Gold nanoparticle-assisted delivery of brain-derived neurotrophic factor to cerebral organoids

作     者：Sung Bum Park Hye-Jin Cho Sang Rin Moon Kyoung Jin Choi Won Hoon Jung Ki Young Kim Byumseok Koh Sung Bum Park;Hye-Jin Cho;Sang Rin Moon;Kyoung Jin Choi;Won Hoon Jung;Ki Young Kim;Byumseok Koh

作者机构：Therapeutics and Biotechnology DivisionKorea Research Institute of Chemical Technology141 Gajeong-roYuseong-guDaejeon 34114Republic of Korea Chemical Platform Technology DivisionKorea Research Institute of Chemical Technology141 Gajeong-roYuseong-guDaejeon 34114Republic of Korea 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2022年第15卷第4期

页      面：3099-3105页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1007[医学-药学(可授医学、理学学位)] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0836[工学-生物工程] 0702[理学-物理学] 10[医学] 

基　　金：The authors greatly acknowledge the financial support from the Ministry of Science and ICT(No.2021R1A2C2011195) the Korea Research Institute of Chemical Technology of Republic of Korea(Nos.SI2131-50 and SI2152-20) 

主　　题：gold nanoparticles cerebral organoids delivery penetration differentiation viability 

摘      要：Gold nanoparticle(AuNP)-assisted delivery of proteins/drugs to cells or in vivo systems has long been ***,their interaction with in vivo mimicking organoids is still largely ***,we conjugated brain-derived neurotropic factor(BDNF)to the AuNP surface and monitored how AuNP-BDNF interacts with cerebral *** suggest that AuNP-BDNF can successfully enter cerebral organoids and can be found up to 15.21μm inside cerebral ***-BDNF does not induce significant cytotoxicity to cerebral organoids at concentrations up to 2 nM and increases the expression of 75 genes compared to control cerebral *** data suggest the successful delivery of BDNF through AuNP-BDNF conjugation in cerebral organoids,and the conjugation can affect its differentiation.