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Journal of Computational Mathematics 2024年第4期42卷 1109-1123页

作者： Guangqiang lan yu Jiang College of Mathematics and Physics Beijing University of Chemical TechnologyBeijing 100029China

Convergence of modified truncated Euler-Maruyama(MTEM)method for stochastic differential equations(SDEs)with(1/2+α)-Holder continuous diffusion coefficients are investigated in this *** prove that the MTEM method for... 详细信息

关键词： Stochastic differential equations Modified truncated Euler-Maruyama method Strong convergence One-sided Lipschitz Holder continuous

Demonstration of high-dimensional controlled quantum teleportation for the first time

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 163-164页

作者： yu-Bo Sheng lan Zhou College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China College of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China

Controlled quantum teleportation(CQT) [1] is the tripartite version of quantum teleportation and it allows the teleportation of an unknown quantum state under the control of a third party. Compared with low-dimensional counterparts,high-dimensional CQT can exhibit larger information transmission capacity and a higher control power [2,3].

关键词： quantum dimensional high

Burning Numbers of Barbells

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 526-538页

作者： hui-qing LIU Rui-ting ZHANG Xiao-lan HU Hubei Key Laboratory of Applied Mathematics&Faculty of Mathematics and Statistic Hubei UniversityWuhan 430062China Hubei Key Laboratory of Mathematical Sciences&School of Mathematics and Statistics Central China Normal UniversityWuhan 430079China

Motivated by a discrete-time process intended to measure the speed of the spread of contagion in a graph,the burning number b(G)of a graph G,is defined as the smallest integer k for which there are vertices x1,…xk su... 详细信息

关键词： burning number short/long barbell isometric subtree cycle

Nanoparticle targeting cGAS-STING signaling in disease therapy

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Nano Research 2024年第8期17卷 7315-7336页

作者： lan Zhou yu Huang yuzhang Wu Shupei Tang Frontier Medical Training Brigade Third Military Medical UniversityHutubi 831200China Department of Gastroenterology Xinqiao HospitalThird Military Medical UniversityChongqing 400037China Institute of Immunology Third Military Medical UniversityChongqing 400038China Shigatse Branch Xinqiao HospitalThird Military Medical UniversityShigatse 857000China

The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon(IFN)genes(cGAS-STING)signaling pathway is crucial for sensing abnormal DNA accumulation in the *** binds to abnormal DNA,cGAS catalyzes the production of second messenger cyclic dinucleotides,followed by the activation of downstream *** activation induces the expression of type I interferon and other inflammatory cytokines,ultimately initiating an immune *** to the involvement of the cGAS-STING pathway in various diseases,including infection,tumor,autoimmune disease and kidney disease,ongoing research is focused on developing drugs and treatment methods to target and regulate this *** the development of nanotechnology,nanomedicines targeting cGAS-STING signaling are of great significance in clinical applications due to their targeted delivery,controlled drug release,improved solubility,multifunctionality,and enhanced *** comprehensive review focuses on the most recent progress of nanoplatforms targeting cGAS-STING in disease therapy,aiming to provide references and guidelines for further design and optimization of nanomedicines.

关键词： nanomedicine cGAS-STING pathway and related disease anti-tumor nanotherapy anti-viral nanotherapy

Weak Merging Scenario of CLASH Cluster A209

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Research in Astronomy and Astrophysics 2024年第4期24卷 174-182页

作者： Wen-Cheng Feng Heng yu Hai-hui Zhao Xiao-lan Hou Shu-Mei Jia Cheng-Kui Li yu-Lin Cheng Paolo Tozzi Ming Sun Yong Chen Department of Physics and Institute of Theoretical Physics Nanjing Normal UniversityNanjing 210023China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China Department of Astronomy Yunnan UniversityKunming 650091China INAF—Osservatorio Astrofisico di Arcetri Largo E.Fermi50122 FirenzeItaly Department of Astronomy University of VirginiaP.O.Box 400325CharlottesvilleVA 22904-4325USA

We study the structural and dynamical properties of A209 based on Chandra and XMM-Newton *** obtain detailed temperature,pressure,and entropy maps with the contour binning method,and find a hot region in the NW *** X-ray brightness residual map and corresponding temperature profiles reveal a possible shock front in the NW direction and a cold front feature in the SE *** with the galaxy luminosity density map we propose a weak merger scenario.A young sub-cluster passing from the SE to NW direction could explain the optical subpeak,the intracluster medium temperature map,the X-ray surface brightness excess,and the X-ray peak offset together.

关键词： X rays:galaxies:clusters galaxies:clusters:intracluster medium galaxies:clusters:Abell 209

A direct electrochemical biosensor for rapid glucose detection based on nitrogen-doped carbon nanocages

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Rare Metals 2024年第5期43卷 2184-2192页

作者： lan-lan Li yu Zhao Li-Jia Pan Jian-Bin Xu Yi Shi College of Mechanical and Electrical Engineering Henan Agricultural UniversityZhengzhou 450002China School of Electronic Science and Engineering Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China Department of Electronic Engineering The Chinese University of HongKongHongkong 999077China

Given the increasing number of diabetic patients,rapid and accurate detection of glucose in body fluids is *** study developed a direct electrochemical biosensor for glucose based on nitrogen-doped carbon nanocages(NCNCs).NCNCs possess a large specific surface area of 1395 m^(2)·g^(-1),a high N atomic content of 9.37%and good biocompatibility,which is favorable for enzyme loading and electron *** surface average concentration of electroactive glucose oxidase on NCNCs was 2.82×10^(-10)mol·cm^(-2).The NCNC-based direct electrochemical biosensor exhibited a high sensitivity of 13.7μA·(mmol·L^(-1))^(-1)·cm^(-2),rapid response time of 5 s and an impressive electron-transferrate constant(ks)of 1.87 s^(-1).Furthermore,we investigated an NCNC-based direct electron transfer(DET)biosensor for sweat glucose detection,which demonstrated tremendous promise for non-invasive wearable diabetes diagnosis.

关键词： Direct electron transfer(DET) Nitrogen-doped carbon nanocages(NCNCs) Glucose oxidase Biosensor

Huangqin Decoction Delays Progress of Colitis-Associated Carcinogenesis by Regulating Nrf2/HO-1 Antioxidant Signal Pathwayin Mice

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Chinese Journal of Integrative Medicine 2024年第2期30卷 135-142页

作者： GU Li-mei LI He-zhong GAO Lei LI hui WEI lan-fu PAN Cheng-yu WU Ke-xuan TIAN Yao-zhou Department of Gastrointestinal Endoscopy Affiliated Hospital of Nanjing University of Chinese MedicineNanjing(210029)China Department of Gastroenterology Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing(210028)China School of Integrated Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing(210023)China

Objective:To investigate the effect of Huangqin Decoction(HQD)on nuclear factor erythroid 2 related-factor 2(Nrf2)/heme oxygenase(HO-1)signaling pathway by inducing the colitis-associated carcinogenesis(CAC)model mice with azoxymethane(AOM)/dextran sodium sulfate(DSS).Methods:The chemical components of HQD were analyzed by liquid chromatography-quadrupole-time-of-flight mass spectrometry(LC-Q-TOF-MS/MS)to determine the molecular constituents of *** 48 C57BL/6J mice were randomly divided into 6 groups by a random number table,including control,model(AOM/DSS),mesalazine(MS),low-,medium-,and high-dose HQD(HQD-L,HQD-M,and HQD-H)groups,8 mice in each *** for the control group,the mice in the other groups were intraperitoneally injected with AOM(10 mg/kg)and administrated with 2.5%DSS orally for 1 week every two weeks(totally 3 rounds of DSS)to construct a colitis-associated carcinogenesis mouse *** mice in the HQD-L,HQD-M and HQD-H groups were given HQD by gavage at doses of 2.925,5.85,and 11.7 g/kg,respectively;the mice in the MS group was given a suspension of MS at a dose of 0.043 g/kg(totally 11 weeks).The serum levels of malondialdehyde(MDA)and superoxide dismutase(SOD)were measured by enzyme-linked immunosorbent *** mRNA and protein expression levels of Nrf2,HO-1,and inhibitory KELCH like ECH-related protein 1(Keap1)in colon tissue were detected by quantitative real-time PCR,immunohistochemistry,and Westem blot,***:LC-Q-TOF-MS/MS analysis revealed that the chemical constituents of HQD include baicalin,paeoniflorin,and glycyrrhizic *** to the control group,significantly higher MDA levels and lower SOD levels were observed in the model group(P<0.05),whereas the expressions of Nrf2 and HO-1 were significantly decreased,and the expression of Keap1 increased(P<0.01).Compared with the model group,serum MDA level was decreased and SOD level was increased in the HQD-M,HQD-H and MS groups(P<0.05).Higher expressions of

关键词： Huangqin Decoction colitis-associated carcinogenesis nuclear factor erythroid 2 related-factor 2/heme oxygenase signaling pathway oxidative stress Chinese medicine

Lacticaseibacillus rhamnosus Probio-M9 may be vertically transmitted from mother to infant during lactation based on faeces metagenomics

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Food Science and Human Wellness 2024年第2期13卷 721-728页

作者： lan Yang Lai-yu Kwok Zhihong Sun Heping Zhang Key Laboratory of Dairy Biotechnology and Engineering Ministry of EducationInner Mongolia Agricultural UniversityHohhot 010018China Key Laboratory of Dairy Products Processing Ministry of Agriculture and Rural AffairsInner Mongolia Agricultural UniversityHohhot 010018China Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering Inner Mongolia Agricultural UniversityHohhot 010018China

Probiotics exert beneficial effects on the *** study aimed to investigate whether maternally ingested Lacticaseibacillus rhamnosus Probio-M9 during pregnancy could access and colonize the infant *** study recruited one pregnant woman,who ingested Probio-M9 daily from 35 weeks of gestation to *** of the mother-infant pair were regularly collected from one month before delivery to 6 months of infant's age for metagenomic ***-M9 genomes were mappable to all infant fecal samples,suggesting the ingested probiotics could be vertically transmitted from mother to ***-or mother-specific differential metabolic pathways were found between the maternal and infant's gut microbiome,implicating apparent differences in the intestinal metagenomic potential/function between the mother and the *** conclusion,maternal ingestion of Probio-M9 during the final weeks of gestation could deliver to the infant *** findings provided novel insights into shaping infant's gut microbiota.

关键词： Metagenomic analysis Lacticaseibacillus rhamnosus Gut microbiome Mother Infant

Emerging mechanisms and implications of c GAS-STING signaling in cancer immunotherapy strategies

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Cancer Biology & Medicine 2024年第1期21卷 45-64页

作者： Jiawen Zhang Sihui yu Qiao Peng Ping Wang lan Fang Tongji University Cancer Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Obstetrics and Gynecology Zhongshan HospitalFudan UniversityShanghai 200032China

The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer *** this landscape,the innate immune system,a critical sentinel protecting against tumor incursion,is a key *** cyclic GMP-AMP synthase(c GAS)and stimulator of interferon genes(STING)pathway has been found to be a linchpin of innate immunity:activation of this signaling pathway orchestrates the production of type I interferon(IFN-α/β),thus fostering the maturation,differentiation,and mobilization of immune effectors in the tumor ***,STING activation facilitates the release and presentation of tumor antigens,and therefore is an attractive target for cancer *** strategies to activate the STING pathway,including use of pharmacological agonists,have made substantial advancements,particularly when combined with immune checkpoint *** approaches have shown promise in preclinical and clinical settings,by enhancing patient survival *** review describes the evolving understanding of the c GAS-STING pathway's involvement in tumor biology and ***,this review explores classical and non-classical STING agonists,providing insights into their mechanisms of action and potential for optimizing immunotherapy *** challenges and complexities,the c GAS-STING pathway,a promising avenue for enhancing cancer treatment efficacy,has the potential to revolutionize patient outcomes.

关键词： cGAS-STING pathway type I interferon cyclic dinucleotide STING agonist cancer immunotherapy

An effective'salt in dimethyl sulfoxide/water'electrolyte enables high-voltage supercapacitor operated at-50℃

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Journal of Energy Chemistry 2024年第6期93卷 361-367,I0009页

作者： Yingbin Liu Chang yu Xuedan Song Siyi Hou Shuqin lan Jinhe yu yuanyang Xie Jieshan Qiu State Key Lab of Fine Chemicals Frontier Science Center for Smart MaterialsSchool of Chemical EngineeringLiaoning Key Lab for Energy Materials and Chemical EngineeringDalian University of TechnologyDalian 116024LiaoningChina School of Chemistry Frontier Science Center for Smart MaterialsLiaoning Key Lab for Energy Materials and Chemical EngineeringDalian University of TechnologyDalian 116024LiaoningChina College of Chemical Engineering State Key Laboratory of Chemical Resource EngineeringBeijing University of Chemical TechnologyBeijing 100029China

Compared with organic electrolytes,aqueous electrolytes exhibit significantly higher ionic conductivity and possess inherent safety features,showcasing unique advantages in ***,challenges remain for low-salt aqueous electrolytes operating at high voltage and low ***,we report a low-salt(0.87 m,m means mol kg^(-1))'salt in dimethyl sulfoxide/water'hybrid electrolyte with non-flammability via hybridizing aqueous electrolyte with an organic co-solvent of dimethyl sulfoxide(hydrogen bond acceptor).As a result,the 0.87 m hybrid electrolyte exhibits enhanced electrochemical stability,a freezing temperature below-50℃,and an outstanding ionic conductivity of 0.52mS cm~(-1)at-50℃.Dimethyl sulfoxide can anchor water molecules through intermolecular hydrogen bond interaction,effectively reinforcing the stability of water in the hybrid ***,the interaction between dimethyl sulfoxide and water molecules diminishes the involvement of water in the generation of ordered ice crystals,finally facilitating the low-temperature performance of the hybrid *** paired with the 0.87 m'salt in dimethyl sulfoxide/water'hybrid electrolyte,the symmetric supercapacitor presents a 2.0 V high operating voltage at 25℃,and can operate stably at-50℃.Importantly,the suppressed electrochemical reaction of water at-50℃further leads to the symmetric supercapacitor operated at a higher voltage of 2.6 *** modification strategy opens an effective avenue to develop low-salt electrolytes for high-voltage and low-temperature aqueous supercapacitors.

关键词： Dimethyl sulfoxide Co-solvent High voltage Low temperature Supercapacitors