Efficacy of multigrain supplementation in type 2 diabetes mellitus:A pilot study protocol for a randomized intervention trial
作者机构：Food Technology DivisionSchool of Industrial TechnologyUniversiti Sains MalaysiaGelugor 11800Pulau PinangMalaysia Oncology and Radiological Sciences ClusterAdvanced Medical and Dental InstituteUniversiti Sains MalaysiaBertam 13200Pulau PinangMalaysia
出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)
年 卷 期：2023年第14卷第5期
页 面：606-616页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Beta-glucan Clinical trial Multigrain Type 2 diabetes mellitus Glycemic control
摘 要：BACKGROUND Uncontrolled type 2 diabetes mellitus(T2DM)may lead to microvascular complications(nephropathy,retinopathy,and neuropathy)and cardiovascular *** beta-glucan content in grains has the potential to improve insulin sensitivity,lowering postprandial glucose response and reducing inflammation degrees.A proper combination of grains not only satisfies human body’s need,but also provides essential and reasonable nutritional ***,no trial has been conducted to evaluate the roles of multigrain in *** To determine the efficacy of multigrain supplementation among T2DM *** From October 2020 to June 2021,a total of 50 adults living with T2DM,who were receiving standard diabetes care at Day Care Clinic,were randomized into either a supplementation group or a control *** supplementation group received twice daily 30 g multigrain supplement(equivalent to 3.4 g beta-glucan)with standard medication for 12 wk,while the control group was prescribed with standard *** such as glycemic control(HbA1c,FPG,and HOMO-IR),cardiometabolic profile(lipid profile,renal function test,and liver function test),oxidative stress status,nutritional status,and quality of life(QoL)were assessed at two time points:Baseline and the end of the treatment period(week 12).RESULTS The primary outcomes were the mean difference of glycated haemoglobin(%),fasting plasma glucose,and serum insulin as intervention *** outcomes included the measurement of cardiometabolic profile,antioxidative and oxidative stress status,nutritional status indices,and *** outcomes involved the determination of safety and tolerability,and supplementation *** The present clinical trial will reveal the effectiveness of multigrain supplementation among T2DM patients for the improvement of diabetes management.
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