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老年冠心病患者PCI术后发生冠状动脉无复流的影响因素分析

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中外医学研究 2024年第10期22卷 111-114页

作者：李明昌首都医科大学石景山教学医院(北京市石景山医院) 北京100043

目的:分析老年冠心病患者经皮冠状动脉介入治疗(PCI)术后发生冠状动脉无复流的影响因素,为临床预防PCI术后冠状动脉无复流的发生提供依据。方法:选择2021年6月—2023年6月首都医科大学石景山教学医院收治的163例行PCI的老年冠心病患者... 详细信息

目的:分析老年冠心病患者经皮冠状动脉介入治疗(PCI)术后发生冠状动脉无复流的影响因素,为临床预防PCI术后冠状动脉无复流的发生提供依据。方法:选择2021年6月—2023年6月首都医科大学石景山教学医院收治的163例行PCI的老年冠心病患者作为研究对象,依照是否存在复流将患者分为无复流组(n=83)和血流正常组(n=80)。比较两组的一般资料及实验室指标,采用logistic回归分析影响老年冠心病患者PCI术后发生冠状动脉无复流的危险因素。结果:两组年龄、饮酒史及家族史比较,差异无统计学意义(P>0.05);无复流组有吸烟史、心绞痛发生史、术前血糖≥11.0 mmol/L及高密度脂蛋白胆固醇(HDL-C)<45 mg/dL患者占比高于血流正常组,差异有统计学意义(P<0.05);logistic分析结果提示,吸烟史及术前血糖≥11.0 mmol/L是老年冠心病患者PCI术后发生冠状动脉无复流发生的危险因素(P<0.05),无心绞痛发生史及HDL-C≥45 mg/dL是老年冠心病患者PCI术后发生冠状动脉无复流发生的保护因素(P<0.05)。结论:有吸烟史及术前血糖≥11.0 mmol/L是PCI术后发生冠状动脉无复流的危险因素,无心绞痛发生史及HDL-C≥45 mg/dL是PCI术后发生冠状动脉无复流的保护因素;冠心病患者应控制血糖血脂,保持健康生活习惯,早日戒烟,发生心绞痛后及时干预治疗。

关键词：老年冠心病经皮冠状动脉介入治疗冠状动脉无复流危险因素

Genetic modification of miR-34a enhances efficacy of transplanted human dental pulp stem cells after ischemic stroke

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Neural Regeneration Research 2023年第9期18卷 2029-2036页

作者： Jianfeng Wang Peibang He Qi Tian Yu Luo Yan He Chengli liu Pian Gong Yujia Guo Qingsong Ye mingchang li Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Center of Regenerative Medicine Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Institute of Regenerative and Translational Medicine Tianyou HospitalWuhan University of Science and TechnologyWuhanHubei ProvinceChina

Human dental pulp stem cells(hDPSCs) promote recovery after ischemic stro ke;however,the therapeutic efficacy is limited by the poor survival of transplanted *** in vitro expe riments in the present study,we used oxygen-glucose deprivation/reoxygenation in hDPSCs to mimic cell damage induced by ischemia/*** found that miRNA-34a-5p(miR-34a) was elevated under oxygen-glucose deprivation/reoxygenation conditions in *** of miR-34a facilitated the prolife ration and antioxidant capacity and reduced the apoptosis of *** r,dual-luciferase reporter gene assay showed WNT1and SIRT1 as the targets of *** miR-34a knockdown cell lines,WNT1 suppression reduced cell prolife ration,and SIRT1 suppression decreased the antioxidant *** r,these results indicated that miR-34a regulates cell prolife ration and antioxidant stress via targeting WNT1 and SIRT1,*** in vivo expe riments,we injected genetically modified hDPSCs(anti34a-hDPSCs) into the brains of *** found that anti34a-hDPSCs significantly inhibited apoptosis,reduced cerebral edema and cerebral infarct volume,and improved motor function in *** study provides new insights into the molecular mechanism of the cell prolife ration and antioxidant capacity of hDPSCs,and suggests a potential gene that can be targeted to improve the survival rate and efficacy of transplanted hDPSCs in brain after ischemic stroke.

关键词： antioxidant capacity HO-1 human dental pulp stem cells ischemic stroke miR-34a Nrf2 proliferation SIRT1 WNT1 β-catenin

Retrospective Environment Carrying Capacity Assessment and Comparison for Marine Reclamation

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Journal of Geoscience and Environment Protection 2014年第2期2卷 36-41页

作者： mingchang li Jingguo Zhang 1Laboratory of Environmental Protection in Water Transport Engineering Tianjin Research Institute of Water Transport Engineering Tianjin China 2Tianjin Oceanic Administration Tianjin China

For improving the managed level and guiding the environmental management of reclamation engineering, a synthetic assessment method based on cloud theory is applied to evaluate the environment carrying capacity of part of Tianjin Port in this paper. This retrospective assessment of carrying capacity aims to obtain the historical development situation of reclamation domain. The research is meaningful and efficient for judging the feasibility of marine reclamation.

关键词： Retrospective Environment Carrying Capacity Assessment Reclamation Cloud Theory

MSC based gene delivery methods and strategies improve the therapeutic efficacy of neurological diseases

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Bioactive Materials 2023年第5期23卷 409-437页

作者： Heng Zhou Yan He Wei Xiong Shuili Jing Xingxiang Duan Zhiyun Huang Gurek SNahal Youjian Peng mingchang li Yaoqi Zhu Qingsong Ye Center of Regenerative Medicine&Department of Stomatology Renmin Hospital of Wuhan UniversityWuhan430060China Institute of Regenerative and Translational Medicine Tianyou Hospital of Wuhan University of Science and TechnologyWuhanHubei430064China Department of Oral and Maxillofacial Surgery Massachusetts General HospitalHarvard Medical SchoolBoston02114MAUSA School of Dentistry University of QueenslandHerston4006QLDAustralia Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhan430060China Department of Oral and Maxillofacial Surgery Hospital of Taikang Tongji(Wuhan)430050WuhanChina

Mesenchymal stem cells(MSCs)are promising seed cells for neural regeneration therapy owing to their plasticity and *** possess several inherent characteristics advantageous for the transplantation-based treatment of neurological disorders,including neural differentiation,immunosuppression,neurotrophy,and ***,the therapeutic efficacy of MSCs alone remains unsatisfactory in most *** improve some of their abilities,many studies have employed genetic engineering to transfer key genes into *** viral and nonviral methods can be used to overexpress therapeutic proteins that complement the inherent ***,to date,different modes of gene transfer have specific drawbacks and *** addition,MSCs can be functionalized through targeted gene modification to facilitate neural repair by promoting neural differentiation,enhancing neurotrophic and neuroprotective functions,and increasing survival and homing *** methods of gene transfer and selection of delivered genes still need to be optimized for improved therapeutic and targeting efficacies while minimizing the loss of MSC *** this review,we focus on gene transport technologies for engineering MSCs and the application of strategies for selecting optimal delivery ***,we describe the prospects and challenges of their application in animal models of different neurological lesions to broaden treatment alternatives for neurological diseases.

关键词： Mesenchymal stem cells Gene delivery Neurological diseases Viral vector Nonviral vectors

Research on Distribution and Assessment Method of Inorganic Nitrogen in Multi-waterway Marine Waters

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Research on Distribution and Assessment Method of Inorganic ...

Research on Cloud Theory Assessment Method for Environmental Carrying Capacity under Port and Waterway Development

作者： li mingchang ZHANG Guangyu SI Qi Tianjin Research Institute of Water Transport Engineering

Following the development of marine economy,multi-waterway construction has resulted in the environmental *** it is very important for researching the pollutant distribution and carrying capacity around multi-waterway *** capacity assessment is an efficient means for obtaining feature pollution factor and its pollution *** this paper,detailed and systematic assessment method and procedure for carrying capacity is developed by combining set pair analysis method with cloud theory,bell function in cloud theory is used for connection degree function in set pair analysis *** calibration results work well in multi-waterway marine *** shows the coupling method has advantages of concision,easyoperation and high precision of set pair analysis method,and the randomness and ambiguity of assessment indexes’ membership can be reflected in the assessment procedure by using the cloud theory,so the assessment results are practical significance.

关键词： carrying capacity cloud theory set pair analysis assessment inorganic nitrogen

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Research on Cloud Theory Assessment Method for Environmental...

Red light-driven generation of reactive oxygen species for the targeted oxidation of glioma cells and thiols over covalent organic framework

作者： li Xin li mingchang ZHANG Guangyu HONG Ningning Tianjin Research Institute of Water Transport Engineering

Multi-port and waterway region comprehensive carrying capacity assessment system has characteristic of complex nonlinearity and *** this paper,synthetic assessment method and systematic procedure for multi-region are presented based on cloud theory.A normalized membership determination method is proposed for meeting the reasonability of index membership *** presented method works well in the multi-port and waterway *** shows the method has advantages of concision,*** randomness and ambiguity of assessment indexes’ membership can be reflected in the assessment procedure,so the assessment results are practical significance,and these can provide reliable basis for the regional scientific management.

关键词： cloud theory comprehensive carrying capacity assessment nonlinear uncertainty

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Chinese Chemical Letters 2023年第12期34卷 509-513页

作者： Heng Wei Xia li Fengwei Huang Shujuan Wu Huimin Ding Qianxue Chen mingchang li Xianjun Lang Renmin Hospital of Wuhan University College of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China

Reactive oxygen species(RoS)are essential for biological processes like cell signaling and chemical processes like organic ***,the sufficient generation of RoS plays a significant role in targeted tumor treatments or oxidation of ***,a hydrazone-linked porphyrin covalent organic framework(Por-DETH-COF)is developed for red light-induced generation of ROS like singlet oxygen(^(1)O_(2))or superoxide(O_(2)·^(-))to undertake different but targeted ***,^(1)O_(2)is adopted in photodynamic therapy(PDT)for the oxidation of glioma *** PDT efficiency of Por-DETH-COF on the apoptosis of glioma cells is explored through flow cytometry and western blot *** apoptosis rate of glioma cells significantly increases over Por-DETH-COF under 660nm red light illumination,suggestive of the potency of^(1)O_(2).Second,O_(2)^(·-)is employed for the targeted oxidation of thiols.A series of thiols could be efficiently oxidized to corresponding disulfides over Por-DETH-COF under 660 nm red light illumination,indicative of the significance of O_(2)^(·-).This work highlights the potential of covalent organic frameworks in generating Ros for precise medical applications of complex chemical environments.

关键词： Reactive oxygen species Covalent organic framework Oxidation Photodynamic therapy Glioma cells

The important role of Computed Tomography Angiography to predict operation effect and prognosis of severe traumatic brain injury

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The important role of Computed Tomography Angiography to pre...

计算流体力学在颅内动脉瘤仿真建模及破裂风险预测中应用的研究进展

第十五届中国医师协会神经外科医师年会

作者： Junhui Chen mingchang li Yuhai Wang Qianxue Chen Department of Neurosurgery Renmin Hospital of Wuhan University Department of Neurosurgery 904~(th) Hospital of Joint Logistic Support Force of PLAWuxi Clinical College of Anhui Medical University Department of Orthopedic 904~(th) Hospital of Joint Logistic Support Force of PLAWuxi Clinical College of Anhui Medical University

Background It was difficult to predict the operative effect and outcome for severe traumatic brain injury(TBI) before *** present of active contrast extravasation at computed tomography angiography(CTA) can predicts in-hospital mortality in patients with nontraumatic intracerebral *** study aims to approve an evaluated method of CTA to predict the effect of operation and outcome in severe *** From 8760 patients with a TBI treated between January 2010 and January 2016,we retrospectively reviewed 358 severe TBI patients who presented to our emergency department and underwent CTA at admission and a follow-up CTA *** experienced readers,blinded to clinical data,reviewed the CTAs to assess for the presence of cerebrovascular changes included cerebrovascular shift(CS),cerebral vasospasm(CVS),large artery occlusion(LAO) and deep venous system occlusion(DVSO).Medical records were reviewed for baseline clinical characteristics and the relationship between cerebrovascular changes and operation effect and 6 months *** Cerebrovascular changes was identified in 197(55.0%) of 358 severe *** hundred seventeen(32.7%) had CS,and just 9(7.7%) of them died,63(53.8%) patients had good ***-four(21.0%) patients had CVS,31(41.9%) had a good outcome,25(33.8%) had severe disability and 18(24.3%) *** were twenty-five(7.0%) patients had LAO and thirty(8.4%) patients had DVSO,all these 55(100%) patients were died regardless whether they had *** Cerebrovascular injuries and changes are frequent after severe TBI,and correlates with prognosis *** is an important tool in evaluating the severity,predicting operation effect and prognosis,and guiding therapy of severe ***,this is a single-hospital retrospectively ***,well-designed,multicentre,randomized controlled trials needed to evaluate the value of the CTA for severe TBI.

关键词： severe TBI CTA Cerebrovascular CVS

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中国脑血管病杂志 2023年第2期20卷 100-105页

作者：魏恒李明昌武汉大学人民医院神经外科 430060

颅内动脉瘤是一种以动脉壁局部扩张为特征的脑血管疾病。颅内动脉瘤破裂导致的蛛网膜下腔出血具有较高的病死率和致残率。近年来,通过计算流体力学的方法开展的血流动力学参数与颅内动脉瘤破裂风险相关性研究取得较大进展,但目前仍存在... 详细信息

颅内动脉瘤是一种以动脉壁局部扩张为特征的脑血管疾病。颅内动脉瘤破裂导致的蛛网膜下腔出血具有较高的病死率和致残率。近年来,通过计算流体力学的方法开展的血流动力学参数与颅内动脉瘤破裂风险相关性研究取得较大进展,但目前仍存在一定的争议。作者就计算流体力学在颅内动脉瘤仿真建模及破裂风险预测中应用的研究进展进行了综述。

关键词：颅内动脉瘤血流动力学计算流体力学建模破裂风险