Application of microfluidic technology based on surface-enhanced Raman scattering in cancer biomarker detection:A review
作者机构：Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha410013China
出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)
年 卷 期：2023年第13卷第12期
页 面：1429-1451页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the Natural Science Foundation of Hunan Province China(Grant No.:2021JJ80078)
主 题：Cancer biomarkers Microfluidic technology Surface-enhanced Raman scattering
摘 要：With the continuous discovery and research of predictive cancer-related biomarkers,liquid biopsy shows great potential in cancer ***-enhanced Raman scattering(SERS)and microfluidic technology have received much attention among the various cancer biomarker detection *** former has ultrahigh detection sensitivity and can provide a unique *** contrast,the latter has the characteristics of miniaturization and integration,which can realize accurate control of the detection samples and high-throughput detection through *** have the potential for point-of-care testing(POCT),and their combination(lab-on-a-chip SERS(LoC-SERS))shows good *** this paper,the basic situation of circulating proteins,circulating tumor cells,exosomes,circulating tumor DNA(ctDNA),and microRNA(miRNA)in the diagnosis of various cancers is reviewed,and the detection research of these biomarkers by the LoC-SERS platform in recent years is described in *** the same time,the challenges and future development of the platform are discussed at the end of the *** the current technology is expected to provide a reference for scholars engaged in related work and interested in this field.
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