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World Journal of Clinical Cases 2025年第9期13卷 13-23页

作者： Ha-Jong Nam Heongrae Ryu Da-Woon Lee Je Yeon Byeon Jun Hyuk Kim Ji hye Lee Soomin Lim Hwan Jun choi Department of Plastic and Reconstructive Surgery Soonchunhyang University Gumi HospitalGumi-si 39371South Korea Department of Plastic and Reconstructive Surgery College of MedicineSoonchunhyang UniversityCheonan-si 31151South Korea Department of Pathology Soonchunhyang University HospitalCheonan-si 31151South Korea Bachelor of Medicine and Bachelor of Surgery University College LondonMedical SchoolLondon WC1E 6DEUnited Kingdom

BACKGROUND The high prevalence of human papillomavirus(HPV)infection in oropharyngeal squamous cell carcinoma(SCC)is well established,and p16 expression is a strong ***-related tumors exhibit unique mechanisms that target p16 and p53 ***,research on HPV prevalence and the combined predictive value of p16 and p53 expression in head and neck cutaneous SCC(HNCSCC),particularly in Asian populations,remains *** retrospective study surveyed 62 patients with HNSCC(2011-2020),excluding those with facial warts or other skin *** To explore the prevalence of HPV and the predictive value of p16 and p53 expression in HNCSCC in Asian *** All patients underwent wide excision and *** staining for HPV,p16,and p53 yielded positive and negative *** relevance of each marker was investigated by categorizing the tumor locations into high-risk and middle-risk zones based on recurrence *** Of the 62 patients,20(32.26%)were male,with an average age of 82.27 years(range 26-103 years).High-risk included 19 cases(30.65%),with the eyelid and lip being the most common sites(five cases,8.06%).Middle-risk included 43 cases(69.35%),with the cheek being the most common(29 cases,46.77%).The p16 expression was detected in 24 patients(38.71%),p53 expression in 42 patients(72.58%),and HPV in five patients(8.06%).No significant association was found between p16 expression and the presence of HPV(P>0.99),with a positive predictive value of 8.33%.CONCLUSION This study revealed that p16,a surrogate HPV marker in oropharyngeal SCC,is not reliable in HNCSCC,providing valuable insights for further research in Asian populations.

关键词： Squamous cell carcinoma Oropharyngeal Non-oropharyngeal Human papillomavirus The p16 The p53

Sandwich-structure transferable free-form OLEDs for wearable and disposable skin wound photomedicine

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Light(Science & Applications) 2019年第1期8卷 96-110页

作者： Yongmin Jeon hye-Ryung choi Jeong Hyun Kwon Seungyeop choi Kyung Mi Nam kyoung-Chan Park Kyung Cheol choi School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Department of Dermatology Seoul National University Bundang Hospital(SNUBH)Seongnam 13620Republic of Korea

Free-form optoelectronic devices can provide hyper-connectivity over space and ***,most conformable optoelectronic devices can only be fabricated on flat polymeric materials using low-temperature processes,limiting their application and *** paper presents free-form optoelectronic devices that are not dependent on the shape or *** medical applications,the transferable OLED(10μm)is formed in a sandwich structure with an ultra-thin transferable barrier(4.8μm).The results showed that the fabricated sandwich-structure transferable OLED(STOLED)exhibit the same high-efficiency performance on cylindricalshaped materials and on materials such as textile and *** the neutral axis is freely adjustable using the sandwich structure,the textile-based OLED achieved both folding reliability and washing reliability,as well as a long operating life(>150 h).When keratinocytes were irradiated with red STOLED light,cell proliferation and cell migration increased by 26 and 32%,*** the skin equivalent model,the epidermis thickness was increased by 39%;additionally,in organ culture,not only was the skin area increased by 14%,but also,reepithelialization was highly *** on the results,the STOLED is expected to be applicable in various wearable and disposable photomedical devices.

关键词： optoelectronic structure transfer

Niche interactions in epidermal stem cells

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World Journal of Stem Cells 2015年第2期7卷 495-501页

作者： hye-Ryung choi Sang-Young Byun Soon-Hyo Kwon kyoung-Chan Park Department of Dermatology Seoul National University Bundang Hospital

Within the epidermis and dermis of the skin, cells secrete and are surrounded by the extracellular matrix(ECM), which provides structural and biochemical support. The ECM of the epidermis is the basement membrane, and collagen and other dermal components constitute the ECM of the dermis. There is significant variation in the composition of the ECM of the epidermis and dermis, which can affect "cell to cell" and "cell to ECM" interactions. These interactions, in turn, can influence biological responses, aging, and wound healing; abnormal ECM signaling likely contributes toskin diseases. Thus, strategies for manipulating cellECM interactions are critical for treating wounds and a variety of skin diseases. Many of these strategies focus on epidermal stem cells, which reside in a unique niche in which the ECM is the most important component; interactions between the ECM and epidermal stem cells play a major role in regulating stem cell fate. As they constitute a major portion of the ECM, it is likely that integrins and type Ⅳ collagens are important in stem cell regulation and maintenance. In this review, we highlight recent research-including our previous work-exploring the role that the ECM and its associated components play in shaping the epidermal stem cell niche.

关键词： Stem cell niche Epidermal stem cells Integrins Type Ⅳ collagen MiR135b

Gold nanoparticle-assisted delivery of brain-derived neurotrophic factor to cerebral organoids

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Nano Research 2022年第4期15卷 3099-3105页

作者： Sung Bum Park hye-Jin Cho Sang Rin Moon kyoung Jin choi Won Hoon Jung Ki Young Kim Byumseok Koh Therapeutics and Biotechnology Division Korea Research Institute of Chemical Technology141 Gajeong-roYuseong-guDaejeon 34114Republic of Korea Chemical Platform Technology Division Korea Research Institute of Chemical Technology141 Gajeong-roYuseong-guDaejeon 34114Republic of Korea

Gold nanoparticle(AuNP)-assisted delivery of proteins/drugs to cells or in vivo systems has long been ***,their interaction with in vivo mimicking organoids is still largely ***,we conjugated brain-derived neurotropic factor(BDNF)to the AuNP surface and monitored how AuNP-BDNF interacts with cerebral *** suggest that AuNP-BDNF can successfully enter cerebral organoids and can be found up to 15.21μm inside cerebral ***-BDNF does not induce significant cytotoxicity to cerebral organoids at concentrations up to 2 nM and increases the expression of 75 genes compared to control cerebral *** data suggest the successful delivery of BDNF through AuNP-BDNF conjugation in cerebral organoids,and the conjugation can affect its differentiation.

关键词： gold nanoparticles cerebral organoids delivery penetration differentiation viability

Gastrointestinal tuberculosis is not associated with proton pump inhibitors:A retrospective cohort study

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World Journal of Gastroenterology 2013年第2期19卷 258-264页

作者： kyoung Sup Hong Seung Joo Kang Jong kyoung choi Ju Han Kim Heewon Seo Suehyun Lee Jae-Woo Jung hye-Ryun Kang Sang-Heon Cho Joo Sung Kim Department of Internal Medicine Drug Safety Monitoring CenterSeoul National University HospitalSeoul National University College of MedicineSeoul 110799South Korea Department of Internal Medicine Seoul National University HospitalSeoul National University College of MedicineSeoul 110799South Korea Division of Biomedical Informatics Systems Biomedical Informatics Research CenterSeoul National University College of MedicineSeoul 110799South Korea

AIM:To evaluate the effect of proton pump inhibitors(PPIs) on the development of gastrointestinal ***:All patients who were more than 20 years old and who had received a prescription for PPIs among those who visited Seoul National University Hospital from January 1,2005 to December 31,2009 were *** to the low sensitivity of the microbiologic test and the nonspecific pathologic findings,the diagnosis of gastrointestinal tuberculosis was confirmed through the presence of active ulcerations and the responses to anti-tuberculosis *** patients were divided into two groups according to treatment duration(group 1:≤ 3 mo;group 2:> 3 mo) and were followed up from the time they took the first prescription of PPIs until their last *** regression analysis was used to calculate the relative risks(RR) and 95%CI,adjusting for ***:Among the 61 834 patients exposed to PPIs(50 534 in group 1;11 300 in group 2),21 patients were diagnosed with PPI-associated gastrointestinal tuberculosis during 124 274 person-years of *** 21 patients,the 12 who revealed only scar changes in the colonoscopy were excluded from the statistical *** those who remained,2 were excluded because they underwent gastrointestinal endoscopy within 4 wk of the first prescription for *** exposure to PPI was associated with a higher mean age(55.0 ± 14.5 in group 1 vs 58.2 ± 13.3 in group 2,P < 0.001) and a higher Charlson co-morbidity index(0.50 ± 0.93 in group 1 vs 0.77 ± 1.14 in group 2,P < 0.001).The true incidence of active gastrointestinal tuberculosis was 0.65 per 1000 person-years in group 1 and 0.03 per 1 000 person-years in group *** the less-than-three-month PPI treatment period in group 1,the over-three-month PPI therapy period in group 2 was not associated with increased risk of acquiring gastrointestinal tuberculosis,after adjusting for age and co-morbidities,whereas the Charlson co-morbidity index was associated

关键词： Proton pump inhibitor Acid suppression Tuberculosis Gastrointestinal tuberculosis Tuberculous colitis

Endoplasmic reticulum stress-induced accumulation of VAMP721/722 requires CALRETICULIN 1 and CALRETICULIN 2 in Arabidopsis

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Journal of Integrative Plant Biology 2019年第9期61卷 974-980页

作者： Soohong Kim Yunjin choi Chian Kwon hye Sup Yun Department of Molecular Biology Dankook UniversityCheonan 31116Korea Department of Biological Sciences Konkuk UniversitySeoul 05029Korea

Excessive demand for translation and protein folding in the endoplasmic reticulum(ER) can cause ER stress in plants. Here, we show that CALRETICULIN 1(CRT1) and CRT2 are critical components in the accumulation of VESICLE-ASSOCIATED MEMBRANE PROTEIN 721(VAMP721) and VAMP722 during ER stress responses. We show that CRT2 interacts with VAMP722 and that CRT1/2 post-translationally maintain elevated VAMP721/722 levels under ER *** greater growth inhibition in VAMP721/722-deficient plants, induced by tunicamycin, suggests that plants under ER stress maintain physiological homeostasis, at least in part, by regulating VAMP721/722 levels, as VAMP721/722 are known to participate in various biological processes.

关键词： Endoplasmic reticulum VAMP721/722 in Arabidopsis

Comments on "Direct Radiative Forcing of Anthropogenic Aerosols over Oceans from Satellite Observation"

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Advances in Atmospheric Sciences 2013年第1期30卷 10-14页

作者： hye-Ryun OH Chang-Hoi HO Yong-Sang choi School of Earth and Environmental Sciences Seoul National University Department of Environmental Science and Engineering Ewha Womans University

Previous observational studies have estimated anthropogenic aerosol direct radiative forcing over oceans without due consideration of cloudy-sky aerosols. However, when interaction between clouds and aerosols located below or above the cloud level is taken into account, the aerosol direct radiative forcing is larger by as much as 5 W m-2 in most mid-latitude regions in the Northern Hemisphere.

关键词： cloudy-sky aerosol forcing anthropogenic aerosol aerosol optical depth satellite observations

Assessment of colon polyp morphology: Is education effective?

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World Journal of Gastroenterology 2017年第34期23卷 6281-6286页

作者： Jae Hyun Kim kyoung Sik Nam hye Jung Kwon Youn Jung choi kyoungwon Jung Sung Eun Kim Won Moon Moo In Park Seun Ja Park Division of Gastroenterology Department of Internal MedicineKosin University College of Medicine

AIM To determine the inter-observer variability for colon polyp morphology and to identify whether education can improve agreement among *** For purposes of the tests, we recorded colonoscopy video clips that included scenes visualizing the polyps. A total of 15 endoscopists and 15 nurses participated in the study. Participants watched 60 video clips of the polyp morphology scenes and then estimated polyp morphology(pre-test). After education for 20 min, participants performed a second test in which the order of 60 video clips was changed(post-test). To determine if the effectiveness of education was sustained, four months later, a third, follow-up test was performed with the same *** The overall Fleiss' kappa value of the inter-observer agreement was 0.510 in the pre-test, 0.618 in the post-test, and 0.580 in the follow-up test. The overall diagnostic accuracy of the estimation for polyp morphology in the pre-, post-, and follow-up tests was 0.662, 0.797, and 0.761, respectively. After education, the inter-observer agreement and diagnostic accuracy of all participants improved. However, after four months, the inter-observer agreement and diagnostic accuracy of expert groups were markedly decreased, and those of beginner and nurse groups remained similar to pre-test levels. CONCLUSION The education program used in this study can improve inter-observer agreement and diagnostic accuracy in assessing the morphology of colon polyps; it is especially effective when first learning endoscopy.

关键词： Colon polyp Morphology Education

Effect of PAIP1 on the metastatic potential and prognostic significance in oral squamous cell carcinoma

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International Journal of Oral Science 2022年第1期14卷 113-122页

作者： Neeti Swarup kyoung-Ok Hong Kunal Chawla Su-Jung choi Ji-Ae Shin Kyu-Young Oh hye-Jung Yoon Jae-Il Lee Sung-Dae Cho Seong-Doo Hong Department of Oral Pathology School of Dentistry and Dental Research InstituteSeoul National UniversitySeoulRepublic of Korea Department of Computer Science School of Interactive ComputingGeorgia Institute of TechnologyAtlantaGAUSA

Poly Adenylate Binding Protein Interacting protein 1(PAIP1) plays a critical role in translation initiation and is associated with the several cancer types. However, its function and clinical significance have not yet been described in oral squamous cell carcinoma(OSCC) and its associated features like lymph node metastasis(LNM). Here, we used the data available from Gene Expression Omnibus(GEO), The Cancer Genome Atlas(TCGA), and Clinical Proteomic Tumor Analysis Consortium(CPTAC) to analyze PAIP1 expression in oral cancer. The publicly available data suggests that PAIP1 mRNA and protein levels were increased in OSCC. The high PAIP1 expression was more evident in samples with advanced stage, LNM, and worse pattern of invasion. Moreover, the in vitro experiments revealed that PAIP1 knockdown attenuated colony forming, the aggressiveness of OSCC cell lines, decreasing MMP9 activity and SRC phosphorylation. Importantly, we found a correlation between PAIP1 and pSRC through the analysis of the IHC scores and CPTAC data in patient samples. Our findings suggest that PAIP1 could be an independent prognostic factor in OSCC with LNM and a suitable therapeutic target to improve OSCC patient outcomes.

关键词： squamous invasion metastasis