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Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1. experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao Zhang jun-Zheng Wang li-Tao Yang Qian yue Ke-jun Kang yuan-Jing li Hai-Peng An C.Greeshma Jian-Ping Chang yun-Huan Chen Jian-Ping Cheng Wen-Han Dai Zhi Deng Chang-Hao Fang xin-Ping Geng Hui Gong Qiu-ju Guo Xu-yuan Guo li He Sheng-ming He Jin-Wei Hu Han-xiong Huang Tu-Chen Huang Hai-Tao Jia xi Jiang S.Karmakar Hao-Bin li Jian-min li Jin li Qian-yun li Ren-ming-Jie li Xue-Qian li yu-Lan li yi-Fan liang Bin liao Fong-Kay lin Shin-Ted lin Jia-Xuan liu Shu-Kui liu Yan-Dong liu yu liu yuan-yuan liu Zhong-Zhi liu Hao Ma yu-Cai Mao Qi-yuan Nie Jin-Hua Ning Hui Pan Ning-chun Qi Jie Ren xi-Chao Ruan Ze She Manoj Kumar Singh Tian-xi Sun Chang-Jian Tang Wei-You Tang Yang Tian Guang-Fu Wang li Wang Qing Wang yu-Feng Wang yun-xiang Wang Henry-Tsz-King Wong Shi-Yong Wu yu-Cheng Wu Hao-Yang xing Rui Xu yin Xu Tao Xue yu-Lu Yan Nan yi chun-Xu yu Hai-jun yu Jian-Feng yue ming Zeng Zhi Zeng Feng-Shou Zhang Lei Zhang Zhen-Hua Zhang Zhen-yu Zhang Kang-Kang Zhao ming-Gang Zhao Ji-Fang Zhou Zu-ying Zhou Jing-jun Zhou Key Laboratory of Particle and Radiation Imaging(ministry of Education)and Department of {1. Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 school of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 school of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1.,1.008 kg)in the china Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discri{1.ation methods were used to suppress the background in the energy region of interest(ROI,1.89–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1.2)^(0ν)>1.0×1.^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

Effects of soil salinity on rhizosphere soil microbes in transgenic Bt cotton fields

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Journal of Integrative Agriculture 2017年第7期16卷 1624-1633页

作者： LUO jun-{1. ZHANG Shuai ZHU xiang-zhen LU li-min WANG chun-yi li chun-hua cui Jin-jie ZHOU Zhi-guo State Key Laboratory of Cotton Biology Institute of Cotton Research Chinese Academy of Agricultural Sciences College of Agriculture Nanjing Agricultural University/Key Laboratory of Crop Physiology & Ecology in Southern China Ministry of Agriculture

With increased cultivation of transgenic Bacillus thuringiensis （Bt） cotton in the saline alkaline soil of china, assessments of transgenic crop biosafety have focused on the effects of soil salinity on rhizosphere microbes and Bt protein residues. In 2013 and 2014, investigations were conducted on the rhizosphere microbial biomass, soil enzyme activities and Bt protein contents of the soil under transgenic Bt cotton （variety GK19） and its parental non-transgenic cotton （Simian 3） cultivated at various salinity levels （1.15, 6.00 and 11.46 dS m-1）. Under soil salinity stress, trace amounts of Bt proteins were ob- served in the Bt cotton GK19 rhizosphere soil, although the protein content increased with cotton growth and increased soil salinity levels. The populations of slight halophilic bacteria, phosphate solubilizing bacteria, ammonifying bacteria, nitrifying bacteria and denitrifying bacteria decreased with increased soil salinity in the Bt and non-Bt cotton rhizosphere soil, and the microbial biomass carbon, microbial respiration and soil catalase, urease and alkaline phosphatase activity also decreased. Correlation analyses showed that the increased Bt protein content in the Bt cotton rhizosphere soil may have been caused by the slower decomposition of soil microorganisms, which suggests that salinity was the main factor influencing the relevant activities of the soil microorganisms and indicates that Bt proteins had no clear adverse effects on the soil microorganisms. The results of this study may provide a theoretical basis for risk assessments of genetically modified cotton in saline alkaline soil.

关键词： soil salinity Bt cotton soil microorganisms microbial biomass carbon microbial respiration soil enzyme activityBt protein

The biotypes and host shifts of cotton-melon aphids Aphis gossypii in northern china

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Journal of Integrative Agriculture 2018年第9期17卷 2066-2073页

作者： ZHANG Shuai LUO jun-yu WANG li WANG chun-yi LU li-min ZHANG li-juan ZHU xiang-zhen cui Jin-jie State Key Laboratory of Cotton Biology Institute of Cotton ResearchChinese Academy of Agricultural SciencesAnyang 455000P.R.China

Aphis gossypfi is a globally distributed species and therefore has a highly variable life cycle. Populations of A. gossypii in northern{1. exhibit greater genotypic diversity and a broader host range, yet the details of life cycles of different biotypes is still unclear. In this study, the Cytb and 1.S gene regions of A. gossypfi collected from 5 common summer hosts and 4 primary hosts were analyzed. A total of 57 haplotypes were obtained from 1.046 individual A. gossyp# sequences. The sequence included 44 variable sites, 27 of which were parsimony informative sites and 1. of which were singleton variable sites. The most frequent 3 haplotypes were found in 896 individuals, representing a total of 85.7% of all individuals and 36 haplotypes were found in 1.individual. A neighbor-joining tree was constructed using 21.haplotypes that were found in more than 2 individuals. Considering the individual host plant, 5 biotypes were identified. Type 1.corresponded exactly to the cucurbit host-race and the other 4 biotypes were found as cotton host-races. Type 3 was the most abundant biotype in cotton fields in northern{1..

关键词： cotton-melon aphid Cytb and 1.S genes haplotype biotype cotton field

Magnetic property recovery in Nd-Fe-B bonded magnet wastes with chemical reaction and physical dissolution

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Journal of Rare Earths 2021年第11期39卷 1396-1401,I0003页

作者： min liu Haiyuan cui Qingyan li Peihong Zhu Weiqiang liu Qingmei Lu Dongtao Zhang Zaisheng Pang xi yu chunhui yu Shanshun Zha Youhao liu xiaofei yi ming yue Laboratory of Advanced Functional Materials Ministry of EducationFaculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Ganzhou Fortune Electronic Co. Ltd.Canzhou 341000China Earth-Panda Advanced Magnetic Materials Co. Ltd.Hefei 231500China

The main difficulty for the recovery of Nd-Fe-B bonded magnet wastes is how to completely remove the epoxy *** this study,chemical reaction and physical dissolution were combined to remove the epoxy resins by adding ammonia-water and mixed organic ***-water can react with the epoxy functional group of epoxy resin to generate *** organic solvents of alcohol,dimethyl formamide(DMF),and tetrahydrofuran(THF) can dissolve the generated polyols and residual epoxy *** the optimum processing conditions,the epoxy resins in the waste magnetic powders are substantially *** oxygen and carbon contents in the recycled magnetic powder are reduced from 1.500 × 1.^(-6) to 1.00 × 1.^(-6) and from 1.500 × 1.^(-6) to 21.0 × 1.^(-6) with the reduction ratio of88.1. and 89.2%,*** recycled magnetic powder presents improved magnetic properties with MS of 1.306 × 1.^(-1. A·m^(2)/g,Mr of 0.926 × 1.^(-1. A·m^(2)/g,Hcj of 1.1.0 T,and(BH)max of 1.5.732 kJ/m^(3),which reach 99.8%,99.4%,95.9%,and 96.9% of the original magnetic powders,respectively.

关键词： Nd-Fe-B bonded magnet wastes Epoxy resin Open-loop reaction Physical dissolution Recycled magnetic powders Rare earths

Efficient generation of functional hepatocytelike cells from mouse liver progenitor cells via indirect co-culture with immortalized human hepatic stellate cells

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Hepatobiliary & Pancreatic Diseases International 2016年第2期15卷 173-179页

作者： xiao-Ping Pan yi-Ni Wang xiao-Peng yu chun-xia Zhu Jian-Zhou li Wei-Bo Du yi-min Zhang Hong-cui Cao Yan-Hong Zhang Dan-Hua Zhu George C Yeoh Lan-juan li Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases State Key Laboratory for Diagnosis and Treatment of Infectious Diseases First Affiliated Hospital Zhejiang University School of Medicine College of Basic Medical Sciences Zhejiang Chinese Medical University Biochemistry & Molecular Biology Crawley University of Western Australia

BACKGROUND： Differentiation of liver progenitor cells（LPCs） to functional hepatocytes holds great potential to develop new strategies for hepatocyte transplantation and the screening of drug-induced cytotoxicity. However, reports on the efficient and convenient hepatic differentiation of LPCs to hepatocytes are few. The present study aims to investigate the possibility of generating functional hepatocytes from LPCs in an indirect co-culture ***： Mouse LPCs were co-cultured in Transwell plates with an immortalized human hepatic stellate cell line（HSCli） we previously established. The morphology, expression of hepatic markers, and functions of mouse LPC-derived cells were monitored and compared with those of conventionally cultured LPCs. RESULTS： Co-culturing with HSC-li cells induced differentiation of mouse LPCs into functional hepatocyte-like cells. The differentiated cells were morphologically transformed into hepatocyte-like cells 3 days after co-culture initiation. In addition, the differentiated cells expressed liver-specific genes and possessed hepatic functions, including glycogen storage, lowdensity lipoprotein uptake, albumin secretion, urea synthesis, and cytochrome P450 1A2 enzymatic ***： Our method, which employs indirect co-culture with HSC-li cells, can efficiently induce the differentiation of LPCs into functional hepatocytes. This finding suggests that this co-culture system can be a useful method for the efficient generation of functional hepatocytes from LPCs.

关键词： liver progenitor cells indirect co-culture cell differentiation hepatocytes immortalized human hepatic stellate cells

Changing trends of clinicopathologic features and survival duration after surgery for gastric cancer in Northeast{1.

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World Journal of Gastrointestinal Oncology 2020年第10期12卷 1119-1132页

作者： Zhao Zhai Zi-yu Zhu xi-liang Cong Bang-ling Han Jia-liang Gao xin yin yu Zhang Sheng-Han Lou Tian-yi Fang yi-min Wang chun-Feng li Xue-Feng yu Yan Ma ying-Wei Xue Department of Gastroenterological Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND Through analyzing the data from a single institution in Northeast china,this study revealed the possible c{1.nicopathologic characteristics that influence the prognosis of patients with gastric cancer(GC).AIM To evaluate the changing trends of c{1.nicopathologic features and survival duration after surgery in patients with GC in Northeast china,which is a highprevalence area of *** The study analyzed the difference in c{1.nicopathologic features and survival duration after surgery of 5887 patients who were histologically diagnosed with GC at the Harbin Medical university Cancer *** study mainly analyzed the data in three periods,2000 to 2004(Phase 1.,2005 to 2009(Phase 2),and 201. to 201.(Phase 3).RESULTS Over time,the postoperative survival rate significantly increased from 2000 to *** the past 1. years,compared with Phases 1.and 2,the tumor size was smaller in Phase 3(P1.,but the proportion of high-medium differentiated tumors increased(P1..The proportion of early GC gradually increased from 3.9%to 1..4%(P1..A surprising improvement was observed in the mean number of retrieved lymph nodes,ranging from 1..4 to 27.5(P1..The overall 5-year survival rate increased from 24%in Phase 1.to 43.8%in Phase *** multivariate analysis,it was found that age,tumor size,histologic type,tumor-node-metastasis stage,depth of invasion,lymph node metastasis,surgical approach,local infiltration,radical extent,number of retrieved lymph nodes,and age group were independent risk factors that influenced the prognosis of patients with *** The c{1.nical features of GC in Northeast china changed during the observation *** increasing detection of early GC and more standardized surgical treatment effectively prolonged {1.fetimes.

关键词： Gastric cancer Clinicopathologic features Survival Time trends Epidemiology Gastrectomy

Gonadotropin-releasing hormone positively regulates steroidogenesis via extracellular signal-regulated kinase in rat Leydig cells

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Asian Journal of Andrology 2011年第3期13卷 438-445,512页

作者： Bing Yao Hai-Yan liu yu-chun Gu Shan-Shan Shi xiao-Qian Tao xiao-jun li yi-Feng Ge ying-xia cui Guo-Bin Yang Department of Reproduction and Genetics Nanjing Jingling Hospital Nanjing 210002 China Nanjing Normal university Nanjing 210046 China Department of Physiology The Medical School University of Birmingham Edgbaston B15 2TT UK Medical Administration Division Nanjing Jingling Hospital Nanjing 210002 China

Gonadotropin-releasing hormone （GnRH） is secreted from neurons within the hypothalamus and is necessary for reproductive function in all vertebrates. GnRH is also found in organs outside of the brain and plays an important role in Leydig cell steroidogenesis in the testis. However, the signalling pathways mediating this function remain largely unknown. In this study, we investigated whether components of the mitogen-activated protein kinase （MAPK） pathways are involved in GnRH agonist （GnRHa）-induced testis steroidogenesis in rat Leydig cells. Primary cultures of rat Leydig cells were established. The expression of 3β-hydroxysteroid dehydrogenase （3β-HSD） and the production of testosterone in response to GnRHa were examined at different doses and for different durations by RT-PCR, Western blot analysis and radioimmunoassay （RIA）. The effects of GnRHa on ERK1.2, JNK and p38 kinase activation were also investigated in the presence or absence of the MAPK inhibitor PD-98059 by Western blot analysis. GnRHa induced testosterone production and upregulated 3β-HSD expression at both the mRNA and protein levels; it also activated ERK1.2, but not JNK and p38 kinase. Although the maximum effects of GnRHa were observed at a concentration of 1.0 nmnol L-1.after 24 h, activation of ERKI/2 by GnRHa reached peak at 5 min and it returned to the basal level within 60 min. PD-98059 completely blocked the activation of ERKI/2, the upregulation of 3β-HSD and testosterone production. Our data show that GnRH positively regulates steroidogenesis via ERK signalling in rat Leydig cells. ERK1.2 activation by GnRH may be responsible for the induction of 3β-HSDgene expression and enzyme production, which may ultimately modulate steroidogenesis in rat Leydig cells.

关键词： 3β-HSD ERK1.2 GnRH JNK Leydig cell p38

Association of cumulative resting heart rate exposure with rapid renal function decline:a prospective cohort study with 27,564 older adults

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老年心脏病学杂志:英文版 2023年第9期20卷 673-683页

作者： xi JIANG xian SHAO xing li Pu-Fei BAI Hong-Yan liU Jia-Mian CHEN Wei-xi WU Zhuang cui Fang HOU chun-Lan LU Sai-jun ZHOU Pei yu NHC Key Laboratory of Hormones and Development Chu Hsien-I Memorial Hospital and Tianjin Institute of EndocrinologyTianjin Medical UniversityTianjinChina Tianjin Key Laboratory of Metabolic Diseases Tianjin Medical UniversityTianjinChina Ordos Center Hospital OrdosInner MongoliaSudu StreetKangbashi DistrictOrdos CityChina Department of Epidemiology and Health Statistics Tianjin Medical UniversityHeping DistrictTianjinChina Community Health Service Center Jiefang RoadTanggu StreetBinhai New DistrictTianjinChina

OBJECTIVE To evaluate the prospective association between cumulative resting heart rate(cumRHR)and rapid renal function decline(RRFD)in a cohort of individuals aged 60 and *** In the Tianjin Chronic Kidney Disease Cohort Study,the individuals who underwent three consecutive physical examinations between 2014 and 2017,with estimated glomerular filtration rate(eGFR)greater than 60 mL/min per 1.73 m2 and aged 60 years or older were enrolled.A total of 27,564 patients were prospectively followed up from January 1,2017 to December 31,*** 3-year cumRHR was *** primary outcome was RRFD,defined as an annualized decline in eGFR of 5 mL/min per 1.73 m2 or *** and restricted spline regression models and subgroup analysis were used to investigate the association of cumRHR with RRFD after adjusting for all *** During a median follow-up of 3.2 years,a total of 4,347(15.77%)subjects developed *** fully-adjusted models,compared with the lowest quartile of cumRHR,the odds ratio(OR)for the highest was 1.44(1.28–1.61),P27.97 beats/min per year)increment in cumRHR was associated with a 17%(Plinear positive correlation(P for non-linear=0.803).Participants with a 3-year cumRHR≥207(beats/min)*year(equivalent to≥69 beats/min per year in 3 years)were found to be at a higher risk of *** The cumRHR is significantly associated with a higher risk of RRFD among older *** results might provide an effective goal for managing and delaying the decline of renal function in the older adults.

关键词： prospective Kidney function

Peutz-Jeghers综合征脆性组氨酸三连体基因突变与癌变的关系

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癌症 2003年第1期22卷 50-54页

作者：赵喜荣康连春周永双贾义星陈竹康素海李文梅赵敏崔建涛孙安乐吕有勇山西省太原市中国人民解放军第264医院山西太原030001 北京大学临床肿瘤学院北京市肿瘤研究所分子生物学实验室北京100034

背景与目的:Peutz-Jeghers综合征(Peutz-Jegherssyndrome,PJS)是一种常染色体显性遗传性疾病。脆性组氨酸三连体(fragilehistidinetriad,FHIT)基因是定位于3p1..2脆性位点区域的重要抑癌基因。我们以往的研究结果认为PJS患者在3p1..2区域可能存在易感基因。本文旨在明确PJS患者FHIT基因突变与癌变的关系和FHIT基因的改变及规律。方法:应用变性高效液相色谱(DHPLC)分析、聚合酶链反应-单链构象多肽分析技术(PCR-SSCP)和DNA测序方法,对6个PJS家系中的1.个患者及其20例正常家族成员的FHIT基因进行了研究。结果:在6个家系中,有1.患者的FHIT基因第1.9位核苷酸由G→T,相应的第54位密码子编码的氨基酸由谷氨酸变成终止密码子;在第62位密码子处存在碱基G插入,使读码框架发生移位,在第1.1.密码子处提前出现终止密码子;在2例癌变患者的息肉标本DNA和癌标本DNA中检测到FHIT基因第8外显子的纯合性缺失;在3个散发的PJS患者中发现,患者与其母亲在第8外显子,有相同的SSCP带型和DHPLC峰型,DNA测序结果显示,在第98位密码子处发生同义突变,由CAT→CAC,相应编码的氨基酸未发生改变,均为苏氨酸。另外,有7例患者和2例正常人在FHIT基因的第6内含子5'端第42位核苷酸位点发生由A→G的点突变。

关键词：基因突变高效液相色谱 PCR-SSCP Peutz-Jeghers综合征脆性组氨酸三连体癌变