BP180 is a Prognostic Factor in Head and Neck Squamous Cell Carcinoma
作者单位：Shengjing Hospital of China Medical University 日本国立癌症研究中心 日本顺天堂大学 日本医科大学
会议名称：《2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会》
会议日期：2023年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：Background/Aim:Prognosis plays a vital role in head and neck squamous cell carcinoma(HNSCC) patient management and decision-making,the identification of prognostic factor BP180 was required in *** and Methods:Protein expression of bullous pemphigoid antigen II(BP180) was verified by immunohistochemistry(IHC) in a tissue microarray study of 202 ***:IHC analysis revealed that protein expression of BP180 among HNSCC patients differed significantly in the presence and absence of neural invasion,and according to T status in laryngeal and pharyngeal cancer subgroups.Οverall survival and multivariate analysis showed that positive BP180-IHC and advanced clinical stage were significant independent positive predictors of mortality in HNSCC *** addition,in the oral cancer subgroup,independent positive predictors were positive BP180-IHC,advanced N status and neural *** laryngeal and pharyngeal cancer subgroups,predictors were positive BP180-IHC and advanced clinical ***:BP180 is a prognostic factor in head and neck squamous cell carcinoma.