Rapid transformation of branched pancreatic duct-derived intraductal tubulopapillary neoplasm into an invasive carcinoma: A case report

作     者：Kenta Yamamoto Yutaka Takada Takuya Kobayashi Ryo Ito Yuka Ikeda Shogo Ota Kanna Adachi YukariShimada Motohito Hayashi Toshinao Itani Satsuki Asai Kojiro Nakamura 

作者机构：Department of Gastroenterology and HepatologyKobe City Nishi-Kobe Medical CenterKobe 651-2273HyogoJapan Department of PathologyKobe City Nishi-Kobe Medical CenterKobe 651-2273HyogoJapan Department of Surgery and Gastroenterological SurgeryKobe City Nishi-Kobe Medical CenterKobe 651-2273HyogoJapan 

出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)

年 卷 期：2023年第14卷第12期

页      面：620-627页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Intraductal tubulopapillary neoplasm Pancreatic tumors Neoplasia Carcinoma Pancreaticoduodenectomy Case report 

摘      要：BACKGROUND Intraductal tubulopapillary neoplasm(ITPN)is a rare disease accounting for approximately 3%of all intraductal pancreatic tumors,with intraductal papillary mucinous neoplasm(IPMN)being one of the most common differential *** ITPN and IPMN display slow growth.A branched pancreatic duct type is commonly observed in IPMN,whereas ITPN derived from the branched pancreatic duct has been reported in a limited number of cases;hence,its pathogenesis remains *** SUMMARY Here,we present the case of a patient with ITPN localized in a branched pancreatic duct,with poorly controlled irritable bowel syndrome.A contrastenhanced computed tomography scan of the abdomen incidentally revealed a 5-mm oligemic nodule-like change in the body of the *** ultrasound(EUS)indicated a 10-mm hypoechoic mass without any cystic structures that had grown within 2 ***-guided fine needle aspiration was performed for definitive diagnosis,and the findings suggested ductal papillary *** pancreatectomy was performed,and the tumor was pathologically diagnosed as ITPN with an invasive cancerous component,pT3N1aM0,pStage IIB(International Cancer Control,8^(th) edition).The patient underwent treatment with postoperative adjuvant chemotherapy(S-1 monotherapy);however,relapse was observed 1 year and 10 mo after surgical resection,and subsequent treatment involving a combination of chemotherapy and radiotherapy was *** therapy has since facilitated a stable disease *** Regardless of the microscopic size of the neoplasm,early diagnosis of ITPN with EUS-guided fine needle aspiration and surgical resection are crucial.