A novel aged mouse model of recurrent intracerebral hemorrhage in the bilateral striatum

作     者：Li-Min Wang Zhi-Hua Liu Hong-Lei Ren Xue-Mei Chen Jun-Min Wang Hui-Min Cai Li-Ping Wei Hui-Hong Tian Jian Wang Li-Juan Wang Li-Min Wang;Zhi-Hua Liu;Hong-Lei Ren;Xue-Mei Chen;Jun-Min Wang;Hui-Min Cai;Li-Ping Wei;Hui-Hong Tian;Jian Wang;Li-Juan Wang

作者机构：The Second School of Clinical MedicineSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of NeurologyGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangdong Neuroscience InstituteGuangzhouGuangdong ProvinceChina School of MedicineSouth China University of TechnologyGuangzhouGuangdong ProvinceChina Department of NeurologyTianjin Neurological InstituteTianjin Medical University General HospitalTianjinChina Department of AnatomySchool of Basic Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第2期

页      面：344-349页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the Natural Science Foundation of Guangdong Province of China,No.2018A030313427 the Science and Technology Program of Guangzhou of China,No.202002030393(both to LMW) 

主　　题：animal model cognition impairment depression-like behavior dopaminergic neurons emotion intracerebral hemorrhage motor neurologic function recurrent intracerebral hemorrhage 

摘      要：The current animal models of stroke primarily model a single intracerebral hemorrhage(ICH)attack,and there is a lack of a reliable model of recurrent *** this study,we established 16-month-old C57 B L/6 male mouse models of ICH by injecting collagenaseⅦ-S into the left ***-one days later,we injected collagenaseⅦ-S into the right striatum to simulate recurrent *** results showed that mice subjected to bilateral striatal hemorrhage had poorer neurological function at the early stage of hemorrhage,delayed recovery in locomotor function,motor coordination,and movement speed,and more obvious emotional and cognitive dysfunction than mice subjected to unilate ral striatal *** findings indicate that mouse models of bilateral striatal hemorrhage can well simulate clinically common recurrent *** models should be used as a novel tool for investigating the pathogenesis and treatment targets of recurrent ICH.