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Endosonographic surveillance of 1-3 cm gastric submucosal tumors originating from muscularis propria

World Journal of Gastroenterology 2017年第12期23卷 2194-2200页

作者： ming-luen hu keng-liang wu chi-sin changchien seng-kee chuah yi-chun chiu division of hepato-gastroenterology department of internal medicine kaohsiung chang gung memorial hospital and chang gung university college of medicine

AIM To observe the natural course of 1-3 cm gastric submucosal tumors originating from the muscularis propria(SMTMPs).METHODS By reviewing the computerized medical records over a period of 14 years(2000-2013), patients with 1-3 cm gastric SMTMPs who underwent at least two endoscopic ultrasound(EUS) examinations were enrolled. Tumor progression was defined as a ≥ 1.2 times enlargement in tumor diameter observed during EUS surveillance. All patients were divided into stationary and progressive subgroups and further analyzed. We also reviewed the patients in the progressive subgroup again in *** A total of 88 patients were studied, including 25 in the progressive subgroup. The mean time of EUS surveillance was 24.6 mo in the stationary subgroup and 30.7 mo in the progressive subgroup. Risk factors for tumor progression included larger tumor size and irregular border. Initial tumor size > 14.0 mm may be considered a cut-off size for predicting tumor progression. Seventeen patients underwent surgery, of whom 13 had gastrointestinal stromal tumors(GISTs) and 4 had leiomyomas. Tumor progression was found only in patients with GISTs. All of the tumors exhibited benign behaviors without metastasis until *** Most 1-3 cm gastric SMTMPs(71.6%) are indolent. Tumor progression was found only in GISTs, and it is a good predictor for differentiating GISTs from leiomyomas. Predictors of tumor progression include larger tumor size(> 14.0 mm) and irregular border.

关键词： Gastrointestinal stromal tumor Submucosal tumors originating from the muscularis propria Stomach Endosonographic surveillance

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Current status in the treatment options for esophageal achalasia

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World Journal of Gastroenterology 2013年第33期19卷 5421-5429页

作者： Seng-Kee Chuah Chien-Hua Chiu Wei-Chen Tai Jyong-Hong Lee Hung-I Lu Chi-Sin Changchien Ping-Huei Tseng keng-liang wu Gastrointestinal Motility Unit Division of HepatogastroenterologyKaohsiung Chang Gung Memorial Hospitaland Chang Gung University College of Medicine Division of General Medicine Department of MedicineKaohsiung Chang Gung Memorial Hospitaland Chang Gung University College of Medicine Digestive Disease Center Department of Medical ResearchShow-Chwan Memorial Hospital Division of Thoracic and Cardiovascular Surgery Kaohsiung Chang Gung Memorial Hospital Department of Internal Medicine Graduate Institute of Clinical MedicineNational Taiwan University Hospital and College of MedicineNational Taiwan University

Recent advances in the treatment of achalasia include the use of high-resolution manometry to predict the outcome of patients and the introduction of peroral endoscopic myotomy(POEM).The first multicenter randomized,controlled,2-year follow-up study conducted by the European Achalasia Trial group indicated that laparoscopic Heller myotomy(LHM)was not superior to pneumatic dilations(PD).Publications on the long-term success of laparoscopic surgery continue to *** addition,laparoscopic single-site surgery is applicable to advanced laparoscopic operations such as LHM and anterior *** optimal treatment option is an ongoing matter of *** this review,we provide an update of the current progress in the treatment of esophageal *** new conclusive data prove otherwise,LHM is considered the most durable treatment for achalasia at the expense of increased reflux-associated ***,PD is the first choice for non-surgical treatment and is more *** PD according to an"on-demand"strategy based on symptom recurrence can achieve long-term *** making should be based on clinical evidence that identifies a subcategory of patients who would benefit from specific treatment *** has shown promise but its long-term efficacy and safety need to be assessed further.

关键词： Esophageal achalasia Endoscopic pneumatic dilations Botulinum injection Peroral endoscopic myotomy Minimally invasive Heller myotomy

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2011 update on esophageal achalasia

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World Journal of Gastroenterology 2012年第14期18卷 1573-1578页

作者： Seng-Kee Chuah Pin-I Hsu keng-liang wu Deng-Chyang wu Wei-Chen Tai Chi-Sin Changchien Division of Gastroenterology Kaohsiung ChangGung Memorial Hospital College of Medicine Chang GungUniversity Kaohsiung 833 Taiwan Division of Gastroenterology Department of Inter-nal Medicine Kaohsiung Veterans General Hospital NationalYang-Ming University Kaohsiung 813 Taiwan Cancer Center Division of Gastroenterol-ogy Department of Internal Medicine Kaohsiung MedicalUniversity Hospital Kaohsiung Medical University Kaohsiung807 Taiwan

There have been some breakthroughs in the diagnosis and treatment of esophageal achalasia in the past few ***,the introduction of high-resolution manometry with pressure topography plotting as a new diagnostic tool has made it possible to classify achalasia into three *** most favorable outcome is predicted for patients receiving treatment for type Ⅱ achalasia (achalasia with compression).Patients with typeⅠ(classic achalasia) and type Ⅲ achalasia (spastic achalasia) experience a less favorable ***,the first multicenter randomized controlled trial published by the European Achalasia Trial group reported 2-year follow-up results indicating that laparoscopic Heller myotomy was not superior to endoscopic pneumatic dilation (PD).Although the follow-up period was not long enough to reach a convincing conclusion,it merits the continued use of PD as a generally available technique in ***,the novelendoscopic technique peroral endoscopic myotomy is a promising option for treating achalasia,but it requires increased experience and cautious *** all this good news,the bottom line is a real break-through from the basic studies to identify the actual cause of achalasia that may impede treatment success is still anticipated.

关键词： Esophageal achalasia High resolution manometry Endoscopic pneumatic dilations Minimally invasive surgical procedures Peroral endoscopic myotomy

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Trousseau's syndrome in a patient with advanced stage gastric cancer

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World Journal of Gastroenterology 2015年第34期21卷 10049-10053页

作者： Tai-Long Chien Kung-Ming Rau Wen-Jung Chung Wei-Chen Tai Shih-Ho Wang Yi-Chun Chiu keng-liang wu Yeh-Pin Chou Chia-Che wu Yen-Hao Chen Seng-Kee Chuah Division of Gastroenterology Department of Internal MedicinePin-Tung An-Tai Hospital Division of Oncology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Division of Cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Division of Hepatogastroenterology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Division of General Surgery Department of SurgeryKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine

Patients with cancer are at high risk for thrombotic events,which are known collectively as Trousseau's syndrome. Herein,we report a 66-year-old male patient who was diagnosed with terminal stage gastric cancer and liver metastasis and who had an initial clinical presentation of upper gastrointestinal bleeding. Acute ischemia of the left lower leg that resulted in gangrenous changes occurred during admission. Subsequent angiography of the left lower limb was then performed. This procedure revealed arterial thrombosis of the left common iliac artery with extension to the external iliac artery,the left common iliac artery,the posterior tibial artery,and the peroneal artery,which were occluded by thrombi. Aspiration of the thrombi demonstrated that these were not tumor thrombi. The interesting aspect of our case was that the disease it presented as arterial thrombotic events,which may correlate with gastric adenocarcinoma. In summary,we suggested that the unexplained thrombotic events might be one of the initial presentations of occult malignancy and that thromboprophylaxis should always be considered.

关键词： Gastric cancer Arterial thrombotic events Troussea

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First-week clinical responses to dexlansoprazole 60 mg and esomeprazole 40 mg for the treatment of grades A and B gastroesophageal reflux disease

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World Journal of Gastroenterology 2017年第47期23卷 8395-8404页

作者： Chih-Ming liang Ming-Te Kuo Pin-I Hsu Chao-Hung Kuo Wei-Chen Tai Shih-Cheng Yang keng-liang wu Hsing-Ming Wang Chih-Chien Yao Cheng-En Tsai Yao-Kuang Wang Jiunn-Wei Wang Chih-Fang Huang Deng-Chyang wu Seng-Kee Chuah 无 Division of Hepato-Gastroenterology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Division of Gastroenterology Department of Internal MedicineKaohsiung Veterans General HospitalNational Yang-Ming University Division of Gastroenterology Department of Internal MedicineKaohsiung Medical University Hospital and Kaohsiung Medical University Division of Family Physicians Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taiwan Acid-Related Disease Study Group

AIM To compare the one-week clinical effects of single doses of dexlansoprazole and esomeprazole on grades A and B erosive *** We enrolled 175 adult patients with gastroesophageal reflux disease(GERD). The patients were randomized in a 1:1 ratio into two sequence groups to define the order in which they received single doses of dexlansoprazole(n = 88) and esomeprazole(n = 87) for an intention-to-treat analysis. The primary endpoints were the complete symptom resolution(CSR) rates at days 1, 3, and 7 after drug *** Thirteen patients were lost to follow-up, resulting in 81 patients in each group for the per-protocol analysis. The CSRs for both groups were similar at days 1, 3 and 7. In the subgroup analysis, the female patients achieved higher CSRs in the dexlansoprazole group than in the esomeprazole group at day 3(38.3% vs 18.4%, P = 0.046). An increasing trend toward a higher CSR was observed in the dexlansoprazole group at day 7(55.3% vs 36.8%, P = 0.09). In the esomeprazole group, female sex was a negative predictive factor for CSR on post-administration day 1 [OR =-1.249 ± 0.543; 95%CI: 0.287(0.099-0.832), P = 0.022] and day 3 [OR =-1.254 ± 0.519; 95%CI: 0.285(0.103-0.789), P = 0.016]. Patients with spicy food eating habits achieved lower CSRs on day 1 [37.3% vs 21.4%, OR =-0.969 ± 0.438; 95%CI: 0.380(0.161-0.896), P = 0.027]. CONCLUSION The overall CSR for GERD patients was similar at days 1-7 for both the dexlansoprazole and esomeprazole groups, although a higher incidence of CSR was observed on day 3 in female patients who received a single dose of dexlansoprazole.

关键词： Dexlansoprazole Esomeprazole Oneweek response Complete symptom resolution rate Gastroesophageal reflux disease

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Effect of ginger on gastric motility and symptoms of functional dyspepsia

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World Journal of Gastroenterology 2011年第1期17卷 105-110页

作者： Ming-Luen Hu Christophan K Rayner keng-liang wu Seng-Kee Chuah Wei-Chen Tai Yeh-Pin Chou Yi-Chun Chiu King-Wah Chiu Tsung-Hui Hu Division of Hepatogastroenterology Department of Internal Medicine Chang Gung Memorial Hospital- Kaohsiung Medical Center Chang Gung University College of Medicine Kaohsiung 83301 Taiwan Discipline of Medicine University ofAdelaide Royal Adelaide Hospital Adelaide SA 5000 Australia

AIM:To evaluate the effects of ginger on gastric motility and emptying,abdominal symptoms,and hormones that influence motility in ***:Eleven patients with functional dyspepsia were studied twice in a randomized double-blind *** an 8-h fast,the patients ingested three capsules that contained ginger(total 1.2 g) or placebo,followed after 1 h by 500 mL low-nutrient *** area,fundus area and diameter,and the frequency of antral contractions were measured using ultrasound at frequent intervals,and the gastric half-emptying time was calculated from the change in antral *** sensations and appetite were scored using visual analog questionnaires,and blood was taken for measurement of plasma glucagon-like peptide-1(GLP-1),motilin and ghrelin concentrations,at intervals throughout the ***:Gastric emptying was more rapid after ginger than placebo [median(range) half-emptying time 12.3(8.5-17.0) min after ginger,16.1(8.3-22.6) min after placebo,P ≤ 0.05].There was a trend for more antral contractions(P = 0.06),but fundus dimensions and gastrointestinal symptoms did not differ,nor did serum concentrations of GLP-1,motilin and ***:Ginger stimulated gastric emptying and antral contractions in patients with functional dyspepsia,but had no impact on gastrointestinal symptoms or gut peptides.

关键词： Ginger(Zinger offinale) Functional dyspepsia Gastric emptying Antral contraction Abdominal ultrasound Ghrelin Glucagon-like peptide-1 Motilin

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Upper gastrointestinal carcinoid tumors incidentally found by endoscopic examinations

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World Journal of Gastroenterology 2005年第44期11卷 7028-7032页

作者： Tsung-Hui Hu Chung-Mou Kuo King-Wah Chiu Chung-Huang Kuo keng-liang wu Yeh-Pin Chou Sheng-Nan Lu Shue-Shian Chiou Chi-Sin Changchien Hock-Liew Eng Department of Hepato-Gastroenterology Chang Gung Memorial Hospital 123 Ta-Pei Road Niao-sung Hsiang Kaohsiung HsienTaiwan China Department of Pathology Chang Gung Memorial Hospital 123 Ta-Pei Road Niao-sung Hsiang Kaohsiung HsienTaiwan China

AIM: This study shares Asian clinical experiences of carcinoid tumors that originated in the upper gastrointestinal ***: From May 1987 to June 2002, we had found only 13 cases of histologically confirmed carcinoid tumors in the upper gastrointestinal tract by endoscopic examinations. There were eight males and five *** mean age was 53.16±20.51 years that ranged from 26 to 82 years. Each of their clinical presentations,locations, tumor morphology, and size and the treatment outcome were analyzed and ***: One patient had a polypoid lesion at the lower esophagus, nine were stomach lesions and three located at the duodenum. All patients with polypoid and submucosal tumor types were of small size (＜1.7 cm) and all patients survived after simple excision or *** of the five patients in tumor mass forms died and the tumors were more than 2.0 cm in ***: Carcinoid tumors rarely originated from the upper gastrointestinal tract and are usually found accidentally after endoscopic study. Bigger size (more than 2 cm) tumor masses may indicate a more severe disease and poor prognosis.

关键词： Upper gastrointestinal carcinoid tumors Tumor morphology Sizes Treatment courses Prognosis

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Pseudoachalasia in a patient after truncal vagotomy surgery successfully treated by subsequent pneumatic dilations

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World Journal of Gastroenterology 2006年第31期12卷 5087-5090页

作者： Seng-Kee Chuah Chung-Mou Kuo keng-liang wu Chi-Sin Changchien Tsung-Hui Hu Chi-Chih Wang Yi-Chun Chiu Yeh-Pin Chou Pin-I Hsu King-Wah Chiu Chung-Huang Kuo Shue-Shian Chiou Chuan-Mo Lee Gastrointestinal Motility UnitDivision of Hepatogastroenterology Department of Internal MedicineChang Gung Memorial HospitalChang Gung UniversityCollege of MedicineKaohsiungTaiwanChina Department of SurgeryChang Gung Memorial Hospital Chang Gung UniversityCollege of MedicineKaohsiungTaiwanChina Kaohsiung Veteran General HospitalTaiwan China

Pseudoachalasia is a difficult condition for the clinician to differentiate from idiopathic achalasia even by manometry, radiological studies or endoscopy. Its etiology is usually associated with tumors. In most cases, the diagnosis is made after surgical explorations. The proposed pathogenesis of the disease is considered as mechanical obstruction of the distal esophagus or infiltration of the malignancy that affects the inhibitory neurons of the meyenteric plexus in the majority of cases. Surgery has been reported as a cause of pseudoachalasia. We report a 70-year-old man who suffered from deglutination disorder caused by pseudo-achalasia after truncal vagotomy. The patient was symptom-free after a nine-year follow-up and complete recovery of esophageal motility status from pseudoachalasia after pneumatic dilations. We also reviewed the literature of pseudoachalasia.

关键词： Truncal vagotomy Pseudo-achalasia Deglutination disorder Pneumatic dilations Sustain reversed esophageal motility

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“Zero‑Strain” NiNb_(2)O_(6) Fibers for All‑Climate Lithium Storage

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Nano-Micro Letters 2025年第1期17卷 348-360页

作者： Yan Zhao Qiang Yuan Liting Yang Guisheng liang Yifeng Cheng Limin wu Chunfu Lin Renchao Che College of Physics Donghua UniversityShanghai 201620People’s Republic of China School of Materials Science and Engineering Institute of Materials for Energy and EnvironmentQingdao UniversityQingdao 266071People’s Republic of China Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China Inner Mongolia University Hohhot 010021People’s Republic of China

Niobates are promising all-climate Li^(+)-storage anode material due to their fast charge transport,large specific capacities,and resistance to electrolyte ***,their moderate unit-cellvolume expansion(generally 5%–10%)during Li^(+)storage causes unsatisfactory long-term ***,“zero-strain”NiNb_(2)O_(6) fibers are explored as a new anode material with comprehensively good electrochemical *** Li^(+)storage,the expansion of electrochemical inactive NiO_(6) octahedra almost fully offsets the shrinkage of active NbO_(6) octahedra through reversible O *** superior volume-accommodation capability of the NiO_(6) layers guarantees the“zero-strain”behavior of NiNb_(2)O_(6) in a broad temperature range(0.53%//0.51%//0.74%at 25//−10//60℃),leading to the excellent cyclability of the NiNb_(2)O_(6) fibers(92.8%//99.2%//91.1%capacity retention after 1000//2000//1000 cycles at 10C and 25//−10//60℃).This NiNb_(2)O_(6) material further exhibits a large reversible capacity(300//184//318 mAh g−1 at 0.1C and 25//−10//60℃)and outstanding rate performance(10 to 0.5C capacity percentage of 64.3%//50.0%//65.4%at 25//−10//60℃).Therefore,the NiNb_(2)O_(6) fibers are especially suitable for large-capacity,fast-charging,long-life,and all-climate lithium-ion batteries.

关键词： NiNb_(2)O_(6)porous fiber “Zero-strain”mechanism Electrochemical property Harsh-temperature operation Operando characterization

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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao Yuan Li Xi Liu Wenping liang Yu Li Liyong wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

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