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Intestinal barrier dysfunction in cirrhosis: Current concepts in pathophysiology and clinical implications

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World Journal of Hepatology 2015年第17期7卷 2058-2068页

作者： Georgios I Tsiaoussis Stelios F Assimakopoulos Athanassios C Tsamandas Christos K Triantos konstantinos C Thomopoulos Department of Gastroenterology and Hepatology University Hospital of Patras Department of Internal Medicine University Hospital of Patras Department of Pathology University Hospital of Patras

The intestinal lumen is a host place for a wide range of microbiota and sets a unique interplay between local immune system, inflammatory cells and intestinal epithelium, forming a physical barrier against microbial invaders and toxins. Bacterial translocation is the migration of viable or nonviable microorganisms or their pathogen-associated molecular patterns, such as lipopolysaccharide, from the gut lumen to the mesenteric lymph nodes, systemic circulation and other normally sterile extraintestinal sites. A series of studies have shown that translocation of bacteria and their products across the intestinal barrier is a commonplace in patients with liver disease. The deterioration of intestinal barrier integrity and the consulting increased intestinal permeability in cirrhotic patients play a pivotal pathophysiological role in the development of severe complications as high rate of infections, spontaneous bacterial peritonitis, hepatic encephalopathy, hepatorenal syndrome, variceal bleeding, progression of liver injury and hepatocellular carcinoma. Nevertheless, the exact cellular and molecular mechanisms implicated in the phenomenon of microbial translocation in liver cirrhosis have not been fully elucidated yet.

关键词： Cirrhosis Intestinal barrier Tight junction Bacterial translocation Intestinal bacterial overgrowth

Does therapist's attitude affect clinical outcome of lumbar facet joint injections?

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World Journal of Radiology 2016年第6期8卷 628-634页

作者： Marcus Middendorp konstantinos Kollias Hanns Ackermann Annina Splettstoβer Thomas J Vogl M Fawad Khan Adel Maataoui Department of Nuclear Medicine Goethe University Institute for Diagnostic and Interventional Radiology Goethe University Institute of Biostatistics and Mathematical Modeling Goethe University radprax MVZ

AIM: To investigate if the clinical outcome of intraarticular lumbar facet joint injections is affected by the therapist's attitude. METHODS: A total of 40 patients with facet jointassociated chronic low back pain were randomly divided into two groups. All patients received computed tomography-guided, monosegmental intra-articular facet joint injections. Following the therapeutic procedure, the patients of the experimental group(EG) held a conversation with the radiologist in a comfortable atmosphere. During the dialog, the patients were encouraged to ask questions and were shown four images. The patients of the control group(CG) left the clinic without any further contact with the radiologist. Outcome was assessed using a pain-based Verbal Numeric Scale at baseline, at 1 wk and at 1, 3, and 6 mo after first treatment. RESULTS: The patient demographics showed no differences between the groups. The patients of the EG received 57 interventional procedures in total, while the patients of the CG received 70 interventional procedures. In both groups, the pain scores decreased significantly over the entire observation period. Compared to the CG, the EG showed a statistically significant reduction of pain at 1 wk and 1 mo post-treatment, while at 3 and 6 mo after treatment, there were no significant differences between both groups. CONCLUSION: Our results show a significant effect on pain relief during the early post-interventional period in the EG as compared to the CG. The basic principle behind the higher efficacy might be the phenomenon of hetero-suggestion.

关键词： Facet joint injection Hetero-suggestion Low back pain Lumbar spine Magnetic resonance imaging Facet joint osteoarthritis

Sedation-risk-free colonoscopy for minimizing the burden of colorectal cancer screening

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World Journal of Gastrointestinal Endoscopy 2010年第3期2卷 81-89页

作者： Felix W Leung Abdulrahman M Aljebreen Emilio Brocchi Eugene B Chang Wei-Chih Liao Takeshi Mizukami Melvin Schapiro konstantinos Triantafyllou Research and Medical Services Sepulveda Ambulatory Care CenterVeterans Affairs Greater Los Angeles Healthcare SystemNorth Hills David Geffen School of Medicine University of CaliforniaLos Angeles King Khalid University Hospital Department of Internal Medicine and Gastro-enterology University of Bologna Department of Medicine University of Chicago School of MedicineChicago Department of Internal Medicine National Taiwan University Hospital Endoscopy Center Yokohama Municipal Citizen's Hospital Hepatogastroenterology Unit 2nd Dep artment of Internal Medicine-PropaedeuticAttikon Univer-sity General HospitalMedical SchoolAthens University

Unsedated colonoscopy is available worldwide,but is not a routine option in the United States(US).We conducted a literature review supplemented by our experience and expert commentaries to provide data to support the use of unsedated colonoscopy for colorectal cancer *** data from 1966 to 2009 were searched to identify relevant articles on the *** were summarized and co-authors provided critiques as well as accounts of unsedated colonoscopy for screening and *** colonoscopy was initially dev eloped as an unsedated ***-re lated discomfort led to wide adoption of sedation in the US,although unsedated colonoscopy remains the usual practice *** increased use of colonoscopy for colorectal cancer screening in healthy,asymptomatic individuals suggests a reass-essment of the burden of sedation in colonoscopy for screening is appropriate in the US for lowering costs and minimizing complications for patients.A water method developed to minimize discomfort has shown promise to enhance outcomes of unsedated *** use of scheduled,unsedated colono scopy in the US appears to be feasible for colorectal cancer *** to assess its applicability in diverse practice settings deserve to be conducted and supported.

关键词： Unsedated colonoscopy Sedation-risk-free colonoscopy Colon cancer screening

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框架结构弹塑性分析的一种有效数值方法

钢结构(中英文) 2010年第7期 75-75页

作者： konstantinos V.Spiliopoulos Theodoros N.Patsios

框架结构的不完全弹塑性分析是一个非线性过程,按照假定的加载模式,利用荷载因子进行逐步加载。基于力学和数值方法,研究框架结构的极限承载力和变形能力。假定材料为理想弹塑性,并利用零长度塑性铰模拟塑性行为。该方法基于增量方程,... 详细信息

框架结构的不完全弹塑性分析是一个非线性过程,按照假定的加载模式,利用荷载因子进行逐步加载。基于力学和数值方法,研究框架结构的极限承载力和变形能力。假定材料为理想弹塑性,并利用零长度塑性铰模拟塑性行为。该方法基于增量方程,类似于求解两个连续塑性铰之间的凸二次参数规划问题。利用虚荷载因子将凸二次参数规划转化为凸二次规划,并使用标准算法求解凸二次规划问题,可满足出现塑性铰的要求并自动判别塑性。该方法起初仅适用于纯弯作用,后延伸至弯矩-轴力共同作用。分别分析单调、变化、循环加载作用下的算例。整个过程稳定、可靠、高效,并比基于直接刚度法的交替位移方法更省时。

关键词：数值方法二次规划力学方法图论塑性铰板弯曲弯矩-轴力共同作用有限元静力弹塑性循环加载

History of the infantile hepatic hemangioma:From imaging to generating a differential diagnosis

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World Journal of Clinical Pediatrics 2016年第3期5卷 273-280页

作者： Maria Gnarra Gerald Behr Alison Kitajewski June K Wu Sudha A Anupindi Carrie J Shawber Nick Zavras Dimitrios Schizas Chris Salakos konstantinos P Economopoulos Vascular Biology Program Department of SurgeryBoston Children's Hospital and Harvard Medical School Department of Radiology Columbia University Medical Center Department of Surgery Columbia University Medical Center Department of Radiology the Children's Hospital of PhiladelphiaUniversity of Pennsylvania Perelman School of Medicine Department of OB/GYN Columbia University Medical Center Department of Pediatric Surgical "ATTIKO" General University Hospital Society of Junior Doctors Surgery Working Group Department of Surgery Massachusetts General HospitalHarvard Medical School

We aim to provide an up-to-date summary of infantile hepatic hemangioma(IHH) and its misnomers and to dialectically present the differential diagnosis of these rare entities of the *** peer-reviewed articles on hepatic infantile hemangiomas,published between 2000 and 2015,were reviewed for this *** is the most common hepatic vascular tumor in *** a liver mass is identified in an infant,the differential diagnosis ranges from vascular malformations to benign and malignant tumors including mesenchymal hamartoma,hepatoblastoma,metastatic neuroblastoma,so careful physical examination,imaging studies,and,if indicated,tumor markers and biopsy,are of pivotal importance to ascertain the correct *** the benign nature of IHHs,some of these lesions may demand medical and/or surgical intervention,especially for multiple and diffuse *** can include hepatomegaly,hypothyroidism and cardiac ***,a close follow-up is required until complete involution of the *** propose an algorithm to guide the physicians towards the proper management of hepatic lesions.

关键词： Hepatic hemangiomas Infant Children Vascular tumors

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素数计数函数的一个无穷多次成立显式公式

数学译林 2023年第3期42卷 286-286页

作者： konstantinos Gaitanas 陆柱家(译) 陈凌宇(校) 不详

下文中,π(n)表示不超过n的素数的个数,[n]表示n的整数部分.定理1文对于无穷多个自然数几,下述公式成立:π(n)=n/[ln n-1/2]证明*** Rosser和Lowell Schoenfeld在其著名的论文[2]中证明了下述不等式成立。

关键词：整数部分计数函数显式公式素数不等式自然数无穷

国际糖尿病足工作组:糖尿病足溃疡周围动脉病变诊断、预后与管理指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分

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感染．炎症．修复 2019年第4期20卷 195-206页

作者： Robert J.Hinchliffe Rachael O.Forsythe Jan Apelqvist Ed J.Boyko Robert Fitridge Joon Pio Hong konstantinos Katsanos Joseph L.Mills Sigrid Nikol Jim Reekers Maarit Venermo R.Eugene Zierler Nicolaas C.Schaper 无许樟荣(译) 冉兴无(审校) Bristol Centre for Surgical Research University of BristolBristolUK British Heart Foundation/University of Edinburgh Centre for Cardiovascular Science University of EdinburghEdinburghScotlandUK Department of Endocrinology University Hospital of MalmoSweden Seattle Epidemiologic Research and Information Centre-Department of Veterans Affairs Puget Sound Health Care System and the University of Washington SeattleWashingtonUSA Vascular Surgery The University of AdelaideAdelaideSouth AustraliaAustralia Asan Medical Center University of Ulsan SeoulKorea Patras University Hospital School of Medicine RionPatrasGreece SALSA(Southern Arizona Limb Salvage Alliance) University of Arizona Health Sciences CenterTucsonArizonaUSA Asklepios Klinik *** HamburgGermany Department of Vascular Radiology Amsterdam Medical CentreThe Netherlands Helsinki University Hospital University of HelsinkiFinland Department of Surgery University of WashingtonSeattleWashingtonUSA Div.Endocrinology MUMC+CARIM and CAPHRI InstituteMaastrichtThe Netherlands International Working Group on the Diabetic Foot(IWGDF) 战略支援部队特色医学中心北京100101 四川大学华西医院四川成都610041

1999年以来,国际糖尿病足工作组(IWGDF)已经多次发表循证医学基础上的糖尿病足预防与管理指南。该指南是有关糖尿病足溃疡合并周围动脉病变(PAD)患者的诊断、预后和管理指南,更新了以前IWGDF指南的内容。高达50%的糖尿病足溃疡患者同时... 详细信息

1999年以来,国际糖尿病足工作组(IWGDF)已经多次发表循证医学基础上的糖尿病足预防与管理指南。该指南是有关糖尿病足溃疡合并周围动脉病变(PAD)患者的诊断、预后和管理指南,更新了以前IWGDF指南的内容。高达50%的糖尿病足溃疡患者同时患有PAD,这种病变使得患者截肢和心血管病变的风险明显增加。这类患者的诊断、预后和治疗明显地不同于那些没有PAD的糖尿病患者,但仅有很少的关于这类患者的高质量的研究强调了这点。我们遵循GRADE方法来提出临床问题并以至少包括患者-干预-比较-结局(PICO)形式说明重要结局,进行了系统的医学科学文献评价,写出推荐意见及其合理性。这类推荐是建立在系统文献评价的循证医学基础上的,没有证据时则在权衡利弊和患者选择、便宜性和干预的费用等因素后,采用专家的观点。这里我们发布更新的2019年糖尿病足溃疡合并PAD患者的有关PAD诊断、预后和管理的指南,以及一些需要未来特别关注的研究课题。

关键词：糖尿病足足溃疡指南周围动脉病变外科诊断预后血管病变

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斯科茨大楼,新加坡

世界建筑 2020年第10期 70-75,136页

作者： Ben van Berkel Astrid Piber with Ger Gijzen konstantinos Chrysos Luis Etchegorry Cynthia Markhoff Elisabeth Brauner Shany Barath Thomas van Bekhoven Iris Pastor Rodrigo Canizares Albert Gnodde Mo Ching Ying Lai Grete Veskivali Philipp Weisz Samuel Bernier Lavigne Lukasz Walczak Alicja Chola Cheng Gong Darren Soh(摄影) EdmonLeong(摄影) UN Studio 不详

斯科茨大楼SOHO公寓位于新加坡的黄金地段,靠近乌节路豪华购物区,眺望邻近公园和新加坡城市全景。该塔楼拥有18,500m12、共231个居住单位,包含一至三居室的公寓、四居室的楼顶公寓、宽敞的绿植园林、空中花园、楼顶公寓顶层花园以及各... 详细信息

斯科茨大楼SOHO公寓位于新加坡的黄金地段,靠近乌节路豪华购物区,眺望邻近公园和新加坡城市全景。该塔楼拥有18,500m12、共231个居住单位,包含一至三居室的公寓、四居室的楼顶公寓、宽敞的绿植园林、空中花园、楼顶公寓顶层花园以及各种娱乐设备。UN Studio创始人及首席建筑师本·范·贝克尔表示:“这个大楼是新加坡城市的一个趣味点,跳出了一般的惯常设计手法,我们创造了一个空中的街区,一个每个区域都拥有独特功效的垂直城市。”

关键词：空中花园设计手法垂直城市娱乐设备贝克尔新加坡城市独特功效科茨