1 Reproduce the 20th Century Climate Change over China?

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Atmospheric and Oceanic Science Letters 2013年第1期6卷 21-26页

作者： XIN Xiao-Ge WU Tong-Wen li Jiang-Long WANG Zai-Zhi li wei-ping WU Fang-Hua Beijing Climate Center China Meteorological Administration

The historical simulation of phase five of the Coupled Model Intercomparison Project （CMIP5） ex- periments performed by the Beijing Climate Center cli- mate system model （BCC_CSM1.1） is evaluated regard- ing the time evolutions of the global and China mean sur- face air temperature （SAT） and surface climate change over China in recent decades. BCC CSM1.1 has better capability at reproducing the time evolutions of the global and China mean SAT than BCC_CSM1.0. By the year 2005, the BCC_CSM1.1 model simulates a warming am- plitude of approximately I℃ in China over the 1961- 1990 mean, which is consistent with observation. The distributions of the warming trend over China in the four seasons during 1958-2004 are basically reproduced by BCC CSM1.1, with the warmest occurring in winter. Al- though the cooling signal of Southwest China in spring is partly reproduced by BCC_CSM1.1, the cooling trend over central eastern China in summer is omitted by the model. For the precipitation change, BCC_CSM1.1 has good performance in spring, with drought in Southeast China. After removing the linear trend, the interannual correlation map between the model and the observation shows that the model has better capability at reproducing the summer SAT over China and spring precipitation over Southeast China.

关键词： BCC_CSM climate system model simula- tion climate change

Effects of Roundabout 5 on adhesion, invasion and potential motility of human tongue carcinoma Tb cells

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Chinese Medical Journal 2011年第15期124卷 2367-2371页

作者： XIAO Rui ZHAO yuan WANG li-jing li wei-ping Institute of Stomatology Chinese People＇s Liberation Army General Hospital Beijing 100853 China Department of Oral Basic Science College of Stomatology Lanzhou University Lanzhou Gansu 730000 China Institute of Basic Medical Sciences Guangdong Pharmaceutical University Guangzhou Guangdong 510006 China

Background Roundabout 5 （R5） is a monoclonal antibody which can neutralize the binding of Roundabout 1 （Robol） to Slit2. Oral squamous cell carcinoma angiogenesis was significantly inhibited when R5 blocked slit-robo signaling pathway. However, the effect of R5 on the invasion of tongue cancer cells has not been investigated clearly. Methods In this study, we treated human brain metastasis of tongue cancer cell lines （Tb cells） with R5 at different concentrations, and the control Tb cells were treated with 10 mg/ml immunoglobin G 2b （IgG2b）. The effect of R5 on the proliferation, adhension, invasion and motility of Tb cells was evaluated by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl tetrazolium bromide （Ml-r） assay, cell attachment assay on fibronectin （FN）, wound assay and chemotaxis assay, respectively. And gelatin-incorporated sodium dodecyl sulfate-polyacrylamide gel electrophoresis （SDS-PAGE） was used to investigate the activity of matrix metalloproteinase-2 （MMP2） and matrix metalloproteinase-9 （MMP9）. Results R5 had no effect on the proliferation of Tb cells. However, R5 could significantly inhibit the motility, attachment and chemotaxis of Tb cells to FN, and it could also significantly inhibit the activity of MMP2 and MMP9 in Tb cells. Conclusion R5 can inhibit the adhesion, invasion and motility of human tonaue carcinoma Tb cells.

关键词： human tongue carcinoma Roundabout 5 fibronectin

Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats

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Acta Pharmacologica Sinica 2006年第9期27卷 1103-1110页

作者： Yu ZHOU San-hua FANG Yi-lu YE li-sheng CHU wei-ping ZHANG Meng-ling WANG Er-qing wei~2 Department of Pharmacology,School of Medicine,Zhejiang University,Hangzhou 310031,China Department of Pharmacology School of Medicine Zhejiang University Hangzhou China

Aim:To investigate the effects of caffeic acid on early and delayed injuries afterfocal cerebral ischemia in rats,and the possible relation to ***:Transient focal cerebral ischernia was induced by middlecerebral artery occlusion in Sprague-Dawley *** acid(10 and 50 mg/kg)was ip injected for 5 d after *** brain injuries were observed,and thelevels of cysteinyl leukotrienes and leukotriene B4in the brain tissue ***:Caffeic acid(50 mg/kg)ameliorated neurological dysfunctionand neuron loss,and decreased infarct volume 24 h after ischemia;it attenuatedbrain atrophy,infarct volume,and particularly astrocyte proliferation 14 d *** addition,it reduced the production of leukotrienes(5-lipoxygenasemetabolites)in the ischemic hemispheres 3 h and 7 d after ***:Caffeic acid has protective effect on both early and delayed injuries after focalcerebral ischemia in rats;and this effect may partly relate to 5-lipoxygenaseinhibition.

关键词： caffeic acid focal cerebral ischemia neuron astrocyte 5-lipoxygenase leukotriene

Bioactive compounds from Paecilomyces tenuipes regulating the function of the hypothalamo-hypophyseal system axis in chronic unpredictable stress rats

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Chinese Medical Journal 2007年第12期120卷 1088-1092页

作者： YIN Yan-yan MING liang ZHENG li-fang KAN Hong-wei li Chun-ru li wei-ping Department of Pharmacology Anhui Medical University Hefei 230032 China Research Center of Entomogenous Fungi Anhui Agricultural University Hefei 230024 China

Background A bioactive compound from Paecilomyces tenuipes （BCPT） has an inhibitory effect on monoamine oxidase A （MAO-A） and monoamine oxidase B （MAO-B） in vitro and in vivo, which indicates BCPT may be a potential antidepressant. In this study we aimed to study the antidepressant effects of BCPT in the chronic unpredictable stress （CUS） model in rats and explore underlying mechanisms in the hypothalamic-pituitary-adrenal （HPA） axis. Methods The antidepressant effects of BCPT were studied in the chronic unpredictable stress model in rats. Animals were housed isolated, except the control group. Rats were exposed daily to different random stressors from day 1 to 21. Awarding response was detected by calculating the 24-hour consumption of sucrose water. Cortisol （CORT） and adrenocorticotropic hormone （ATCH） contents in serum and arginine vasopressin （AVP） contents in the pituitary body were detected by radio immunoassays. Total RNA of hippocampus or hypothalamus was extracted and subjected to reverse transcription-polymerase chain reaction （RT-PCR） for the measurement of corticotrophin releasing hormone （CRH） mRNA or mineralocorticoid receptor （MR） mRNA and glucocorticoid receptor （GR） mRNA levels. Statistical analyses were performed using one way analysis of variance （ANOVA） followed by Student-Newman-Keuls （SNK） test. Results Chronic unpredictable stress resulted in reduction of sensitivity to reward and abnormality in the HPA axis in the animal model. BCPT improved the reward reaction as measured by increasing sucrose consumption, remarkably reduced serum CORT and ACTH levels and the AVP content in the pituitary body in the CUS-treated rats, decreased the expression of CRH mRNA, enhanced the expression of hippocampus MR mRNA, GR mRNA and decreased the ratio of MR/GR. Conclusions BCPT has potentially antidepressant-like activity and normalized the HPA axis hyperactivity in a CUS model of depression in rats. This may be an important mechanism of its antidepressan

关键词： Paecilomyces tenuipes depression stress hypothalamo-hypophyseal system

HBV genotype C is independently associated with cirrhosis in community-based population

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World Journal of Gastroenterology 2010年第3期16卷 379-383页

作者： Yin, Jian-Hua Zhao, Jun Zhang, Hong-wei Xie, Jia-Xin li, wei-ping Xu, Guo-Zhang Shen, Jie Dong, Hong-Jun Zhang, Jun Wang, lin Han, Jian-Kang Wang, Hong-Yang Cao, Guang-Wen Second Mil Med Univ Dept Epidemiol Shanghai 200433 Peoples R China Second Mil Med Univ Affiliated Hosp 3 Dept Hepatobiliary Surg Shanghai 200438 Peoples R China Second Mil Med Univ Dept Ultrasonog Affiliated Hosp 1 Shanghai 200433 Peoples R China Municipal Ctr Dis Control & Prevent Ningbo Ningbo 315010 Zhejiang Peoples R China Municipal Ctr Dis Control & Prevent Soochow Suzhou 215007 Jiangsu Peoples R China Dist Ctr Dis Control & Prevent Yangpu Shanghai 200090 Peoples R China Municipal Ctr Dis Control & Prevent Huzhou Huzhou 313000 Zhejiang Peoples R China Second Mil Med Univ Lab Signal Transduct Affiliated Hosp 3 Shanghai 200438 Peoples R China

AIM:To determine the association of hepatitis B virus (HBV) genotypes with probable cirrhosis and fatty liver in community-based ***: A multi-stage cluster probability sampling method was applied to recruit 10 167 subjects aged between 6 and 72 years from our epidemiological bases in Eastern China. After excluding the subjects co-infected with hepatitis C or hepatitis D viruses, the hepatitis B surface antigen (HBsAg)-positive subjects were examined for HBV genotype, serum viral load, alanine aminotransferase (ALT), hepatitis B e antigen (HBeAg) status, and ultrasonographic changes. Logistic regression models were used to determine the factors associated with probable cirrhosis and fatty ***: Of 634 HBsAg-positive subjects with HBV genotype determined, 82 had probable cirrhosis (ultrasonographic score ≥5), 42 had ultrasonographic fatty liver. Probable cirrhosis was only found in the HBeAg-negative subjects, and more frequently found in the subjects with genotype C than in those with genotype B (14.8% vs 8.0%, P=0.018). In HBeAg-negative subjects, high viral load was frequently asso-ciated with abnormal ALT level, while ALT abnormality was more frequent in those with probable cirrhosis than those without (19.5% vs 7.8%, P=0.001). Univariate analysis showed that age, sex, HBV genotypes, and viral load were not significantly associated with ultrasonographic fatty liver, whereas ALT abnormality was significantly related to ultrasonographic fatty liver (OR=4.54,95% CI:2.11-9.75, Plity were independently associated with probable cirrhosis (AOR=2.30,95% CI:1.26-4.19; AOR =1.81,95% CI:1.10-2.99;AOR=1.74,95% CI:1.03-2.95; AOR=2.98,95% CI:1.48-5.99, respectively).CONCLUSION: A crude prevalence of probable cirrhosis is 12.9% in the community-based HBV-infected subjects. HBV genotype C is independently associated with probable cirrhosis in the HBe

关键词： Hepatitis B virus Genotype Viral load Alanine aminotransferase Probable cirrhosis Ultrasonography

Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge wei Xilei liu Dai li Xiaoqi Pang Fanglian Chen Hailong Cao ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

Novel Simplex Unscented Transform and Filter

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Journal of Electronic Science and Technology of China 2008年第1期6卷 61-65页

作者： Wan-Chun li ping wei Xian-Ci Xiao School of ElectronicEngineering University of Electronic Science and Technology of ChinaChengdu 610054 China

In this paper,a new simplex unscented transform（UT）based Schmidt orthogonal algorithm and a new filter method based on this transform are *** filter has less computation consumption than UKF（unscented Kalman filter）,SUKF（simplex unscented Kalman filter）and EKF（extended Kalman filter）.Computer simulation shows that this filter has the same performance as UKF and SUKF,and according to the analysis of the computational requirements of EKF,UKF and SUKF,this filter has preferable practicality ***,the appendix shows the efficiency for this UT.

关键词： Extended Kalman filter modify unscented Kalman filter (MUKF) simplex unscentedtransform unscented Kalman fulter.

小花三脉紫菀和狭叶三脉紫菀的区别:形态学和细胞学证据

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植物分类学报 2005年第1期43卷 31-36页

作者：黎维平刘胜祥湖南师范大学生命科学学院长沙410081 华中师范大学生命科学学院武汉430079

产自湖北神农架的狭叶三脉紫菀Aster ageratoides var. gerlachii (Hance) Chang一直被各种文献和有关标本馆误定为小花三脉紫菀A. ageratoides var. micranthus ling。我们对二者进行了野外采集和形态学、细胞学的比较研究,分析了导致... 详细信息

产自湖北神农架的狭叶三脉紫菀Aster ageratoides var. gerlachii (Hance) Chang一直被各种文献和有关标本馆误定为小花三脉紫菀A. ageratoides var. micranthus ling。我们对二者进行了野外采集和形态学、细胞学的比较研究,分析了导致错误鉴定的原因,重新确定了二者的界限。小花三脉紫菀无横走地下茎,这一性状具有重要的分类学价值。核型研究发现,小花三脉紫菀为二倍体,2n=2x=18=18m,核型属1A型;狭叶三脉紫菀则是四倍体,2n=4x=36=32m+4sm (2SAT),核型属2A型。二变种的染色体数目、核型均为首次报道。狭叶三脉紫菀在湖北为新分布记录。

关键词：小花三脉紫菀狭叶三脉紫菀形态学细胞学比较研究横走地下茎染色体核型分析神农架

Clinical value of continuous administration of sorafenib in combination with modified transarterial chemoembolization in patients with unresectable hepatocellular carcinoma

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Chinese Medical Journal 2013年第2期126卷 385-386页

作者： HUANG Yong-hui CHEN wei li Jia-ping CHEN Bin YANG Jian-yong Department of Interventional Radiology First Affiliated Hospitalof Sun Yat-sen University Guangzhou Guangdong 510080 China

Hepatocellular carcinoma （HCC） is a major threat to human health in China with high morbidity andmortality. Surgical resection and liver transplantation are the most promising treatments for HCC. The majority of patients, however, are not eligible for surgery due to 1 advanced tumor, multifocal disease or poor liver reserve. Recently, transarterial chemoembolization （TACE） improved survival compared with best supportive care in two individual clinical trials.2 Sorafenib is a multikinase inhibitor that targets both tumor cell proliferation and angiogenesis. The current standard of practice is to treat BCLC stage B HCC with TACE alone and more advanced （BCLC stage C） HCC with sorafenib only.1

关键词： hepatocellular carcinoma, progression-free survival, sorafenib transarterial chemoembolization