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Assessment of Seasonal Rainfall Prediction in Ethiopia: Evaluating a Dynamic Recurrent Neural Network to Downscale ECMWF-SEAS5 Rainfall

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Advances in Atmospheric Sciences 2024年第11期41卷 2230-2244页

作者： Abebe KEBEDE kirsten warrach-sagi Thomas SCHWITALLA Volker WULFMEYER Tesfaye ABEBE Markos WARE Hawassa University College of Agriculture P.O.Box 05HawassaEthiopia Institute of Physics and Meteorology University of HohenheimP.O.Box 70599StuttgartGermany Arba Minch University Water Institute of Technology Faculty of Meteorology and HydrologyP.O.Box 21Arba MinchEthiopia

Seasonal rainfall plays a vital role in both environmental dynamics and decision-making for rainfed agriculture in Ethiopia, a country often impacted by extreme climate events such as drought and flooding. Predicting the onset of the rainy season and providing localized rainfall forecasts for Ethiopia is challenging due to the changing spatiotemporal patterns and the country's rugged topography. The Climate Hazards Group Infra Red Precipitation with Station Data(CHIRPS), ERA5-Land total precipitation and temperature data are used from 1981–2022 to predict spatial rainfall by applying an artificial neural network(ANN). The recurrent neural network(RNN) is a nonlinear autoregressive network with exogenous input(NARX), which includes feed-forward connections and multiple network layers, employing the Levenberg Marquart algorithm. This method is applied to downscale data from the European Centre for Medium-range Weather Forecasts fifth-generation seasonal forecast system(ECMWF-SEAS5) and the Euro-Mediterranean Centre for Climate Change(CMCC) to the specific locations of rainfall stations in Ethiopia for the period 1980–2020. Across the stations, the results of NARX exhibit strong associations and reduced errors. The statistical results indicate that, except for the southwestern Ethiopian highlands, the downscaled monthly precipitation data exhibits high skill scores compared to the station records, demonstrating the effectiveness of the NARX approach for predicting local seasonal rainfall in Ethiopia's complex terrain. In addition to this spatial ANN of the summer season precipitation, temperature, as well as the combination of these two variables, show promising results.

关键词： station prediction downscaling artificial neural networks rainfall

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Data-driven analysis of chemicals,proteins and pathways associated with peanut allergy:from molecular networking to biological interpretation

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Food Science and Human Wellness 2024年第3期13卷 1322-1335页

作者： Emmanuel Kemmler Julian Braun Florent Fauchère Sabine Dölle-Bierke kirsten Beyer Robert Preissner Margitta Worm Priyanka Banerjee Institute for Physiology Charité-University Medicine BerlinBerlin 10115Germany Member of the KFO339 FOOD@Berlin 10115Germany Si-M/“Der Simulierte Mensch”a science framework of Technische Universität Berlin and Charité-Universitätsmedizin Berlin Berlin 10115Germany Charité-Universitätsmedizin Berlin corporate member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlin 10115Germany Division of Allergy and Immunology Department of DermatologyVenerology and AllergyCharité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt-Universität zu BerlinBerlin 10115Germany Pediatrics Campus VirchowCharité-University Medicine BerlinBerlin 10115Germany

Peanut allergy is majorly related to severe food induced allergic *** food including cow's milk,hen's eggs,soy,wheat,peanuts,tree nuts(walnuts,hazelnuts,almonds,cashews,pecans and pistachios),fish and shellfish are responsible for more than 90%of food ***,we provide promising insights using a large-scale data-driven analysis,comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts,tree nuts(walnuts,almonds,cashews,pecans and pistachios)and ***,we have analysed the chemical compositions of peanuts in different processed form raw,boiled and *** the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors(PPARs)and its isoform and their interaction with dietary lipids may have significant effect on allergic *** results obtained from this study will direct future experimeantal and clinical studies to understand the role of dietary lipids and PPARisoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.

关键词： Allergy informatics Knowledge-graph Data analysis Food allergy Peroxisome proliferator-activated receptors Fatty acids

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SARS-CoV-2 variants are associated with different clinical courses in children with MIS-C

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World Journal of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emelia Bainto Helen Harvey Adriana H.Tremoulet Jane C.Burns kirsten B.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research Center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Background Recent infection with SARS‑CoV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-C).SARS‑CoV-2 has undergone different *** publications exist about specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-C at Rady Children’s Hospital-San Diego between May 2020 and March *** epidemiologic data,including viral genomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-C waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to C,20G,21C(Epsilon),20I(Alpha),and 20J(Gamma).The third wave had Delta strains(clades 21A,21I,and 21J),and the fourth had Omicron variants(clades 21K,21L,and 22C).MIS-C presented with similar symptoms and laboratory findings across all *** patients were admitted to the pediatric intensive care unit(PICU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-CoV-2 triggered MIS-C with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： Complications COVID-19 MIS-C SARS-CoV-2 variants

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How completely are randomized controlled trials of non-pharmacological interventions following concussion reported? A systematic review

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Journal of Sport and Health Science 2024年第4期13卷 537-547页

作者： Jacqueline Josee van Ierssel Olivia Galea kirsten Holte Caroline Luszawski Elizabeth Jenkins Jennifer O’Neil Carolyn A Emery Rebekah Mannix Kathryn Schneider Keith Owen Yeates Roger Zemek Children’s Hospital of Eastern Ontario Research Institute OttawaON K1H 8L1Canada The Centre for Health Activity and Rehabilitation ResearchUniversity of OtagoDunedin 9016New Zealand Sport Injury Prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada Alberta Children’s Hospital Research Institute University of Calgary CalgaryAB T2N 1N4Canada Hotchkiss Brain Institute University of CalgaryCalgaryAB T2N 4N1Canada Department of Psychology University of CalgaryCalgaryAB T2N 1N4Canada g Faculty of MedicineUniversity of OttawaOttawaON K1H 8M5Canada School of Rehabilitation Sciences University of OttawaOttawaON K1H 8M5Canada Bruyere Research Institute OttawaON K1N 5C8Canada Departments of Pediatrics and Emergency Medicine Harvard Medical SchoolBostonMA 02115USA Departments of Pediatrics and Emergency Medicine University of OttawaOttawaON K1H 8M5Canada

Purpose:The study aimed to examine the reporting completeness of randomized controlled trials(RCTs)of non-pharmacological interventions following ***:We searched MEDLINE,Embase,PsycInfo,CINAHL,and Web of Science up to May *** reviewers independently screened studies and assessed reporting completeness using the Template for Intervention Description and Replication(TIDieR),Consensus on Exercise Reporting Template(CERT),and international Consensus on Therapeutic Exercise aNd Training(i-CONTENT)*** information was sought my study authors where reporting was *** of bias(ROB)was assessed with the Cochrane ROB-2 *** examining non-pharmacological interventions following ***:We included 89 RCTs(n=53 high ROB)examining 11 different interventions for concussion:sub-symptom threshold aerobic exercise,cervicovestibular therapy,physical/cognitive rest,vision therapy,education,psychotherapy,hyperbaric oxygen therapy,transcranial magnetic stimulation,blue light therapy,osteopathic manipulation,and head/neck *** scores were:TIDieR 9/12(75%;interquartile range(IQR)=5;range:5-12),CERT 17/19(89%;IQR=2;range:10-19),and i-CONTENT 6/7(86%;IQR=1;range:5-7).Percentage of studies completely reporting all items was TIDieR 35%(31/89),CERT 24%(5/21),and i-CONTENT 10%(2/21).Studies were more completely reported after publication of TIDieR(t_(87)=2.08;p=0.04)and CERT(t_(19)=2.72;p=0.01).Reporting completeness was not strongly associated with journal impact factor(TIDieR:rs=0.27;p=0.01;CERT:r_(s)=-0.44;p=0.06;i-CONTENT:r_(s)=-0.17;p=0.48)or ROB(TIDieR:rs=0.11;p=0.31;CERT:rs=0.04;p=0.86;i-CONTENT:rs=0.12;p=0.60).Conclusion:RCTs of non-pharmacological interventions following concussion demonstrate moderate to good reporting completeness,but are often missing key components,particularly modifications,motivational strategies,and qualified *** completeness improved after TIDieR and CERT publication,but p

关键词： Concussion Intervention Randomized controlled trial Systematic review

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Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iBoneFIT project

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Journal of Sport and Health Science 2024年第3期13卷 419-427页

作者： Andres Marmol-Perez Jose J.Gil-Cosano Esther Ubago-Guisado Francisco J.Llorente-Cantarero Juan Francisco Pascual-Gázquez kirsten K.Ness Vicente Martinez-Vizcaino Jonatan R.Ruiz Luis Gracia-Marco Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of Epidemiology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and Education Loyola University AndalusiaSeville 41704Spain Biosanitary Research Institute ibs.GranadaGranada 18012Spain Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Cordoba 14004Spain CIBEROBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of Specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and Social Research Center Universidad de Castilla-La ManchaCuenca 13001Spain

Background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(aBMD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with aBMD are unknown in this ***,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific aBMD Z-scores at the total body,total hip,femoral neck,and lumbar *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,***‑energy X‑ray absorptiometry was used to measure aBMD(g/cm2).Associations between muscle strength and aBMD were evaluated in multivariable linear regression *** regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low aBMD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass *** More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference *** strength deficits were associated with lower aBMD Z-scores at all sites(B=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low aBMD Z-scores at all *** 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low aBMD Z-scores at total body,total hip,and femoral *** Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower aBMD Z-scores at all *** results suggest that interventions designed to improve muscle strength in t

关键词： Bone health Childhood cancer DXA Lean mass Resistance training

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Evaluating current ethical values of OpenStreetMap using value sensitive design

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Geo-Spatial Information Science 2023年第3期26卷 362-378页

作者： Ruba Jaljolie Talia Dror David N.Siriba sagi Dalyot Engineering Civil and Environmental EngineeringThe TechnionMapping and Geo-InformationTechnion CityIsrael Department of Geospatial and Space Technology University of NairobiNairobiKenya

The crowdsourced OpenStreetMap mapping platform is utilized by countless stakeholders worldwide for various purposes and ***,researchers,governments,commercial,and humanitarian organizations,in addition to the engineers,professionals,and technical developers,use OpenStreetMap both as data contributors and *** storage,usage,and integration of volunteered geographical data in software applications often create complex ethical dilemmas and values regarding the relationships between different categories of *** is therefore common for moral preferences of stakeholders to be *** paper investigates the integration of ethical values in OpenStreetMap using the value sensitive design methodology that examines technical,empirical,and conceptual aspects at each design *** use the Humanitarian OpenStreetMap Team,an existing volunteered geographic information initiative,as a case *** investigation shows that although OpenStreetMap does integrate ethical values in its organizational structure,a deeper understanding of its direct and indirect stakeholders’perspectives is still *** study is expected to assist organizations that contribute to or use OpenStreetMap in recognizing and preserving existing and important ethical *** the best of our knowledge,this is the first attempt to evaluate ethical values methodically and comprehensively in the design process of the OpenStreetMap platform.

关键词： Value Sensitive Design(VSD) OpenStreetMap(OSM) ethical values Volunteered Geographic Information(VGI) crowdsourcing geographic data contributors and consumers

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Utilization of α-olefins obtained by pyrolysis of waste high density polyethylene to synthesize α-olefin-succinic-anhydride based cold flow improvers

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燃料化学学报 2009年第3期37卷 302-310页

作者： Norbert MISKOLCZI Richard sagi László BARTHA Lívia FORCEK University of Pannonia Chemical Engineering and Process Engineering Institute Department of Hydrocarbon and Coal Processing Egyetem street 10 Veszprém H-8200 HUNGARY

浪费聚合物热分解获得的石蜡富人烃部分的利用的一条新线路被调查。-olefin-succinic-anhydride 基于中介倒点镇静剂添加剂因为柴油被综合，在哪个反应需要的石蜡被废物的热分解获得高密度的聚乙烯(HDPE ) 。石蜡的部分被塑料废物的de... 详细信息

浪费聚合物热分解获得的石蜡富人烃部分的利用的一条新线路被调查。-olefin-succinic-anhydride 基于中介倒点镇静剂添加剂因为柴油被综合，在哪个反应需要的石蜡被废物的热分解获得高密度的聚乙烯(HDPE ) 。石蜡的部分被塑料废物的de聚合在 500 滓鲥?在一个试管反应堆生产???????????????????????禧?????迋????骤??????吗鲥??????禧哉????嫪????滓?????篤?廯??????可??????????????裍??妢???????臙???????蚨?蚨？？

关键词：添加剂石油炼制成份燃料化学高温分解

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Joy of gardening: a hospital-based cooking and gardening program

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World Journal of Pediatrics 2020年第5期16卷 533-536页

作者： Grace Kim kirsten Thompson Department of Pediatrics University of WashingtonSeattleWA 98105USA Department of Nutrition Seattle Children's HospitalOC 7.820PO Box 5371SeattleWA 98105USA

Background Nutrition interventions aid in implementing healthy ***-enhanced nutrition intervention programs have been conducted in *** sought to assess feasibility of a hospital-based cooking and gardening *** The cohort study implemented a 3-week integrated cooking and gardening program in the United States(Seattle,WA).We recruited participants with ages 8-15 years from ambulatory *** conducted three 3-week series hospitalbased cooking and gardening *** and parents were given pre-and post-program(1 year)*** surveys assessed child participation in food preparation and gardening,strengths and weaknesses of the program,and identified parents'opinions towards sustaining healthy *** Eighteen children participated in the hospital-based cooking and gardening *** l-year follow-up,78%of participants were gardening at home and 100%of participants were cooking at *** Novel approaches to combat obesity are needed.A hospital-based cooking and gardening program is a novel intervention to consider for nutrition education.

关键词： Child nutrition Community health education Health education Healthy lifestyle Healthy nutrition

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Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between

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Cell Research 2005年第1期15卷 72-77页

作者： Natalia JURA,Herbert ARCHER,Dafna BAR-sagi Department of Molecular Genetics and Microbiology Stony Brook University Stony Brook NY 11794-5222 USA.Graduate Program in Molecular and Cellular Biology Stony Brook University Stony Brook NY 11794-5222 USA. Department of Molecular Genetics and Microbiology Stony Brook University Stony Brook NY 11794-5222 USA.Graduate Program in Molecular and Cellular Biology Stony Brook University Stony Brook NY 11794-5222 USA. Department of Molecular Genetics and Microbiology Stony Brook University Stony Brook NY 11794-5222 USA.

Pancreatic cancer is a challenging disease for patients, doctors and researchers who for decades have searched for a cure for this deadly malignancy. Although existing mouse models of pancreatic cancer have shed light on the mecha- nistic basis of the neoplastic conversion of the pancreas, their impact in terms of offering new diagnostics and therapeu- tic modalities remains limited. Chronic pancreatitis is an inflammatory disease of the pancreas that is associated with a gradual damage of the organ and an increased risk of developing neoplastic lesions. In this review, we propose that detailed studies of chronic inflammatory processes in the pancreas will provide insights into the evolution of pancreatic cancer. This information may prove useful in the design of effective therapeutic strategies to battle the disease.

关键词： pancreatic cancer chronic pancreatitis hereditary pancreatitis inflammation mouse models.

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An assessment of the climatic suitability of Afriski Mountain Resort for outdoor tourism using the Tourism Climate Index(TCI)

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Journal of Mountain Science 2019年第11期16卷 2453-2469页

作者： kirsten NOOME Jennifer M.FITCHETT School of Geography Archaeology and Environmental Studies University of the Witwatersrand

Tourism Climatic Indices(TCIs)are widely used in the global North to quantify the climatic suitability of a destination for *** one such study has been conducted in southern Africa to *** is in a chronic shortage of research on tourism and climate change in the southern *** study presents the application of the TCI in Lesotho,calculated for the eastern Lesotho *** region has an emerging tourism sector,which primarily comprises outdoor *** include hiking,horse-riding,music festivals,mountain biking,cultural visits,sightseeing,and at the Afriski lodge,skiing and *** activities are reliant on climatic conditions that are conducive to the activity taking place,prolonged periods outdoors,and tourist satisfaction of the *** is a major determinant of both the length of season for these activities and the timing of peak tourist *** temperatures and changes in relative humidity and precipitation pose real threats to hiking,sightseeing and snow tourism at *** reliance of tourism in the region on specific climatic conditions for successful tourism prompted the use of the *** results classify the eastern Lesotho Highlands as having‘good'climatic conditions with an overall TCI score of 64 for the period *** TCI scores for the eastern Lesotho reveal a bimodal-shoulder,meaning the peak climatic conditions are in the regional summer months(December to February).This conflicts with the peak tourist seasons of summer and winter,which align with South African school holidays,and the timing of the most profitable tourism activity(skiing)which occurs during the winter months of June,July and *** is landlocked by South *** analysis for South Africa reveals more suitable climatic conditions for tourism than Lesotho,with significantly higher scores of 80-89.

关键词： Climate Tourism Climatic Index(TCI) Lesotho Highlands Outdoor tourism Snow tourism

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