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Dietary peptides in aging:Evidence and prospects

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Food science and Human Wellness 2020年第1期9卷 1-7页

作者： khus.want s.bhullar Jianping Wu Department of Agricultural Food and Nutritional ScienceUniversity of AlbertaEdmontonABCanada Department of Pharmacology University of AlbertaEdmontonABCanada

With improvements in healthcare and lifestyle,the proportion of the aging population is rising steadily across the *** physiological functions are altered during aging and resemble those occurring in disease conditions involving metabolic and mitochondrial ***,there is an urge to better develop dietary or medicinal interventions targeting the mechanisms underlying aging and aging-related *** reports indicate that in geroscience,dietary interventions such as bioactive peptides to slow aging are a matter of’when’rather than’if’.Leading targets for peptides include the metabolic-mitochondrial pathway accompanied by improved nutrient *** of these pathways diminish aging biomarkers in various model organisms and confers protection against a growing list of age-related *** derived bioactive peptides are characterized modulators of these pathways,while some verified in vivo and even clinically approved,and numerous others are under *** brief review focuses on the latest scientific advances in understanding the anti-aging ability of bioactive peptides as well as delineates the possible future directions in this process.

关键词： Dietary peptides Anti-aging Aging biomarkers

Outcomes and efficacy of magnetic resonance imaging-compatible sacral nerve stimulator for management of fecal incontinence: A multi-institutional study

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World Journal of Radiology 2024年第2期16卷 32-39页

作者： Binit Katuwal Amy Thorsen Kunal Kochar Ryba bhullar Ray King Ernesto Raul Drelichman Vijay K Mittal Jasneet singh bhullar Department of surgery Ascension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States Department of Colon and Rectal surgery Alina Health Abbott Northwestern HospitalMinneapolisMN 55407United States Colon and Rectal surgery Advocate Illinois MasonicPark RidgeIL 60068United States Volunteer student Department of ResearchAscension Providence HospitalSouthfieldMI 48075United States Colon and Rectal surgery University of WisconsinMadisonWI 53715United States General and Colorectal surgery Ascension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States Department of surgery Department of Medical EducationAscension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States

BACKGROUND Fecal incontinence(FI)is an involuntary passage of fecal matter which can have a significant impact on a patient’s quality of *** modalities of treatment exist for *** nerve stimulation is a well-established treatment for *** the increased need of magnetic resonance imaging(MRI)for diagnostics,the In-terstim which was previously used in sacral nerve stimulation was limited by MRI *** MRI-compatible Interstim was approved by the United states Food and Drug Administration in August 2020 and has been widely *** To evaluate the efficacy,outcomes and complications of the MRI-compatible *** Data of patients who underwent MRI-compatible Medtronic Interstim placement at UPMC Williamsport,University of Minnesota,Advocate Lutheran General Hospital,and University of Wisconsin-Madison was pooled and *** demographics,clinical features,surgical techniques,complications,and outcomes were *** the Reporting of Observational studies in Epidemiology(sTROBE)cross-sectional reporting guidelines were *** seventy-three patients had the Interstim *** mean age was 63.29±12.2 ***-seven(78.1%)patients were females and forty-two(57.5%)patients had *** addition to incontinence,overlapping symptoms included diarrhea(23.3%),fecal urgency(58.9%),and urinary incontinence(28.8%).Fifteen(20.5%)patients underwent Peripheral Nerve Evaluation before proceeding to definite implant ***-two(43.8%)patients underwent rechargeable Interstim ***(4.1%)patients needed removal of the *** of the external lead connection was observed in 7(9.6%)patients after the stage I *** explanation for one patient was due to ***(9.6%)patients had other complications like nerve pain,hematoma,infection,lead fracture,and *** mean follow-up was 6.62±3.5 ***-eight(93.2%)patients reported significant improvement of symptoms on

关键词： Fecal incontinence sacral nerve stimulation Interstim Magnetic resonance imaging sacral neuromodulation

Variation in the plant-mediated methane transport and its importance for methane emission from intact wetland peat mesocosms

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Journal of Plant Ecology 2013年第4期6卷 298-304页

作者： Gurbir s.bhullar Peter J.Edwards Harry Olde Venterink Institute of Integrative Biology ETH ZurichUniversitätstrasse 168092 ZurichSwitzerland

Aims and Methods Vascular plants are known to influence the production,transport and oxidation of methane in wetland soils,but these processes are not well *** plants grown in intact peat cores,we compared the influence upon methane emissions of 20 forb and graminoid species from European *** measured plant-mediated transport of methane(conduit or chimney effect)using a novel agar-sealing technique that prevented methane exchange from the bare soil to the *** Findings the plant-mediated transport(chimney effect)represented between 30%and almost 100%of the total methane flux,with graminoids exhibiting greater internal transport than *** general,plants with less dense root tissues and a relatively larger root volume exhibited a larger chimney *** species(12 out of 20)signif-icantly reduced methane emissions compared to bare soil and only one species,succisa pratensis,increased *** suggest that characterising vegetation in terms of plant functional traits and plant processes offers an effective method for estimating methane emis-sions from ***,we found no correlation between the magnitude of the chimney effect and the overall influence of different plant species on methane *** introducing a useful tool to study plant-mediated transport,this work suggests that characterising vegetation in terms of functional traits could improve estimates of methane emissions from wetlands,which in turn could help in designing mitigation strategies.

关键词： functional group graminoid forb agar-sealing conduit gas transportreceived

Olfactory receptor gene evolution is unusually rapid across Tetrapoda and outpaces chemosensory phenotypic change

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Current Zoology 2020年第5期66卷 505-514页

作者： Laurel R.Yohe Matteo Fabbri Michael Hanson Bhart-Anjan s.bhullar Department of Earth&Planetary science Peabody Museum of Natural HistoryYale UniversityNew HavenCT06511USA

Chemosensation is the most ubiquitous sense in animals,enacted by the products of complex gene families that detect environmental chemical cues and larger-scale sensory structures that process these *** there is a general conception that olfactory receptor(OR)genes evolve rapidly,the universality of this phenomenon across vertebrates,and its magnitude,are *** supposed correlation between molecular rates of chemosensory evolution and phenotypic diversity of chemosensory systems is largely *** combine comparative genomics and sensory morphology to test whether OR genes and olfactory phenotypic traits evolve at faster rates than other genes or *** published genomes,we identified ORs in 21 tetrapods,including amphibia ns,reptiles,birds,and mammals and compared their rates of evolution to those of orthologous non-OR protein-coding *** found that,for all clades investigated,most OR genes evolve nearly an order of magnitude faster than other protein-coding genes,with many OR genes showing signatures of diversifying selection across nearly all taxa in this *** rapid rate of evolution suggests that chemoreceptor genes are in "evolutionary overdrive,"perhaps evolving in response to the ever-changing chemical space of the *** obtain complementary morphological data,we stained whole fixed specimens with iodine,μCT-scanned the specimens,and digitally segmented chemosensory and nonchemosensory brain *** then estimated phenotypic variation within traits and among *** we found considerable variation in chemosensory structures,they were no more diverse than nonchemosensory *** suggest chemoreceptor genes evolve quickly in reflection of an ever-changing chemical space,whereas chemosensory phe no types and processing regions are more conserved because they use a standardized or constrained architecture to receive and process a range of chemical cues.

关键词： chemosensation diversifying selection olfaction olfactory bulb olfactory receptor tetrapod

Prediction of Crohn's disease aggression through NOD2/CARD15 gene sequencing in an Australian cohort

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World Journal of Gastroenterology 2014年第17期20卷 5008-5016页

作者： Maneesha bhullar Finlay Macrae Gregor Brown Margie smith Ken sharpe Department of Colorectal Medicine and Genetics 3 CentreThe Royal Melbourne HospitalParkville 3052Australia Department of Molecular Genetics CMR Room 204PathologyThe Royal Melbourne HospitalParkville 3052Australia Department of statistics University of MelbourneParkville 3050Australia

AIM: To investigate the association between mutations in oligomerisation domain 2/caspase recruitment domains 15 (NOD2/CARD15) and the natural history of Crohn’s disease (CD) to identify patients who would benefit fr... 详细信息

关键词： Inflammatory bowel disease, Oligomerisation domain 2/caspase recruitment domains 15, Genotyping, Crohn’ s disease, Natural history

Dielectric and conducting behavior of gadolinium–terbium fumarate heptahydrate crystals

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Journal of Advanced Dielectrics 2015年第3期5卷 19-26页

作者： M.D.shah B.want solid state Research Laboratory Department of Physics University of KashmirSrinagar 190006India

Gadolinium-terbium fumarate heptahydrate crystals were grown in silica gel by using single gel diffusion *** crystals were characterized by different physico-chemical techniques of *** X-ray diffraction results showed that the grown material is purely crystalline in *** analyses suggested the chemical formula of the compound to be Gd Tb(C_(4)H_(2)O_(4)_(3)·7H_(2)*** dispersive X-ray analysis confirmed the presence of Gd and Tb in the title *** dielectric and conductivity studies of the grown compound were carried as function offrequency of applied field and the *** grown material showed a dielectric anomaly which was correlated with its thermal *** ac conductivity of the material showed Jonscher's power law behavior:σ(ω)=σ_(0)+Aω^(s),with a temperature-dependent power exponent s(s found to be a function of temperature and frequency.

关键词： single crystal growth characterization mixed rare earth compound ionic conductivity

Electrical and mechanical studies on ferroelectric lithium rubidium sulphate crystals

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Journal of Advanced Dielectrics 2018年第3期8卷 17-27页

作者： F.A.Najar G.B.Vakil B.want Department of Physics University of Kashmir Srinagar 190006India solid state Research Laboratory Department of Physics University of KashmirSrinagar 190006India

slow evaporation method was used to grow single crystals of lithium rubidium sulphate with high *** crystal X-ray diffraction analysis shows that at room temperature,the crystal belongs to a monoclinic system with the space group P21/*** physical parameters like plasma energy,Penn gap,Fermi energy and electronic polarizability have been evaluated for the grown *** relation between electronic polarizability and diamagnetic susceptibility for the crystal has been established on the basis of Kirkwood’s semiempirical *** ac conductivity and dielectric behavior of the grown crystal were systemically investigated as a function of frequency and *** title compound obeys Jonscher’s power law relations:ð(ω)=σo+Aω^(s),with exponent sstudy,it is observed that both small and large polarons take part in conduction process,and at low temperature,both the band and hopping mechanisms are responsible for *** impedance and modulus studies,it is observed that only one conduction relaxation is observed in the crystal at low *** activation energy of the dielectric relaxation(0.41 eV)and that of the conduction(Econd¼0:43 eV)are in agreement,as a result,there is no difference among the conduction and relaxation species at high *** scanning calorimetric analysis of the crystal shows three endothermic peaks at 166℃,185℃,and 202℃,from which various thermodynamic parameters such asΔH,Δs andΔC_(p) have been *** Vickers hardness test,we have determined the mechanical strength,and other parameters which include fracture toughness,brittleness index,yield strength,and stiffness constant for the crystal.

关键词： slow evaporation monoclinic conductivity impedance activation energy

Patients’experiences with‘sludge’(administrative burden)in the cancer screening process and its relationship with screening completion,experience and health system distrust

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Family Medicine and Community Health 2024年第S2期12卷 8-17页

作者： Michelle s Rockwell Brianna Chang Vivian Zagarese Jamie K Turner Ally southworth YingXing Wu Paul Yeaton Li Li Jeffrey s stein sarah H Parker John W Epling Department of Family and Community Medicine Virginia Tech Carilion School of MedicineRoanokeVirginiaUSA Department of Family and Community Medicine Carilion ClinicRoanokeVirginiaUSA Virginia Tech Carilion school of Medicine RoanokeVirginiaUSA Department of Health systems and Implementation science Virginia Tech Carilion School of MedicineRoanokeVirginiaUSA Graduate Program in Translational Biology Medicineand HealthVirginia TechRoanokeVirginiaUSA Health Analytics Research Team Carilion ClinicRoanokeVirginiaUSA Division of Gastroenterology Department of Internal MedicineCarilion ClinicRoanokeVirginiaUSA Department of Family Medicine University of Virginia School of MedicineCharlottesvilleVirginiaUSA Center for Health Behaviors Research Fralin Biomedical Research Institute at VTCRoanokeVirginiaUSA

Objective‘sludge’refers to administrative burdens or frictions that preclude people from getting what they want or need(eg,duplicative forms,complicated instructions,long waiting times).This mixed methods study evaluated patients’perceptions of sludge in the colorectal cancer(CRC)screening process and some impacts of this *** We employed an exploratory sequential mixed methods study design that comprised patient interviews and a patient *** interviews informed final survey revisions and captured contextual data about patients’experiences with *** transcripts were inductively and deductively analysed to identify overarching *** survey quantified sludge,delayed or forgone screenings,screening experience(Net Promoter score)and health system distrust(Health system Distrust scale).We usedχ2 or t-tests for univariable comparisons and logistic or linear regressions to evaluate the association between cumulative sludge score and delayed or forgone screenings,screening experience and health system *** were integrated for *** southeastern United *** Patients who were 45–75 years of age,at average risk for CRC and had either completed or been referred for CRC screening(colonoscopy or stool-based test)within the previous 12 *** 22 interview participants and 255 survey participants completed the study.38(15%)survey participants rated their screening experience as poor(Net Promoter score=0–7 out of 10).The mean(sD)Health system Distrust scale score was 22.4(6.3)out of 45 possible points(higher score=greater distrust).Perceptions of sludge in the CRC screening process varied,with long waiting times and burdensome communication being the most common sources(58%and 35%of participants,respectively).sludge was positively associated with delayed or forgone screenings(OR=1.42,95%CI 1.28,1.57,pscreening experience(OR=1.15,95%CI 1.04,1.28,p=0.009)and health system distrust(β=0.47,p

关键词： sludge screening burden

Auxetic Behavior of Flat and Curved Indenters into a Half-space

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材料科学与工程（中英文A版） 2012年第5期2卷 436-441页

作者： s.K. bhullar J.L. Wegner A. Mioduchowski Department of Mechanical Engineering University of Victoria Victoria B.C. Canada VSW 3P6 Department of Mechanical Engineering University of Alberta Edmonton AB Canada T6G 2G8

A mathematical model of rigid indenter into an auxetic elastic half-space with or without friction is developed and based on complex variable theory, the solutions for stress arising from curved and flat indenters into a half-space are computed. Generally, it has been assumed that the perfect confirmity of flat-on-flat designs minimizes the contact stresses (e. g., between the tibial and femoral components). In this paper, the performance of curved and flat indenters is compared for auxetic and non-auxetic materials. Further, wear remains a limiting factor in the longevity of ultra-high molecular weight polyethylene components (for example for total joint replacement) and the magnitude and location of the stresses can vary substantially (in particular, for total knee replacement). The materials chosen for numerical calculations are auxetic UHMWPE and conventional UHMWPE and results are shown graphically.

关键词：弹性半空间细胞压头曲面平面超高分子量聚乙烯特性 UHMWPE