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j.urnal of Pharmaceutical Analysis 2023年第12期13卷 1429-1451页

作者： Changhong nie Ibrahim Shaw Chuanpin Chen Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha410013China

With the continuous discovery and research of predictive cancer-related biomarkers,liquid biopsy shows great potential in cancer ***-enhanced Raman scattering(SERS)and microfluidic technology have received much attention among the various cancer biomarker detection *** former has ultrahigh detection sensitivity and can provide a unique *** contrast,the latter has the characteristics of miniaturization and integration,which can realize accurate control of the detection samples and high-throughput detection through *** have the potential for point-of-care testing(POCT),and their combination(lab-on-a-chip SERS(LoC-SERS))shows good *** this paper,the basic situation of circulating proteins,circulating tumor cells,exosomes,circulating tumor dNA(ctdNA),and microRNA(miRNA)in the diagnosis of various cancers is reviewed,and the detection research of these biomarkers by the LoC-SERS platform in recent years is described in *** the same time,the challenges and future development of the platform are discussed at the end of the *** the current technology is expected to provide a reference for scholars engaged in related work and interested in this field.

关键词： Cancer biomarkers Microfluidic technology Surface-enhanced Raman scattering

Optical recording of brain functions based on voltage-sensitive dyes

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Chinese Chemical Letters 2021年第6期32卷 1879-1887页

作者： Qian Yu Xing Wang Liming nie State Key Laboratory of Molecular Vaccinology and Molecular diagnosis&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361102China

To better understand the spatial distribution of brain functions,we need to monitor and analyze neuronal *** technique has provided an important method for the exploration of some neural ***,this method cannot simultaneously detect the activities of nerve cell ***,methods that can monitor the spatial distribution of neuronal population activity are demanded to explore brain ***-sensitive dyes(VSds)shift their absorption or emission optical signals in response to different membrane potentials,allowing assessing the global electrical state of *** recording technique coupled with VSds is a promising method to monitor the brain functions by detecting optical signal *** review focuses on the fast and slow responses of VSds to membrane potential changes and optical recordings utilized in the central nervous *** this review,we attempt to show how VSds and optical recordings can be used to obtain brain functional monitoring at high spatial and temporal *** of brain functions will not only greatly improve the cognition of information transmission of complex neural network,but also provide new methods of treating brain diseases such as Parkinson’s and Alzheimer’s diseases.

关键词： Voltage-sensitive dyes Cyanine dyes Membrane potential Brain function Photoacoustic imaging

Effect of Impeller Solidity on the Generating Performance for Solar Power Generation

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j.urnal of Electronic Science and Technology 2021年第4期19卷 308-318页

作者： j.a Liu Rui Tian j.ng nie with the College of Energy and Power Engineering Inner Mongolia University of TechnologyHohhot 010051 with the College of Aeronautics Inner Mongolia University of TechnologyHohhot 010051

According to current solar power research,both the generating unit’s minimum start-up speed and power generation system’s minimum flow rate for operation decrease with the increase in the impeller ***,a high solidity should be achieved,as this translates more power for a solar power system in the start-up and shut-down ***,increasing the number of blades does not increase the impeller solidity;therefore,there is an optimal number of blades needed to achieve the preferred *** paper begins by selecting the blade airfoil and then performs a theoretical analysis based on the relationship between the blade number and chord *** are conducted to measure the starting and stopping wind speeds and power characteristics for different numbers of *** results show that a maximum impeller solidity of 0.2862 is achieved,as well as the minimum flow speed at the start-up,and the maintenance of the solar chimney power generation system is optimized when there are four blades.

关键词： Blade number impeller solidity solar chimney power generation

Operational optimization of copper flotation process based on the weighted Gaussian process regression and index-oriented adaptive differential evolution algorithm

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Chinese j.urnal of Chemical Engineering 2024年第2期66卷 167-179页

作者： Zhiqiang Wang dakuo He Haotian nie College of Information Science and Engineering Northeastern UniversityShenyang 110004China State Key Laboratory of Synthetical Automation for Process Industries Northeastern UniversityShenyang 110004China

Concentrate copper grade(CCG)is one of the important production indicators of copper flotation processes,and keeping the CCG at the set value is of great significance to the economic benefit of copper flotation industrial *** paper addresses the fluctuation problem of CCG through an operational optimization ***,a density-based affinity propagationalgorithm is proposed so that more ideal working condition categories can be obtained for the complex raw ore ***,a Bayesian network(BN)is applied to explore the relationship between the operational variables and the *** on the analysis results of BN,a weighted Gaussian process regression model is constructed to predict the CCG that a higher prediction accuracy can be *** ensure the predicted CCG is close to the set value with a smaller magnitude of the operation adj.stments and a smaller uncertainty of the prediction results,an index-oriented adaptive differential evolution(IOAdE)algorithm is proposed,and the convergence performance of IOAdE is superior to the traditional differential evolution and adaptive differential evolution ***,the effectiveness and feasibility of the proposed methods are verified by the experiments on a copper flotation industrial process.

关键词： Weighted Gaussian process regression Index-oriented adaptive differential evolution Operational optimization Copper flotation process

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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j.urnal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua j. j.nggeol Na j.j.y Liu Young-j. Kim Wangyun Won department of Chemical and Biological Engineering Korea University department of Chemical Engineering (Integrated process) Kyung Hee University department of Chemical Engineering and Materials Science Ewha Womans University department of Chemical Engineering Pukyong National University Resources Engineering Plant Research department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass maj.rly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HdO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HdO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRdSCHARdOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

Grain size effect on wear resistance of WC-Co cemented carbides under different tribological conditions

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j.urnal of Materials Science & Technology 2019年第11期35卷 2435-2446页

作者： Haibin Wang Mark Gee Qingfan Qiu Hannah Zhang Xuemei Liu Hongbo nie Xiaoyan Song Zuoren nie College of Materials Science and Engineering Key Laboratory of Advanced Functional MaterialsEducation Ministry of ChinaBeijing University of TechnologyBeijing 100124China National Physical Laboratory Hampton RoadTeddingtonTW110LWUK Xiamen Tungsten Co. Ltd.Xiamen 361009China

The grain-size dependence of wear resistance of WC-Co cemented carbides(with mean WC grain sizes of 2.2μm,1.6μm,0.8μm and 0.4μm,respectively)was investigated under different tribological *** results showed that the grain size had opposite effects on wear resistance of the cemented carbides in dry sliding wear and microabrasion *** the former condition,with decrease of WC grain size hence the increase of hardness,plastic deformation,fracture,fragmentation and oxidation were all mitigated,leading to a drastic decrease in the wear *** the latter condition,pull-out of WC grains after Co removal dominated the wear,so that the hardness of cemented carbide was not a core *** a result,the wear resistance of the cemented carbide generally showed a decreasing trend with decrease of the grain size,except for a slight increase in the ultrafine-grained cemented ***-pass scratching of the cemented carbides under various loads indicated the same failure mechanism as that in the sliding wear ***,the reasons for severe surface oxidation of the coarse-grained cemented carbides were disclosed.

关键词： Cemented carbide Grain size Fracture Surface oxidation Grain pull-out Wear resistance

Numerical Simulation of duct Flow with Fog droplets

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j.urnal of Thermal Science 2010年第6期19卷 533-539页

作者： Abhilash Suryan j. K. Lee d. S. Kim H. d. Kim department of Mechanical Engineering Andong National University FMTRC Daejoo Machinery Co.

Evaporative cooling is a widely used air cooling technique. In this method, evaporation of a liquid in the surrounding air cools the air in contact with it. In the current investigation, numerical simulations are carded out to visualize the evaporation and dynamics of tiny water droplets of different diameters in a long air duct. The effect of initial droplet size on the temperature and relative humidity distribution of the air stream in the duct is investigated. Three different initial conditions of air are considered to verify the influence of ambient conditions. droplet spray patterns are also analyzed to identify the suitable locations for the spray nozzles within the duct. The resuits obtained are displayed in a series of plots to provide a clear understanding of the evaporative cooling process as well as the droplet dynamics within the ducts.

关键词： Evaporative cooling Fog droplet Two-phase flow Relative humidity

Enhanced optical absorption in semiconductor nano- particles enabled by nearfield dielectric scattering

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Nano Research 2017年第4期10卷 1292-1301页

作者： Kowsalya d. Rasamani j.nathan j. Foley IV Brittney Beidelman Yugang Sun department of Chemistry Temple University 1901 North 13th Street Philadelphia Pennsylvania 19122 USA department of Chemistry William Paterson University 300 Pompton Road Wayne New Jersey 07470 USA department of Physics Bryn Mawr College 101 North Merion Avenue Bryn Mawr Pennsylvania 19010 USA

The optical absorption of semiconducting AgBr nanocubes is significantly increased by up to 5 times in the measured spectral range when they are bonded to the surface of dielectric SiO2 nanospheres through electrostatic interaction. The absorption enhancement factor depends on the wavelength and the size of the SiO2 nanoparticles （NPs）. Finite-difference time-domain calculations provide the nearfield intensity mapping of a heterostructure that is composed of a AgBr nanocube in close contact with a SiO2 nanosphere. The electric-field distributions indicate the field enhancement near the SiO2/AgBr interface due to light scattering and absorption enhancement in the AgBr nanocube, implying that the enhanced scattering nearfield increases the absorption cross section of the AgBr nanocube. The absorption cross-section spectra calculated using Mie theory agree with the experimental observations. This discovery sheds light on the utilization of dielectric spherical particles to increase the absorption in semiconductor NPs, thus improving the light-harvesting efficiency for solar-energy conversion.

关键词： enhanced scattering nearfield dielectric scattering absorption enhancement Mie theory

Compression of surface texture acceleration signal based on spectrum characteristics

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Virtual Reality & Intelligent Hardware 2023年第2期5卷 110-123页

作者： dongyan nie Xiaoying SUN College of Communication Engineering Jilin UniversityChangchun 130022China International Center of Future Science Jilin UniversityChangchun 130012China

Background Adequate data collection can enhance the realism of online rendering or offline playback of haptic surface textures.A parallel challenge is to reduce communication delays and improve storage space *** Based on the similarity of the short-term amplitude spectrum trend,this study proposes a frequency-domain compression method.A compression framework is designed,which first maps the amplitude spectrum into grayscale images,compresses them with a still image compression method,and then adaptively encodes the maximum amplitude and part of the initial phase for each time window to achieve the final *** The comparison between the original signal and the recovered signal shows that when the time-frequency similarity is 90%,the average compression ratio of our method is 9.85%in the case of a single interaction *** subj.ctive score for similarity was found to be high,with an average of *** Our method can be used for offline compression of vibrotactile *** multi-interaction points in space,the trend similarity grayscale image can be reused,and the compression ratio is further reduced.

关键词： Compression Vibrotactile Haptics Surface texture Spectrum characteristics

MECHANICS OF RELAXING SiGe ISLANdS ON A VISCOUS GLASS

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Acta Mechanica Sinica 2002年第5期18卷 441-456页

作者： R. Huang H. Yin j. Liang j. C. Sturm K. d. Hobart Z. Suo Mechanical and Aerospace Engineering department and Princeton Materials Institute Princeton University Princeton USA department of Aerospace Engineering and Engineering Mechanics University of Texas at Austin Austin USA Center for Photonics and Optoelectronic Materials and department of Electrical Enineering Princeton University Princeton USA Naval Research Laboratory Washington DC USA

A process has been developed recently to fabricate a structure com- prising,from top to bottom,a SiGe thin film,a glass layer,and a Si *** SiGe film is a perfect crystal,and is under biaxial *** SiGe film is patterned into *** annealing,the glass flows and the islands *** resulting strain-free islands are used as substrates,to grow epitaxial optoelectronic *** article describes a series of studies on the annealing process,combining experiment and theory.A small island relaxes by expansion,starting at the edges and diffusing to the center.A large island wrinkles before the expansion reaches the *** some time,the wrinkles either disappear,or cause the island to fracture. We model the island as an elastic plate,and the glass layer as a viscous *** strains in the islands are measured by X-ray diffraction and Raman spectroscopy,and the wrinkle amplitudes by atomic force *** data are compared with the theoretical *** determine the conditions under which the islands relax by expansion without significant wrinkling,and demonstrate that a cap layer suppresses wrinkles,relaxing a large island crack-free.

关键词： semiconductor fabrication stress relaxation viscous flow elastic plate fracture