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亮菌甲素片在健康人体的药代动力学和相对生物利用度

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中国临床药理学杂志 2008年第1期24卷 47-50页

作者：王岩李鹏飞吉林大学第一医院药剂科长春130021 第二炮兵总医院药剂科北京100088

目的研究亮菌甲素片(利胆药)在健康人体的药代动力学和相对生物利用度。方法用随机交叉给药自身为对照法,20名健康受试者单次口服亮菌甲素参比和受试制剂各40mg;用液相色谱-串联质谱法测定血浆中亮菌甲素的浓度,计算两种制剂的药代动力... 详细信息

目的研究亮菌甲素片(利胆药)在健康人体的药代动力学和相对生物利用度。方法用随机交叉给药自身为对照法,20名健康受试者单次口服亮菌甲素参比和受试制剂各40mg;用液相色谱-串联质谱法测定血浆中亮菌甲素的浓度,计算两种制剂的药代动力学参数和相对生物利用度。结果受试制剂和参比制剂主要药代动力学参数,tmax分别为(0.35±0.09)、(0.36±0.08)h;Cmax分别为(32.94±11.52)、(31.15±8.23)***-1;t1/2分别为(0.42±0.19)、(0.37±0.11)h;AUC0-t分别为(12.92±3.91)、(12.80±4.03)***-1;AUC0-∞分别为(13.10±3.93)、(12.95±4.07)***-1。受试制剂与参比制剂的平均相对生物利用度为(102.00±16.19)%。结论亮菌甲素片参比制剂与受试制剂生物等效。

关键词：亮菌甲素片液相色谱-串联质谱法药代动力学生物等效性

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基于改进LS-SVM的来波方位估计

计算机工程 2010年第6期36卷 204-205,209页

作者：李鹏飞张旻解放军电子工程学院309研究室合肥230037 安徽省电子制约技术重点实验室合肥230037

提取已知方位信号的协方差矩阵的上三角部分作为样本特征,构建方位估计模型。针对最小二乘支持向量机最优参数难以选定的问题,采用实值编码的启发式遗传算法,以模型的来波方位估计性能为目标,实现基于高斯核函数的SVM参数优化,提高了来... 详细信息

提取已知方位信号的协方差矩阵的上三角部分作为样本特征,构建方位估计模型。针对最小二乘支持向量机最优参数难以选定的问题,采用实值编码的启发式遗传算法,以模型的来波方位估计性能为目标,实现基于高斯核函数的SVM参数优化,提高了来波方位估计精度。实验结果表明,该方法估计精度较高、实时性好,在无线电测向领域具有广阔应用前景。

关键词：最小二乘支持向量机遗传算法来波方位估计

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子宫颈癌治疗前评估的规范化

中国实用妇科与产科杂志 2021年第1期37卷 41-44页

作者：刘萍李朋飞南方医科大学南方医院妇产科广东广州510515

在FIGO 2018子宫颈癌分期系统中,病理学和影像学检查可纠正临床分期,但子宫颈癌患者治疗前的临床分期及治疗方式选择仍主要是基于临床评估,规范的临床评估是规范治疗的前提和基础。文章从初治子宫颈癌患者的临床评估问题着手,结合新技... 详细信息

在FIGO 2018子宫颈癌分期系统中,病理学和影像学检查可纠正临床分期,但子宫颈癌患者治疗前的临床分期及治疗方式选择仍主要是基于临床评估,规范的临床评估是规范治疗的前提和基础。文章从初治子宫颈癌患者的临床评估问题着手,结合新技术、新方法,提出子宫颈癌治疗前规范化评估的建议和策略。

关键词：子宫颈肿瘤临床评估规范化人工智能

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多谐波脉冲星信号时延估计方法

物理学报 2015年第21期64卷 490-499页

作者：宋佳凝徐国栋李鹏飞哈尔滨工业大学卫星技术研究所哈尔滨150001 哈尔滨理工大学电气与电子工程学院哈尔滨150001

针对脉冲星导航技术中延时估计这一关键问题,提出了频域上直接使用脉冲星信号测量到达时间集合进行时延估计的方法——多谐波脉冲星信号时延估计(MHSPE)方法.该方法建立在频域上相位时延的极大似然估计的基础上,通过高次谐波对脉冲星观... 详细信息

针对脉冲星导航技术中延时估计这一关键问题,提出了频域上直接使用脉冲星信号测量到达时间集合进行时延估计的方法——多谐波脉冲星信号时延估计(MHSPE)方法.该方法建立在频域上相位时延的极大似然估计的基础上,通过高次谐波对脉冲星观测信号提取出各谐波相位的极大似然估计,然后取频谱上各谐波的幅值进行归一化作为各谐波相位的权值,最后取各谐波相位的加权平均作为该时刻的相位估计.理论上证得MHSPE算法对相位的估计是无偏、一致的,相比于频域上一次谐波的极大似然估计,MHSPE方法的信噪比随谐波数m的增加而增加,当各谐波幅值相同时,信噪比可提高m1/2倍;与脉冲星信号时延的克拉美罗界比较,脉冲星信号时域的导数在频域上的反映就是各谐波分量的数量,因此随着谐波次数的增加脉冲星信号时延估计可极大趋近克拉美罗界.采用RXTE航天器对Crab脉冲星的实测数据检验MHSPE方法的性能,实验结果表明,针对低信噪比的脉冲星信号,MHSPE可获得高精度的相位估计,随观测时间增加,估计精度快速收敛于克拉美罗界.

关键词：脉冲星导航克拉美罗界极大似然估计谐波相位

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牛发情周期卵泡发育及其研究方法进展

畜牧兽医学报 2013年第3期44卷 333-339页

作者：李鹏飞吕丽华山西农业大学生命科学学院太谷030801 山西农业大学动物科技学院太谷030801

牛发情周期内排卵卵泡的数量和质量与其繁殖性能直接相关。本文就牛发情周期内有关卵泡发育的概念提出、理论建立、研究技术进展进行综述,并对研究前景进行展望。可以确定,随着新技术、新方法的应用,对牛卵泡生长和闭锁机理的进一步研... 详细信息

牛发情周期内排卵卵泡的数量和质量与其繁殖性能直接相关。本文就牛发情周期内有关卵泡发育的概念提出、理论建立、研究技术进展进行综述,并对研究前景进行展望。可以确定,随着新技术、新方法的应用,对牛卵泡生长和闭锁机理的进一步研究将会极大改善牛的繁殖性能。

关键词：牛发情周期卵泡波发育繁殖性能

Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi liang fei Yang Zixiao li Qian li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

三维成像声呐在水下灌注桩缺陷检测中的应用探讨

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岩土工程学报 2021年第S2期43卷 170-173页

作者：吉同元李鹏飞张润章定文东南大学交通学院华设设计集团股份有限公司道路交通工程国家级实验教学示范中心(东南大学)

桩基是桥梁工程的重要组成部分,桩基水下结构存在混凝土剥落、破损等质量问题,三维成像声呐能够识别和测量水下结构病害情况,基于三维成像声呐进行了"模型试验-数据处理-工程应用"系统性研究,研究表明:数据后处理能够有效去除噪点,清晰... 详细信息

桩基是桥梁工程的重要组成部分,桩基水下结构存在混凝土剥落、破损等质量问题,三维成像声呐能够识别和测量水下结构病害情况,基于三维成像声呐进行了"模型试验-数据处理-工程应用"系统性研究,研究表明:数据后处理能够有效去除噪点,清晰呈现试件部分外形轮廓,保留目标物几何信息,并能够较好识别试件缺陷;点云图像大尺寸测量结果准确,尺寸小于5cm时,误差在2cm以内;三维成像声呐在桥梁桩基水下部分的外观完整性检测效果较好,能够识别桩基混凝土剥落,并进行剥落厚度测量,误差在3cm内,满足工程检测需求。

关键词：桥梁桩基声学可视化模型试验点云处理

Representation of Shakespeare's Feminism in The Merchant of Venice

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海外英语 2017年第14期 153-155页

作者：唐明琪彭立飞贵州理工学院大学外语教学部贵州理工学院大外部

The paper focuses on analyzing the female character Portia in Shakespeare's play The Merchant of Venice, by adopting feminist theory from Beauvoir, Horney, and Wollstonecraft, and examining some of the social rules in Elizabethan age. By creating the rebellious heroine Portia, Shakespeare doubted and challenged the social rituals in his age. Thus Shakespeare's feminism is well demonstrated in this play.

关键词： Shakespeare Feminism The Merchant of Venice Elizabethan age Beauvoir

Research on Anti-noise Processing Method of Production Signal Based on Ensemble Empirical Mode Decomposition(EEMD)

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Journal of Northeast Agricultural University(English Edition) 2017年第4期24卷 69-79页

作者： Fang Jun-long Yu Xiao-juan Wang Rui-fa Wang Run-tao li peng-fei Shao Chang-hui College of Electrical and Information Northeast Agricultural University State Grid Corporation of Heilongjiang Electric Power Co. Ltd.

The grain production prediction is one of the most important links in precision agriculture. In the process of grain production prediction, mechanical noise caused by the factors of difference in field topography and mechanical vibration will be mixed in the original signal, which undoubtedly will affect the prediction accuracy. Therefore, in order to reduce the influence of vibration noise on the prediction accuracy, an adaptive Ensemble Empirical Mode Decomposition(EEMD) threshold filtering algorithm was applied to the original signal in this paper: the output signal was decomposed into a finite number of Intrinsic Mode Functions(IMF) from high frequency to low frequency by using the Empirical Mode Decomposition(EMD) algorithm which could effectively restrain the mode mixing phenomenon; then the demarcation point of high and low frequency IMF components were determined by Continuous Mean Square Error criterion(CMSE), the high frequency IMF components were denoised by wavelet threshold algorithm, and finally the signal was reconstructed. The algorithm was an improved algorithm based on the commonly used wavelet threshold. The two algorithms were used to denoise the original production signal respectively, the adaptive EEMD threshold filtering algorithm had significant advantages in three denoising performance indexes of signal denoising ratio, root mean square error and smoothness. The five field verification tests showed that the average error of field experiment was 1.994% and the maximum relative error was less than 3%. According to the test results, the relative error of the predicted yield per hectare was 2.97%, which was relative to the actual yield. The test results showed that the algorithm could effectively resist noise and improve the accuracy of prediction.

关键词： production signal signal denoising processing adaptive EEMD threshold filtering algorithm prediction accuracy