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f.rmation Mechanisms of.Some f.atures in Siliceous Upper Cretaceous-Lower Tertiary Beds of.Jordan-Undulations, Geodes, Boudinages

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Open Journal of.Geology 2024年第4期14卷 569-577页

作者： Elias Salameh Hani khoury Department of.Geology University of Jordan Amman Jordan

Geode, boudinage, and undulation structures are widely distributed in the siliceous beds of.the Upper Cretaceous/Tertiary rocks in Jordan. Their f.rmation was attributed to tectonic f.rces, syngenetic processes, organic disintegration processes, subaquatic gliding, compaction and settlement, and meteoritic impacts. In this work, the structural f.atures in the siliceous beds of.Jordan are attributed to an interplay of.load and directed pressures, and mineralogical transf.rmation processes (opal-A to opal-CT to quartz), governed by pH changes. Tectonic directed pressure was acting in an ESE-WSW direction and is common in the silicif.ed limestone of.Upper Cretaceous.

关键词： Undulations Geodes Boudinages Opal-A Porcelanite Chert Transf.rmations pH Changes Stress f.elds Jordan

Two-Stream Approximation to the Radiative Transf.r Equation:A New Improvement and Comparative Accuracy with Existing Methods

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Advances in Atmospheric Sciences 2024年第2期41卷 278-292页

作者： f.Momo TEMGOUA L.Akana NGUIMDO DNJOMO Environmental Energy Technologies Laboratory(EETL) Faculty of SciencesUniversity of YaoundéPO Box 812 YaoundéCameroon Department of.Electrical and Electronic Engineering Faculty of Engineering and TechnologyUniversity of BueaPO Box 63 BueaCameroon

Mathematical modeling of.the interaction between solar radiation and the Earth's atmosphere is f.rmalized by the radiative transf.r equation(RTE), whose resolution calls f.r two-stream approximations among other methods. This paper proposes a new two-stream approximation of.the RTE with the development of.the phase f.nction and the intensity into a third-order series of.Legendre polynomials. This new approach, which adds one more term in the expression of.the intensity and the phase f.nction, allows in the conditions of.a plane parallel atmosphere a new mathematical f.rmulation of.γparameters. It is then compared to the Eddington, Hemispheric Constant, Quadrature, Combined Delta f.nction and Modif.ed Eddington, and second-order approximation methods with ref.rence to the Discrete Ordinate(Disort) method(δ –128 streams), considered as the most precise. This work also determines the conversion f.nction of.the proposed New Method using the f.ndamental def.nition of.two-stream approximation(f.TSA) developed in a previous work. Notably,New Method has generally better precision compared to the second-order approximation and Hemispheric Constant methods. Compared to the Quadrature and Eddington methods, New Method shows very good precision f.r wide domains of.the zenith angle μ 0, but tends to deviate f.om the Disort method with the zenith angle, especially f.r high values of.optical thickness. In spite of.this divergence in ref.ectance f.r high values of.optical thickness, very strong correlation with the Disort method(R ≈ 1) was obtained f.r most cases of.optical thickness in this study. An analysis of.the Legendre polynomial series f.r simple f.nctions shows that the high precision is due to the f.ct that the approximated f.nctions ameliorate the accuracy when the order of.approximation increases, although it has been proven that there is a limit order depending on the f.nction f.om which the precision is lost. This observation indicates that increasing the order of.app

关键词： Radiative Transf.r Equation two-stream method Legendre polynomial optical thickness moments of.specif.c intensity conversion f.nction transmittance ref.ectance

Spermotrend Improves Semen Quality and Inf.rtility in Men with Varicocele —Spermotrend and Male Inf.rtility

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Advances in Reproductive Sciences 2024年第2期12卷 83-97页

作者： Melida Aguilar Chamorro Sergio Antonio Vargas collado David Marquez Soriano Clinica Seniors Managua Nicaragua Scientif.c Department Catalysis S.L. Madrid Spain

Background: Inf.rtility af.ects 8% - 12% of.couples globally, with approximately half.of.the cases reported in males. Oxidative stress is a common f.ctor increased in the varicocele condition and particularly af.ects spermatozoa, due to their sensitivity to oxidative signals and testicular hypotrophy. The objective of.this clinical trial is to study the ef.ectiveness of.Spermotrend in the improvement of.sperm parameters in male inf.rtility. Methods: A total of.170 males aged > 18 years with a diagnosis of.inf.rtility and varicocele were consecutively enrolled in a Phase II, open-label clinical trial. Spermotrend was administered 1 capsule (450 mg) orally every 8 hours f.r 6 months and was evaluated through semen analysis at 4 and 6 months of.f.llow-up. Results: The trial results show a signif.cant improvement f.llowing the administration of.Spermotrend over 6 months in sperm concentration (44.1% at baseline vs. 64.1% at 6 months), sperm survival (28.2% with sperm survival ≥ 2 hours vs.56.5%), normalization of.sperm morphology (31.2% vs. 72.9%). Varicocele condition decreased in all patients and, by the end of.the study, 55.3% of.patients had normal venous f.ow and dilation. Only 5.9% of.the patients showed grade 2 varicocele at the end of.the study, while 38.8% showed grade 1 varicocele, with no patients showing grade 3 varicocele. Regarding testicular hypotrophy, 90.6% of.the patients completed the study with normalized testicular volume by recovering normal venous f.ow. Conclusion: A short-term course of.Spermotrend may signif.cantly improve sperm parameters associated with male inf.rtility. Clinical Trial Registration: The clinical trial protocol was registered in the international clinical trial registry, ***, with the code: NCT05222841 on 15/06/2021.

关键词： Antioxidants Dietary Supplementation Male Inf.rtility Spermatogenesis Varicocele Pygeum af.icanum

The Importance of.Posterior Tibial Slope in TKR: Pre and Post-Operative Measurements in United States Osteoarthritic Patients

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Open Journal of.Orthopedics 2024年第8期14卷 374-379页

作者： f.ederick f. Buechel Sr f.ederick f. Buechel Jr Rutgers New Jersey Medical School Department of Orthopaedic Surgery Newark USA Lenox Hill Hospital Department of Orthopaedic Surgery New York USA

Background: Sagittal plane placement of.the tibial component in total knee replacement (TKR) has important implications f.r maximizing the range of.f.exion motion, allowing collateral ligaments to f.nction more normally, as well as providing ideal compressive loading on the tibial bone-prosthesis interf.ce. This study attempts to quantif. the normal posterior tibial slope (PTS) angle pre-operatively and post-operatively in osteoarthritic patients af.er using a conventional extramedullary tibial resection guide to assess its ef.ectiveness. Methods: f.rty-nine primary cementless total knee replacements in 34 osteoarthritic patients were measured radiographically pre-operatively and one year post-operatively to determine the PTS and its ef.ect on range of.motion. Lateral X-rays, using the anterior cortical line of.the tibia, were employed f.r all measurements. Results: Pre-operative PTS measured 11.83˚ (range 5˚ - 18˚), while post-operative PTS of.implanted tibial components measured 11.30o (range 4˚ - 18˚). The pre-operative range of.motion of.112˚ (range 30˚ to 135˚) was improved to 119˚ (range 90˚ to 135˚) post-operatively af.er 1 year. Conclusions: Anterior tibial shaf. ref.rencing using a conventional extramedullary tibial resection guide provides an easy and convenient method f.r reproducing the anatomical PTS during TKR. This methodology provided improvement in average range of.motion f.om 112˚ pre-operatively to 119˚ post-operatively at one year.

关键词： Posterior Tibial Slope Posterior Tibial Inclination Extramedullary Tibial Resection Guide Total Knee Alignment

Metastatic pancreatic and lung cancer patient in complete remission f.llowing immunotherapy: A case report and review of.literature

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World Journal of.Gastrointestinal Oncology 2024年第5期16卷 2233-2240页

作者： Joaquina Martínez-Galán Cristina Jiménez-Luna Isabel Rodriguez Elisabeth Maza Carlos García-collado Antonio Rodríguez-f.rnández Javier Luis López-Hidalgo Octavio Caba Department of.Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain Instituto de Investigación Biosanitaria Ibs.GranadaGranada 18012Spain Institute of.Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain Pharmacogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain Department of.Medicina Nuclear Virgen de las Nieves University HospitalGranada 18014Spain Department of.Anatomía Patológica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGROUND Metastatic pancreatic ductal adenocarcinoma(PDAC)is a lethal malignancy with dispiriting survival *** is a promising approach to many cancer types,but achieves poor outcomes in advanced PDAC due to its immunosuppressive tumor *** describe a case of.metastatic PDAC ef.ectively treated with *** SUMMARY We report the case of.a 67-year-old woman with unresectable locally advanced PDAC,treated with gemcitabine plus nab-paclitaxel f.llowed by radiotherapy plus *** nine months,pancreatic tumor progression was observed at the level of.the hepatic hilum with the appearance of.a new pulmonary nodule suggestive of.a second primary,conf.rmed by lef. lung *** immunotherapy was then initiated with pembrolizumab,an immune checkpoint inhibitor targeting programmed cell death protein-1 that covers the two tumor *** patient showed a complete metabolic response that was maintained throughout the *** patient continues to be disease-f.ee at 5.6 years since the start of.*** These results suggest that the administration of.pembrolizumab af.er chemoradiotherapy has a benef.cial ef.ect in patients with metastatic *** our knowledge,this is the f.rst reported case of.a patient with metastatic PDAC and metastatic lung cancer showing such a long-lasting complete response af.er pembrolizumab treatment without curative *** studies are required to determine biomarkers that identif. PDAC patients most likely to benef.t f.om this immunotherapy.

关键词： Pancreatic ductal adenocarcinoma Lung cancer Immunotherapy Pembrolizumab Programmed cell death protein-1 Case report

Macroscopic Traversable Wormholes: Minimum Requirements

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International Journal of.Astronomy and Astrophysics 2024年第3期14卷 230-243页

作者： Peter K. f. Kuhf.ttig Department of.Mathematics Milwaukee School of Engineering Milwaukee USA

While wormholes are just as good a prediction of.Einstein’s theory as black holes, they are subject to severe restrictions f.om quantum f.eld theory. To allow f.r the possibility of.interstellar travel, a macroscopic wormhole would need to maintain suf.iciently low radial tidal f.rces. It is proposed in this paper that the assumption of.zero tidal f.rces, i.e., the limiting case, is suf.icient f.r overcoming the restrictions f.om quantum f.eld theory. The f.asibility of.this approach is subsequently discussed by 1) introducing the additional conditions needed to ensure that the radial tidal f.rces can indeed be suf.iciently low and 2) by viewing traversable wormholes as emergent phenomena, thereby increasing the likelihood of.their existence.

关键词： Morris-Thorne Wormholes Traversability Minimum Requirements Stability Compatibility with Quantum f.eld Theory

On an Invariant of.Tournament Digraphs

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Journal of.Applied Mathematics and Physics 2024年第7期12卷 2711-2722页

作者： Boris f. Melnikov Bowen Liu f.culty of.Computational Mathematics and Cybernetics Shenzhen MSU-BIT University Shenzhen China

To date, it is unknown whether it is possible to construct a complete graph invariant in polynomial time, so f.st algorithms f.r checking non-isomorphism are important, including heuristic algorithms, and f.r successf.l implementations of.such heuristics, both the tasks of.some modif.cation of.previously described graph invariants and the description of.new invariants remain relevant. Many of.the described invariants make it possible to distinguish a larger number of.graphs in the real time of.a computer program. In this paper, we propose an invariant f.r a special kind of.directed graphs, namely, f.r tournaments. The last ones, f.om our point of.view, are interesting because when f.xing the order of.vertices, the number of.dif.erent tournaments is exactly equal to the number of.undirected graphs, also with f.xing the order of.vertices. In the invariant we are considering, all possible tournaments consisting of.a subset of.vertices of.a given digraph with the same set of.arcs are iterated over. f.r such subset tournaments, the places are calculated in the usual way, which are summed up to obtain the f.nal values of.the points of.the vertices;these points f.rm the proposed invariant. As we expected, calculations of.the new invariant showed that it does not coincide with the most natural invariant f.r tournaments, in which the number of.points is calculated f.r each participant. So f.r, we have conducted a small number of.computational experiments, and the minimum value of.the pair correlation between the sequences representing these two invariants that we f.und is f.r dimension 15.

关键词： Graph Directed Graph Tournament ?nvariant

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巴多林腺Merkel细胞癌

世界核心医学期刊文摘（妇产科学分册） 2005年第12期1卷 42-42页

作者： khoury-collado f. Elliott K.S. Lee Y.- C. 李跃萍 Department of.Obstetrics and Gynecology State University of New York Downstate Medical Center 450 Clarkson Avenue Brooklyn NY 11203 United States

Background. There are a f.w cases of.“ small cell neuroendocrine carcinoma” of.the Bartholin’ s gland as well as Merkel cell carcinoma of.the vulva reported in the gynecologic oncology literature, most with aggressive clinical behavior. Merkel cells were originally described in the epidermis with neuroendocrine properties. Merkel cell carcinoma is dif.erent f.om the neuroendocrine small cell (oat cell) tumor arising in the lung and other internal organs based on morphology and immunohistochemistry. Case. A 49- year- old f.male was diagnosed with a f.GO stage I Merkel cell carcinoma of.the Bartholin’ s gland. The tumor originated f.om the duct and stained with endocrine markers and cytokeratin 7 and 20. She was treated with radical wide local excision and bilateral inguinal lymph node dissection f.llowed by radiation therapy to the pelvis, perineum, vulva, and inguinal regions. Two years af.er the diagnosis, she is alive with no evidence of.recurrent disease. Conclusion. This is a case of.Merkel cell carcinoma of.the Bartholin’ s gland discovered in the early stage with a survival of.2 years f.llowing diagnosis and treatment with no evidence of.disease recurrence.

关键词：巴多林腺 Merkel细胞燕麦细胞神经内分泌癌肿瘤起源淋巴结清扫术局部切除临床行为免疫组织化学腹股沟区

Impaired Cognition and Stroke Rehabilitation Outcomes: Are They Related?

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Open Journal of.Therapy and Rehabilitation 2024年第2期12卷 101-116页

作者： Eric f. Tanlaka Torri Trojand f.culty of.Nursing University of Windsor Windsor Canada

Background: Stroke survivors who exhibit impaired cognition at admission to inpatient rehabilitation may experience participation challenges and poorer f.nctional outcomes than those without impaired cognition. Dif.erences in f.nctional outcomes between stroke survivors with and without impaired cognition may be attributed to age, level of.cognitive impairment, and severity of.stroke. Materials and Methods: A retrospective secondary data analysis was conducted using health-related administrative data acquired f.om a Southwestern Ontario hospital’s stroke rehabilitation database. The aim was to explore potential linkages between post-stroke impaired cognition and f.nctional gains, rehabilitation stays, and living settings af.er discharge f.om rehabilitation. Results: An aggregate sample of.393 males and 314 f.males subclassif.ed as experiencing mild, moderate, and severe stroke was analyzed. At inpatient rehabilitation admission, 21.5% (n = 152) of.these patients had no impaired cognition, 33.7% (n = 238) had mild impaired cognition, 22.2% (n = 157) had moderate impaired cognition, and 22.6% (n = 160) had severe impaired cognition. Cognitively impaired stroke patients were signif.cantly (p 0.001) older, had (mostly) moderate to severe stroke with signif.cantly (p = 0.012) more moderate cognitive impairment, had signif.cantly (p 0.001) longer rehabilitation stays, and a high propensity f.r being discharged to longer-term care f.cilities compared to non-cognitively impaired patients. Conclusion: Presence of.signif.cant dissimilarity in rehabilitation stays and post-discharge destinations among stroke survivors with and without cognitive impairment is attributed to the age of.the patient, level of.cognitive impairment, and rigorous rehabilitation interventions.

关键词： Stroke Impaired Cognition Inpatient Rehabilitation f.nctional Outcomes