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Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis

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World Journal of Gastroenterology 2024年第13期30卷 1871-1886页

作者： Kentaro Kojima kenji Watanabe Mikio Kawai Soichi Yagi Koji Kaku Maiko Ikenouchi Toshiyuki sato Koji Kamikozuru Yoko Yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Department of Gastroenterology Hyogo Medical UniversityNishinomiya 663-8501Japan Department of Gastroenterology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Internal Medicine for Inflammatory Bowel Disease The University of ToyamaToyama 930-0194Japan Center for Clinical Research and Education Hyogo Medical UniversityNishinomiya 663-8501Japan

BACKGROUND Real-world data on tofacitinib(TOF)covering a period of more than 1 year for a sufficient number of Asian patients with ulcerative colitis(UC)are *** To investigate the long-term efficacy and safety of TOF treatment for UC,including clinical *** We performed a retrospective single-center observational analysis of 111 UC patients administered TOF at Hyogo Medical University as a tertiary inflammatory bowel disease *** consecutive UC patients who received TOF between May 2018 and February 2020 were *** were followed up until August *** primary outcome was the clinical response rate at week *** outcomes included clinical remission at week 8,cumulative persistence rate of TOF administration,colectomy-free survival,relapse after tapering of TOF and predictors of clinical response at week 8 and week *** The clinical response and remission rates were 66.3%and 50.5%at week 8,and 47.1%and 43.5%at week 48,*** overall cumulative clinical remission rate was 61.7%at week 48 and history of anti-tumor necrosis factor-alpha(TNF-α)agents use had no influence(P=0.25).The cumulative TOF persistence rate at week 48 was significantly lower in patients without clinical remission than in those with remission at week 8(30.9%vs 88.1%;P<0.001).Baseline partial Mayo Score was significantly lower in responders vs non-responders at week 8(odds ratio:0.61,95%confidence interval:0.45-0.82,P=0.001).Relapse occurred in 45.7%of patients after TOF tapering,and 85.7%of patients responded within 4 wk after *** 6 patients with herpes zoster(HZ)developed the infection after achieving remission by *** TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α*** relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off *** attention is needed for tapering and H

关键词： Ulcerative colitis Tofacitinib Janus kinase inhibitor Real-world Biologics

Semiconductor Optical Amplifier and Gain Chip Used in Wavelength Tunable Lasers

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ZTE Communications 2021年第3期19卷 81-87页

作者： sato kenji ZHANG Xiaobo ZTE Photonics Nanjing 210000China Southeast University Nanjing 211189China

The design concept of semiconductor optical amplifier(SOA)and gain chip used in wavelength tunable lasers(TL)is discussed in this *** design concept is similar to that of a conventional SOA or a laser;however,there are a few different *** SOA in front of the tunable laser should be polarization dependent and has low optical confinement *** obtain wide gain bandwidth at the threshold current,the gain chip used in the tunable laser cavity should be something between SOA and fixed-wavelength laser design,while the fixed-wavelength laser has high optical confinement *** discussion is given with basic equations and some simulation results on saturation power of the SOA and gain bandwidth of gain chip are shown.

关键词： external cavity gain chip saturation power semiconductor optical amplifier tunable laser

Feedback Effects of Mirror Loss in λ/8 Phase-Shifted DFB-LDs

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Feedback Effects of Mirror Loss in λ/8 Phase-Shifted DFB-LD...

Effects of docosahexaenoic acid or arachidonic acid supplementation on the behavior of cardiomyocytes derived from human pluripotent stem cells

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作者： Yidong Huang Tetsuro Okuda kenji sato Yoshiharu Muroya Kenichi Kobayashi Kansai Electronics Research Laboratory NEC Corporation Kansai Electronics Research Laboratory NEC Corporation Kansai Electronics Research Laboratory NEC Corporation Kansai Electronics Research Laboratory NEC Corporation Kansai Electronics Research Laboratory NEC Corporation

Fedback effects of mheor loss (FEML) in DFB-LDs ware demonstwd for the first time. By changingthe phase-shift in DFB-LDs, we contrlled successfullythe lasing wavelength deviation from *** Bragg deviation dependence of theFEML was clarified theoretically and *** relative intensity noise in λ/8 phase-shiftedDFB-LDs under external optical feedback proved thatnegative FEML could make the DFB-LDs more stableand insensitive to external fluctalions.

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BIOCELL 2023年第5期47卷 1095-1106页

作者： MIZUNA YANO KOTA HIROI TETSUYA YUASA kenji INOUE OSAMU YAMAMOTO TAKAO NAKAMURA DAISUKE sato ZHONGGANG FENG Graduate School of Science and Engineering Yamagata UniversityYonezawa9928510Japan Faculty of Health Sciences Japan Healthcare UniversitySapporo0620053Japan

Background:Human heart changes its energetic substrates from lactate and glucose to fatty acids during the neonatal *** the lack of fatty acids in media for the culture of cardiomyocytes derived from human pluripotent stem cells(hiPS-CM),researchers have supplemented mixtures of fatty acids to hiPS-CM and reported the enhancement in the maturation of *** our previous studies,we separately supplemented two polyunsaturated fatty acids(PUFAs),docosahexaenoic acid(DHA)or arachidonic acid(AA),to rat fetal cardiomyocytes and found that the supplementations upregulated the expressions of mRNAs for cardiomyocyte differentiation,fatty acid metabolism,and cellular *** enhancement in cellular contractility was attributed to the improvement in intercellular connection rather than a direct enhancement of the contractile ***:This study reports the successive results of the effects of DHA or AA supplementation on *** addition to the contractile force and mRNA measurements used in the previous study,we further investigated the effect of different cellular aggregations on the contractile force output by means of finite element analysis,measured glucose and fatty acids metabolites,and assessed cTNT and MLC2v expressions through immunofluorecsence ***:It showed that the sole supplementation of albumin-conjugated DHA or AA can be taken up by hiPS-CM without other uptake-enhancing factors,and the supplementations may activate the CD36_ERRγmetabolic *** or AA supplementation increased the cellular contractile ratio on collagen gels and AA supplementation stimulated hiPS-CM aggregation to form cellular *** enhancement effect on the hiPS-CM contractile force was modest since the increase in contractile force was not *** supplementation was more effective than DHA supplementation because it significantly upregulated mRNA expressions of P300 and ***,finite element analysis showed that the formati

关键词： Human iPS cells Cardiomyocytes Polyunsaturated fatty acid mRNA expression Contractility Fatty acid metabolism

数种鱼类肌肉里可溶于酸的胶原蛋白中的羟基脯氨酸含量

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生物资源 1991年第2期 58-58页

作者： kenji sato 黄权

在本文中,作者叙述了从表1所列的22种鱼类肌肉里分离出的酸溶胶原蛋白中的羟基脯氨酸含量。作者提出了一种分析肌肉里胶原蛋白含量的简化方法,一是以从鱼肉中分离出的胶原蛋白量为基础;二是以肌肉组织水解出的羟基脯氨酸含量为基础。制... 详细信息

在本文中,作者叙述了从表1所列的22种鱼类肌肉里分离出的酸溶胶原蛋白中的羟基脯氨酸含量。作者提出了一种分析肌肉里胶原蛋白含量的简化方法,一是以从鱼肉中分离出的胶原蛋白量为基础;二是以肌肉组织水解出的羟基脯氨酸含量为基础。制备出的酸溶胶原蛋白,先通过蒸馏水彻底渗析,然后冻干。按照Laemmli的方法,根据胶

关键词：胶原蛋白冻干脯氨酸含量鱼类水生动物

Treatment strategy for pancreatic head cancer with celiac axis stenosis in pancreaticoduodenectomy:A case report and review of literature

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World Journal of Gastroenterology 2022年第8期28卷 868-877页

作者： Eiji Yoshida Yasutoshi Kimura Takuro Kyuno Ryoko Kawagishi Kei sato Tsuyoshi Kono Takehiro Chiba Toshimoto Kimura Hitoshi Yonezawa Osamu Funato Makoto Kobayashi kenji Murakami Akinori Takagane Ichiro Takemasa Department of Surgery Hakodate Goryoukaku HospitalHakodate City 040-8611Japan Department of Surgery Surgical Oncology and ScienceSapporo Medical UniversitySapporo City 060-8543HokkaidoJapan Department of Diagnostic Radiology Hakodate Goryoukaku HospitalHakodate City 040-8611Japan

BACKGROUND During pancreaticoduodenectomy in patients with celiac axis(CA)stenosis due to compression by the median arcuate ligament(MAL),the MAL has to be divided to maintain hepatic blood flow in many ***,MAL division often fails,and success can only be determined *** overcome this problem,we performed endovascular CA stenting preoperatively,and thereafter safely performed *** present this case as a new preoperative treatment strategy that was *** SUMMARY A 77-year-old man with a diagnosis of pancreatic head cancer presented to our department for *** assessment revealed CA stenosis caused by *** performed endovascular stenting in the CA preoperatively because we knew that going into the operation without a strategy could lead to ischemic ***-antiplatelet therapy(DAPT)–which is needed when a stent is inserted–was then administered in parallel with neoadjuvant chemotherapy(NAC).This allowed us to administer DAPT for a sufficient period before the main pancreaticoduodenectomy procedure while obtaining therapeutic effects from *** stomach-preserving pancreaticoduodenectomy was *** operation did not require any unusual techniques and was performed ***,the patient progressed well,without any ischemic ***,curative resection was confirmed,and the patient had no recurrence or complications due to ischemia up to six months *** Preoperative endovascular stenting,with NAC and DAPT,is effective and safe prior to pancreaticoduodenectomy in potentially resectable pancreatic cancer.

关键词： Pancreaticoduodenectomy Celiac axis stenosis Median arcuate ligament Endovascular stenting Pancreatic head cancer Case report

Comparison of the low-density lipoprotein cholesterol target value and the preventive effect of statins in elderly patients and younger patients

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Journal of Geriatric Cardiology 2017年第6期14卷 383-391页

作者： Akihiro Endo Taiji Okada Misun Pak Yuzo Kagawa Shimpei Ito Hirotomo sato kenji Kageshima Yasuyuki Yoshida Kazuaki Tanabe Division of Cardiology Shimane University Faculty of Medicine Izumo Japan Division of Cardiology Tottori Prefectural Central Hospital Tottori Japan

ObjectiveTo 估计低密度的脂蛋白胆固醇(LDL-C ) 目标价值和 statins 的预防效果是否在调查的老、更年轻的 *** 之间是不同的在早狭窄以外为周期性的局部缺血的检查从 2007 年 1 月经历了冠的 angiography 到 2016年12月的有以前的经皮... 详细信息

ObjectiveTo 估计低密度的脂蛋白胆固醇(LDL-C ) 目标价值和 statins 的预防效果是否在调查的老、更年轻的 *** 之间是不同的在早狭窄以外为周期性的局部缺血的检查从 2007 年 1 月经历了冠的 angiography 到 2016年12月的有以前的经皮的冠的干预的 304 个病人。病人们被分类进二个组：年龄 75 年(老组：n = 140 ) 并且 < 75 年(更年轻的组：n = 164 ) 。在完成的 LDL-C 水平之间的关系，发生 statins 的近来冠的事件，和有效性是 *** 后续， 179 个病人经历了晚冠的 revascularization。周期性的局部缺血作为急性冠的症候群(交流) 介绍发生在 83 种情况中。Kaplan-Meier 曲线分析在更年轻的组，揭示了那周期性的交流在有 LDL-C 的病人是显著地更低的 < 70 mg/dL 比在那些与 LDL-C 从 70 到 < 100 mg/dL (P = 0.035 ) ；然而，在老组这些之间没有差别(P = 0.863 ) 。相反，周期性的交流在有 LDL-C 从 70 mg/dL 到的病人是不太经常的 < 100 mg/dL 比在那些与在老组的 LDL-C 100 mg/dL (P = 0.033 ) 。Statin 使用与减少的周期性的交流被联系(P = 0.005 ) ；而且，仅仅使用 statins 是在老组的一个独立预言者(HR：0.375；P = 0.007 ) LDL-C 到的 .ConclusionsStrict 控制 < 70 mg/dL 为在更年轻的病人减少周期性的交流的发生是有效的。然而， LDL-C < 100 mg/dL 可能作为为在日本老病人的 ischemic 事件的第二等的预防的 LDL-C-lowering 治疗的目标价值足够。

关键词：低密度脂蛋白胆固醇他汀类药物预防作用老年人患者急性冠状动脉综合征冠状动脉造影介入治疗

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Open Journal of Epidemiology 2013年第2期3卷 33-39页

作者： Susumu sato Shinichi Demura Toshiro sato kenji Takahashi Graduate School of Natural Science and Technology Kanazawa University Kanazawa Japan Kanazawa Institute of Technology Nonoichi Japan Niigata University of Health and Welfare Niigata Japan Teikyo Heisei University Ichihara Japan

This study aimed to determine age-related fall risk characteristics among 2324 Japanese community-dwelling elderly through comparisons between young-old and old-old populations. Fall risk characteristics associated with “physical function”, “disease and physical symptom”, “behavior and character”, and “environment” were evaluated, and whether each individual has a high-risk symptom for each risk factor was assessed. The frequencies of individuals for all 16 risk types, which were determined by a combination of the four risk factors, were calculated. The prevalence of each risk type and the incidence of falling in each risk type were calculated within the young-old and old-old groups, and significant differences between these percentages were examined using the chi-square test. The prevalence of the no high-risk symptom group was significantly lower in the old-old group (17.0%) than in the young-old group (45.2%). Although there was no significant difference in the prevalence of the single high-risk symptom group, the prevalence of the two or more high-risk symptom groups was significantly higher in the old-old group. The incidence of fall among the elderly with high-risk symptoms did not change with age, although the incidence of fall with no high-risk symptom increased in the old-old group. Furthermore, high prevalence was observed in risk types with high-risk symptoms for “physical function” and “behavior and character”, particularly in the symptoms of gait, going up and down stairs, and fear of falling. These age-related differences are interesting and meaningful.

关键词： Prevalence of High-Risk Symptom Incidence of Fall Fall Risk Type

Synthesis of P(NIPAM-co-Am)/Mesoporous Silica Composites and Their Temperature- Responsive Anion Exchange

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Journal of Materials Science and Chemical Engineering 2015年第7期3卷 7-15页

作者： kenji Murakami Yasuto sato Yukihiko Inoue Department of Materials Science Faculty of Engineering Science Akita University Akita City Japan

The purpose of this study is to examine the structure and the temperature-responsive anion exchange property of amino-functionalized mesoporous silica coated with temperature-responsive copolymer, poly(N-isopropylacrylamide-co-acrylamide) (P(NIPAM-co-Am)). For this purpose, the composites which contained 0, 10, or 20 wt% of Am were synthesized. From the TG results, it was found that the amounts of copolymer immobilized on the mesoporous silica were 1.6 - 2.6 wt%. XRD patterns revealed that the structures of composites were hexagonal and almost the same as that of original mesoporous silica without polymer. At low temperature the methyl orange (MO) anions adsorbed and desorbed reversibly with changing pH of the solution, while at high temperature the MO anions did not. This temperature, at which the amount of adsorbed MO anions changed considerably, shifted to the higher temperature side with increasing the amount of added Am.

关键词： Mesoporous Silica Temperature-Responsive Anion Exchanger N-Isopropylacrylamide Acrylamide Transition Temperature