Ethanol extract of Chondracanthus tenellus(Harvey)Hommersand attenuates lipopolysaccharide-induced inflammatory and oxidative response by blocking the NF-κB,MAPKs,and PI3K/Akt signaling pathways
作者机构：Anti-Aging Research CenterDong-eui UniversityBusan 47340Republic of Korea Department of BiochemistryCollege of Korean MedicineDong-eui UniversityBusan 47227Republic of Korea Division of Basic SciencesCollege of Liberal StudiesDong-eui UniversityBusan 47340Republic of Korea Department of Marine Life SciencesSchool of Marine Biomedical SciencesJeju National UniversityJeju 63243Republic of Korea Department of Parasitology and GeneticsCollege of MedicineKosin UniversityBusan 49104Republic of Korea Department of ChemistryCollege of Natural SciencesPusan National UniversityBusan 46241Republic of Korea Department of Biological SciencesCollege of Natural SciencesPusan National UniversityBusan 46241Republic of Korea Department of Food and NutritionCollege of NursingHealthcare Sciences&Human EcologyDong-eui UniversityBusan 47340Republic of Korea
出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)
年 卷 期：2021年第11卷第10期
页 面：450-459页
核心收录：
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
基 金：This research was a part of the project titled‘Omics based on fishery disease control technology development and industrialization(20150242)’ funded by the Ministry of Oceans and Fisheries Republic of Korea
主 题：Chondracanthus tenellus Inflammation ROS NF-κB RAW 264.7 cells
摘 要：Objective:To investigate whether the ethanol extract of Chondracanthus tenellus(Harvey)Hommersand,a type of red algae,could exhibit anti-inflammatory potential in lipopolysaccharide(LPS)-stimulated ***:The ethanol extract of Chondracanthus tenellus was applied to 100 ng/mL LPS-stimulated RAW 264.7 cells,and cell viability,phagocytic ability,levels of pro-inflammatory factors,and the production of reactive oxygen species were *** identify the underlying mechanism of the ethanol extract of Chondracanthus tenellus,the expression of inflammation-regulated genes was ***:The ethanol extract of Chondracanthus tenellus had no cytotoxic effect at concentrations below 300μg/mL,and reduced the LPS-induced production of inflammatory mediators including nitric oxide(NO)and prostaglandin ***,the extract markedly suppressed the expression of inducible NO synthase and cyclooxygenase-2,as well as the production of reactive oxygen *** LPS-induced up-regulation of pro-inflammatory cytokines was attenuated by treatment with the ethanol extract of Chondracanthus tenellus,reducing their extracellular *** Chondracanthus tenellus extract also inhibited LPS-mediated activation of nuclear factor-kappa B(NF-κB).In addition,the phosphorylation of mitogen activated protein kinases(MAPKs)and phosphatidylinositol 3 kinase(PI3K)/Akt was markedly increased by LPS,which was significantly abolished by the Chondracanthus tenellus ***:Our findings indicate that the ethanol extract of Chondracanthus tenellus exhibited potential anti-inflammatory and antioxidant effects through downregulating the NF-κB,MAPKs,and PI3K/Akt signaling pathways in LPS stimulated RAW 264.7 *** ***:Our findings indicate that the ethanol extract of Chondracanthus tenellus exhibited potential anti-inflammatory and antioxidant effects through downregulating the NF-κB,MAPKs,and PI3K/Akt signaling pathways in LPS stimu
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