检索结果-南通市图书馆

High-frequency magnetic stimulation attenuates beta-amyloid protein 1-42 neurotoxicity in organotypic hippocampal slices

引用

Neural Regeneration Research 2010年第18期5卷 1365-1372页

作者： Don-Kyu Kim Young Chul Yoon Soo Ahn Chae kyung Mook Seo Tai Ryoon Han Si-hyun Kang Department of Physical Medicine and Rehabilitation Chung-Ang University College of Medicine Department of Neurology Chung-Ang University College of Medicine Department of Pediatrics Chung-Ang University College of Medicine Department of Physical Medicine and Rehabilitation Seoul National University

Repetitive transcranial magnetic stimulation （rTMS） has been utilized as a therapeutic tool for neurodegenerative disorders including Alzheimer＇s disease. However, the precise mechanisms of its clinical effects remain unknown. β-amyloid （Aβ） exhibits direct neurotoxic effects and is closely related to neuronal degeneration in Alzheimer＇s disease. Therefore, it has been hypothesized that the neuroprotective effects of rTMS are related to the mechanisms of protection against Aβ neurotoxicity. Organotypic hippocampal slices were prepared from 8-day old, Sprague Dawley rats. The tissue slices were exposed to 100 μmol/L Al3142 since day 12 in vitro with and without high-frequency （20 Hz） magnetic stimulation. Magnetic stimulation efficacy was evaluated by measuring neuronal nuclei （NeuN） protein expression and by observing cultures following propidium iodide fluorescence staining and bromodeoxyuridine （BrdU） immunohistochemistry. Lactate dehydrogenase activity was detected in the culture media to evaluate hippocampal neuronal damage. Our results demonstrated that high-frequency magnetic stimulation significantly reversed the reduction of NeuN protein expression because of Aβ1-42 exposure （P 〈 0.05） and significantly reduced the number of damaged cells in the hippocampal slices （P 〈 0.05）. However, lactate dehydrogenase levels and anti-BrdU staining results did not reveal any statistical differences These findings indicate that high-frequency magnetic stimulation might have protective effect on hippocampal neurons from Aβ1-42 neurotoxicity.

关键词： organotypic hippocampus amyloid beta-protein magnetic stimulation nerve degeneration/metabolism nerve degeneration/pathology organ culture techniques rats, Sprague Dawiey

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhanced light emission from AlGaN/GaN multiple quantum wells using the localized surface plasmon effect by aluminum nanoring patterns

引用

Photonics Research 2018年第1期9卷 30-36页

作者： kyung ROCK SON BYEONG RYONG LEE MIN HO JANG hyun CHUL PARK YONG HOON CHO TAE GEUN KIM School of Electrical Engineering Korea University Anam-ro 145 Seongbuk-gu Seoul 02841 South Korea Department of Physics and KI for the NanoCentury Korea Advanced Institute of Science and Technology Daejeon 305-701 South Korea

We investigate the localized surface plasmon(LSP) effect by Al nanorings on the AlGaN/GaN multiple quantum well(MQW) structure emitting at 365 nm. For this experiment, first, the size of Al nanorings is optimized to maximize the energy transfer(or coupling) between the LSP and MQW using the silica nanospheres. Then, the Al nanorings with an outer diameter of 385 nm, which exhibit a strong absorption peak in the near-ultraviolet region, are applied to the top surface of the AlGaN/GaN MQW. The photoluminescence(PL) intensity of the MQW structure with Al nanorings increased by 227% at 365 nm compared to that without Al *** improvement is mainly attributed to an enhanced radiative recombination rate in the MQWs through the energy-matched LSPs by the temperature-dependent PL and time-resolved PL analyses. The radiative lifetime was about two times shorter than that of the structure without Al nanorings at room temperature. In addition, the measured PL efficiency at room temperature of the structure with Al nanorings was 33%, while that of the structure without Al nanorings was 19%, implying that LSP-QW coupling together with the nanoring array pattern itself played important roles in the enhancement.

关键词：等离子体通讯技术能量转移量子

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Arabidopsis thaliana RECEPTOR DEAD KINASE1 Functions as a Positive Regulator in Plant Responses to ABA

引用

Molecular Plant 2017年第2期10卷 223-243页

作者： Dhinesh Kumar Ritesh Kumar Dongwon Baek Tae-kyung hyun Woo Sik Chung Dae-Jin Yun Jae-Yean Kim Division of Applied Life Sciences Plant Molecular Biology and Biotechnology Research Center Gyeongsang National University Jinju 660-701 Korea Department of Industrial Plant Science and Technology Conege of Agricultural Life and Environmental Sciences Chungbuk National University Cheongju 28644Korea These authors contributed equally to this article.

Abscisic acid （ABA） is a major phytohormone involved in important stress-related and developmental plant processes. Membrane-delimited ABA signal transduction plays an important role in early ABA signaling, but the molecular mechanisms connecting core signaling components to the plasma membrane remain un- clear. Plants have evolved a large number of receptor-like kinases （RLKs） to modulate diverse biological processes by perceiving extracellular stimuli and activating downstream signaling responses. In this study, a putative leucine-rich repeat-RLK gene named RECEPTOR DEAD KINASE1 （AtRDK1） was identified and characterized in Arabidopsis thaliana. RDK1 promoter-GUS analysis revealed that RDK1 is expressed ubiq- uitously in the various tissues in Arabidopsis, and its expression is mainly induced by ABA. In the presence of ABA, RDKl-deficient rdkl-1 and rdkl-2 lines showed significant resistance in cotyledon greening and root growth, whereas RDKl-overexpressing lines showed enhanced sensitivity. Consistently, the expres- sion of ABA-responsive genes was significantly downregulated in rdkl mutant seedlings, which were also hypersensitive to drought stress with increased water loss. Interestingly, RDK1 was found to be an atypical kinase localized to the plasma membrane and did not require its kinase activity during ABA-mediated inhi- bition of seedling development. Accordingly, RDK1 interacted in the plasma membrane with type 2C protein phosphatase ABSClSIC ACID INSENSITIVE1 （ABI1）; this interaction was further enhanced by exogenous application of ABA, suggesting that RDKl-mediated recruitment of ABI1 onto the plasma membrane is important for ABA signaling. Taken together, these results reveal an important role for RDK1 in plant responses to abiotic stress conditions in an ABA-dependent manner.

关键词： ABA abiotic stress Arabidopsis atypical kinases protein phosphatases receptor-like kinases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Machining characteristics of complex prism pattern on electroplated roll by copper

引用

中国有色金属学会会刊：英文版 2009年第B9期19卷 288-294页

作者： Tae-Jin JE Sang-Cheon PARK Kang-Won LEE Yeong-Eun YOO Doo-Sun CHOI kyung-hyun WHANG Myung-Chang KANG Nano-Machining Laboratory Division of Nano-Mechanical Systems Korea Institute of Machinery and Materials Nano-Mechatronics Department University of Science and TechnologySinseongnoYouseong-GuDaejeonKorea National Core Research Center for Hybrid Materials Solution Pusan National University

The BLU (back light unit) is the core component of the LCD for notebook, mobile-phone, navigation, as well as large sized TV, PID (public information display), etc. In order to enhance optical efficiency of LCD, optical films with the uniform prism patterns have been used for BLU by stacking two films up orthogonally. In this case, light interference-phenomenon occurred such as Morie, wet-out, u-turning, etc. It caused several problems such as low brightness, spots and stripes in LCD. Recently, the high-luminance micro complex prism patterns are actively studied to avoid the light interference-phenomenon and enhance the optical efficiency. In this study, the roll master to manufacture complex micro prism pattern film was machined by using the high precision lathe. The machined patterns on the roll master were 50, 45, 40, 35, 30, 25, 20, 15, 10 and 5 μm in the pitch with 25.0, 22.5, 20.0, 17.5, 15.0, 12.5, 10.0, 7.5, 5.0 and 2.5 μm in the peak height, respectively. The roll was 2 000 mm in length and 320 mm in diameter. The electroplated roll by copper and the natural single crystal diamond tool was used for machining the patterns. The cutting force was measured and analyzed for each cutting condition by using the dynamometer. The chips and the surfaces after being machined were analyzed by SEM and microscope.

关键词：车床加工微棱镜铜电镀特征光学效率光学薄膜笔记本电脑金刚石工具

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Conditioned secretome of adipose-derived stem cells improves dextran sulfate sodium-induced colitis in mice

引用

World Journal of Gastroenterology 2021年第23期27卷 3342-3356页

作者： Seunghun Lee Jeonghoon Heo Eun-kyung Ahn Jae hyun Kim Young-Ho Kim Hee-kyung Chang Sang-Joon Lee Jongsik Kim Seun-Ja Park Department of Colorectal Surgery Kosin University College of MedicineBusan 49267South Korea Department of Molecular Biology and Immunology Kosin University College of MedicineBusan 49267South Korea Department of Gastroenterology Kosin University College of MedicineBusan 49267South Korea Department of Pathology Kosin University College of MedicineBusan 49267South Korea Department of Ophthalmology Kosin University College of MedicineBusan 49267South Korea Department of Anatomy Kosin University College of MedicineBusan 49267South Korea

BACKGROUND Inflammatory bowel diseases(IBD)is related to uncontrolled immune ***,there is no successful treatment for significant improvement in *** cells display their therapeutic effects through their repopulating capacity or secreting *** To investigate the effects of conditioned mouse adipose-derived stem cells(mADSCs)secretome on colitis-induced *** mADSCs were isolated from adipose tissue of C57BL/6 *** mADSCs secrectome was obtained by culturing of mADSCs with lipopolysaccharides(LPS,1μg/mL)for 24 *** colitis was induced by 2%dextran sulfate sodium(DSS)drinking water for 7 d and then normal drinking water for 4 *** mice were treated with normal culture medium(NM group),conditioned mADSCs secretome(CM group)or mADSCs(SC group).The length of colon and histopatholgy of colon tissues were *** mRNA expression levels of inflammatory cytokines in colon tissue and the serum interleukin(IL)-6 levels were *** The isolated mADSCs maintained the mADSCs specific gene expression profiles during *** conditioned mADSCs secretome released by the treatment of mADSCs with LPS contained mainly inflammatory chemokines,colony-stimulating factors and inflammatory *** loss of body weight and reduction in colon length were ameliorated in the CM *** conditioned mADSCs secretome reduced the histological score in colon *** expression of IL-1b and IL-6 mRNAs in colon tissues significantly inhibited in the CM group compared to SC group and NM group,*** elevation of serum IL-6 levels was also ameliorated in the CM *** results indicate that the conditioned mADSCs secretome suppressed the synthesis of inflammatory cytokines in damaged colon tissue and the elevation of serum IL-6 concentration in DSS-induced mice CONCLUSION Conditioned mADSCs secretome might play regenerative roles by the suppression of IL-6 in serum and tissue during acute colitis,and may be

关键词： Adipose-derived stem cells Conditioned secretome Cytokines Interleukin-6 Colitis Regeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of tool deflection on micro channel pattern of 6:4 brass with rectangular tool

引用

中国有色金属学会会刊：英文版 2009年第B9期19卷 164-170页

作者： Tae-Jin JE Kang-Won LEE Sang-Cheon PARK Jae-Gu KIM Doo-Sun CHOI Kyoung-Taik PARK kyung-hyun WHANG Nano Mechanical Systems Research Division Korea Institute of Machinery & Materials (KIMM)

Machining experiment of micro channel structure with 6:4 brass was carried out by shaping process using a single crystal diamond tool. FEM simulation using solid cantilever beam model was analyzed. In result of experiment, tool deflection is observed as machining characteristics through result of experiments such as surface roughness, cutting force and burr formations. And the influence of tool deflection is experimentally proved.

关键词：金刚石工具挠度通道模式黄铜矩形实验证明加工特性有限元模拟

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Functional Analysis for Rolling Leaf of Somaclonal Mutants in Rice (Oryza sativa L.)

引用

American Journal of Plant Sciences 2011年第1期2卷 56-62页

作者： Young-Hie Park hyun-Suk Lee gi-Hwan Yi Jae-Keun Sohn kyung-Min Kim 不详

This study was carried out to facilitate the functional analysis of rice genes. Some 297 insertion plants (1.7%) of the entire lines with the endogenous retrotransposon Tos17 were produced. Phenotypes of these plants in the S2 genera-tion were observed in the field according to different leaf types. Rolling leaf mutants showed thinner sclerenchyma-tous cells, defective arrangement of vascular bundles, and well-formed bulliform cells as compared to the parental cultivar. Two new copies of Tos17 were detected in the rolling leaf type. In the new leaf type, the copy number and activation of Tos12, 15 did not appear as ‘Ilpum’. Flanking sequence tag (FST) analysis of Tos17 in the rolling leaf mutant indicated that new copies of Tos17 were transposed on chromosomes 11 and 12. Annotated homologues of the tagging genes on chromosome 11 were arabinoxylan rabinofuranohydrolase isoenzyme AXAH-I and II. The tagging gene in chromosome 12 was highly correlated with 6 kinds of genes including a transcript regulated factor and a rough sheath 2-like protein. This rolling leaf and flanking sequence data will stimulate the functional analysis of rice genes.

关键词： Tissue Culture Somaclonal Variation Mutant Opaque Endosperm Tos Element

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Correlation of Microstructure and Hydrogen Delayed Fracture for 1GPa Steels

引用

Journal of Iron and Steel Research International 2011年第S1期18卷 252-254页

作者： Hee Jae Kang Ji Tae Park Soon Tae Ahn kyung Mox Cho Nam hyun Kang Department of Materials Science and Engineering Pusan National UniversityBusan 609-735Korea Samhwa Steel 339-4 Samrak-dongSasang-guBusan 617-825Korea

Automobile industry tries to reduce the weight of automobile using high-strength ***,the high-strength steels are highly susceptible to delayed-fracture caused by hydrogen *** increasing the strength,hydrogen embrittlement is more sensitive to diffusible *** mechanism of delayed-fracture and the relationship with the microstructure and alloying elements are still *** study analyzed the effect of the size and the spheroidization rate for the carbides on hydrogen-induced delayed fracture for 1GPa TS steel.

关键词： hydrogen delayed fracture microstructure spheroidization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Isothermal Annealing on Nano Ti-Carbides Precipitation

引用

Journal of Iron and Steel Research International 2011年第S1期18卷 287-289页

作者： Cheol-ho Park Woo-jin Kim Nam-hyun Kang hyung-hyup Do kyung-Mox Cho Department of Materials Science and Engineering Pusan National UniversityBusan 609-735Korea Technical Research Laboratories Hyundai steelsDangjinChungnam 343-711Korea

Transmission electron microscopy was used to investigate the effect of isothermal holding temperature and time on the nano Ti-precipitates.A holding temperature was varied systematically from 400℃ to 1200℃.The isothermal holding was continued for 30s,300s and 900s,*** carbides of (Ti,Nb)C were precipitated significantly at 900℃.The size of carbides was approximately 10nm at 30s holding and increased to 20～30nm at 900s *** holding at 1000℃ showed the increased amount of carbides larger than *** 800℃,nano (Ti,Nb)C was not observed at 30s and it was examined at *** size of nano (Ti,Nb)C was smaller than that of 900℃.As the isothermal temperature decreased to 700 ℃,the nano (Ti,Nb)C was only seen at 900s holding and the size of carbides was smaller than *** (Ti,Nb)C was disappeared at isothermal holding below 600℃.The kinetics of nano (Ti,Nb)C precipitation were studied as a function of isothermal holding temperature and time,respectively,using the precipitate growth equations.

关键词： Ti carbide hot rolled steel hole expansion ratio isothermal holding nano precipitates

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ethanol extract of Chondracanthus tenellus(Harvey)Hommersand attenuates lipopolysaccharide-induced inflammatory and oxidative response by blocking the NF-κB,MAPKs,and PI3K/Akt signaling pathways

引用

Asian Pacific Journal of Tropical Biomedicine 2021年第10期11卷 450-459页

作者： Da Hye Kwon Cheol Park Hyesook Lee Su hyun Hong gi-Young Kim Hee-Jae Cha Suhkmann Kim Heui-Soo Kim Hye-Jin Hwang Yung hyun Choi Anti-Aging Research Center Dong-eui UniversityBusan 47340Republic of Korea Department of Biochemistry College of Korean MedicineDong-eui UniversityBusan 47227Republic of Korea Division of Basic Sciences College of Liberal StudiesDong-eui UniversityBusan 47340Republic of Korea Department of Marine Life Sciences School of Marine Biomedical SciencesJeju National UniversityJeju 63243Republic of Korea Department of Parasitology and Genetics College of MedicineKosin UniversityBusan 49104Republic of Korea Department of Chemistry College of Natural SciencesPusan National UniversityBusan 46241Republic of Korea Department of Biological Sciences College of Natural SciencesPusan National UniversityBusan 46241Republic of Korea Department of Food and Nutrition College of NursingHealthcare Sciences&Human EcologyDong-eui UniversityBusan 47340Republic of Korea

Objective:To investigate whether the ethanol extract of Chondracanthus tenellus(Harvey)Hommersand,a type of red algae,could exhibit anti-inflammatory potential in lipopolysaccharide(LPS)-stimulated ***:The ethanol extract of Chondracanthus tenellus was applied to 100 ng/mL LPS-stimulated RAW 264.7 cells,and cell viability,phagocytic ability,levels of pro-inflammatory factors,and the production of reactive oxygen species were *** identify the underlying mechanism of the ethanol extract of Chondracanthus tenellus,the expression of inflammation-regulated genes was ***:The ethanol extract of Chondracanthus tenellus had no cytotoxic effect at concentrations below 300μg/mL,and reduced the LPS-induced production of inflammatory mediators including nitric oxide(NO)and prostaglandin ***,the extract markedly suppressed the expression of inducible NO synthase and cyclooxygenase-2,as well as the production of reactive oxygen *** LPS-induced up-regulation of pro-inflammatory cytokines was attenuated by treatment with the ethanol extract of Chondracanthus tenellus,reducing their extracellular *** Chondracanthus tenellus extract also inhibited LPS-mediated activation of nuclear factor-kappa B(NF-κB).In addition,the phosphorylation of mitogen activated protein kinases(MAPKs)and phosphatidylinositol 3 kinase(PI3K)/Akt was markedly increased by LPS,which was significantly abolished by the Chondracanthus tenellus ***:Our findings indicate that the ethanol extract of Chondracanthus tenellus exhibited potential anti-inflammatory and antioxidant effects through downregulating the NF-κB,MAPKs,and PI3K/Akt signaling pathways in LPS stimulated RAW 264.7 *** ***:Our findings indicate that the ethanol extract of Chondracanthus tenellus exhibited potential anti-inflammatory and antioxidant effects through downregulating the NF-κB,MAPKs,and PI3K/Akt signaling pathways in LPS stimu

关键词： Chondracanthus tenellus Inflammation ROS NF-κB RAW 264.7 cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：