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BP180 is a Prognostic Factor in Head and Neck Squamous Cell Carcinoma

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BP180 is a Prognostic Factor in Head and Neck Squamous Cell ...

2022CCtB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： Xue Meng MAtSUMOtO FUMIHIKO tAISUKE MORI NAMI MIURA YOSHINORI INO KAORU ONIDANI KENYA kobayashi YUSUKE MAtSUZAKI SEIICHI YOSHIMOtO KAtSUHISA IKEDA KAZUFUMI HONDA Shengjing Hospital of China Medical University 日本国立癌症研究中心日本顺天堂大学日本医科大学

Background/Aim:Prognosis plays a vital role in head and neck squamous cell carcinoma(HNSCC) patient management and decision-making,the identification of prognostic factor BP180 was required in *** and Methods:Protein expression of bullous pemphigoid antigen II(BP180) was verified by immunohistochemistry(IHC) in a tissue microarray study of 202 ***:IHC analysis revealed that protein expression of BP180 among HNSCC patients differed significantly in the presence and absence of neural invasion,and according to t status in laryngeal and pharyngeal cancer subgroups.Οverall survival and multivariate analysis showed that positive BP180-IHC and advanced clinical stage were significant independent positive predictors of mortality in HNSCC *** addition,in the oral cancer subgroup,independent positive predictors were positive BP180-IHC,advanced N status and neural *** laryngeal and pharyngeal cancer subgroups,predictors were positive BP180-IHC and advanced clinical ***:BP180 is a prognostic factor in head and neck squamous cell carcinoma.

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Development of Dust Monitor for Rapid Detection of Plutonium with Background Compensation System

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Development of Dust Monitor for Rapid Detection of Plutonium...

the Second Asian and Oceanic Congress for Radiation Protection

作者： Yukihisa SANADA Hirohide kobayashi tetsuo HASHIMOtO Radiation Protection Department Nuclear Fuel Cycle Engineering Research Laboratories Japan Atomic Energy Agency （JAEA） Ibaraki Japan Radiation Protection Department Nuclear Fuel Cycle Engineering Research Laboratories Japan Atomic Energy Agency （JAEA） Ibaraki Japan Faculty of Science Niigata University Niigata Japan

the dust monitor for rapid detection of α-emitting artificial radionuclides such as plutonium with Rn-progenies background compensation system was developed by applying a time interval analysis（tIA）.the tIA method,which is one kind of delayed coincidence method,was applied to β-α decay events with microsecond scale（half-life of 214Po:164μs）.time intervals of neighboring pulses were analyzed by a single time interval analysis（StA）of the tIA *** situ experiments,dust samples on the filter（HE-40t;pore size 8μm）were collected at workplaces in reprocessing plant for measuring the 214Bi-214Po correlated *** that,the measurement of the 214Bi-214Po correlated events was carried out using the developed ***,through an experiment using the filter collected dust placed on a small 241Am source,increment of α-ray counting rate due to the 241Am source was detected clearly by background *** present method will apply for on-line monitoring of α-ray measurement,because the method is able to detect any additional artificial nuclides by compensating any changes of background due to Rn-progeny.

关键词： 214Bi-214Po time interval analysis dust monitor Pu radon progeny

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用高压浆料喷射法来改变明胶的分子量分布

明胶科学与技术 2003年第1期23卷 36-40页

作者： t.Ohno Y.Okawa H.kobayashi ChibaUniversity FacultyofEngineeringDepartmentofImageScience1-33Yayoi-choInage-KuChiba263Japan

明胶是非均一水溶性蛋白质的混合物,它具有很宽的分子量分布,分子量从几千至上百万.明胶的物理和照相性能取决于其分子量分布[1-5],所以控制明胶的分子量分布极为重要.

关键词：分子量分布明胶照相性能凝胶渗透色谱 GPC 浆料混合物水溶性蛋白质分级高压

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Prevention of Hearing Loss by Alteration of the Systemic Immune System

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Advances in Aging Research 2019年第2期8卷 29-41页

作者： H. Iwai M. Inaba D. B. Van K. Suzuki t. Sakagami Y. Yun Y. kobayashi A. Kanda Department of Otolaryngology Head and Neck Surgery Kansai Medical University Osaka Japan First Department of Medicine Kansai Medical University Osaka Japan

Although congenital sensorineural hearing loss (SHL) in the bilateral cochleae mainly results from genetic abnormalities, chronic SHL progressing in later life is often influenced by systemic immune disturbances, including autoimmunity, chronic inflammation, and immunosenescence. We have investigated the relationship between the inner ear and systemic immunity and reviewed the possibilities to prevent SHL, including autoimmune SHL and age-related SHL. We also demonstrated two lymphocyte populations, interleukin 1 receptor type II (IL-1R2)-positive t cells (t1R2) and naturally occurring regulatory t cells (ntregs) in CD4+ t cells, which increase with aging, suppress host immune function and promote organ degeneration. Alterations in systemic immunity by fewer microbial antigen challenges in the living environment, elimination of immune suppressive lymphocytes, or immune rejuvenation with a reconstituted thymus may contribute not only to renew the cochlear function in SHL, but also to extend the healthy life of functional organs in a vigorous and youthful body, one of humanity’s greatest dreams.

关键词： Autoimmune Sensorineural Hearing Loss Age-Related Sensorineural Hearing Loss Inflammation Immune Senescence Interleukin 1 Receptor type II-Positive t Cells Naturally Occurring Regulatory t Cells Immune Rejuvenation thymus

Determination of PAHs in atmospheric size-resolved particles by direct thermal desorption and comprehensive two dimensional gas chromatography coupled to quadrupole mass spectrometer

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Determination of PAHs in atmospheric size-resolved particles...

30th International Symposium on Capillary Chromatography、4th GC×GC Symposium、16th National Symposium and Exhibition on Chromatography,i.e. 1st Dalian International Symposium and Exhibition on Chromatography

作者： leda,t. Ochiai,N. Sasamoto,K. Fushimi,A. Hasegawa,S. tanabe,K. kobayashi,S. GERStEL K.K. 2-13-18NakaneMeguro-kuTokyo 152-0031Japan GERStEL K.K. 2-13-18NakaneMeguro-kuTokyo 152-0031Japan GERStEL K.K. 2-13-18NakaneMeguro-kuTokyo 152-0031Japan National Institute for Environmental Studies 16-2OnogawaTsukuba 305-8506Japan National Institute for Environmental Studies 16-2OnogawaTsukuba 305-8506Japan National Institute for Environmental Studies 16-2OnogawaTsukuba 305-8506Japan National Institute for Environmental Studies 16-2OnogawaTsukuba 305-8506Japan

＜正＞Polycyclic aromatic hydrocarbons（PAHs）in atmospheric particles have received increased attention because some of these compounds have some potential to cause health ***,particle matters less than 100 nanometers in diameter are thought to pose the greatest health risk because such small particles can reach deeply into the ***,quantification of size-resolved particles is important to determine their toxicity ***,sample amount of size-resolved particles is generally very sma11（μg level）so that highly sensitive analysis is essential.

关键词： KEY WORDS GC×GC Direct thermal desorption PAHs Quadrupole mass spectrometer Atmospheric size-resolved particles

羊膜移植在有严重角膜受累的毒性表皮坏死综合征急性期中的作用

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世界核心医学期刊文摘（眼科学分册） 2006年第5期2卷 59-60页

作者： kobayashi A. Yoshita t. Sugiyama K. 喻平平 Department of Ophthalmology Kanazawa University Graduate School of Medical Science 13-1 Takara-machi Kanazawa Ishikawa 920-8641 Japan Dr.

Objective: to report successful management of acute stage toxic epidermal necrolysis (tEN) by amniotic membrane transplantation. Design: Interventional case report. Method/Intervention: A 6-year-old boy who had convulsions and fever due to encephalitis was treated by oral phenobarbital. two weeks later, he developed a high fever and skin rashes involving >40%of the body, with a positive Nikolsky sign and oral blisters. Examination under general anesthesia performed 5 days after the onset of eye symptoms showed severe inflammation and ulceration on the lid margin and the tarsal conjunctiva in both eyes, a total corneal epithelial defect in the right eye, and a geographical corneal epithelial defect in the left eye. Amniotic membrane was transplanted in both eyes as a patch to cover the entire ocular surface, including upper and lower lid margins. Results: Fourteen days after amniotic membrane transplantation, complete corneal and conjunctival epithelialization was observed in the left eye. However, a second amniotic membrane transplantation was performed in the right eye, which still had a total corneal and conjunctival epithelial defect, and resulted in complete epithelialization 14 days later. Corrected visual acuity improved to 20/16 without any superficial punctate keratitis in both eyes 6 months postoperatively. Minimal symblepharon and peripheral scarring were observed only in the right eye. Conclusions: Amniotic membrane transplantation performed at the acute phase of tEN is highly effective not only in reducing inflammation and preventing scarring in the conjunctival surface, but also in restoring corneal epithelial integrity in eyes with both corneal and conjunctival ulceration. As a result, in this case it prevented sight-threatening cicatricial complications at the chronic stage.

关键词：眼角膜上皮表皮坏死羊膜移植治疗毒性急性期综合征病例报道镇静安眠症状发生结膜炎症

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EStROGEN RECEPtOR GENE POLYMORPHISM AS A GENEtIC DEtERMINANt OF BONE MASS

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ESTROGEN RECEPTOR GENE POLYMORPHISM AS A GENETIC DETERMINANT...

第二届国际骨质疏松研讨会

作者： H.Orimo S.Inoue S.kobayashi M.Sano Y.Ouchi M.Shiraki t.Hosoi Minitstry of Finance Tokyo Hospital Department of Geriatrics Faculty of MedicineUniversity of Tokyo Research Institute and Practice for Involutional Diseases

＜正＞the pathogenesis of postmenopausal osteoporosis should be related to variations in the response to estrogen deficiency which may reflect genetically determined variations in biosynthesis and/or function of estrogen *** examined the relationship between polymorphisms of estrogen receptor（ER） gene and bone mineral density（BMD） and bone metabolic markers in postmenopausal women. Restriction fragment length polymorphisms（RFLPs） of ER gene and its relation to BMD were examined in 121 postmenopausal healthy women（66.7±0.9 yr,mean±standard error of the mean） in *** RFLPs were represented as Pp（PvuII） and Xx（XbaI）,capital letters signifying the absence of,and small letters the presence of restriction *** the PPxx genotype,Z score values of BMD were significantly lower（lumbar spine;p=0.005,total body;p=0.013） than those for other *** Px haplotype was associated with a low BMD in postmenopausal *** relationship of dinucleotide repeat polymorphisms in the upstream of ER gene and BMD as well as bone metabolic markers was also detected in the same population of *** data suggest that some variation of the ER gene linked to these genetic markers may be associated with the pathogenesis of postmenopausal osteoporosis and may be used to explain some genetic backgrounds for this disease in Japanese women.

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新型直列3缸1.2L机械增压汽油机

汽车与新动力 2014年第1期46卷 7-12页

作者： A.kobayashi t.Satou H.Isaji S.takahashi t.Miyamoto 虞展

介绍新型1.2 L 3缸HR12DDR型汽油机,其开发目标是达到欧洲B级车市场最低的二氧化碳排放,并通过优异的动力输出性能来满足用户的驾驶乐趣。同时,该汽油机的开发目的也是为了满足日趋收紧的法规要求,以及将来取代轿车柴油机。2011年,该汽... 详细信息

介绍新型1.2 L 3缸HR12DDR型汽油机,其开发目标是达到欧洲B级车市场最低的二氧化碳排放,并通过优异的动力输出性能来满足用户的驾驶乐趣。同时,该汽油机的开发目的也是为了满足日趋收紧的法规要求,以及将来取代轿车柴油机。2011年,该汽油机已被应用在日产汽车欧洲市场的Micra车型上,达到了新欧洲行驶循环的二氧化碳排放限值95 g/km。为了降低燃油消耗率,通过提高压缩比,最大限度地提高热效率,并尽可能降低机械摩擦损失。通过汽油直接喷射系统优化燃烧。选择带有旁通阀和电磁离合器的机械增压系统,在不牺牲动力性的前提下实现更好的燃油经济性。详细介绍了HR12DDR型汽油机及其应用的技术亮点。

关键词：小排量汽油机机械增压低二氧化碳排放高动力输出电磁离合器旁通阀

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黄铜矿环境无污染低温氯化新工艺

过程工程学报 2008年第3期8卷 535-539页

作者：付念新岩崎巌玉川建雄小林斡男东北大学材料与冶金学院辽宁沈阳110004 Natural Resources Research Institute University of Minnesota Colcraine MN 55722 USA 日本产业技术综合研究所环境管理技术研究部门日本茨城筑波市305-8569

研究了流化床反应器低温氯化黄铜矿过程,考察了氯气供给量、温度和物料粒度对氯化行为、物料流动状况及反应产物的影响.结果表明,为使黄铜矿充分氯化,氯气需适当过量;排气氯浓度不应超过0.015%,以避免S2Cl2及FeCl3挥发较多;提高温度可... 详细信息

研究了流化床反应器低温氯化黄铜矿过程,考察了氯气供给量、温度和物料粒度对氯化行为、物料流动状况及反应产物的影响.结果表明,为使黄铜矿充分氯化,氯气需适当过量;排气氯浓度不应超过0.015%,以避免S2Cl2及FeCl3挥发较多;提高温度可有效降低产物的硫含量,较佳温度为270℃,硫含量可降至2%～3%;物料粘结是温度过高、低熔点共晶软熔所致;物料粒度较大(147～208μm)有利于流化床呈稳定流动状态.在二段氯化实验中,下段反应器排出的氯气和S2Cl2在上段中消耗于黄铜矿氯化,最佳操作条件下(下段温度270℃且排气残氯浓度不超过0.015%,上段温度250～270℃),可得到硫含量平均2.8%的充分氯化产物,系统可连续、顺畅工作.

关键词：黄铜矿低温氯化物料粘结流化床

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