Association of cumulative resting heart rate exposure with rapid renal function decline:a prospective cohort study with 27,564 older adults

作     者：Xi JIANG Xian SHAO Xing LI Pu-Fei BAI Hong-Yan LIU Jia-Mian CHEN Wei-Xi WU Zhuang CUI Fang HOU Chun-Lan LU Sai-Jun ZHOU Pei YU Xi JIANG;Xian SHAO;Xing LI;Pu-Fei BAI;Hong-Yan LIU;Jia-Mian CHEN;Wei-Xi WU;Zhuang CUI;Fang HOU;Chun-Lan LU;Sai-Jun ZHOU;Pei YU

作者机构：NHC Key Laboratory of Hormones and DevelopmentChu Hsien-I Memorial Hospital and Tianjin Institute of EndocrinologyTianjin Medical UniversityTianjinChina Tianjin Key Laboratory of Metabolic DiseasesTianjin Medical UniversityTianjinChina Ordos Center HospitalOrdosInner MongoliaSudu StreetKangbashi DistrictOrdos CityChina Department of Epidemiology and Health StatisticsTianjin Medical UniversityHeping DistrictTianjinChina Community Health Service CenterJiefang RoadTanggu StreetBinhai New DistrictTianjinChina 

出 版 物：《老年心脏病学杂志:英文版》 (Journal of Geriatric Cardiology)

年 卷 期：2023年第20卷第9期

页      面：673-683页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

基　　金：funded by Tianjin Science and Technology Major Special Project Engineering Public Health Science and Technology Major Special Project (No.21ZXGWSY00100) Tianjin Natural Science Foundation Key Projects (22JCZDJC00590,21JCQNJC00460) Tianjin Key Medical Discipline(Specialty) Construct Project (No.TJYXZDXK-032A) The Science and technology talent project of Tianjin Health Commission (No. RC20175) The Scientific Research Funding of Tianjin Medical University Chu Hsien-I Memorial Hospital (No.ZXY-ZDSYSZD-1) China International Medical Exchange Foundation Key Fund Project (No.Z-2017-26-1902) Tianjin Municipal Health Care Commission Scientific Research Fund Project (ZC20128) 

主　　题：prospective Kidney function 

摘      要：OBJECTIVE To evaluate the prospective association between cumulative resting heart rate(cumRHR)and rapid renal function decline(RRFD)in a cohort of individuals aged 60 and *** In the Tianjin Chronic Kidney Disease Cohort Study,the individuals who underwent three consecutive physical examinations between 2014 and 2017,with estimated glomerular filtration rate(eGFR)greater than 60 mL/min per 1.73 m2 and aged 60 years or older were enrolled.A total of 27,564 patients were prospectively followed up from January 1,2017 to December 31,*** 3-year cumRHR was *** primary outcome was RRFD,defined as an annualized decline in eGFR of 5 mL/min per 1.73 m2 or *** and restricted spline regression models and subgroup analysis were used to investigate the association of cumRHR with RRFD after adjusting for all *** During a median follow-up of 3.2 years,a total of 4,347(15.77%)subjects developed *** fully-adjusted models,compared with the lowest quartile of cumRHR,the odds ratio(OR)for the highest was 1.44(1.28–1.61),P***,each 1-standard deviation(27.97 beats/min per year)increment in cumRHR was associated with a 17%(P0.001)increased risk of RRFD,with a linear positive correlation(P for non-linear=0.803).Participants with a 3-year cumRHR≥207(beats/min)*year(equivalent to≥69 beats/min per year in 3 years)were found to be at a higher risk of *** The cumRHR is significantly associated with a higher risk of RRFD among older *** results might provide an effective goal for managing and delaying the decline of renal function in the older adults.