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Indications of pro-inflammatory cytokines in laparoscopic and open liver resection for early-stage hepatocellular carcinoma

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Hepatobiliary & pancreatic Diseases International 2024年第3期23卷 257-264页

作者： kevin tak-pan ng Li pang Jia-Qi Wang Wong Hoi She Simon Hing-Yin Tsang Chung Mau Lo Kwan Man Tan To Cheung Department of Surgery HKU-SZH&School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background:Our clinical practice of laparoscopic liver resection(LLR)had achieved better short-term and long-term benefits for patients with hepatocellular carcinoma(HCC)over open liver resection(OLR),but the underlying mechanisms are not clear.This study was to find out whether systemic inflammation plays an important role.Methods:A total of 103 patients with early-stage HCC under liver resection were enrolled(LLR group,n=53;OLR group,n=50).The expression of 9 inflammatory cytokines in patients at preoperation,postoperative day 1(POD1)and POD7 was quantified by Luminex Multiplex assay.The relationships of the cytokines and the postoperative outcomes were compared between LLR and OLR.Results:Seven of the circulating cytokines were found to be significantly upregulated on POD1 after LLR or OLR compared to their preoperative levels.Compared to OLR,the POD1 levels of granulocytemacrophage colony-stimulating factor(GM-CSF),interleukin-6(IL-6),IL-8,and monocyte chemoattractant protein-1(MCP-1)in the LLR group were significantly lower.Higher POD1 levels of these cytokines were significantly correlated with longer operative time and higher volume of blood loss during operation.The levels of these cytokines were positively associated with postoperative liver injury,and the length of hospital stay.Importantly,a high level of IL-6 at POD1 was a risk factor for HCC recurrence and poor disease-free survival after liver resection.Conclusions:Significantly lower level of GM-CSF,IL-6,IL-8,and MCP-1 after liver resection represented a milder systemic inflammation which might be an important mechanism to offer better short-term and long-term outcomes in LLR over OLR.

关键词： Laparoscopic liver resection Open liver resection Hepatocellular carcinoma Postoperative cytokines Inflammatory responses

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Potential transformation of organic matter by microbes in cryoconite,Tibetan Plateau

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Science China Earth Sciences 2024年第6期67卷 1978-1989页

作者： Bixi GUO Yongqin LIU kevin Xu ZHOng Quan SHI Chen HE Qiang ZHEng Ruanhong CAI State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Center for the pan-Third Pole Environment Lanzhou UniversityLanzhou 730000China Department of Earth Oceanand Atmospheric SciencesUniversity of British ColumbiaVancouverBC V6T 1Z4Canada State Key Laboratory of Heavy Oil Processing Petroleum Molecules Engineering Center(PMEC)China University of PetroleumBeijing 102249China State Key Laboratory for Marine Environmental Science Collage of Ocean and Earth SciencesXiamen UniversityXiamen 361102China Fujian Key Laboratory of Marine Carbon Sequestration Xiamen UniversityXiamen 361005China

Microorganisms play an essential role in the glacier carbon cycle;how they transform organic matter in mountain glacial cryoconite remains to be studied.Here,we applied ultra-high resolution Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS)and deep sequencing of 16S rRNA gene,to investigate the temporal microbial transformation of dissolved organic matter(DOM)of the Tibetan Plateau cryoconite.During the 60-day incubation,we found that DOM in cryoconite underwent a three-stage transformation,with decreasing bioavailability over time.The microbial community did not change much in the first week while degrading DOM molecules that were associated with higher H/C_(wa)and lower O/C_(wa).During days 15-30,DOM composition remained stable while microbial diversity increased.By day 60,the DOM was microbially converted into a higher state of recalcitrance,with higher values of aromatic index,O/C_(wa),and lower H/C_(wa),which contained molecules containing more heteroatoms.Cooperation among various microbial taxa,like Cyanobacteria,Bacteroidota,Gammaproteobacteria,Firmicutes,and Actinobacteriota,drove the DOM transformation in cryoconite.This study sheds light on the in-situ transformation of DOM composition meditated by microbial populations in cryoconite at a temporal scale,providing new insights into understanding the microbial roles in the glacier organic carbon transformation.

关键词： Cryoconite Dissolved organic matter Biodegradation Microbial community Temporal variation

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Investigation on the mechanism of Qiangxinhuoli prescription in the treatment of chronic heart failure based on p38-MAPK signaling pathway

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Traditional Medicine Research 2024年第7期9卷 13-24页

作者： Di Guo Qiu-Han Zheng Di Wang Zhi pan Xiao-Ling Shang College of Basic Medicine Changchun University of Chinese MedicineChangchun 130117China. Jilin Ginseng Academy Changchun University of Chinese MedicineChangchun 130117China.

Background:The aim of this study is to investigate the mechanism of action underlying the therapeutic effects of the national patent Chinese medicine compound“Qiangxinhuoli prescription(QXHLF)”on chronic heart failure(CHF).Methods:In vitro,the H_(9)C_(2) cell model was induced by AngII,and cell proliferation and related protein expression were detected by Cell Counting Kit-8 and Western blot.In vivo,A rat model of CHF was prepared by ligation of the left anterior descending coronary artery.The effects of QXHLF on cardiac function in CHF rats were evaluated by cardiac index,hemodynamic changes,enzyme-linked immunosorbent assay,hematoxylin-eosin staining,immunohistochemistry,Western blot and RT-PCR.The expression of pro-apoptotic factors and anti-apoptotic factors,as well as TGFβ1,p-p38,tak 1 mRNA,and protein,were detected.Results:In vitro,QXHLF has a significant inhibitory effect on the proliferation of H_(9)C_(2) cells.QXHLF can reduce the expression levels of tak 1,TGFβ1,p-p38,Caspase3 and BAX proteins in H_(9)C_(2) cells,and increase the expression level of BCL_(2) protein.In vivo,QXHLF has the potential to increase left ventricular systolic pressure,m aximum rate of change in left ventricular pressure while decreasing left ventricular end diastolic pressure,and inhibiting the serum levels of brain natriuretic peptide.Moreover,QXHLF exhibits significant improvements in the pathological alterations of myocardial cells and fibers in CHF rats,leading to enhanced myocardial tissue morphology and notable advantages in combating myocardial fibrosis.QXHLF can reduce the levels of BAX and Caspase3 and up-regulate the expression of BCL_(2),thereby inhibiting cardiomyocyte apoptosis.Furthermore,QXHLF demonstrates inhibitory effects on the mRNA and protein expression levels of TGFβ_(1),tak_(1),and p-p38 in the heart tissue of the CHF rat model.Conclusion:These findings indicate that QXHLF has a therapeutic effect on CHF by inhibiting the p38-MAPK signaling pathway,reducing myocardial fibrosis,preventing apoptosis,inhibiti

关键词： chronic heart failure Qiangxinhuoli prescription p38MAPK pathway H_(9)C_(2) Action mechanism

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New Record Ocean Temperatures and Related Climate Indicators in 2023

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Advances in Atmospheric Sciences 2024年第6期41卷 1068-1082页

作者： Lijing CHEng John ABRAHAM kevin E.TRENBERTH Tim BOYER Michael EMANN Jiang ZHU Fan WAng Fujiang YU Ricardo LOCARNINI John FASULLO Fei ZHEng Yuanlong LI Bin ZHAng Liying WAN Xingrong CHEN Dakui WAng Licheng FEng Xiangzhou SOng Yulong LIU Franco RESEGHETTI Simona SIMONCELLI Viktor GOURETSKI Gengxin CHEN Alexey MISHONOV Jim REAGAN Karina VON SCHUCKMANN Yuying pan Zhetao TAN Yujing ZHU Wangxu WEI Guancheng LI Qiuping REN Lijuan CAO Yayang LU International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of St.Thomas School of EngineeringMinnesota 55105USA NSF National Center for Atmospheric Research BoulderColorado 80307USA University of Auckland Auckland 1010New Zealand National Oceanic and Atmospheric Administration National Centers for Environmental InformationSilver SpringMaryland 20910USA Department of Earth and Environmental Science University of PennsylvaniaPhiladelphiaPennsylvania 19104USA Institute of Oceanology Chinese Academy of SciencesQingdao 266071China National Marine Environmental Forecasting Center Ministry of Natural Resources of ChinaBeijing 100081China Oceanographic Data Center Chinese Academy of SciencesQingdao 266071China College of Oceanography Hohai UniversityNanjing 210098China National Marine Data and Information Service Tianjin 300171China Italian National Agency for New Technologies Energy and Sustainable Economic DevelopmentS.Teresa Research CenterLerici 19032Italy Istituto Nazionale di Geofisica e Vulcanologia Sede di BolognaBologna 40128Italy South China Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou 510301China ESSIC/CISESS-MD University of MarylandCollege ParkMD20740USA Mercator Ocean International Toulouse 31400France Eco-Environmental Monitoring and Research Center Pearl River Valley and South China Sea Ecology and Environment AdministrationMinistry of Ecology and EnvironmentPRCGuangzhou 510611China National Meteorological Information Center China Meteorological AdministrationBeijing 100081China International Research Center of Big Data for Sustainable Development Goals Beijing 100094China

The global physical and biogeochemical environment has been substantially altered in response to increased atmospheric greenhouse gases from human activities.In 2023,the sea surface temperature(SST)and upper 2000 m ocean heat content(OHC)reached record highs.The 0–2000 m OHC in 2023 exceeded that of 2022 by 15±10 ZJ(1 Zetta Joules=1021 Joules)(updated IAP/CAS data);9±5 ZJ(NCEI/NOAA data).The Tropical Atlantic Ocean,the Mediterranean Sea,and southern oceans recorded their highest OHC observed since the 1950s.Associated with the onset of a strong El Niño,the global SST reached its record high in 2023 with an annual mean of~0.23℃ higher than 2022 and an astounding>0.3℃ above 2022 values for the second half of 2023.The density stratification and spatial temperature inhomogeneity indexes reached their highest values in 2023.

关键词： ocean heat content salinity stratification global warming climate

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A transcription assay for EWS oncoproteins in Xenopus oocytes

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Protein & Cell 2010年第10期1卷 927-934页

作者： King pan ng Felix Cheung kevin A.W.Lee Department of Biology The Hong Kong University of Science and TechnologyClear Water BayKowloon Hong KongChina

Aberrant chromosomal fusion of the Ewing's sarcoma oncogene(EWS)to several different cellular partners produces the Ewing's family of oncoproteins(EWSfusion-proteins,EFPs)and associated tumors(EFTs).EFPs are potent transcriptional activators,dependent on the N-terminal region of EWS(the EWS-activationdomain,EAD)and this function is thought to be central to EFT oncogenesis and maintenance.Thus EFPs are promising therapeutic targets,but detailed molecular studies will be pivotal for exploring this potential.Such studies have so far largely been restricted to intact mammalian cells while recent evidence has indicated that a mammalian cell-free transcription system may not support bona fide EAD function.Therefore,the lack of manipulatable assays for the EAD presents a significant barrier to progress.Using Xenopus laevis oocytes we describe a plasmid-based micro-injection assay that supports efficient,bona fide EAD transcriptional activity and hence provides a new vehicle for molecular dissection of the EAD.

关键词： EWS/ATF1 Ewing's sarcoma microinjection Xenopus oocytes transcription EWS-activation domain

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The RNA Pol Ⅱ sub-complex hsRpb4/7 is required for viability of multiple human cell lines

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Protein & Cell 2012年第11期3卷 846-854页

作者： Yang Zhao Kim K.C.Li King pan ng Chi Ho ng kevin A.W.Lee Division of Life Science The Hong Kong University of Science and TechnologySai KungHong Kong S.A.R.China

The evolutionarily conserved RNA Polymerase Ⅱ Rpb4/7 sub-complex has been thoroughly studied in yeast and impacts gene expression at multiple levels including transcription,mRNA processing and decay.In addition Rpb4/7 exerts differential effects on gene expression in yeast and Rpb4 is not obligatory for yeast(S.cerevisiae)survival.Specialised roles for human(hs)Rpb4/7 have not been extensively described and we have probed this question by depleting hsRpb4/7 in established human cell lines using RNA interference.We find that Rpb4/7 protein levels are inter-dependent and accordingly,the functional effects of depleting either protein are co-incident.hsRpb4/7 exhibits gene-specific effects and cells initially remain viable upon hsRpb4/7 depletion.However prolonged hsRpb4/7 depletion is cytotoxic in the range of cell lines tested.Protracted cell death occurs by an unknown mechanism and in some cases is accompanied by a pronounced elongated cell morphology.In conclusion we provide evidence for a gene-specific role of hsRpb4/7 in human cell viability.

关键词： RNA PolymeraseⅡ hsRpb4/7 sub-complex gene expression cell viability cell shape

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Docetaxel-induced nail toxicity： a case of severe onycholysis and topic review

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Chinese Medical Journal 2011年第16期124卷 2559-2560页

作者： Chi-pan Lau Pun Hui tak-cheung Chan Department of Clinical Oncology Prince of Wales Hospital TheChinese University of Hong Kong State Key Laboratory inOncology in South China Sir Y. K. Pao Centre for Cancer HongKong China

Docetaxel is a commonly-used anti-cancer chemotherapeutic agent given its efficacy in a large variety of solid tumors. It is associated with various adverse effects one of which is nail toxicity. We report a case of severe onycholysis as a result of treatment with docetaxel in a patient who suffered from metastatic nasopharyngeal carcinoma. The case report will be followed by a discussion on the possible mechanism and preventive strategies for taxane-induced nail toxicity.

关键词： Docetaxel onycholysis nail toxicity

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Forest biodiversity, relationships to structural and functional attributes, and stability in New England forests

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Forest Ecosystems 2018年第2期5卷 177-188页

作者： Yude pan kevin McCullough David Y. Hollinger USDA Forest Service Durham NH USA USDA Forest Service Madison WI USA

Background： Forest biodiversity is the foundation of many ecosystem services, and the effect of biodiversity on ecosystem functioning and processes （BEF） has been a central issue in biodiversity studies. Although many hypotheses have been developed to interpret global gradients of biodiversity, there has not been complete agreement on mechanisms controlling biodiversity patterns and distributions. Differences may be due to limited observation data and inconsistencies of spatial scales in analysis. Methods： In this study, we take advantage of USDA Forest Service forest inventory and analysis （FIA） data for exploring regional forest biodiversity and BEF in New England forests. The FIA data provide detailed information of sampled plots and trees for the region, including 6000 FIA plots and more than 33,000 individual trees. Biodiversity models were used to analyze the data. Results： Tree species diversity increases from the north to the south at a rate about 2-3 species per latitudinal degree. Tree species diversity is better predicted by tree height than forest age or biomass. Very different distribution patterns of two common maple species, sugar maple （Acer sdcchorum） and red maple （Acer rubrum）, highlight the vulnerability of sugar maple and its potential replacement by red maple on New England landscapes. Red maple generally already outperforms sugar maple, and will likely and continuously benefit from a changing climate in New England. Conclusions： We conclude that forest structure （height） and resources （biomass） are more likely foundational characteristics supporting biodiversity rather than biodiversity determining forest productivity and/or biomass. The potential replacement of red maple for sugar maple in the New England areas could affect biodiversity and stability of forest ecosystem functioning because sugar maple plays important ecological roles distinct from red maple that are beneficial to other tree species in northern hardwood forests. Such a change may not affect forest resilience in terms of for

关键词： Forest biodiversity Biodiversity effect on function （BEF） New England Forest inventory data Species diversity Latitudinal diversity gradient Forest stability of ecosystem functioning Forest resilience Sugar maple Red maple Changing climate

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A review of UHMWPE wear-induced osteolysis:the role for early detection of the immune response

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Bone Research 2016年第2期4卷 72-84页

作者： Adrese M Kandahari Xinlin Yang kevin A Laroche Abhijit S Dighe Dongfeng pan Quanjun Cui Department of Orthopaedic Surgery University of Virginia Department of Radiology and Medical Imaging University of Virginia

In a world where increasing joint arthroplasties are being performed on increasingly younger patients, osteolysis as the leading cause of faiIure after total joint arthroplasty （TJA） has gained considerable attention. Ultra-high molecular weight polyethylene wear-induced osteolysis is the process by which prosthetic debris mechanicaIly released from the surface of prosthetic joints induces an immune response that favors bone catabolism, resulting in loosening of prostheses with eventual failure or fracture. The immune response initiated is innate in that it is nonspecific and self-propagating, with monocytic cells and osteoclasts being the main effectors. To date, detecting disease early enough to implement effective intervention without unwanted systemic side effects has been a major barrier. These barriers can be overcome using newer in vivo imaging techniques and modules linked with fluorescence and/or chemotherapies. We discuss the pathogenesis of osteolysis, and provide discussion of the challenges with imaging and therapeutics. We describe a positron emission tomography imaging cinnamoyl-Phe-（D）-Leu-Phe-（D）-Leu-Phe-Lys module, specific to maerophages, which holds promise in early detection of disease and localization of treatment. Further research and increased collaboration among therapeutic and three-dimensional imaging researchers are essential in realizing a solution to clinical osteolysis in TJA.

关键词： UHMWPE RANKL A review of UHMWPE wear-induced osteolysis

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Optimal allocation of plug-in electric vehicle charging stations in the distribution network with distributed generation

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Green Energy and Intelligent Transportation 2023年第3期2卷 53-64页

作者： Ebunle Akupan Rene Willy Stephen Tounsi Fokui Paule kevin Nembou Kouonchie Department of Electrical and Electronic Engineering University of BueaP.O Box 63BueaCameroon Teleconnect GmbH Am Lehmberg 5401157DresdenGermany Department of Electrical Engineering Pan African University Institute for Basic SciencesTechnology and InnovationP.O.Box 62000-00200NairobiKenya

The transportation sector is characterized by high emissions of greenhouse gases(GHG)into the atmosphere.Consequently,electric vehicles(EVs)have been proposed as a revolutionary solution to mitigate GHG emissions and the dependence on petroleum products,which are fast depleting.EVs are proliferating in many countries worldwide and the fast adoption of this technology is significantly dependent on the expansion of charging stations.This study proposes the use of the hybrid genetic algorithm and particle swarm optimization(GA-PSO)for the optimal allocation of plug-in EV charging stations(PEVCS)into the distribution network with distributed generation(DG)in high volumes and at selected buses.Photovoltaic(PV)systems with a power factor of 0.95 are used as DGs.The PVs are penetrated into the distribution network at 60%and six penetration cases are considered for the optimal placement of the PEVCSs.The optimization problem is formulated as a multi-objective problem minimizing the active and reactive power losses as well as the voltage deviation index.The IEEE 33 and 69 bus distribution networks are used as test networks.The simulation was performed using MATLAB and the results obtained validate the effectiveness of the hybrid GA-PSO.For example,the integration of PEVCSs results in the minimum bus voltage still within accepted margins.For the IEEE 69 bus network,the resulting minimum voltage is 0.973 p.u in case 1,0.982 p.u in case 2,0.96 p.u in case 3,0.961 p.u in case 4,0.954 p.u in case 5,and 0.965 p.u in case 6.EVs are a sustainable means of significantly mitigating emissions from the transportation sector and their utilization is essential as the worldwide concern of climate change and a carbon-free society intensifies.

关键词： Electric vehicles Charging stations Distributed generation Photovoltaic Genetic algorithm Particle swarm optimization

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