Yield of alarm features in predicting significant endoscopic findings among hospitalized patients with dyspepsia

作     者：Lama Ibrahim Maamoun Basheer Tawfik Khoury Wisam Sbeit 

作者机构：Department of Internal MedicineGalilee Medical CenterNahariya 22001Israel Department of GastroenterologyGalilee Medical CenterNahariya 22001Israel Azrieli Faculty of MedicineBar-Ilan UniversitySafed 1311502Israel 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2024年第30卷第26期

页      面：3210-3220页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：The study protocol conforms to the ethical guidelines of the 1975 Declaration of Helsinki and was approved by the human research committee of each institution(Approval No.0189-21-NHR) 

主　　题：Dyspepsia Endoscopy Weight loss Anti-aggregate medications Persistent vomiting Odynophagia 

摘      要：BACKGROUND Dyspepsia is a very prevalent upper gastrointestinal tract symptoms *** of these symptoms might arise from serious underlying diseases,so the promotion of evidence-based guidelines could potentially better align evaluation and *** To determine the value of alarm features as a predictive factor for significant endoscopic findings(SEFs)among hospitalized patients presenting with *** We conducted a retrospective case-control study including information about 6208 endoscopic procedures performed for hospitalized *** were divided into two groups,with and without SEFs,and compared to elucidate the ability of the different alarm features to predict *** During the study,605 patients fulfilled the inclusion *** the demographics and clinical characteristics of the two groups were compared,tachycardia(P0.05),normocytic anemia,(P0.05),leukocytosis(P0.05),and hypoalbuminemia(P0.05)documented on admission prior to endoscopy were strong predictors of *** the alarm features,upper gastrointestinal bleeding,persistent vomiting,odynophagia[odds ratio(OR)=3.81,P0.05;OR=1.75,P=0.03;and OR=7.81,P=0.07,respectively]were associated with *** weight loss was strongly associated with malignancy as an endoscopic finding(OR=2.05;P0.05).In addition,long-term use of anti-aggregate medications other than aspirin(P0.05)was correlated to *** Novel predictors of SEFs were elucidated in this *** parameters could be used as an adjunctive in decision making regarding performing upper endoscopy in hospitalized patients with dyspepsia.