Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between

作     者：Natalia JURA,Herbert ARCHER,Dafna BAR-SAGI 

作者机构：Department of Molecular Genetics and Microbiology Stony Brook University Stony Brook NY 11794-5222 USA.Graduate Program in Molecular and Cellular Biology Stony Brook University Stony Brook NY 11794-5222 USA. Department of Molecular Genetics and Microbiology Stony Brook University Stony Brook NY 11794-5222 USA.Graduate Program in Molecular and Cellular Biology Stony Brook University Stony Brook NY 11794-5222 USA. Department of Molecular Genetics and Microbiology Stony Brook University Stony Brook NY 11794-5222 USA. 

出 版 物：《Cell Research》 (细胞研究(英文版))

年 卷 期：2005年第15卷第1期

页      面：72-77页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：NIGMS NIH HHS [T32 GM008444] Funding Source: Medline 

主　　题：pancreatic cancer chronic pancreatitis hereditary pancreatitis inflammation mouse models. 

摘      要：Pancreatic cancer is a challenging disease for patients, doctors and researchers who for decades have searched for a cure for this deadly malignancy. Although existing mouse models of pancreatic cancer have shed light on the mecha- nistic basis of the neoplastic conversion of the pancreas, their impact in terms of offering new diagnostics and therapeu- tic modalities remains limited. Chronic pancreatitis is an inflammatory disease of the pancreas that is associated with a gradual damage of the organ and an increased risk of developing neoplastic lesions. In this review, we propose that detailed studies of chronic inflammatory processes in the pancreas will provide insights into the evolution of pancreatic cancer. This information may prove useful in the design of effective therapeutic strategies to battle the disease.