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Predictors of Direct-Acting Antivirals Failure in Patients with Chronic Hepatitis C Virus in Ivory Coast: About 5 Cases

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Open Journal of Gastroenterology 2019年第10期9卷 193-201页

作者： dimitri Hatrydt Kouamé Stanislas Adjéka Doffou Henriette Kissi Anzouan-Kacou Yannick Mfupa Tchana Aboubakar Demba Bangoura Mahassadi Kouamé Alassan Fulgence Bathaix Yao Alain Koffi Attia Thérè se Ndri Yoman Hepatogastroenterology Unit Yopougon Teaching Hospital Yopougon C&ocirc te d’Ivoire

Context and Aim: Direct-acting antivirals are the therapeutic revolution in the management of viral hepatitis C, but often with a few cases of failure. The aim of this study was to identify factors that may be implicated in the failure of direct-acting antiviral therapy in patients with hepatitis C virus in Ivory Coast. Methodology: This was a cross-sectional and descriptive study with a retrospective compendium of data from the year 2016 to the year 2018. This study included all patients with chronic viral hepatitis C, patients naive to antiviral treatment, or pre-treated patients in whom a failure to treatment with direct-acting antiviral has been diagnosed. Results: During the study period, 5 patients out of 14 cases of therapeutic failure were included, i.e. 35.71%. Most of the patients were over 50 years (4 out of 5) and predominantly female (3 out of 5). High blood pressure was the most common comorbidity (3 out of 5 patients). Genotype 1 was found in 4 patients versus 1 case of genotype 2. None of the patients had hepatitis B or HIV coinfection. A viral load > 6log was found in 4 patients at baseline. All our patients had hepatic cytolysis. Two of them were cirrhotic. All 4 cases of genotype 1 benefited from the combination sofosbuvir + ledipasvir for 12 weeks and the case of genotype 2 from the combination sofosbuvir + ribavirin for 24 weeks. The resistance mutations were observed mainly on the sequencing of NS5A at the Y93H, l31M, 28l, 30T, 31V, 58S and 93H genes and a case of mutation on the N3 gene sequencing. Conclusion: Age > 50 years, comorbidities (high blood pressure), polymedication, female gender, genotype 1b, viremia > 6log, and cytolysis were the profile of patients with treatment of HCV by direct-acting antiviral failure.

关键词： HVC Direct-Acting Antivirals Failure Ivory Coast

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Treatment of Chronic Hepatitis B with Tenofovir Disoproxil Fumarate in Ivory Coast

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Open Journal of Gastroenterology 2016年第2期6卷 39-45页

作者： Ya Henriette Kissi Anzouan-Kacou Adjeka Stanislas Doffou Djeinabou Diallo Demba Aboubacar Bangoura Yacouba Adéhouni Hatrydt dimitri Kouamé Alassan Kouamé Mahassadi Fulgence Yao Bathaix Koffi Alain Attia Aya Thérèse Ndri-Yoman Department of Medicine and Hepatogastroenterology University Hospital of Yopougon Abidjan Cote d’Ivoire Department of Pharmacy University Hospital of Yopougon Abidjan Cote d’Ivoire

little data exist on patients treated with tenofovir in Sub-Saharan Africa. Objective: To describe the clinical and laboratory characteristics of patients with viral hepatitis B treated with tenofovir. Material and methods: A descriptive single-center retrospective study, on chronic viral hepatitis B mono-infected, followed in the hepatogastroenterology department of the University Hospital of Yopougon and treated with tenofovir from February 2012 to February 2015. The studied parameters were demographic, clinical, biochemical, serological, virological, abdominal ultrasound. liver fibrosis was assessed either by liver biopsy or non-invasive tests. Results: 110 patients were treated with tenofovir disoproxil fumarate with a mean age of 40.4 years and a male predominance. Clinical examination revealed jaundice in 9% of cases, hepatomegaly in 7.3% of cases, splenomegaly in 9.1% of cases and ascites in 15.5% of cases. The AST averaged 77.3 IU/l, the AlT 76.8 IU/l, prothrombin rate at 76.6% , albumin level at 32.3 g/l, total bilirubin at 29.9 g/l, alpha fetoprotein rate at 15.3 ng/ml. HBe antigen was negative in 76.2% of cases. The average rate of DNA at baseline was 7.4 log10 IU/l. 27.5% was cirrhotic. The average time of starting treatment was 23.7 months. Conclusion: TDF is the first-line treatment for chronic hepatitis B in our country, because it is a well-tolerated, potent therapy with a high threshold for resistance development. Our study population had an average age of 40.4 years. Virological profile was dominated by HBe antigen negative patients and high viral load of HVB DNA. One third of patients were at the stage of cirrhosis. This treatment must be delivered free of charge in all the country hospitals, which is going to improve significantly the natural evolution of the disease and to decrease the incidence of the HCC.

关键词： Chronic Hepatitis B Virus Tenofovir Disoproxil Fumarate Treatment Ivory Coast Sub-Saharan Africa

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Treatment of Chronic Viral Hepatitis with Pegylated Interferon in Ivory Coast

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Open Journal of Gastroenterology 2016年第3期6卷 65-74页

作者： Henriette Ya Kissi Anzouan-Kacou Aboubacar Demba Bangoura Djenabou Diallo Yacouba Adéhouni Adjeka Stanislas Doffou Hartrydt dimitri Kouamé Alassan Kouamé Mahassadi Mamert Fulgence Yao Bathaix Alain Koffi Attia Aya Thérèse Ndri-Yoman Hepatogastroenterology Unit Yopougon Teaching Hospital Yopougon Ivory Coast Pharmacy Unit Yopougon Teaching Hospital Yopougon Ivory Coast

Background: In the Ivory Coast, chronic infection by hepatitis B and C virus is the leading cause of cirrhosis and hepatocellular carcinoma. The absence of universal health coverage makes the treatment inaccessible to all. Objectives: To assess the efficacy of Pegylated Interferon in clinical practice in patients with chronic viral hepatitis B and C and determine the hematologic side effects. Patients and Methods: A descriptive retrospective study from January 2012 to November 2013 on a cohort of patients chronic carriers of hepatitis B virus (n = 11) treated with Pegylated Interferon to 180 mcg per week and hepatitis C virus (n = 30) treated with a combination therapy associating pegylated Interferon to 180 mcg per week and Ribavirin assayed according to the genotype. Results: Out of 1860 patients seen in hepatogastroenterology consultation 422 had viral hepatitis B or C that is a prevalence of 22.7% and 41 patients were treated (9.7%) by Pegylated Interferon. Among these 41 patients mentioned earlier, 30 had HCV (73.17%) with a case of HIV + HVC co-infection, 11 patients had HBV (26.83%) including 3 cases of HBV + HDV co-infection. Patients’ age ranged from 24 - 69 years with an average of 49.2 ± 12.2 years including 46.5 years for HBV and 51.9 years for HCV. The sex ratio was 1.56. The original transaminases were on average 93.37 IU/l for AST and 110.47 for AlT. The average RNA HCV was 1,685,331 IU/ml and the DNA HBV 33,312,767 IU/ml. Patients with HCV were of genotype 1 in 56.66%, genotype 2 in 40% and one case of genotype 4 (3.34%) from Central Africa. Fibrosis score at institution of treatment was significant (≥A2 and/or ≥F2) in 86.9% of cases of Fibrotest®, 100% of cases of Fibrometer®. We observed 48.8% of neutropenia lated Interferon and Ribavirin. For HBV there were 3 partial responses, 3 responders including 1 HBV + HDV co-infected non responder to H

关键词： HBV HCV Pegylated Interferon Ribavirine Africa

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Innovative Education and Training in high power laser plasmas(PowerlaPs) for plasma physics, high power laser-matter interactions and high energy density physics-theory and experiments

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High Power laser Science and Engineering 2019年第2期7卷 22-26页

作者： John Pasley Georgia Andrianaki Andreas Baroutsos dimitri Batani Emmanouil P.Benis Marco Borghesi Eugene Clark Donna Cook Emmanuel D'Humieres Vasilios dimitriou Brendan Dromey Michael Ehret Ioannis Fitilis Anastasios Grigoriadis Satya Kar Evaggelos Kaselouris Ondrej Klimo Michel Koenig Kyriaki Kosma George Koundourakis Milan Kucharik Aveen lavery Jiri limpouch Yannis Orphanos Nektarios A.Papadogiannis Stelios Petrakis Dave Riley Maria Serena Rivetta laura Tejada Pascual Joao Jorge Santos Alexandros Skoulakis Ioannis Tazes Vladimir Tikhonchuk Jocelain Trela Calliope Tsitou luca Volpe Steven White Mark Yeung Michael Tatarakis York Plasma Institute University of York Technological Educational Institute of Crete School of Applied SciencesCentre for Plasma Physics and Lasers-CPPL Universitéde Bordeaux CNRSCEACELIA(Centre Lasers Intenses et Applications) Department of Physics University of Ioannina Centre for Plasma Physics School of Mathematics and PhysicsQueen’s University Belfast Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in Prague lUlI-CNRS Ecole Polytechnique CEA:UniversitéParis-Saclay UPMC Univ Paris 06:Sorbonne Universités ClPU laser-Plasma Chair University of Salamanca Centro de láseres Pulsados(ClPU) Edificio M5.Parque Cientfico.C/Adaja

The Erasmus Plus programme’Innovative Education and Training in high power laser plasmas’,otherwise known as PowerlaPs,is *** PowerlaPs programme employs an innovative paradigm in that it is a multi-centre programme where teaching takes place in five separate institutes with a range of different aims and styles of *** ’in class’ time is limited to four weeks a year,and the programme spans two *** aims to train students from across Europe in theoretical,applied and laboratory skills relevant to the pursuit of research in laserplasma interaction physics and inertial confinement fusion(ICF).lectures are intermingled with laboratory sessions and continuous assessment *** programme,which is led by workers from the Technological Educational Institute(TEI)of Crete,and supported by co-workers from the Queen’s University Belfast,the University of Bordeaux,the Czech Technical-University in Prague,Ecole Polytechnique,the University of Ioannina,the University of Salamanca and the University of York,has just completed its first *** far three learning Teaching Training(lTT)activities have been held,at the Queen’s University Belfast,the University of Bordeaux and the Centre for Plasma Physics and lasers(CPPl)of TEI *** last of these was a two-week long Intensive Programme(IP),while the activities at the other two universities were each five days in *** far work has concentrated upon training in both theoretical and experimental work in plasma physics,high power laser-matter interactions and high energy density *** nature of the programme will be described in detail and some metrics relating to the activities carried out to date will be presented.

关键词： higher education inertial confinement fusion laser-plasma interactions post-graduate education

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白树,蒙彼利埃,法国

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世界建筑 2020年第10期 30-35,137页

作者：无尼古拉斯·莱斯内迪米特里·鲁塞尔天妮(译) Iwan Baan(摄影) 藤本壮介建筑设计事务所尼古拉斯•莱斯内建筑师事务所 DREAM事务所 OXO建筑师事务所不详

起源独特的项目,2013年,蒙彼利埃市议会发起了一项名为“Folie Richter”的竞赛。竞赛旨在征集一个标志性的塔楼方案以丰富城市的建筑传统。任务书强调,这个宏大的项目必须能够融入其周边环境,同时需要涵盖一系列商业及居住空间。导则... 详细信息

起源独特的项目,2013年,蒙彼利埃市议会发起了一项名为“Folie Richter”的竞赛。竞赛旨在征集一个标志性的塔楼方案以丰富城市的建筑传统。任务书强调,这个宏大的项目必须能够融入其周边环境,同时需要涵盖一系列商业及居住空间。导则还清楚地指出:市政厅想要年轻建筑师及有经验的团队……马纳尔·拉赫迪和尼古拉斯•莱斯内是两位都创办了独立事务所的建筑师,他们决定拜访曰本建筑师藤本壮介。

关键词：居住空间蒙彼利埃藤本壮介任务书尼古拉斯市议会市政厅竞赛

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Innovative education and training in high power laser plasmas(PowerlaPs) for plasma physics, high power laser matter interactions and high energy density physics: experimental diagnostics and simulations

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High Power laser Science and Engineering 2020年第1期8卷 30-36页

作者： John Pasley Georgia Andrianaki Andreas Baroutsos dimitri Batani Emmanouil PBenis Andrea Ciardi Donna Cook Vasilios dimitriou Brendan Dromey Ioannis Fitilis Giancarlo Gatti Anastasios Grigoriadis Marine Huault Jose Antonio Pérez Hernández Evaggelos Kaselouris Ondrej Klimo Michel Koenig George Koundourakis Milan Kucharik Jiri limpouch Richard liska Carlos Salgado lopez Sophia Malko Susana Olmos-Miguelanez Yannis Orphanos Valeria Ospina Nektarios APapadogiannis Stelios Petrakis Jan Psikal Maria Serena Rivetta Maria-ose Rodriguez-Conde Joao Jorge Santos Milan Sinor Alexandros Skoulakis Ioannis Tazes laura Tejada Pascual Calliope Tsitou Pavel Vachal luca Volpe Jiri Vyskocil Steven White Mark Yeung Ghassan Zerouli Michael Tatarakis York Plasma Institute University of YorkHeslingtonYork YO105DQUK Hellenic Mediterranean University Institute of Plasma Physics and Lasers-IPPL74100 Rethymnon73133 ChaniaCreteGreece University of Bordeaux CNRSCEACELIA(Centre Lasers Intenses et Applications)UMR 5107F-33405 TalenceFrance Department of Physics University of IoanninaGR 45110 IoanninaGreece lUlI-CNRS CEASorbonne UniversiesEcole PolytechniqueInstitut Polytechnique de Paris-F-91128 Palaiseau CedexFrance Observatoire de Paris 5 Place J JanssenMeudon 92195France Centre for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastBelfast BT71NNUK Centro de láseres Pulsados(ClPU) Edificio M5Parque CientficoC/Adaja 837185 VillamayorSalamancaSpain University of Salamanca 37008 SalamancaSpain Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in PragueBrehova 711519Prague 1Czech Republic University Institute for Educational Sciences University of Salamanca37008 SalamancaSpain Group of Research“Interaction and e learning”(GRIAl) University of Salamanca37008 SalamancaSpain ClPU laser-Plasma Chair at University of Salamanca 37008 SalamancaSpain

The second and final year of the Erasmus Plus programme’Innovative Education and Training in high power laser plasmas’,otherwise known as PowerlaPs,is *** PowerlaPs programme employs an innovative paradigm in that it is a multi-centre programme,where teaching takes place in five separate institutes with a range of different aims and styles of ***’in-class’time is limited to 4 weeks a year,and the programme spans 2 *** aims to train students from across Europe in theoretical,applied and laboratory skills relevant to the pursuit of research in laser plasma interaction physics and inertial confinement *** are intermingled with laboratory sessions and continuous assessment *** programme,which is led by workers from the Hellenic Mediterranean University and supported by co-workers from the Queen’s University Belfast,the University of Bordeaux,the Czech Technical University in Prague,Ecole Polytechnique,the University of Ioannina,the University of Salamanca and the University of York,has just finished its second and final *** learning Teaching Training activities have been held at the Queen’s University Belfast,the University of Bordeaux,the Czech Technical University,the University of Salamanca and the Institute of Plasma Physics and lasers of the Hellenic Mediterranean *** last of these institutes hosted two 2-week-long Intensive Programmes,while the activities at the other four universities were each 5 days in *** addition,a’Multiplier Event’was held at the University of Ioannina,which will be briefly *** this second year,the work has concentrated on training in both experimental diagnostics and simulation techniques appropriate to the study of plasma physics,high power laser matter interactions and high energy density *** nature of the programme will be described in detail,and some metrics relating to the activities carried out will be *** particular,this paper will f

关键词： laser plasma interactions postgraduate education

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一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)

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中华神经外科疾病研究杂志 2014年第5期13卷 433-433页

作者： Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M dimitri l Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P laboratory of Oncology "IRCCS Casa Sollievo della Sofferenza" laboratory of Genetics "IRCCS Casa Sollievo della Sofferenza" Department of Biosciences Biotechnology and BiopharmaceuticsUniversity of Bari "Aldo Moro" lTTA Department of MorphologySurgery and Experimental MedicineHuman Anatomy BranchUniversity of Ferrara Department of Neurosurgery "IRCCS Casa Sollievo della Sofferenza " Department of Pathology "IRCCS Casa Sollievo della Sofferenza" Unit of Biostatistics "IRCCS Casa Sollievo della Sofferenza" Department of Oncology "IRCCS Casa Sollievo della Sofferenza" CIR laboratory for Molecular Medicine and Biotechnology University Campus Biomedico

Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade ***-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and lower Grade Glioma( lGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas.

关键词：神经外科学疾病临床研究医学

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