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Epidemiology and Management of Drug-induced Liver Injury: Importance of the Updated RUCAM

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1239-1245页

作者： Takashi kobayashi Michihiro Iwaki Asako Nogami Masato Yoneda Department of Gastroenterology and Hepatology Yokohama City University Graduate School of MedicineYokohamaJapan

Drug-induced liver injury(DILI)is a major cause of acute liver injury,liver failure,and liver transplantation *** recent years,immune checkpoint inhibitors have become widely *** has led to an increase in DILI,for which pathophysiology and management methods differ significantly from the *** the number of cases of acute liver injury and liver transplantation due to DILI is expected to increase,information about a DILI is becoming more *** is classified into two types according to its etiology:intrinsic DILI,in which the drug or its metabolites cause liver damage that is dose-dependent and predictable;and idiosyncratic DILI,in which liver damage is also dose-independent but *** addition,depending on the course of the disease,chronic DILI or drug-induced autoimmune hepatitis may be *** number of DILI cases caused by antimicrobial agents is decreasing,whereas that caused by drugs for malignant tumors and health foods is *** Roussel Uclaf Causality Assessment Method is widely used to assess causality in *** injury is a type of immune-related adverse *** pattern of hepatic injury in immune-related adverse events is mostly hepatocellular,but mixed type and bile stasis have also been *** cholangitis caused by immune checkpoint inhibitors has also been reported as a unique type of *** mainly comprises withdrawal of immune checkpoint inhibitors and steroid administration;however,mycophenolate mofetil may be considered if the disease is refractory to steroids.

关键词： Drug-induced liver injury Immune-related adverse events Immune checkpoint inhibitor Updated RUCAM

Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials

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Bioactive Materials 2023年第9期27卷 574-593页

作者： Henry F.Duncan Yoshifumi kobayashi Michaela Kearney Emi Shimizu Division of Restorative Dentistry&Periodontology Dublin Dental University HospitalTrinity College DublinUniversity of DublinLincoln PlaceDublinIreland Department of Oral Biology Rutgers School of Dental MedicineNewarkNJUSA

This opinion-led review paper highlights the need for novel translational research in vital-pulp-treatment(VPT),but also discusses the challenges in translating evidence to *** dentistry is expensive,invasive and relies on an outmoded mechanical understanding of dental disease,rather than employing a biological perspective that harnesses cell activity and the *** research has focussed on developing minimally-invasive biologically-based‘fillings’that preserve the dental pulp;research that is shifting the paradigm from expensive high-technology dentistry,with high failure rates,to smart restorations targeted at biological *** VPTs promote repair by recruiting odontoblast-like cells in a material-dependent ***,exciting opportunities exist for development of next-generation biomaterials targeted at regenerative processes in the dentin-pulp *** article analyses recent research using pharmacological-inhibitors to therapeutically-target histone-deacetylase(HDAC)enzymes in dental-pulp-cells(DPCs)that stimulate pro-regenerative effects with limited loss of ***,HDAC-inhibitors have the potential to enhance biomaterial-driven tissue responses at low concentration by influencing the cellular processes with minimal side-effects,providing an opportunity to develop a topically-placed,inexpensive bio-inductive pulp-capping *** positive results,clinical translation of these innovations requires enterprise to counteract regulatory obstacles,dental-industry priorities and to develop strong academic/industry *** aim of this opinion-led review paper is to discuss the potential role of therapeutically-targeting epigenetic modifications as part of a topical VPT strategy in the treatment of the damaged dental pulp,while considering the next steps,material considerations,challenges and future for the clinical development of epigenetic therapeutics or other‘smart’restora

关键词： Epigenetics Vital pulp treatment Histone deacetylase inhibitors Regenerative endodontics Pulp capping

Regulation of the growth of sprouting roots of black locust seedlings using root barrier panels

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Journal of Forestry Research 2023年第3期34卷 655-664页

作者： Satoshi Kitaoka Shiro Matsunami Yannan Wang Saki Fujita kobayashi Makoto Toshiyuki Hirata Takayoshi Koike Graduate School of Agriculture Hokkaido UniversitySapporo 060-8589Japan The Robust Greenhouse Project of Hokkaido University Sapporo 060-8589Japan Present Address:Oyo Cooperation Ltd Sumitomo BuildingTokyo 101-8486Japan Jiangxi Academy of Forestry Nanchang 330029People’s Republic of China Forestry and Forest Products Research Institute Tsukuba 305-8687Japan Field Science Center for Northern Biosphere Hokkaido UniversitySapporo 060-0809Japan Research Faculty of Agriculture Hokkaido UniversitySapporo 060-8589Japan

How can we regulate an invasive alien species of high commercial value?Black locust(Robinia pseudoacacia L.)has a unique capacity for seed dispersal and high *** surveys indicate that black locust increases its growing area with sprouting roots and the elongation of horizontal roots at a soil depth of 10 ***,a method to regulate the development of horizontal roots could be eff ective in slowing the invasiveness of black *** this study,root barrier panels were tested to inhibit the growth of horizontal *** it is labor intensive to observe the growth of roots in the fi eld,it was investigated in a nursery *** decrease in secondary fl ush,an increase in yellowed leafl ets,and the height in the seedlings were *** root barrier panels to a depth of 30 cm eff ectively inhibit the growth of horizontal roots of young black locust.

关键词： Black locust Horizontal roots Nutrients Root barrier panel Sprouting roots

Surgical treatment for a combined anterior cruciate ligament and posterior cruciate ligament avulsion fracture: A case report

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World Journal of Clinical Cases 2022年第12期10卷 3879-3885页

作者： Katsuhiro Yoshida Michiyuki Hakozaki Hideo kobayashi Masashi Kimura Shinichi Konno Department of Orthopaedic Surgery Fukushima Medical University School of MedicineFukushima 960-1295Japan Higashi-Shirakawa Orthopaedic Academy Fukushima Medical University School of MedicineFukushima 960-1295Japan Department of Orthopaedic Surgery Sukagawa HospitalFukushima 962-0022Japan Gunma Sports Medicine Research Center Zenshukai HospitalGunma 379-2115Japan

BACKGROUND Independent avulsion fractures with anterior cruciate ligament(ACL)or posterior cruciate ligament(PCL)attachment are relatively common among tibial intercondylar eminence fractures,and their postoperative outcomes are generally ***,huge avulsion fractures of the intercondylar eminence containing the attachment site of both the ACL and the PCL are extremely rare,and the reported clinical outcomes are *** SUMMARY We describe a 30-year-old Japanese male's huge avulsion fracture of the intercondylar eminence of a tibia containing the attachment site of both the ACL and PCL,together with a complete tear of the medial collateral ligament and a partial tear of both the medial and lateral menisci caused by a fall from a high *** of these injuries were treated surgically,with anatomical reduction and stable *** limb function at 1 year post-surgery was excellent(Lysholm score:100 points).CONCLUSION Although this patient's complete surgical repair was complex,it should be performed in similar cases for an excellent final clinical outcome.

关键词： Avulsion fracture Intercondylar eminence Tibia Anterior cruciate ligament Posterior cruciate ligament Meniscal tear

Excited state calculations using variational quantum eigensolver with spin-restricted ansätze and automatically-adjusted constraints

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npj Computational Materials 2023年第1期9卷 2204-2212页

作者： Shigeki Gocho Hajime Nakamura Shu Kanno Qi Gao Takao kobayashi Taichi Inagaki Miho Hatanaka School of Fundamental Science and Technology Faculty of Science and TechnologyKeio UniversityYokohama 223-8522Japan Quantum Computing Center Keio UniversityYokohama 223-8522Japan IBM Quantum–IBM Research Tokyo Tokyo 103-8510Japan Mitsubishi Chemical Corporation Science&Innovation CenterYokohama 227-8502Japan

The ground and excited state calculations at key geometries, such as the Frank–Condon (FC) and the conical intersection (CI)geometries, are essential for understanding photophysical properties. To compute these geometries on noisy intermediate-scalequantum devices, we proposed a strategy that combined a chemistry-inspired spin-restricted ansatz and a new excited statecalculation method called the variational quantum eigensolver under automatically-adjusted constraints (VQE/AC). Unlike theconventional excited state calculation method, called the variational quantum deflation, the VQE/AC does not require the pre-determination of constraint weights and has the potential to describe smooth potential energy surfaces. To validate this strategy,we performed the excited state calculations at the FC and CI geometries of ethylene and phenol blue at the complete active spaceself-consistent field (CASSCF) level of theory, and found that the energy errors were at most 2 kcal mol−1 even on the ibm_kawasakidevice.

关键词： properties quantum variational

Rapid transformation of branched pancreatic duct-derived intraductal tubulopapillary neoplasm into an invasive carcinoma: A case report

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World Journal of Clinical Oncology 2023年第12期14卷 620-627页

作者： kenta Yamamoto Yutaka Takada Takuya kobayashi Ryo Ito Yuka Ikeda Shogo Ota Kanna Adachi YukariShimada Motohito Hayashi Toshinao Itani Satsuki Asai Kojiro Nakamura Department of Gastroenterology and Hepatology Kobe City Nishi-Kobe Medical CenterKobe 651-2273HyogoJapan Department of Pathology Kobe City Nishi-Kobe Medical CenterKobe 651-2273HyogoJapan Department of Surgery and Gastroenterological Surgery Kobe City Nishi-Kobe Medical CenterKobe 651-2273HyogoJapan

BACKGROUND Intraductal tubulopapillary neoplasm(ITPN)is a rare disease accounting for approximately 3%of all intraductal pancreatic tumors,with intraductal papillary mucinous neoplasm(IPMN)being one of the most common differential *** ITPN and IPMN display slow growth.A branched pancreatic duct type is commonly observed in IPMN,whereas ITPN derived from the branched pancreatic duct has been reported in a limited number of cases;hence,its pathogenesis remains *** SUMMARY Here,we present the case of a patient with ITPN localized in a branched pancreatic duct,with poorly controlled irritable bowel syndrome.A contrastenhanced computed tomography scan of the abdomen incidentally revealed a 5-mm oligemic nodule-like change in the body of the *** ultrasound(EUS)indicated a 10-mm hypoechoic mass without any cystic structures that had grown within 2 ***-guided fine needle aspiration was performed for definitive diagnosis,and the findings suggested ductal papillary *** pancreatectomy was performed,and the tumor was pathologically diagnosed as ITPN with an invasive cancerous component,pT3N1aM0,pStage IIB(International Cancer Control,8^(th) edition).The patient underwent treatment with postoperative adjuvant chemotherapy(S-1 monotherapy);however,relapse was observed 1 year and 10 mo after surgical resection,and subsequent treatment involving a combination of chemotherapy and radiotherapy was *** therapy has since facilitated a stable disease *** Regardless of the microscopic size of the neoplasm,early diagnosis of ITPN with EUS-guided fine needle aspiration and surgical resection are crucial.

关键词： Intraductal tubulopapillary neoplasm Pancreatic tumors Neoplasia Carcinoma Pancreaticoduodenectomy Case report

Research progress in interface modification and thermal conduction behavior of diamond/metal composites

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International Journal of Minerals,Metallurgy and Materials 2022年第2期29卷 200-211页

作者： Ping Zhu Pingping Wang Puzhen Shao Xiu Lin Ziyang Xiu Qiang Zhang Equo kobayashi Gaohui Wu School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Key Laboratory of Advanced Structure-Function Integrated Materials and Green Manufacturing Technology School of Material Science and EngineeringHarbin Institute of TechnologyHarbin 150001China Industrial Technology Research Institute of Heilongjiang Province Harbin 150001China Department of Materials Science and Engineering Tokyo Institute of TechnologyTokyo 152-8550Japan

Diamond/metal composites are widely used in aerospace and electronic packaging fields due to their outstanding high thermal conductivity and low ***,the difference in chemical properties leads to interface incompatibility between diamond and metal,which has a considerable impact on the performance of the *** improve the interface compatibility between diamond and metal,it is necessary to modify the interface of *** paper reviews the experimental research on interface modification and the application of computational simulation in diamond/metal *** computational simulation with experimental methods is a promising way to promote diamond/metal composite interface modification research.

关键词： diamond/metal interface modification thermal conductivity computational simulation

Research Activities of Nanodimensional Standards Using Atomic Force Microscopes,Transmission Electron Microscope,and Scanning Electron Microscope at the National Metrology Institute of Japan

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Nanomanufacturing and Metrology 2022年第2期5卷 83-90页

作者： Ichiko Misumi Ryosuke Kizu Hiroshi Itoh Kazuhiro Kumagai Keita kobayashi Tomoo Sigehuzi National Institute of Advanced Industrial Science and Technology AIST Tsukuba Central 51-1-1 HigashiIbaraki305-8565TsukubaJapan

With the progress in nanotechnology,the importance of nanodimensional standards is *** nanodimensional standards requires multiple types of high-precision microscopy *** National Metrology Institute of Japan(NMIJ),one of the research domains in the National Institute of Advanced Industrial Science and Technology(AIST),is developing nanodimensional standards using atomic force,transmission electron,and scanning electron *** current status of nanodimensional standards in NMIJ is introduced herein.

关键词： Nanodimensional standards Calibration Uncertainty AFM TEM SEM

Primary hepatic neuroendocrine neoplasm diagnosed by somatostatin receptor scintigraphy:A case report

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World Journal of Clinical Cases 2022年第7期10卷 2222-2228页

作者： Miho Akabane Yuta kobayashi Keiichi Kinowaki Satoshi Okubo Junichi Shindoh Masaji Hashimoto Division of Hepatobiliary-pancreatic Surgery Department of Gastroenterological SurgeryToranomon HospitalTokyo 105-8470Japan Department of Diagnostic Pathology Toranomon HospitalTokyo 105-8470Japan

BACKGROUND Primary hepatic neuroendocrine neoplasm(NEN)is a rare condition,and it is difficult to differentiate between primary and metastatic hepatic ***,we report a case of primary hepatic NEN that initially mimicked a hemangioma but showed a gradual increase in size on long-term careful *** SUMMARY A 47-year-old woman was incidentally diagnosed with a 12-mm liver mass,suspected to be a *** then,regular follow-up had been carried *** years later,she was referred to our institute due to the tumor(located in segment 4)having increased to 20 *** imaging studies depicted no apparent extrahepatic *** emission tomography(PET)/computed tomography exhibited significant accumulation in the mass lesion,which made us consider the possibility of *** hepatectomy was *** histopathological diagnosis was neuroendocrine tumor grade 2,with somatostatin receptor 2 a/5 *** somatostatin receptor scintigraphy(SRS)showed no other site,leading to the diagnosis of NEN of primary hepatic *** gradual growth of the hepatic NEN over 10 years suggested that it was likely to be a primary liver *** In this case,positivity on PET and postoperative SRS may have helped determine whether the tumor was primary or metastatic.

关键词： Hepatic neoplasm Scintigraphy Surgery Positron-emission tomography Clinical decision-making Case report