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Risk of critical limb ischemia in long-term uterine cancer survivors:A population-based study

World Journal of Clinical Cases 2022年第36期10卷 13293-13303页

作者： Min-Chi Chen Jung-Jung Chang Miao-Fen Chen Ting-Yao Wang Cih-En Huang kuan-der lee Chao-Yu Chen Department of Public Health Chang Gung UniversityTaoyuan 333Taiwan Department of Obstetrics and Gynecology Chang Gung Memorial HospitalChiayi 612Taiwan Division of Cardiovascular Disease Department of Internal MedicineChang Gung Memorial HospitalChiayi 612Taiwan Department of Radiation Oncology Change Gung Memorial HospitalLinkouTaoyuan 333Taiwan Division of Hematology and Oncology Department of Internal MedicineChang Gung Memorial HospitalChiayi 612Taiwan Graduate Institute of Clinical Medical Sciences College of MedicineChang Gung UniversityTaoyuan 333Taiwan Department of Medicine Taipei Medical University HospitalTaipei 100Taiwan Department of Medical Research Taichung Veterans General HospitalTaichung 407Taiwan Department of Post-Baccalaureate Medicine College of MedicineNational Chung Hsing UniversityTaichung 402Taiwan Department of Early Childhood Care and Education Shu-Zen Junior College of Medicine and ManagementKaohsiung 821Taiwan

BACKGROUND The risk of critical limb ischemia(CLI)which causes ischemic pain or ischemic loss in the arteries of the lower extremities in long-term uterine cancer(UC)survivors remains unclear,especially in Asian patients,who are younger at the diagnosis of UC than their Western *** To conduct a nationwide population-based study to assess the risk of CLI in UC long-term *** UC survivors,defined as those who survived for longer than 5 years after the diagnosis,were identified and matched at a 1:4 ratio with normal *** Cox models were used to assess the risk of *** From 2000 to 2005,1889 UC survivors who received surgery alone or surgery combined with radiotherapy(RT)were classified into younger(onset ageder(onset age≥50 years,n=995)*** compared with normal controls,the younger patients with diabetes,hypertension,and receiving hormone replacement therapy(HRT)were more likely to develop *** contrast,the risk of CLI was associated with adjuvant RT,obesity,hypertension,and HRT in the older *** the UC survivors,those who were diagnosed at an advanced age(>65 years,aHR=2.48,P=0.011),had hypertension(aHR=2.18,P=0.008)or received HRT(aHR=3.52,P=0.020)were at a higher risk of *** In this nationwide study,we found that the risk factors associated with CLI were similar in both cohorts except for adjuvant RT that was negligible in the younger group,but positive in the older *** the survivors,hypertension,advanced age,and HRT were more hazardous than *** prevention should include CLI as a late complication in UC survivorship programs.

关键词： Uterine cancer Critical limb ischemia Radiotherapy Survivorship

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HNF-4α determines hepatic differentiation of human mesenchymal stem cells from bone marrow

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World Journal of Gastroenterology 2010年第40期16卷 5092-5103页

作者： Mong-Liang Chen kuan-der lee Huei-Chun Huang Yue-Lin Tsai Yi-Chieh Wu Tzer-Min Kuo Cheng-Po Hu Chungming Chang Division of Molecular and Genomic Medicine National Health Research Institutes Department of Hematology and Oncology Chang Gung Memorial Hospital Institute of Microbiology and Immunology National Yang-Ming University Department of Life Science Tunghai University

AIM: To investigate the differentiation status and key factors to facilitate hepatic differentiation of human bone-marrow-derived mesenchymal stem cells (MSCs). METHODS: Human MSCs derived from bone marrow were induced into hepatocyte-like cells following a previously published protocol. The differentiation status of the hepatocyte-like cells was compared with various human hepatoma cell lines. Overexpression of hepatocyte nuclear factor (HNF)-4α was mediated by adenovirus infection of these hepatocyte-like cells. The expression of interesting genes was then examined by either re-verse transcription-polymerase chain reaction (RT-PCR) or real-time RT-PCR methods. RESULTS: Our results demonstrated that the differentiation status of hepatocyte-like cells induced from human MSCs was relatively similar to poorly differentiated human hepatoma cell lines. Interestingly, the HNF-4 isoform in induced MSCs and poorly differentiated human hepatoma cell lines was identified as HNF4γ instead of HNF-4α. Overexpression of HNF-4α in induced MSCs significantly enhanced the expression level of hepatic-specific genes, liver-enriched transcription factors, and cytochrome P450 (P450) genes. CONCLUSION: Overexpression of HNF-4α improves the hepatic differentiation of human MSCs from bone marrow and is a simple way of providing better cell sources for clinical applications.

关键词： Bone marrow Cytochrome P450 genes Differentiation of hepatocyte Hepatocyte nuclear factor 4 Human mesenchymal stem cells

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Urban rail transit disruption management: Research progress and future directions

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Frontiers of Engineering Management 2024年第1期11卷 79-91页

作者： Lebing WANG Jian Gang JIN Lijun SUN der-Horng lee School of Naval Architecture Ocean&Civil Engineeringand State Key Laboratory of Ocean EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Civil Engineering McGill UniversityMontrealQuebec H3A 0C3Canada ZJU-UIUC Institute Zhejiang UniversityHaining 314400China

Urban rail transit (URT) disruptions present considerable challenges due to several factors: i) a high probability of occurrence, arising from facility failures, disasters, and vandalism;ii) substantial negative effects, notably the delay of numerous passengers;iii) an escalating frequency, attributable to the gradual aging of facilities;and iv) severe penalties, including substantial fines for abnormal operation. This article systematically reviews URT disruption management literature from the past decade, categorizing it into pre-disruption and post-disruption measures. The pre-disruption research focuses on reducing the effects of disruptions through network analysis, passenger behavior analysis, resource allocation for protection and backup, and enhancing system resilience. Conversely, post-disruption research concentrates on restoring normal operations through train rescheduling and bus bridging services. The review reveals that while post-disruption strategies are thoroughly explored, pre-disruption research is predominantly analytical, with a scarcity of practical pre-emptive solutions. Moreover, future research should focus more on increasing the interchangeability of transport modes, reinforcing redundancy relationships between URT lines, and innovating post-disruption strategies.

关键词： urban rail transit disruption management resilient network train rescheduling bus bridging services

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Drug repurposing screen identifies vidofludimus calcium and pyrazofurin as novel chemical entities for the development of hepatitis E interventions

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Virologica Sinica 2024年第1期39卷 123-133页

作者： Hongbo Guo Dan Liu kuan Liu Yao Hou Chunyang Li Qiudi Li Xiaohui Ding Monique M.A.Verstegen Jikai Zhang Lingli Wang Yibo Ding Renxian Tang Xiucheng Pan Kuiyang Zheng Luc J.Wvan der Laan Qiuwei Pan Wenshi Wang Department of Pathogen Biology and Immunology Jiangsu Key Laboratory of Immunity and MetabolismJiangsu International Laboratory of Immunity and MetabolismXuzhou Medical UniversityXuzhou221004China Department of Gastroenterology and Hepatology Erasmus MC-University Medical CenterRotterdamNL-3015 CNthe Netherlands Department of Surgery Erasmus MC Transplant InstituteUniversity Medical CenterRotterdam3015CENL-3015 CNthe Netherlands Department of Infectious Diseases The Affiliated Hospital of Xuzhou Medical UniversityXuzhou221002China

Hepatitis E virus(HEV)infection can cause severe complications and high mortality,particularly in pregnant women,organ transplant recipients,individuals with pre-existing liver disease and immunosuppressed ***,there are still unmet needs for treating chronic HEV ***,we screened a best-in-class drug repurposing library consisting of 262 drugs/*** screening,we identified vidofludimus calcium and pyrazofurin as novel anti-HEV *** calcium is the next-generation dihydroorotate dehydrogenase(DHODH)inhibitor in the phase 3 pipeline to treat autoimmune diseases or SARS-CoV-2 *** selectively targets uridine monophosphate synthetase(UMPS).Their anti-HEV effects were further investigated in a range of cell culture models and human liver organoids models with wild type HEV strains and ribavirin treatment failure-associated HEV ***,both drugs exhibited a sizeable therapeutic window against *** instance,the IC50 value of vidofludimus calcium is 4.6–7.6-fold lower than the current therapeutic doses in ***,their anti-HEV mode of action depends on the blockage of pyrimidine ***,two drugs robustly inhibited ribavirin treatment failure-associated HEV mutants(Y1320H,G1634R).Their combination with IFN-αresulted in synergistic antiviral *** conclusion,we identified vidofludimus calcium and pyrazofurin as potent candidates for the treatment of HEV *** on their antiviral potency,and also the favorable safety profile identified in clinical studies,our study supports the initiation of clinical studies to repurpose these drugs for treating chronic hepatitis E.

关键词： Hepatitis Evirus(HEV) Drug repurposing Vidofludimus calcium Pyrazofurin Pyrimidine biosynthesis

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Classification and technical target of water electrolysis for hydrogen production

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Journal of Energy Chemistry 2024年第8期95卷 554-576,I0012页

作者： Kahyun Ham Sooan Bae Jaeyoung lee Ertl Center for Electrochemistry and Catalysis Gwangju Institute of Science and Technology(GIST)123 Cheomdangwagi-RoBuk-guGwangju 61005South Korea Department of Heterogeneous Reactions Max Planck Institute for Chemical Energy ConversionStiftstr.34-36Mülheim an der RuhrGermany School of Earth Sciences and Environmental Engineering GIST123 CheomdangwagiroBuk-guGwangju 61005South Korea International Future Research Center of Chemical Energy Storage and Conversion Processes GIST123 CheomdangwagiroBuk-guGwangju 61005South Korea eSuS Co. Ltd.#408S6 BuildingSchool of Environment and Energy EngineeringGIST123 CheomdangwagiroBuk-guGwangju 61005South Korea

Continuous efforts are underway to reduce carbon emissions worldwide in response to global climate *** electrolysis technology,in conjunction with renewable energy,is considered the most feasible hydrogen production technology based on the viable possibility of large-scale hydrogen production and the zero-carbon-emission nature of the ***,for hydrogen produced via water electrolysis systems to be utilized in various fields in practice,the unit cost of hydrogen production must be reduced to$1/kg H_(2).To achieve this unit cost,technical targets for water electrolysis have been suggested regarding components in the *** this paper,the types of water electrolysis systems and the limitations of water electrolysis system components are *** suggest guideline with recent trend for achieving this technical target and insights for the potential utilization of water electrolysis technology.

关键词： Water electrolysis Hydrogen production Technical target Electrochemistry

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Air-stable,all-dry transferred ReS_(2)/GaSe heterostructure-based NO_(2)gas sensor

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Journal of Materials Science & Technology 2024年第1期168卷 79-87页

作者： A.Venkatesan Hyeyoon Ryu Anupom Devnath Hyungyu Yoo Seunghyun lee Department of Electronic Engineering Kyung Hee UniversityYongin-Si 17104South Korea Department of Electronics and Information Convergence Engineering Kyung Hee UniversityYongin-Si 17104South Korea

Two-dimensional(2D)materials have gained considerable attention in chemical sensing owing to their naturally high surface-to-volume ***,the poor response time and incomplete recovery re-strict their application in practical,high performance gas *** this work,we fabricated air-stable ReS_(2)/GaSe heterostructure-based NO_(2)gas sensors with excellent gas sensing response,recovery,selectiv-ity and a low limit of detection(LOD)toward nitrogen dioxide(NO_(2)).The ReS_(2)/GaSe heterostructure was prepared via mechanical exfoliation and an all-dry transfer *** the sensing measurements,temperature-dependant transport measurements were carried *** Schottky Barrier Height(SBH)of the ReS_(2)/GaSe heterostructure was calculated and the corresponding transport mechanisms were *** fabricated gas sensors showed a significant response enhancement with full reversibility to-ward ppm-level NO_(2)(response of∼17%at 3 ppm,a LOD of∼556 ppb)at an operating temperature of(33°C).In particular,the total response and recovery time of the ReS_(2)/GaSe was revealed to be less than 4 min(∼38 s and∼174 s,respectively)for the 250 ppm concentration,which is one of the best response and recovery time toward ppm-level NO_(2).The excellent sensing performances and recovery characteris-tics of the ReS_(2)/GaSe structure are attributed to its efficient charge separation,unique interlayer coupling and desirable band *** atomically thin,ultrasensitive gas sensor that operates at room tem-perature is a strong technological contender to conventional metal oxide gas sensors,which often require elevated temperatures.

关键词： 2D materials All-dry transfer Gas sensor Van der Waals heterostructure ReS_(2)/GaSe Gas sensing response Transition metal dichalcogenide

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Dual-logic-in-memory implementation with orthogonal polarization of van der Waals ferroelectric heterostructure

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InfoMat 2024年第2期6卷 107-117页

作者： Jingjie Niu Sumin Jeon Donggyu Kim Sungpyo Baek Hyun Ho Yoo Jie Li Ji-Sang Park Yoonmyung lee Sungjoo lee SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan UniversitySuwonRepublic of Korea Department of Nano Science and Technology Sungkyunkwan UniversitySuwonRepublic of Korea Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwonRepublic of Korea IMEC HeverleeBelgium Department of Nano Engineering Sungkyunkwan UniversitySuwonRepublic of Korea

The rapid advancement of AI-enabled applications has resulted in an increasing need for energy-efficient computing ***-in-memory is a promising approach for processing the data stored in memory,wherein fast and efficient computations are possible owing to the parallel execution of reconfigurable logic *** this study,a dual-logic-in-memory device,which can simultaneously perform two logic operations in four states,is demonstrated using van der Waals ferroelectric field-effect transistors(vdW FeFETs).The proposed dual-logic-in-memory device,which also acts as a twobit storage device,is a single bidirectional polarization-integrated ferroelectric field-effect transistor(BPI-FeFET).It is fabricated by integrating an in-plane vdW ferroelectric semiconductor SnS and an out-of-plane vdW ferroelectric gate dielectric material—CuInP_(2)S_(6).Four reliable resistance states with excellent endurance and retention characteristics were *** two-bit storage mechanism in a BPI-FeFET was analyzed from two perspectives:carrier density and carrier injection controls,which originated from the out-of-plane polarization of the gate dielectric and in-plane polarization of the semiconductor,*** conventional multilevel FeFETs,the proposed BPIFeFET does not require additional pre-examination or erasing steps to switch from/to an intermediate polarization,enabling direct switching between the four memory *** utilize the fabricated BPI-FeFET as a dual-logic-inmemory device,two logical operations were selected(XOR and AND),and their parallel execution was *** types of logic operations could be implemented by selecting different initial states,demonstrating various types of functions required for numerous neural network *** flexibility and efficiency of the proposed dual-logic-in-memory device appear promising in the realization of next-generation low-power computing systems.

关键词： ferroelectric field-effect transistor in-plane ferroelectricity logic-in-memory out-of-plane ferroelectricity

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Are life insurance futures a safe haven during COVID‑19?

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Financial Innovation 2023年第1期9卷 397-423页

作者： kuan‑Min Wang Yuan‑Ming lee Department of Finance Overseas Chinese University100 Chiao Kwang RoadTaichung 40721Taiwan Department of Finance Southern Taiwan University of Science and TechnologyNo.1Nantai StYung‑Kang CityTainanTaiwan

This study aims to examine whether life insurance futures can serve as a hedge against the COVID-19 pandemic and whether they have the characteristics of a safe haven under the impact of the health shocks of the COVID-19 *** chose three life insurance stock futures in India and one in Taiwan as samples,including the market index of the two countries and the number of confirmed COVID-19 cases as sample *** used the growth rate of COVID-19 cases as the threshold variable,esti-mated the asymmetric threshold vector autoregression model,and found that insur-ance futures in the regime with a significant growth rate of confirmed COVID-19 cases can hedge against COVID-19 risks;therefore,insurance futures are a safe haven for the *** further estimated the time-varying parameter vector autoregression model,and the impulse response results showed that insurance futures are a safe haven for COVID-19 pandemic risks.

关键词： Insurance futures TVAR TVP-VAR Safe haven Impulse response

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Endoscopic salvage therapy after failed biliary cannulation using advanced techniques:A concise review

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World Journal of Gastroenterology 2022年第29期28卷 3803-3813页

作者： Yung-kuan Tsou kuang-Tse Pan Mu Hsien lee Cheng-Hui Lin Department of Gastroenterology and Hepatology Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Medicine Chang Gung UniversityTaoyuan 333Taiwan Department of Medical Imaging and Intervention Chang Gung Memorial HospitalTaoyuan 333Taiwan

Therapeutic endoscopic retrograde cholangiopancreatography(ERCP)begins with successful biliary ***,it is not always be *** failure of the initial ERCP is attributed to two main aspects:the papilla/biliary orifice is endoscopically accessible,or it is *** the papilla/biliary orifice is accessible,bile duct cannulation failure can occur even with advanced cannulation techniques,including double guidewire techniques,transpancreatic sphincterotomy,needle-knife precut papillotomy,or *** is currently no consensus on the next steps of treatment in this ***,this review aims to propose and discuss potential endoscopic options for patients who have failed ERCP due to difficult bile duct *** options include interval ERCP,percutaneous-transhepatic-endoscopic rendezvous procedures(PTE-RV),and endoscopic ultrasound-assisted rendezvous procedures(EUS-RV).The overall success rate for interval ERCP was 76.3%(68%-79% between studies),and the overall adverse event rate was 7.5%(0-15.9% between studies).The overall success rate for PTE-RV was 88.7%(80.4%-100%between studies),and the overall adverse event rate was 13.2%(4.9%-19.2% between studies).For EUS-RV,the overall success rate was 82%-86.1%,and the overall adverse event rate was 13%-15.6%.Because interval ERCP has an acceptably high success rate and lower adverse event rate and does not require additional expertise,facilities,or other specialists,it can be considered the first choice for salvage ***-RV can also be considered if local experts are *** patients in urgent need of biliary drainage,PTE-RV should be considered.

关键词： Difficult biliary cannulation Endoscopic ultrasound Rendezvous Endoscopic retrograde cholangiopancreatography Percutaneous transhepatic biliary drainage Interval

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Efficacy of multigrain supplementation in type 2 diabetes mellitus:A pilot study protocol for a randomized intervention trial

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World Journal of Diabetes 2023年第5期14卷 606-616页

作者： Nur Anis Mohd Ariffin Mastura Mohd Sopian Lai kuan lee Food Technology Division School of Industrial TechnologyUniversiti Sains MalaysiaGelugor 11800Pulau PinangMalaysia Oncology and Radiological Sciences Cluster Advanced Medical and Dental InstituteUniversiti Sains MalaysiaBertam 13200Pulau PinangMalaysia

BACKGROUND Uncontrolled type 2 diabetes mellitus(T2DM)may lead to microvascular complications(nephropathy,retinopathy,and neuropathy)and cardiovascular *** beta-glucan content in grains has the potential to improve insulin sensitivity,lowering postprandial glucose response and reducing inflammation degrees.A proper combination of grains not only satisfies human body’s need,but also provides essential and reasonable nutritional ***,no trial has been conducted to evaluate the roles of multigrain in *** To determine the efficacy of multigrain supplementation among T2DM *** From October 2020 to June 2021,a total of 50 adults living with T2DM,who were receiving standard diabetes care at Day Care Clinic,were randomized into either a supplementation group or a control *** supplementation group received twice daily 30 g multigrain supplement(equivalent to 3.4 g beta-glucan)with standard medication for 12 wk,while the control group was prescribed with standard *** such as glycemic control(HbA1c,FPG,and HOMO-IR),cardiometabolic profile(lipid profile,renal function test,and liver function test),oxidative stress status,nutritional status,and quality of life(QoL)were assessed at two time points:Baseline and the end of the treatment period(week 12).RESULTS The primary outcomes were the mean difference of glycated haemoglobin(%),fasting plasma glucose,and serum insulin as intervention *** outcomes included the measurement of cardiometabolic profile,antioxidative and oxidative stress status,nutritional status indices,and *** outcomes involved the determination of safety and tolerability,and supplementation *** The present clinical trial will reveal the effectiveness of multigrain supplementation among T2DM patients for the improvement of diabetes management.

关键词： Beta-glucan Clinical trial Multigrain Type 2 diabetes mellitus Glycemic control

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