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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui zhang sonata S Y Yau kwok-fai so.li zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

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Normal tension glaucoma: from the brain to the eye or the inverse?

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Neural Regeneration Research 2019年第11期14卷 1845-1850页

作者： Hui-Jun zhang Xue-song Mi kwok-fai so Department of Ophthalmology the First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Guangdong-Hong Kong-Macao Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina State Key Laboratory of Brain and Cognitive Sciences PokfulamHong Kong Special Administrative RegionChina Department of Ophthalmology The University of Hong KongPokfulamHong Kong Special Administrative RegionChina

Glaucoma is a chronic, progressive optic neuropathy characterized by the loss of peripheral vision first and then central vision. Clinically, normal tension glaucoma is considered a special subtype of glaucoma, in which the patient’s intraocular pressure is within the normal range, but the patient experiences typical glaucomatous changes. However, increasing evidence has challenged the traditional pathophysiological view of normal tension glaucoma, which is based only on intraocular pressure, and breakthroughs in central nervous system imaging may now greatly increase our knowledge about the mechanisms underlying normal tension glaucoma. In this article, we review the latest progress in understanding the pathogenesis of normal tension glaucoma and in developing imaging techniques to detect it, to strengthen the appreciation for the connection between normal tension glaucoma and the brain.

关键词： nerve regeneration normal tension glaucoma open angle glaucoma neurodegenerative diseases visual field cerebrospinal fluid pressure imaging techniques pathogenesis magnetic resonance imaging diffusion tensor imaging metabolic changes neural regeneration

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Treadmill Exercise Reshapes Cortical Astrocytic and Neuronal Activity to Improve Motor Learning Deficits Under Chronic Alcohol Exposure

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Neuroscience Bulletin 2024年第9期40卷 1287-1298页

作者： linglin liu Lanzhi Luo Ji-an Wei Xintong Xu kwok-fai so.li zhang Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhou510632China College of life Science and Technology Jinan UniversityGuangzhou510632China State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongPok Fu LamHong Kong SARChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdao266113China Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghai200438China The First Affiliated Hospital of Xinxiang Medical University Xinxiang453003China

Alcohol abuse induces various neurological disorders including motor learning deficits,possibly by affecting neuronal and astrocytic *** exercise is one effective approach to remediate synaptic loss and motor deficits as shown by our previous *** this study,we unrevealed the role of exercise training in the recovery of cortical neuronal and astrocytic *** a chronic alcohol injection mouse model,we found the hyperreactivity of astrocytes along with dendritic spine loss plus lower neuronal activity in the primary motor *** treadmill exercise training,on the other hand,improved neural spine formation and inhibited reactive astrocytes,alleviating motor learning deficits induced by alcohol *** data collectively support the potency of endurance exercise in the rehabilitation of motor functions under alcohol abuse.

关键词： Alcohol abuse Motor learning Dendritic spine Reactive astrocyte

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Treadmill exercise improves hippocampal neural plasticity and relieves cognitive deficits in a mouse model of epilepsy

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Neural Regeneration Research 2024年第3期19卷 657-662页

作者： Hang Yu Mingting Shao Xi Luo Chaoqin Pang kwok-fai so Jiandong Yu li zhang Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina Department of Neurosurgery The First Affiliated Hospital of Bengbu Medical CollegeBengbuShandong ProvinceChina School of Psychology Shanghai University of SportShanghaiChina

Epilepsy frequently leads to cognitive dysfunction and approaches to treatment remain *** regular exercise effectively improves learning and memory functions across multiple neurological diseases,its application in patients with epilepsy remains ***,we adopted a 14-day treadmill-exercise paradigm in a pilocarpine injection-induced mouse model of *** assays confirmed the improvement of object and spatial memory after endurance training,and electrophysiological studies revealed the maintenance of hippocampal plasticity as a result of physical *** of the mechanisms underlying this effect revealed that exercise protected parvalbumin interneurons,probably via the suppression of neuroinflammation and improved integrity of blood-brain *** summary,this work identified a previously unknown mechanism through which exercise improves cognitive rehabilitation in epilepsy.

关键词： blood-brain barrier cognition hippocampus interneurons long-term potentiation microglial cell neuroinflammation spatial memory temporal epilepsy treadmill exercise

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Treadmill Exercise Relieves Chronic Restraint Stress-induced Cognitive Impairments in Mice Via Activating Protein Phosphatase 2A

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Neuroscience Bulletin 2021年第10期37卷 1487-1492页

作者： Wenjing zhang Haining Ou Borui zhang Meifeng Zheng Lan Yan Yang Chen kwok-fai so.li zhang Department of Rehabilitation The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510700China Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhou 510600China School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhou 510080China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou 510700China

Dear Editor,Aerobic exercise is well known to improve cognitive functions including hippocampus-dependent spatial memory[1]and object recognition[2].Regarding the molecular mechanisms,the indispensable role of brain-derived neurotrophic factor(BDNF)in governing exercise-induced neural plasticity has been demonstrated for the improvement of learning and memory[3].Our recent study further demonstrated the activation of mechanistic target of rapamycin pathways downstream of BDNF to drive synaptic protein synthesis upon persistent exercise[4],but leaving the effect of exercise on the post-translational modification of proteins largely unknown.

关键词： exercise translational indispensable

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soluble Nogo receptor 1 fusion protein protects neural progenitor cells in rats with ischemic stroke

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Neural Regeneration Research 2019年第10期14卷 1755-1764页

作者： Hai-Wei He Yue-lin zhang Bao-Qi Yu Gen Ye Wei You kwok-fai so Xin li School of Medicine South China University of TechnologyGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Department of Emergency and Critical Care MedicineGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong ProvinceChina Department of Physiology and Pathophysiology School of Basic Medical SciencesCapital Medical UniversityKey Laboratory of Remodelling- related Cardiovascular DiseasesMinistry of EducationBeijingChina School of Biomedical Sciences The State Key Laboratory of Brain and Cognitive sciencesLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina

soluble Nogo66 receptor-Fc protein(sNgR-Fc)enhances axonal regeneration following central nervous system ***,the underlying mechanisms remain *** this study,we investigated the effects of sNgR-Fc on the proliferation and differentiation of neural progenitor *** photothrombotic cortical injury model of ischemic stroke was produced in the parietal cortex of Sprague-Dawley *** rats with photothrombotic cortical injury were randomized to receive infusion of 400μg/kg sNgR-Fc(sNgR-Fc group)or an equal volume of phosphate-buffered saline(photothrombotic cortical injury group)into the lateral ventricle for 3 *** effects of sNgR-Fc on the proliferation and differentiation of endogenous neural progenitor cells were examined using BrdU *** function was evaluated with the Morris water maze *** further examine the effects of sNgR-Fc treatment on neural progenitor cells,photothrombotic cortical injury was produced in another group of rats that received transplantation of neural progenitor cells from the hippocampus of embryonic Sprague-Dawley *** animals were then given an infusion of phosphate-buffered saline(neural progenitor cells group)or sNgR-Fc(sNgR-Fc+neural progenitor cells group)into the lateral ventricle for 3 ***-Fc enhanced the proliferation of cultured neural progenitor cells in vitro as well as that of endogenous neural progenitor cells in vivo,compared with phosphate-buffered saline,and it also induced the differentiation of neural progenitor cells into *** with the photothrombotic cortical injury group,escape latency in the Morris water maze and neurological severity score were greatly reduced,and distance traveled in the target quadrant was considerably increased in the sNgR-Fc group,indicating a substantial improvement in neurological ***,compared with phosphate-buffered saline infusion,sNgR-Fc infusion strikingly improved the survival and differentiation of grafted

关键词： neural regeneration Nogo-66 receptor Nogo66 receptor-Fc protein neural progenitor cells proliferation differentiation stroke photothrombotic cortical injury transplantation neurological function nerve regeneration

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Amygdala neural ensemble mediates mouse social investigation behaviors

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National Science Review 2023年第1期10卷 108-126页

作者： Ji-an Wei Qing Han Zhihua Luo linglin liu Jing Cui Jiahui Tan Billy K.C.Chow kwok-fai so.li zhang Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macau Institute of CNS RegenerationJinan University School of Biological Sciences The University of Hong Kong State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of Medicine The University of Hong Kong Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay Area Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Co-Innovation Center of Neuroregeneration Nantong University Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation Sciences Institute of Clinical Research for Mental Health Jinan University

Innate social investigation behaviors are critical for animal survival and are regulated by both neural circuits and neuroendocrine *** understanding of how neuropeptides regulate social interest,however,is incomplete at the current *** this study,we identified the expression of secretin(SCT) in a subpopulation of excitatory neurons in the basolateral *** distinct mole cular and physiological features,BLASCT+cells projected to the medial prefrontal cortex and were necessary and sufficient for promoting social investigation behaviors,whilst other basolateral amygdala neurons were anxiogenic and antagonized social ***,the exogenous application of secretin effectively promoted social interest in both healthy and autism spectrum disorder model *** results collectively demonstrate a previously unrecognized group of amygdala neurons for mediating social behaviors and suggest promising strategies for social deficits.

关键词： social interaction basolateral amygdala secretin

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In vivo neuronal and astrocytic activation in somatosensory cortex by acupuncture stimuli

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Neural Regeneration Research 2022年第11期17卷 2526-2529页

作者： Xiao-Yue Chang Kai Chen Tong Cheng Pui To Lai li zhang kwok-fai so Edward S.Yang Key Laboratory of CNS Regeneration(Minstry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Electrical and Electronic Engineering The University of Hong KongHong Kong Special Administrative RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Guangzhou Regenerative Medicine and Health Guangdong Laboratory GuangzhouGuangdong ProvinceChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina

Acupuncture is a medical treatment that has been widely pra cticed in China for over 3000 years,yet the neural mechanisms of acupuncture are not fully *** hypothesized that neurons and astrocytes act independently and synergistically under acupuncture *** investigate this,we used two-photon in vivo calcium reco rding to observe the effects of acupuncture stimulation at ST36(Zusanli)in *** stimulation in peripheral acupoints potentiated calcium signals of pyramidal neurons and astrocytes in the somatosensory cortex and resulted in late-onset calcium transients in *** inhibition of neurons augmented the astrocytic *** findings suggest that acupuncture activates neuronal and astrocytic activity in the somatosensory co rtex and provide evidence for the involvement of both neurons and astrocytes in acupuncture treatment.

关键词： acupuncture astrocyte chemogenetic neuron N-methyl-D-aspartate receptor somatosensory cortex transient receptor potential A1 two-photon in vivo imaging

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Neuromodulation-Based Stem Cell Therapy in Brain Repair:Recent Advances and Future Perspectives

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Neuroscience Bulletin 2021年第5期37卷 735-745页

作者： Ti-Fei Yuan Yi Dong li zhang Jieyu Qi Chun Yao Yongjun Wang Renjie Chai Yan liu kwok-fai so Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China State Key Laboratory of Brain and Cognitive Sciences the University of Hong KongJiulongHong Kong SARChina Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education East China Normal UniversityShanghai 200241China Joint International Research Laboratory of CNS Regeneration Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhou 510632China Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhou 510632China Key Laboratory for Developmental Genes and Human Disease Ministry of EducationInstitute of Life SciencesSoutheast UniversityNanjing 210096China Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNantong UniversityNanjing 226001China Institute for Stem Cell and Neural Regeneration State Key Laboratory of Reproductive MedicineSchool of PharmacyNanjing Medical UniversityNanjing 211166China

Stem cell transplantation holds a promising future for central nervous system repair. Current challenges, however, include spatially and temporally defined cell differentiation and maturation, plus the integration of transplanted neural cells into host circuits. Here we discuss the potential advantages of neuromodulation-based stem cell therapy, which can improve the viability and proliferation of stem cells, guide migration to the repair site,orchestrate the differentiation process, and promote the integration of neural circuitry for functional *** these advantages of neuromodulation make it one potentially valuable tool for further improving the efficiency of stem cell transplantation.

关键词： Stem cell Rehabilitation Neuromodulation Transcranial magnetic stimulation Transcranial direct current stimulation Deep brain stimulation

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Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons

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Neural Regeneration Research 2020年第12期15卷 2335-2343页

作者： Shu-Ting Chen Wan-Jing Lai Wei-Jia zhang Qing-Pei Chen li-Bing Zhou kwok-fai so.ling-ling Shi Guangdong-Hong Kong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Clinical Medicine Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Psychiatry the First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

SHANK2 is a scaffold protein that serves as a protein anchor at the postsynaptic density in *** variants of SHANK2 are strongly associated with synaptic dysfunction and the pathophysiology of autism spectrum *** studies indicate that early neuronal developmental defects play a role in the pathogenesis of autism spectrum disorder,and that insulin-like growth factor 1 has a positive effect on neurite *** investigate the effects of SHANK2 knockdown on early neuronal development,we generated a sparse culture system using human induced pluripotent stem cells,which then differentiated into neural progenitor cells after 3–14 days in culture,and which were dissociated into single *** in the experimental group were infected with shSHANK2 lentivirus carrying a red fluorescent protein reporter(shSHANK2 group).Control neurons were infected with scrambled sh Control lentivirus carrying a red fluorescent protein reporter(sh Control group).Neuronal somata and neurites were reconstructed based on the lentiviral red fluorescent protein *** dendritic and motility changes in VGLUT1^+glutamatergic neurons and TH+dopaminergic neurons were then evaluated in both *** with sh Control VGLUT1^+neurons,the dendritic length and arborizations of shSHANK2 VGLUT1^+neurons were shorter and fewer,while cell soma speed was ***,dendritic length and arborization were significantly increased after insulin-like growth factor 1 treatment of shSHANK2 neurons,while cell soma speed remained *** results suggest that insulin-like growth factor 1 can rescue morphological defects,but not the change in neuronal ***,our findings demonstrate that SHANK2 deficiency perturbs early neuronal development,and that IGF1 can partially rescue the neuronal defects caused by SHANK2 *** experimental procedures and protocols were approved by the Laboratory Animal Ethics Committee of Jinan Universi

关键词： cells factor growth in vitro model neural differentiation neurogenesis plasticity

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