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某型船用大功率液控离合器传动系统联合仿真研究

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机械传动 2024年第1期48卷 120-127页

作者：王学志闫泽冯丽菊陈克鑫王勇帆战庆欣李超曲东越中国船舶集团有限公司第七〇三研究所黑龙江哈尔滨150078 哈尔滨广瀚动力传动有限公司黑龙江哈尔滨150078 哈尔滨工程大学机电工程学院黑龙江哈尔滨150001

进行了有关船用大功率液压驱动齿式离合器运动学及接触动力学的Adams和AMESim联合仿真流程研究,并进行了联合仿真交互操作界面开发,在给定参数下,能够输出可视化的计算结果。仿真分析结果表明,齿式离合器轴向接合过程的动态特性与冲击... 详细信息

进行了有关船用大功率液压驱动齿式离合器运动学及接触动力学的Adams和AMESim联合仿真流程研究,并进行了联合仿真交互操作界面开发,在给定参数下,能够输出可视化的计算结果。仿真分析结果表明,齿式离合器轴向接合过程的动态特性与冲击载荷受到主动端扭转刚度与轮齿端面结构的影响;减压阀最大开口压力为2.5 MPa,该压力下的最大推力为1.884×10^(5) N;在内外圈发生碰撞时,油压会急速上升,如果减压阀的流量不足,则进油油路会泄漏。经过多次联合仿真发现,进口压力在0.008~0.01 MPa就能实现在4 s左右完成离合器的接合脱开过程。

关键词：液压驱动齿式离合器联合仿真接合脱开特性

在不同cYP 2c19基因分型患者中比较维卡格雷和氯吡格雷的抗血小板作用

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中华心血管病杂志 2024年第5期52卷 493-499页

作者：曹伊楠祁子钊任玲李晶裘淼涵王可心孙宏斌龚彦春李毅韩雅玲解放军北部战区总医院心内科沈阳110016 重庆中国药科大学创新研究院重庆401135 江苏威凯尔医药科技有限公司研发部南京211800

目的比较维卡格雷和氯吡格雷在不同细胞色素P450(cYP)2c19基因型患者中的抗血小板作用。方法本研究为维卡格雷Ⅱ期临床研究的事后分析。维卡格雷的Ⅱ期临床研究于2018年8月至2019年6月在国内18家中心纳入接受经皮冠状动脉介入治疗的冠... 详细信息

目的比较维卡格雷和氯吡格雷在不同细胞色素P450(cYP)2c19基因型患者中的抗血小板作用。方法本研究为维卡格雷Ⅱ期临床研究的事后分析。维卡格雷的Ⅱ期临床研究于2018年8月至2019年6月在国内18家中心纳入接受经皮冠状动脉介入治疗的冠心病患者。按照是否携带cYP 2c19*2或*3功能缺失(LOF)等位基因将患者分为LOF携带组(111例)和非LOF携带组(90例);以上两组中,按治疗方案又分别分为维卡格雷5 mg组、维卡格雷6 mg组、维卡格雷7.5 mg组及氯吡格雷组。在基线、负荷量服药后6~8 h、随机后7~10 d及随机后第28天分别采用VerifyNow测定P2Y12反应单位(PRU),并计算血小板聚集抑制百分比(%IPA)。主要研究终点为第28天的%IPA。在北部战区总医院入选的患者中,每组选取8~12例作为预设的亚组进行药代动力学检测,测量参数包括最大血浆浓度时间点(T_(max))、最大血浆浓度(c_(max))及血药浓度-时间曲线下面积(AUc)。结果最终入选201例患者,年龄(58.8±8.5)岁,其中男性139例(69.2%)。非LOF携带患者中,维卡格雷5、6、7.5 mg组与氯吡格雷组在各检测点的PRU和%IPA值的差异均无统计学意义(P均>0.05)。LOF携带患者中,负荷量服药后6~8 h维卡格雷5、6、7.5 mg组与氯吡格雷组的%IPA差异有统计学意义[22.9(14.2,31.5)%比19.8(11.0,28.6)%比29.5(20.9,38.0)%比12.9(3.9,21.9)%,P=0.038],随机后7~10 d 4组的%IPA差异亦有统计学意义[22.4(14.2,30.5)%比34.4(26.1,42.6)%比39.8(31.8,47.9)%比24.7(16.3,33.2)%,P=0.001],随机后第28天维卡格雷各治疗组的%IPA有高于氯吡格雷组的趋势[30.4(21.3,39.6)%比36.5(27.2,45.7)%比40.8(31.8,49.8)%比30.7(21.2,40.2)%,P=0.056]。共35例患者接受了药代动力学检测,结果显示,在非LOF携带者中,不同剂量维卡格雷组与氯吡格雷组的代谢产物M15-2的c_(max)值和AUc差异均无统计学意义(P均>0.05);而在LOF携带者中,维卡格雷5、6、7.5 mg组与氯吡格雷组的AUc差异有统计学意义[(5.6±0.6)h·μg^(-1)·L^(-1)比(6.8±2.7)h·μg^(-1)·L^(-1)比(9.2±3.3)h·μg^(-1)·L^(-1)比(4.2±1.9)h·μg^(-1)·L^(-1),P=0.020]。结论在cYP 2c19基因非LOF携带者中,维卡格雷和氯吡格雷具有相同的抗血小板作用,但在LOF携带者中,维卡格雷的抗血小板作用优于氯吡格雷。

关键词：冠心病经皮冠状动脉介入治疗血小板功能药物基因组学氯吡格雷维卡格雷

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中国维和二级医院检验试剂管理实践与思考

联勤军事医学 2024年第7期38卷 602-605页

作者：张可欣徐欢杨绍俊阿桑杨清翔陆军军医大学第一附属医院检验科重庆400038 西藏军区总医院检验科西藏军区总医院输血科西藏军区总医院医疗保障中心

目的分析临床检验在中国维和医疗分队中的作用,以及在维和实践中常见的检验项目、时间分布和试剂管理问题。方法回顾性分析2021-01/2022-12月在刚果(金)南战区中国二级医院开展的检验项目和试剂相关数据。对检验项目检测数量、时间分... 详细信息

目的分析临床检验在中国维和医疗分队中的作用,以及在维和实践中常见的检验项目、时间分布和试剂管理问题。方法回顾性分析2021-01/2022-12月在刚果(金)南战区中国二级医院开展的检验项目和试剂相关数据。对检验项目检测数量、时间分布、分类分布、检验试剂保质期和存储温度情况进行分析。结果 2021-01/2022-12月期间检验工作总量分布最多的是血常规(567人次),其次是疟疾快检(439人次)、肝功能检测(328人次)。2021、2022年中,在1~2月份和6~8月份期间为检测高峰期,而在4、9和10月份为低谷期。生化检验中,肝功能、肾功能和尿酸检测是最常见的检测项目;临床检验中,血常规、疟疾快检和大便常规检测最常见;免疫检验中,乙肝/五项检测、人类免疫缺陷病毒(human immunodefic.ency virus,HIV)检测和丙型肝炎病毒(hepatitis c virus,HcV)测试最常见。结论检验工作在中国维和二级医院中发挥了重要作用,在准备检验试剂时应针对性重点准备试剂。针对试剂管理问题,选择保存温度要求低、保质期长的试剂,建议提前准备血常规、疟疾和肝功能检测试剂。本研究为提高维和医疗分队的检验质量提供了参考。

关键词：中国二级医院维和检验试剂管理

Effect of Homogenizing Procedures on the Properties of Reaction Sialon Suspension

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厦门大学学报（自然科学版） 2002年第S1期41卷 132-133页

作者： Xavier Venceslau kexin c.en José M F Ferreira Department of ceramics and Glass engineering CICECO University of AveiroDepartment of Ceramics and Glass EngineeringCICECO University of AveiroDepartment of Ceramics and Glass EngineeringCICECO University of Aveiro PortugalPortugalPortugal

Homogeneous, high concentrated ceramic suspensions wi th low viscosity are the key controlling factors for the production of ceramic c omponents through colloidal processing. A well-dispersed suspension can be obta ined by choosing suitable dispersant, solvent, particle size distribution etc. B esides these factors, the homogenizing procedure is also a key step. In this paper, reaction sialon suspensions were prepared using 3-wt% KD1 as dis persant in organic media composed of 60-vol% methyletheylketone and 40-vol% et hanol. Different homogenizing procedures have been used and compared, including planetary milling, low energy ball milling and ultrasonic disaggregation. The ef fects of different homogenizing routes and mixing times on the rheology and stab ility of suspensions, and on the microstructure of slip casting green bodies, ha ve been studied. The varying dispersion effic.encies observed could be attribute d to differences in deagglomeration degrees achieved and in adsorption amount of dispersant onto the surface of reaction sialon powders.

关键词： Effect of Homogenizing Procedures on the Properties of Reaction Sialon Suspension

Polyfunctional conjugated Microporous Polymers for Applications in Direct c—H Arylation of Unactivated Arenes and Aqueous Adsorption of Aromatic Amines

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chemical Research in chinese Universities 2020年第6期36卷 1302-1309页

作者： LUO kexin SU Qing JU Pengyao LI Xiaodong LIU Ziqian SUN Xiaoman LI Guanghua WU Qiaolin college of chemistry Jilin UniversityChangchun 130012P.R.China State Key Laboratory of Inorganic Synthesis and Preparative chemistry Jilin UniversityChangchun 130012P.R.China

Salen-porphyrin-based conjugated microporous polymers(cMPs)have been demonstrated to be an attractive material platform for predesigned structures and promising ***,a new salen-porphyrin-based conjugated microporous polymer(SP-cMP-L)was solvothermally prepared by porphyrin-forming condensation reaction of pyrrole and salen-dialdehyde *** SP-cMP-L was characterized by spectroscopy technologies,and also exhibited excellent thermal and chemical *** porosity of SP-cMP-L was examined by N2 adsorption/desorption *** BET specific surface area of the cMP material was calculated to be 290.4 m^2/g with the pore volume of 0.19 cm^3/*** microstructure property of the resulting material was further evaculated by scanning electron microscopy(SEM)and transmission electron microscopy(TEM).The SP-cMP-L with salen and porphyrin multidentate coordination sites was proposed to serve as an initiator to promote the cross-coupling between aryl halides with unactivated arenes under base mediated *** transition-metal-free catalytic protocol provided high catalytic activity for direct c-H arylation reaction of unactivated arenes,and thus offered a convenient and effic.ent alternative for the construction biaryl *** addition,the salen-porphyrin based cMP material possessed remarkable adsorption capability for the removal of organic amines from water.

关键词： conjugated microporous polymer c-H arylation Aqueous adsorption

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头孢克肟制剂中有关物质结构鉴定与定量分析

沈阳药科大学学报 2024年第2期41卷 206-216,226页

作者：闫晓娟于可欣栗智管一娜李清沈阳药科大学药学院辽宁沈阳110016

目的旨在建立头孢克肟制剂中有关物质结构鉴定与定量分析方法。方法采用HPLc-Q-TOF-MS/MS法对主要杂质结构进行分析。建立HPLc法,采用c18色谱柱(250 mm×4.6 mm,5μm),以乙腈-四丁基氢氧化铵溶液为流动相进行梯度洗脱,检测波长为254 nm... 详细信息

目的旨在建立头孢克肟制剂中有关物质结构鉴定与定量分析方法。方法采用HPLc-Q-TOF-MS/MS法对主要杂质结构进行分析。建立HPLc法,采用c18色谱柱(250 mm×4.6 mm,5μm),以乙腈-四丁基氢氧化铵溶液为流动相进行梯度洗脱,检测波长为254 nm,柱温为40℃,对头孢克肟制剂进行有关物质检测。结果初步鉴定了头孢克肟制剂中9个杂质,分别为杂质A、B、D、E、F、G、H、头孢克肟亚砜和头孢克肟叔丁酯。在建立的HPLc色谱条件下,头孢克肟及各杂质均能达到基线分离,各有关物质的质量浓度在0.1934~20.03μg·mL^(-1)内线性关系良好,r>0.9990;回收率为98.4%~101.8%(RSDc-Q-TOF-MS/MS技术能初步鉴定头孢克肟制剂的杂质结构,该方法能检测不同厂家头孢克肟片剂、颗粒剂、胶囊剂及干混悬剂中的有关物质。

关键词：高效液相色谱法头孢克肟制剂有关物质飞行时间质谱

Novel variants in LAMA3 and cOL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five chinese families

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Frontiers of Medicine 2022年第5期16卷 808-814页

作者： Rongrong Wang Liwei Sun Xiaerbati Habulieti Jiawei Liu kexin Guo Xueting Yang Donglai Ma Xue Zhang McKusick-Zhang center for Genetic Medicine State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China The First Affiliated Hospital of Xinjiang Medical University Urumqi 830001China Department of Dermatology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeNational Clinical Research Center for Dermatologic and Immunologic DiseasesBeijing 100072China

Epidermolysis bullosa(EB)is a group of clinically and genetically heterogeneous diseases characterized by trauma-induced mucocutaneous fragility and blister ***,we investigated five chinese families with EB,and eight variants including a novel nonsense variant(c.47G>A,p.W16*)in LAMA3,a known recurrent variant(c.74c>T,p.P25L)in KRT5,2 novel(c.2531T>A,p.V844E;c.6811_6814del,p.R2271fs)and 4 known(c.6187c>T,p.R2063W;c.7097G>A,p.G2366D;c.8569G>T,p.E2857*;c.3625_3635del,p.S1209fs)variants in cOL7A1 were ***,this study identified a nonsense variant in LAMA3 that causes EB within the chinese population and revealed that this variant resulted in a reduction in LAMA3 mRNA and protein expression levels by nonsense-mediated mRNA *** study expands the mutation spectra of chinese patients with EB.

关键词： epidermolysis bullosa LAMA3 cOL7A1 KRT5 chinese families

New insights for infection mechanism and potential targets of cOVID-19:Three chinese patent medicines and three chinese medicine formulas as promising therapeutic approaches

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chinese Herbal Medicines 2023年第2期15卷 157-168页

作者： kexin Jia Yijie Li Tiegang Liu Xiaohong Gu Xiaojiaoyang Li School of Life Sc.ences Beijing University of Chinese MedicineBeijing 100029China Institute of chinese Epidemic Disease Beijing University of Chinese MedicineBeijing 100029China School of Traditional chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

The coronavirus disease 2019(cOVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-coV-2)with high pathogenicity and infectiousness has become a sudden and lethal pandemic ***,there is no accepted specific drug for cOVID-19 ***,it is extremely urgent to clarify the pathogenic mechanism and develop effective therapies for patients with *** to several reliable reports from china,traditional chinese medicine(TcM),especially for three chinese patent medicines and three chinese medicine formulas,has been demonstrated to effectively alleviate the symptoms of cOVID-19 either used alone or in combination with Western *** this review,we systematically summarized and analyzed the pathogenesis of cOVID-19,the detailed clinical practice,active ingredients investigation,network pharmacology prediction and underlying mechanism verification of three chinese patent medicines and three chinese medicine formulas in the cOVID-19 ***,we summarized some promising and high-frequency drugs of these prescriptions and discussed their regulatory mechanism,which provides guidance for the development of new drugs against ***,by addressing critical challenges,for example,unclear targets and complicated active ingredients of these medicines and formulas,we believe that TcM will represent promising and effic.ent strategies for curing cOVID-19 and related pandemics.

关键词： cOVID-19 Huashi Baidu Formula Jinhua Qinggan Granules Lianhua Qingwen capsule Qingfei Paidu Decoction SARS-coV-2 traditional chinese medicine Xuanfei Baidu Formula Xuebijing Injection

High-throughput sequencing analysis of the regulation of intestinal flora in giant pandas with indigestion using a probiotic agent LyPB

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Journal of Forestry Research 2020年第6期31卷 2589-2595页

作者： Yu Zhang Zhi Zhang Jianzhang Ma Bo Luo Guiquan Zhang Guocai Zhang kexin Yang Gang Wei School of Forestry Northeast Forestry UniversityHarbin 150040People’s Republic of China china conservation and Research center for Giant Panda Ya’anPeople’s Republic of China School of computer Sc.ence and Technology Harbin Institute of TechnologyHarbinPeople’s Republic of China

This study aimed to investigate the eff ect of LyPB on the intestinal microfl ora of giant pandas with indigestion,using high-throughput sequencing(HTS)*** species distribution and microfl oral density and diversity before and after administration of the LyPB probiotic agent were *** evidently has the ability to adjust the fl oral imbalance in the panda’s *** test the eff ects of LyPB on the microfl ora of the panda gut,fecal samples were taken from a healthy giant panda(Anan)without administration of LyPB and from a dyspeptic giant panda Yangyang before and after LyPB *** with the sample obtained from healthy Anan(anan-c)and that obtained from dyspeptic Yangyang before LyPB administration(yangyang1),the sample taken from Yangyang(yangyang2)after LyPB administration displayed a signifi cant increase in the operational taxonomic unit *** increase in the chao index indicated an increase in the microfl oral richness,while an increase in the Shannon index indicated an increase in microfl oral *** phylum and genus levels,a signifi cant increase was observed in the density of probiotic bacteria of phylum fi rmicutes,genus Streptococcus,while a drastic reduction in the density of Escherichia coli/Escherichia coli Shigella/bacteria of genus Shigella was *** obtained in this study shows that LyPB preparations successfully improve the microbial structure within the panda’s intestinal canal by signifi cantly increasing the eff ective microbial community and decreasing the number of pathogenic microbes.

关键词： High-throughput sequencing Intestinal fl ora Pandas Indigestion LyPB