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Extract from Zanthoxylum piperitum Induces Apoptosis of AGS Gastric Cancer Cells through Akt/MDM2/p53 Signaling Pathway

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Chinese journal of Integrative Medicine 2021年第10期27卷 752-759页

作者： Ye Seul Park Gun He Nam kyung jo jo Hye Won Kawk Sang Yung Kim Young Min Kim Department of Biological science and Biotechnology College of Life science and Nano TechnologyHannam University1646 Yuseong-daeroYuseong-guDaejeon 34054South Korea Department of Food Science&Bio Technology Shinansan UniversityDeahakro Danwon-guAnsan-CityGyenggi-doKorea

Objective:To determine the effect of Zanthoxylum piperitum extracet(ZPE)on apoptosis and analyze anticancer substances in ZPE,changes in proteins related to apoptosis,and pathological changes in tumors in ***:Fifteen 4-week-old female BALB/c nu/nu mice were divided into 3 groups depending on ZPE dose,with 5 in each *** gastric carcinoma cells(1 x 10^(6) cells/200 jxL)were subcutaneously injected into the flank of each *** week after the injection of AGS cells,ZPE was administered to the skin tissue[10 or 50 mg/(kg-d)]in the low-and high-dose groups,respectively for 20 *** animals were injected with vehicle *** 3 weeks,the tumor was extracted and carried out for immunohistochemistry,the tendency of apoptosis and p53 in the body was checked using TdT-mediated dUTP nick-end labeling(TUNEL)*** 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay,annexin V dead cell staining,cell cycle arrest and Western blotting,AGS gastric carcinoma cells were incubated with various concentrations of ZPE for 24 *** survival rates were analyzed by MTT *** was analyzed using annexin V dead cell staining and cell cycle arrest and measured using Muse cell ***:High performance liquid chromatography(HPLC)analysis showed that ZPE contained organic sulfur compounds such as alliin and *** assay results revealed that ZPE(10-85»xg/mL)could effectively inhibit the growth of AGS gastric cancer cells at higher concentrations(P<0.05,P<0.01).The annexin V&dead cell staining assay and cell cycle arrest assay confirmed a dose-dependent increase in the apoptosis rate and G!phase in ZPE(10-70 jig/mL)*** decreased the expression of anti-apoptotic proteins(p-Akt,p-MDM2,Bcl-2),while increased pro-apoptotic proteins(cleaved PARP,p53,pro-Caspase 3,Bax).TUNEL assays revealed an increase in cell *** staining confirmed the involvement of ***:ZPE decreases AGS cell

关键词： AGS gastric cancer cells Zanthoxylum piperitum apoptosis Akt/MDM2/p53 signaling pathway active compounds

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua jo jonggeol Na J.Jay Liu Young-Ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

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Combination could be another tool for bowel preparation?

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World journal of Gastroenterology 2016年第10期22卷 2915-2921页

作者： Jae Seung Soh kyung-jo Kim Division of Gastroenterology Department of Internal MedicineHallym University Sacred Heart HospitalUniversity of Hallym College of Medicine Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of Medicine

Optimal bowel preparation increases the cecal intubation rate and detection of neoplastic lesions while decreasing the procedural time and procedural-related complications. Although high-volume polyethylene glycol(PEG) solution is the most frequently used preparation for bowel cleansing, patients are often unwilling to take PEG solution due to its large volume, poor palatability, and high incidence of adverse events, such as abdominal bloating and nausea. Other purgatives include osmotic agents(e.g., sodium phosphate, magnesium citrate, and sodium sulfate), stimulant agents(e.g., senna, bisacodyl, and sodium picosulfate), and prokinetic agents(e.g., cisapride, mosapride, and itopride). A combination of PEG with an osmotic, stimulant, or prokinetic agent could effectively reduce the PEG solution volume and increase patients' adherence. Some such solutions have been found in several published studies to not be inferior to PEG alone in terms of bowel cleansing quality. Although combination methods showed similar efficacy and safety, the value of these studies is limited by shortcomings in study design. New effective and well-tolerated combination preparations are required, in addition to rigorous new validated studies.

关键词： Bowel preparation Colonoscopy Inadequate bowel cleansing Combination methods Intolerance

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Molecular mechanisms regulating NLRP3 inflammasome activation

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Cellular & Molecular Immunology 2016年第2期13卷 148-159页

作者： Eun-Kyeong jo Jin kyung Kim Dong-Min Shin Chihiro Sasakawa Department of Microbiology Chungnam National University School of Medicine Daejeon 301-747 South Korea Infection Signaling Network Research Center Chungnam National University School of Medicine Daejeon 301-747 South Korea Medical Mycology Research Center Chiba University Chiba 260-8673 Japan Nippon Institute for Biological Science Tokyo 198-0024 Japan

Inflammasomes are multi-protein signaling complexes that trigger the activation of inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome complexes, the NLRP3 inflammasome is best characterized and has been linked with various human autoinflammatory and autoimmune diseases. Thus, the NLRP3 inflammasome may be a promising target for anti-inflammatory therapies. In this review, we summarize the current understanding of the mechanisms by which the NLRP3 inflammasome is activated in the cytosol. We also describe the binding partners of NLRP3 inftammasome complexes activating or inhibiting the inflammasome assembly. Our knowledge of the mechanisms regulating NLRP3 inflammasome signaling and how these influence inflammatory responses offers further insight into potential therapeutic strategies to treat inflammatory diseases associated with dysregulation of the NLRP3 inflammasome,

关键词： inflammasome inflammation interaction mechanism NLRP3

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High-index-contrast photonic structures:a versatile platform for photon manipulation

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Light(Science & Applications) 2022年第11期11卷 2617-2632页

作者： Young-Bin Kim Jin-Woo Cho Yun-jo Lee Dukkyu Bae Sun-kyung Kim Department of Applied Physics Kyung Hee UniversityYonginGyeonggido 17104Republic of Korea Hexa Solution Co. LtdSuwonGyeonggi-do 16229Republic of Korea

In optics,the refractive index of a material and its spatial distribution determine the characteristics of light ***,exploring both low-and high-index materials/structures is an important consideration in this *** cavities,which are defined as low-index bases,exhibit a variety of unusual or even unexplored optical characteristics and are used in numerous functionalities including diffraction gratings,localised optical antennas and low-loss *** this report,we discuss the fabrication of hollow cavities of various sizes(O.2-5μm in diameter)that are supported by conformal dielectric/metal shells,as well as their specific applications in the ultraviolet(photodetectors),visible(light-emitting diodes,solar cells and metalenses),near-infrared(thermophotovoltaics)and mid-infrared(radiative coolers)*** findings demonstrate that hollow cavities tailored to specific spectra and applications can serve as versatile optical platforms to address the limitations of current optoelectronic ***,hollow cavity embedded structures are highly elastic and can minimise the thermal stress caused by high *** such,future applications will likely include high-temperature devices such as thermophotovoltaics and concentrator photovoltaics.

关键词： versatile index ultraviolet

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An update on the regulatory mechanisms of NLRP3 inflammasome activation

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Cellular & Molecular Immunology 2021年第5期18卷 1141-1160页

作者： Seungwha Paik Jin kyung Kim Prashanta Silwal Chihiro Sasakawa Eun-Kyeong jo Department of Microbiology Chungnam National University School of MedicineDaejeonKorea Infection Control Convergence Research Center Chungnam National University School of MedicineDaejeonKorea

The NOD-,LRR-,and pyrin domain-containing protein 3(NLRP3)inflammasome is a multiprotein complex involved in the release of mature interleukin-1βand triggering of pyroptosis,which is of paramount importance in a variety of physiological and pathological *** the past decade,considerable advances have been made in elucidating the molecular mechanisms underlying the priming/licensing(Signal 1)and assembly(Signal 2)involved in NLRP3 inflammasome ***,a number of studies have indicated that the priming/licensing step is regulated by complicated mechanisms at both the transcriptional and posttranslational *** this review,we discuss the current understanding of the mechanistic details of NLRP3 inflammasome activation with a particular emphasis on protein-protein interactions,posttranslational modifications,and spatiotemporal regulation of the NLRP3 inflammasome *** also present a detailed summary of multiple positive and/or negative regulatory pathways providing upstream signals that culminate in NLRP3 inflammasome complex assembly.A better understanding of the molecular mechanisms underlying NLRP3 inflammasome activation will provide opportunities for the development of methods for the prevention and treatment of NLRP3 inflammasome-related diseases.

关键词： NLRP3 inflammasome inflammation mechanism interaction

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Sequential disruption of ALV host receptor genes reveals no sharing of receptors between ALV subgroups A, B, and J

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journal of Animal Science and Biotechnology 2019年第2期10卷 410-423页

作者： Hong jo Lee kyung Je Park kyung Youn Lee Yongxiu Yao Venugopal Nair Jae Yong Han Sciences and Research Institute of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Korea The Pirbright Institute WokingSurrey GU24 0NFUK.

Background: Previously, we showed that targeted disruption of viral receptor genes in avian leukosis virus(ALV)subgroups using clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9))-based genome editing confers resistance to ALV subgroups B and J. Here, we used the same strategy to target the receptor expressed by ALV subgroup A(TVA) and generate chicken cells resistant to infection by this ***: CRISPR/Cas9-based disruption of exon 2 within the tva gene of DF-1 fibroblasts conferred resistance to infection by ALV subgroup A regardless of whether frameshift mutations were introduced during editing. Conversely,overexpression of the wild-type TVA receptor(wtTVA) by tva-modified DF-1 clones restored susceptibility to ALV subgroup A. The results confirm that exon 2, which contains the low-density lipoprotein receptor class A domain of TVA, is critical for virus entry. Furthermore, we sequentially modified DF-1 cells by editing the tva, tvb, and Na^+/H^+ exchange 1(chNHE1) genes, which are the specific receptors for ALV subgroups A, B, and J, ***: Simultaneous editing of multiple receptors to block infection by different subgroups of ALV confirmed that ALV subgroups A, B, and J do not share host receptors. This strategy could be used to generate cells resistant to multiple viral pathogens that use distinct receptors for cell entry.

关键词： Avian leukosis virus CRISPR/Cas9 Genome editing Host receptor TVA

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Aging Behavior of Mg-Y-Zr and Mg-Nd-Zr Cast Alloys

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journal of Materials Science & Technology 2008年第1期24卷 80-84页

作者： Yang-Do Kim Nam-Hyun Kang Il-Guk jo kyung-Hyun Kim In-Bae Kim School of Materials Science and Engineering Pusan National University 30 Jangjun-dongGeumjeong-guBusan 609-735Korea Deptartment of Materials Engineering Korea Institute of Machinery & Materials 66 Sangnam-dongChangwonGyeongsangnam-do 641-010Korea

Aging behavior of Mg-3.6Y-0.5Zr and ***-0.5Zr alloys was investigated by microhardness measurement and transmission electron *** the case of Mg-Y-Zr alloy,the presence ofβ″phase,a major strength- ener,having base centered orthorhombic structure with its lattice constants of a-（β″）=0.64 nm,b-（β″）=2.22 nm, and c-（β″）=0.52 nm was *** the case of Mg-Nd-Zr alloy aged at 250℃,the presence ofβ″andβ′phases was *** crystal structure ofβ″phase was found to be DO-（19） and its orientation relationships with Mg matrix were [0001]-（β″）//[0001]-（Mg） and [01（？）0]-（β″）//[01（？）0]-（Mg）.Theβ′phase had face centered cubic structure and its orientation relationships with Mg matrix were [011]-（β′）//[0001]-（Mg） and [（？）1（？）]β′//[（？）110]）-（Mg）. The ***-0.5Zr alloy showed higher hardness compared with Mg-3.6Y-0.5Zr alloy.

关键词： Mg-Y-Zr alloy Mg-Nd-Zr alloy Precipitation sequence

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Reliability and validation of the Korean Compassionate Communication Scale

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Frontiers of Nursing 2019年第3期6卷 175-182页

作者： Hae-kyung jo Sook Kyoung Park EunJu Song Department of Nursing Jeonju UniversityJeonjuJeollabuk-do 55069the Republic of Korea College of Nursing Chonbuk National UniversityJeonjuJeollabuk-do 54896the Republic of Korea Department of Nursing Wonkwang UniversityIksanIksan 54538the Republic of Korea

Objective:The aims of this study were to develop the Korean Compassionate Communication Scale and to test its validity and ***:The Korean Compassionate Communication Scale was developed based on English *** study is a methodological one in its ***:The Korean version of Compassionate Communication Scale contained 20 items and was divided into three factors that explained 63.4%of the total *** scale demonstrated excellent convergent and discriminant validity(100%),and criterionrelated validity(Global Interpersonal Communication Competence r=0.494;self-compassion:r=0.317).Internal consistency was acceptable,and Cronbach’sαof the total items was ***:This study examined The Korean Compassionate Communication Scale as an appropriate measurement of communication ability for nursing ***,this scale suggests that the developed 20 items of the Compassionate Communication Scale can be used for therapeutic relationship and nursing education.

关键词： compassion communication reliability and validity scale

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Comparative outcomes of the pathogen in cultured jones tubes used in lacrimal bypass surgery according to follow up periods

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International journal of Ophthalmology(English edition) 2023年第10期16卷 1623-1629页

作者： Bo Hyun Park Hui kyung Kim Yeon Ji jo jong Soo Lee Department of Ophthalmology Pusan National University School of Medicine&Medical Research Institute of Pusan National University HospitalPusan 49241Republic of Korea

AIM:To evaluate the pathogens in cultured jones tubes used in lacrimal bypass surgery according to the postoperative periods and to obtain data for the prevention of infection of functional lacrimal stent ***:Totally 71 patients(81 eyes)who underwent the removal of jones tubes were enrolled in *** the removed jones tubes were cultured for bacterial and fungal identification and tested for bacterial antibiotic *** results were analyzed according to the duration of the inserted jones tube after lacrimal bypass ***:Of the 81 eyes,bacteria were isolated from 69 eyes(85.2%)and fungi from 6 eyes(7.4%).Among 69 eyes,40.6% showed Staphylococcus aureus(***),11.6% were Pseudomonas aeruginosa(***).Gram-positive bacteria were isolated more than Gramnegative bacteria,but Gram-negative bacteria showed a higher incidence in the jones tube implanted for over 10y(P=0.035).The antibiotic sensitivity test showed that 46.4% of *** were resistant to *** terms of antibiotics commonly used in ocular clinical practice,vancomycin was sensitive to *** and Streptococcus pneumoniae(***),amikacin responded to *** and Proteus mirabilis(***).Trimethoprim/sulfamethoxazole(TMP/SMX)was all sensitive to ***,*** and *** except ***:*** is the most commonly found organism in the jones tube after lacrimal bypass surgery,and 46.4% of them are methicillin-resistant ***(MRSA),sensitive to ***,*** responded with amikacin is dominantly detected in the jones tubes implanted for more than 10y.

关键词： jones tube lacrimal bypass surgery Pseudomonas aeruginosa Proteus mirabilis Staphylococcus aureus

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