Optical recording of brain functions based on voltage-sensitive dyes

作     者：Qian Yu Xing Wang Liming Nie Qian Yu;Xing Wang;Liming Nie

作者机构：State Key Laboratory of Molecular Vaccinology and Molecular Diagnosis&Center for Molecular Imaging and Translational MedicineSchool of Public HealthXiamen UniversityXiamen 361102China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第6期

页      面：1879-1887页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

基　　金：financially supported by the National Natural Science Foundation of China(Nos.81922034,91859113) the Science Fund for Distinguished Young Scholars of Fujian Province(No.2018J06024) 

主　　题：Voltage-sensitive dyes Cyanine dyes Membrane potential Brain function Photoacoustic imaging 

摘      要：To better understand the spatial distribution of brain functions,we need to monitor and analyze neuronal *** technique has provided an important method for the exploration of some neural ***,this method cannot simultaneously detect the activities of nerve cell ***,methods that can monitor the spatial distribution of neuronal population activity are demanded to explore brain ***-sensitive dyes(VSDs)shift their absorption or emission optical signals in response to different membrane potentials,allowing assessing the global electrical state of *** recording technique coupled with VSDs is a promising method to monitor the brain functions by detecting optical signal *** review focuses on the fast and slow responses of VSDs to membrane potential changes and optical recordings utilized in the central nervous *** this review,we attempt to show how VSDs and optical recordings can be used to obtain brain functional monitoring at high spatial and temporal *** of brain functions will not only greatly improve the cognition of information transmission of complex neural network,but also provide new methods of treating brain diseases such as Parkinson’s and Alzheimer’s diseases.