Docetaxel-induced nail toxicity： a case of severe onycholysis and topic review

作     者：Chi-pan Lau Pun Hui Tak-cheung Chan 

作者机构：Department of Clinical Oncology Prince of Wales Hospital TheChinese University of Hong Kong State Key Laboratory inOncology in South China Sir Y. K. Pao Centre for Cancer HongKong China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2011年第124卷第16期

页      面：2559-2560页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 12[管理学] 120203[管理学-旅游管理] 1202[管理学-工商管理] 1002[医学-临床医学] 10[医学] 

主　　题：Docetaxel onycholysis nail toxicity 

摘      要：Docetaxel is a commonly-used anti-cancer chemotherapeutic agent given its efficacy in a large variety of solid tumors. It is associated with various adverse effects one of which is nail toxicity. We report a case of severe onycholysis as a result of treatment with docetaxel in a patient who suffered from metastatic nasopharyngeal carcinoma. The case report will be followed by a discussion on the possible mechanism and preventive strategies for taxane-induced nail toxicity.