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支点弯曲位X线片对运用椎弓根螺钉固定治疗脊柱侧凸中的可预测性

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中华骨科杂志 2010年第6期30卷 I0037-I0042页

作者： kenneth m.c. cheung Deepa Natarajan Dino Samartzis Yat-Wa Wong Wai-Yuen cheung Keith D.K. Luk 宋跃明(译) Investigation performed at the Department of Orthopaedics arid Traumatology Duchess of Kent Children's Hospital Hong Kong China 四川大学华西医院骨科 610041

背景：支点弯曲位X线片在运用钩棒系统治疗青少年特发性脊柱侧凸时能准确预测术后弯曲矫正情况。本研究拟探讨支点弯曲位x线片在运用交替椎弓根螺钉固定治疗脊柱侧凸中的预测性价值。方法：我们对在同一机构内运用交替椎弓根螺钉固定方... 详细信息

背景：支点弯曲位X线片在运用钩棒系统治疗青少年特发性脊柱侧凸时能准确预测术后弯曲矫正情况。本研究拟探讨支点弯曲位x线片在运用交替椎弓根螺钉固定治疗脊柱侧凸中的预测性价值。方法：我们对在同一机构内运用交替椎弓根螺钉固定方法进行手术治疗的胸椎特发性脊柱侧凸患者进行前瞻性放射学分析。测量术前和术后1周时站立后前位脊柱x线片上侧凸的cobb角。计算支点柔韧百分比和支点弯曲矫正指数百分比。结果：42例患者纳入本研究。实施手术时患者的平均年龄是14．6岁，平均融合节段数为9．4个。术前站立位X线片cobb角、支点弯曲位cobb角、支点柔韧度分别为57．9°．21．8°和62．7％。术后1周X线片，平均cobb角为15．4°，弯曲的平均矫正度为73.4％，支点弯曲的平均矫正指数为122．1％。支点弯曲位x线片的角度与支点弯曲矫正指数呈显著正相关，表明支点弯曲化X线片能预测支点弯曲的术后矫正情况。然而，对于僵硬型的脊柱侧凸，椎弓根螺钉固定能为患者带来比支点弯曲位X线片所预测的更理想的矫正效果。结论：据我们所知，本研究是证实支点弯曲位X线片在运用交替椎弓根螺钉固定治疗脊柱侧凸中的预测性价值的首次研究。弯曲的柔韧性能反映支点弯曲矫正指数的程度，即柔韧性差的侧凸畸形能获得一个更大的矫正指数。支点弯曲位x线片具有潜在的预测价值。此外．与钩棒及其他系统相比，椎弓根螺钉固定表现出更好的矫正能力。

关键词：青少年特发性脊柱侧凸椎弓根螺钉固定支点弯曲位可预测性固定治疗 X线片 cobb角预测价值

蛋白多糖在遗传性多发性骨软骨瘤形成中的重要作用

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中国矫形外科杂志 2004年第Z1期 50-52页

作者：杨柳,罗卓荆,颉强,屈波,Danny chan,kenneth m.c. cheung,Kathryn S.E.cheah 第四军医大学西京医院骨科第四军医大学西京医院骨科第四军医大学西京医院骨科第四军医大学西京医院骨科香港大学医学院生物化学系香港大学医学院骨外科学系香港大学医学院生物化学系西安710032 西安710032 西安710032 西安710032

目的 :了解遗传性多发性骨软骨瘤 (HereditarymultipleExostosis ,EXT )中硫酸肝素 (HeparanSulfate ,HS)链及蛋白多糖 (Perlecan)的表达 ,探讨蛋白多糖在遗传性多发性骨软骨瘤发病机制中的作用。方法 :采用免疫组织化学方法 (SABc)对 4... 详细信息

目的 :了解遗传性多发性骨软骨瘤 (HereditarymultipleExostosis ,EXT )中硫酸肝素 (HeparanSulfate ,HS)链及蛋白多糖 (Perlecan)的表达 ,探讨蛋白多糖在遗传性多发性骨软骨瘤发病机制中的作用。方法 :采用免疫组织化学方法 (SABc)对 4例EXT患者骨软骨瘤软骨组织标本中HS及Perlecan的表达进行检测。与正常髂骨嵴软骨 (2例 )及小关节突软骨 (2例 )对照。结果 :遗传性多发性骨软骨瘤软骨组织不具有典型生长板软骨分层结构 ,细胞呈巢状分布 ;4例骨软骨瘤软骨细胞及基质组织中几乎都没有HS的表达 ;Perlecan定位及表达异常 :主要表达于细胞膜内侧 ,而细胞膜表面及细胞外基质表达明显减少。结论 :蛋白多糖侧链HS链及Perlecan的表达改变说明蛋白多糖在遗传性多发性骨软骨瘤发病中起重要作用。

关键词：遗传性多发性骨软骨瘤蛋白多糖

Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis

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Science china(Life Sciences) 2024年第5期67卷 865-878页

作者： Wei Jia Yitao Li kenneth c.P.cheung Xiaojiao Zheng School of chinese medicine Hong Kong Baptist UniversityHong KongChina center for Translational medicine and Shanghai Key Laboratory of Diabetes mellitus Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University School of MedicineShanghai 200233China

Bile acids(BAs)play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune *** the enterohepatic circulation,BAs are synthesized,metabolized,and reabsorbed,with a portion entering the vascular circulation and distributing *** allows BAs to interact with receptors in all major organs,leading to organ-organ interactions that regulate both local and global metabolic processes,as well as the immune *** review focuses on the whole-body effects of BA-mediated metabolic and immunological regulation,including in the brain,heart,liver,intestine,eyes,skin,adipose tissue,and *** BA synthesis and receptor signaling is a promising strategy for the development of novel therapies for various diseases throughout the body.

关键词： bile acid whole body metabolism immunity

Painful intervertebral disc degeneration and inflammation:from laboratory evidence to clinical interventions

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Bone Research 2021年第1期9卷 1-14页

作者： Feng-Juan Lyu Haowen cui Hehai Pan kenneth mc cheung Xu cao James c.Iatridis Zhaomin Zheng School of medicine South China University of TechnologyGuangzhouChina Department of Spine Surgery The First Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Breast Tumor center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Orthopedics&Traumatology The University of Hong KongHong KongSARChina Department of Orthopedic Surgery Johns Hopkins UniversityBaltimoreMDUSA Leni and Peter W.may Department of Orthopedics Icahn School of Medicine at Mount SinaiNew YorkNYUSA Pain Research center Sun Yat-sen UniversityGuangzhouChina

Low back pain(LBP),as a leading cause of disability,is a common musculoskeletal disorder that results in major social and econom.c.*** research has identified inflammation and related signaling pathways as important factors in the onset and progression of disc degeneration,a significant contributor to *** mediators also play an indispensable role in discogenic *** suppression of LBP is a primary goal of clinical practice but has not received enough attention in disc research ***,an overview of the advances in inflammation-related pain in disc degeneration is provided,with a discussion on the role of inflammation in IVD degeneration and pain *** models,m.c.anical models,and spontaneous models as the main animal models to study painful disc degeneration are discussed,and the underlying signaling pathways are ***,potential drug candidates,either under laboratory investigation or undergoing clinical trials,to suppress discogenic LBP by eliminating inflammation are *** hope to attract more research interest to address inflammation and pain in IDD and contribute to promoting more translational research.

关键词： degeneration eliminating enough

Small molecule Organic Nanostructures—Fabrication and Properties

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Journal of materials Science & Technology 2008年第4期24卷 563-568页

作者： A.B.Djurii A.m.c.Ng Kai-Yin cheung man-Kin FUNG Wai-Kin cHAN Department of Physics University of Hong KongPokfulam RoadHong KongHong Kong SARChina Department of chemistry University of Hong KongPokfulam RoadHong KongHong Kong SARChina

Organic materials are of great interest for the development of low cost electronic and optoelectronic devices. Although majority of research on organic materials is concerned with synthesis of novel compounds and organic thin films, organic nanostructures are attracting increasing interest in recent years. We briefly review different growth methods of organic nanostructures, which can be roughly divided into vapor deposition methods and self-assembly techniques in solution. Then we highlight some interesting properties of organic nanostructures, as well as possible applications, includinf field emission, electronic and optoelectronic devices.

关键词： Organic nanostructures Self-assembly Vapor deposition

Engineered polycaprolactone–magnesium hybrid biodegradable porous scaffold for bone tissue engineering

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Progress in Natural Science:materials International 2014年第5期24卷 561-567页

作者： Hoi man Wong Paul K.chu Frankie K.L.Leung kenneth m.c.cheung Keith D.K.Luk Kelvin W.K.Yeung Department of Orthopaedics and Traumatology The University of Hong Kong Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen Hospital Department of Physics and materials Science City University of Hong Kong Peking University Shenzhen Institution

In this paper, we describe the fabrication of a new biodegradable porous scaffold composed of polycaprolactone(PcL) and magnesium(mg)m.c.o-particles. The compressive modulus of PcL porous scaffold was increased to at least 150% by incorporating 29% mg particles with the porosity of 74% using m.c.o-cT analysis. Surprisingly, the compressive modulus of this scaffold was further increased to at least 236% when the silane-coupled mg particles were added. In terms of cell viability, the scaffold modified with mg particles significantly convinced the attachment and growth of osteoblasts as compared with the pure PcL scaffold. In addition, the hybrid scaffold was able to attract the formation of apatite layer over its surface after 7 days of immersion in normal culture medium, whereas it was not observed on the pure PcL scaffold. This in vitro result indicated the enhanced bioactivity of the modified scaffold. moreover, enhanced bone forming ability was also observed in the rat model after 3 months of implantation. Though bony in-growth was found in all the implanted scaffolds. High volume of new bone formation could be found in the mg/PcL hybrid scaffolds when compared to the pure PcL scaffold. Both pure PcL and mg/PcL hybrid scaffolds were degraded after 3 months. However, no tissue inflammation was observed. In conclusion, these promising results suggested that the incorporation of mg m.c.o-particles into PcL porous scaffold could significantly enhance its m.c.anical and biological properties. This modified porous bio-scaffold may potentially apply in the surgical management of large bone defect fixation.

关键词： magnesium Polycaprolactone Biodegradability Biocompatibility m.c.anical properties

Is there an anatom.c.l endophenotype for neurodevelopmental disorders? A review of dual disorder anatom.c.l likelihood estimation (ALE) meta-analyses of grey matter volumes

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chinese Science Bulletin 2011年第32期56卷 3376-3381页

作者： mcALONAN Grainne m YU Kevin K cHAN Raymond c K cHUA Siew E cheung charlton Department of Psychiatry the University of Hong Kong State Key Laboratory for Brain and cognitive Sciences the University of Hong Kong Neuropsychology and Applied cognitive Neuroscience Laboratory Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences

The term "neurodevelopmental disorder" broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of genetic and environmental risk factors postulated to lead to common difficulties in socio-emotional processing, communication and cognitive function. The alternative position is that, while the same traits are affected across these conditions, the nature or direction in which they are modified may be distinct. mRI studies provide a rapidly expanding and rich database which we propose can be used to contribute to this debate. Anatom.c.l likelihood estimation (ALE) is a method of meta-analysis applied to voxel-based mRI studies. We have adapted this method to explore the extent to which schizophrenia and bipolar disorder and schizophrenia and autism share a common brain structural phenotype. We will review this work here and discuss whether there is sufficient other evidence to justify a common framework for further research into the inter-relatedness of such conditions.

关键词：神经疾病似然估计审查工作解剖精神分裂症稳定质数进修

mass budgets of the Lambert, mellor and Fisher Glaciers and basal fluxes beneath their flowbands on Amery Ice Shelf

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Science china Earth Sciences 2007年第11期50卷 1693-1706页

作者： kenneth c. JEZEK Beata m. cSATHó Ute c. HERZFELD Katy L. FARNESS Philippe HUYBREcHTS Byrd Polar Research center The Ohio State University Columbus OH 43210 USA cIRES/NSIDc University of Colorado Boulder Boulder CO 80309-0449 USA Departement Geografie Vrije Universiteit Brussel Pleinlaan 2 B-1050 Brussels Belgium Alfred-Wegener-Institut für Polar-und Meeresforschung Postfach 120161 D-27515 Bremerhaven Germany

We used in situ measurements and remote-sensing data sets to evaluate the mass budgets of the Lambert, mellor and Fisher Glaciers and the basal melting and freezing rates beneath their flowbands on the Amery Ice Shelf. Our findings show the Lambert and mellor Glaciers upstream of the ANARE Lambert Glacier Basin (LGB) traverse may have positive imbalances of 3.9±2.1 Gt a-1 and 2.1±2.4 Gt a-1, respectively, while the Fisher Glacier is approximately in balance. The upstream region as a whole has a positive imbalance of 5.9±4.9 Gt a-1. The three same glaciers downstream of the ANARE LGB traverse line are in negative imbalance, where the whole downstream region has a negative imbalance of -8.5±5.8 Gt a-1. Overall the mass budgets of the Lambert, mellor, and Fisher Glaciers are close to bal-ance, and the collective three-glacier system is also nearly in balance with a mass budget of -2.6±6.5 Gt a-1. The significant positive imbalances for the interior basin upstream of the ice-movement stations established in the early 1970s (GL line) reported previously are possibly due to an overestimate of the total accumulation and an underestimate of the ice flux through the GL line. The mean melting rate is -23.0±3.5 m ice a-1 near the southern grounding line, which decreases rapidly downstream, and transitions to refreezing at around 300 km from the southern extremity of the Amery Ice Shelf. Freezing rates along the flowbands are around 0.5±0.1 to 1.5±0.2 m ice a-1. The per-centage of ice lost from the interior by basal melting beneath the flowbands is about 80%±5%. The total basal melting and refreezing beneath the three flowbands is 50.3±7.5 Gt ice a-1 and 7.0±1.1 Gt ice a-1, respectively. We find a m.c. larger total basal melting and net melting than the results for the whole Amery Ice Shelf derived from previous modeling and oceanographic measurements.

关键词： mass budget basal melting and freezing Lambert Glacier Basin Amery Ice Shelf East Antarctica

Stepwise 3D-spatio-temporal magnesium.c.tionic niche: Nanocomposite scaffold mediated m.c.oenvironment for modulating intramembranous ossification

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Bioactive materials 2021年第2期6卷 503-519页

作者： Jie Shen Bo chen Xinyun Zhai Wei Qiao Shuilin Wu Xuanyong Liu Ying Zhao changshun Ruan Haobo Pan Paul K.chu kenneth m.c.cheung Kelvin W.K.Yeung Department of Orthopaedics and Traumatology The University of Hong KongHong KongChina Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma Department of Orthopaedics and Traumatologythe University of Hong Kong-Shenzhen HospitalShenzhenChina Shanghai Institute of Traumatology and Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesRuijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina School of materials Science and Engineering Nankai UniversityTianjinChina School of materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjinChina ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science&EngineeringHubei UniversityWuhanChina State Key Laboratory of High Performance ceram.c. and Superfine m.c.ostructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghaiChina cixi center of Biomaterials Surface Engineering Shanghai Institute of CeramicsChinese Academy of SciencesNingboChina center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina Department of Physics Department of Materials Science&Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong KongChina

The fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chem.c.l,biological,or physical cues within a local tissue *** understanding of how mammalian cells react to local tissue m.c.oenvironment is paramount important when designing next generation of biomaterials for tissue *** study aims to investigate that the regulation of magnesium.c.tionic(mg^2+)tissue m.c.oenvironment is able to convince early-stage bone regeneration and its m.c.anism undergoes intramembranous *** was discovered that moderate mg^2+content niche(~4.11 mm)led to superior bone regeneration,while mg^2+-free and strong mg^2+content(~16.44 mm)discouraged cell adhesion,proliferation and osteogenic differentiation,thereby bone formation was rarely *** magnesium ions diffused into free mg zone from.c.ncentrated zone in late time point,new bone formation on free mg zone became significant through intramembranous *** study successfully demonstrates that magnesium.c.tionic m.c.oenvironment serves as an effective biochem.c.l cue and is able to modulate the process of bony tissue *** knowledge of how a mg^2+cationic m.c.oenvironment intertwines with cells and subsequent bone formation gained from this study may provide a new insight to develop the next generation of tissuerepairing biomaterials.

关键词： Nanocomposite magnesium ion m.c.oenvironment 3D scaffold Bone tissue regeneration