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Overexpression of p53 predicts colorectal neoplasia risk in patients with inflammatory bowel disease and mucosa changes indefinite for dysplasia

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Gastroenterology Report 2015年第4期3卷 344-349,I0002页

作者： Bela Horvath Ganglei Liu Xianrui Wu keith k lai Bo Shen Xiuli Liu Department of Anatomic Pathology Cleveland ClinicClevelandOHUSA Department of Geriatric Surgery the Second Xiangya Hospital of Central South UniversityChangshaChina Department of Colorectal Surgery Cleveland ClinicClevelandOHUSA Department of Colorectal Surgery the Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Pathology University of Arkansas for Medical SciencesLittle RockARUSA Department of Gastroenterology/Hepatology Cleveland ClinicClevelandOHUSA

Background and aims:We previously demonstrated a significant colorectal neoplasia risk in inflammatory bowel disease(IBD)patients with mucosal changes indefinite for dysplasia(IND)and the potential diagnostic utility of p53 and cytokeratin 7 immunohistochemistry in IBD-associated *** primary aim of this exploratory study was to determine the predictive value of the two markers for neoplasia risk in the IBD-IND ***:We identified 44 eligible cases with IBD and IND in colon biopsy from our pathology *** semi-quantified the expression of p53 and cytokeratin 7 in the colon biopsies by immunohistochemistry and correlated their expression,demographic information,and clinical features with colorectal neoplasia ***:The mean age of the cohort was 46.6615.1 years,with 25(56.8%)being *** median follow-up was 101 months(range:6–247)after IND *** these 44 patients,11(25%)progressed to neoplasia(low-grade dysplasia¼6;high-grade dysplasia¼2;cancer 3)at a median follow-up of 66 months(range:19–145).Univariate analysis demonstrated that age and p53 overexpression were associated with progression to ***:Twenty-five percent of patients with IBD and IND developed colorectal dysplasia or *** of p53 and age are associated with neoplastic progression.

关键词： inflammatory bowel disease ulcerative colitis Crohn’s disease colorectal neoplasia p53 cytokeratin 7

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Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer

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World Journal of Gastroenterology 2014年第45期20卷 17037-17048页

作者： Ru Chen Sheng Pan keith lai Lisa A lai David A Crispin Mary P Bronner Teresa A Brentnall Department of Medicine University of Washington Department of Anatomic Pathology Cleveland Clinic Foundation Division of Anatomic Pathology University of Utah

AIM: To characterize tumor necrosis factor receptor-associated protein 1 (TRAP1) expression in the progression of ulcerative colitis (UC)-associated colorectal cancer.

关键词： Ulcerative colitis Colorectal cancer Inflammation Oxidative stress Tumor necrosis factor receptor-associated protein 1

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Pituitary carcinoma: Two case reports and review of literature

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World Journal of Clinical Oncology 2020年第2期11卷 91-102页

作者： lai Xu karam khaddour Jie Chen keith M Rich Richard J Perrin Jian Li Campian Divisions of Hematology and Oncology Department of MedicineWashington University School of MedicineSt.LouisMO 63110United States Department of Pathology and Immunology Washington University School of MedicineSt.LouisMO 63110United States Department of Neurological Surgery Washington University School of MedicineSt.LouisMO 63110United States

BACkGROUND Pituitary carcinoma is a rare type of malignancy that can be very difficult to diagnose and *** cases were diagnosed at *** in diagnosis often adversely impact patients’*** with prompt diagnosis,treatment decisions remain challenging in the absence of randomized controlled *** SUMMARY We report two cases of pituitary carcinoma in men with a history of pituitary *** the first case,a 55-year-old man was initially diagnosed with pituitary *** underwent subtotal debulking of the tumor followed by adjuvant ***,he developed relapsed disease and multifocal intracranial metastases and a diagnosis of pituitary carcinoma was *** passed away despite several lines of systemic therapies including temozolomide,lomustine and *** 52-year-old man was diagnosed with atypical pituitary adenoma with presentation of sudden onset of vision loss in the right *** had recurrent pituitary carcinoma with spinal metastases,treated with surgery,radiation and *** Pituitary carcinoma is a rare neoplasm with poor prognosis that is difficult to diagnose and *** small number of cases restricts our ability to design randomized clinical *** is largely driven by retrospective studies and case *** molecular biomarkers and comprehensive genomic profiling could help in decisions about diagnosis and management of pituitary carcinoma.

关键词： Pituitary carcinoma Diagnosis Treatment Pituitary adenoma Temozolomide Case report

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The Hong kong consensus recommendations on the diagnosis and management of pancreatic cystic lesions

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 715-735,I0019-I0020页

作者： Tan-To Cheung Yuk Tong Lee Raymond Shing-Yan Tang Wong Hoi She kai Chi Cheng Chin Cheung Cheung keith Wan Hang Chiu kenneth Siu Ho Chok Wing Sun Chow Tak Wing lai Wai-kay Seto Thomas Yau Department of Surgery Queen Mary HospitalThe University of Hong KongHong KongChina Gastroenterologist in private practice Hong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Department of Surgery Kwong Wah HospitalHong KongChina Department of Surgery Tuen Mun HospitalHong KongChina Department of Radiology&Imaging Queen Elizabeth HospitalHong KongChina Department of Medicine The University of Hong KongHong KongChina Department of Surgery Princess Margaret HospitalHong KongChina Department of Medicine School of Clinical MedicineThe University of Hong KongHong KongChina State key Laboratory of Liver Research The University of Hong KongHong KongChina

Background:The finding of pancreatic cystic lesions(PCL)on incidental imaging is becoming increasingly *** studies report a prevalence of 2.2-44.7%depending on the population,imaging modality and indication for imaging,and the prevalence increases with *** with PCL are at risk of developing pancreatic cancer,a disease with a poor *** publication summarizes recommendations for the diagnosis and management of PCL and post-operative pancreatic exocrine insufficiency(PEI)from a group of local ***:Clinical evidence was consolidated from narrative reviews and consensus statements formulated during two online meetings in March *** expert panel included gastroenterologists,hepatobiliary surgeons,oncologists,radiologists,and ***:Patients with PCL require careful investigation and follow-up due to the risk of malignant transformation of these *** should undergo clinical investigation and pancreas-specific imaging to classify lesions and understand the risk profile of the *** indicated,patients should undergo pancreatectomy to excise *** pancreatectomy,patients are at risk of PEI,leading to gastrointestinal dysfunction and ***,such patients should be monitored for symptoms of PEI,and promptly treated with pancreatic enzyme replacement therapy(PERT).Patients with poor response to PERT may require increases in dose,addition of a proton pump inhibitor,and/or further investigation,including tests for pancreatic *** are also at risk of new-onset diabetes mellitus after pancreatectomy;they should be screened and treated with insulin if ***:These statements are an accurate summary of our approach to the diagnosis and management of patients with PCL and will be of assistance to clinicians treating these patients in a similar clinical landscape.

关键词： Pancreatic cystic lesions pancreatic endocrine insufficiency pancreatic enzyme replacement therapy

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A brain structural connectivity biomarker for autism spectrum disorder diagnosis in early childhood

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Psychoradiology 2023年第1期3卷 171-181页

作者： Xi Jiang Xiao-Jing Shou Zhongbo Zhao Yuzhong Chen Fan-Chao Meng Jiao Le Tian-Jia Song Xin-Jie Xu Weitong Guo Xiaoyan ke Xiao-E Cai Weihua Zhao Juan kou Ran Huo Ying Liu Hui-Shu Yuan Yan Xing Ji-Sheng Han Song-Ping Han Yun Li Hua lai Lan Zhang Mei-Xiang Jia Jing Liu Xuan Liu keith M.kendrick Rong Zhang The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for NeuroinformationSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 611731China Neuroscience Research Institute Key Laboratory for NeuroscienceMinistry of Education of ChinaKey Laboratory for NeuroscienceNational Committee of Health and Family Planning of ChinaDepartment of NeurobiologySchool of Basic Medical SciencesPeking UniversityBeijing 100191China State key Laboratory of Cognitive Neuroscience and Leamning Beijing Key Laboratory of Brain Imaging and Connectomicsand IDG/McGovermn Institute for Brain ResearchBeijing Normal UniversityBeijng 100875China Chengdu Women's and Children's Central Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China Child Mental Health Research Center Nanjing Brain Hospital Affliated of Nanjing Medical UniversityNanjing 210029China Radiology Department Peking University Third HospitalBeijing 100191China Department of Pediatrics Peking University Third HospitalBeijing 100191China Wuxi Shenpingxintai Medical Technology Co LtdWuxi 214091China Mental Health Institute Peking UniversityKey Laboratory of Ministry of HealthThe Ministry of Public HealthBeijing 100191China Shandong ke Luo Ni ke(CLINIC)Medical Technology Co LtdDezhou 253011China Autism Research Center of Peking University Health Science Center Beiing 100191China Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking University100191BeijingChina

Background:Autism spectrum disorder(ASD)is associated with altered brain development,but it is unclear which specific structural changes may serve as potential diagnostic markers,particularly in young children at the age when symptoms become fully ***,such brain markers need to meet the requirements of precision medicine and be accurate in aiding diagnosis at an individual rather than only a group ***:This study aimed to identify and model brain-wide differences in structural connectivity using diffusion tensor imaging(DTI)in young ASD and typically developing(TD)***:A discovery cohort including 93 ASD and 26 TD children and two independent validation cohorts including 12 ASD and 9 TD children from three different cities in China were ***-wide(294 regions)structural connectivity was measured using DTI(fractional anisotropy,FA)together with symptom severity and cognitive development.A connection matrix was constructed for each child for comparisons between ASD and TD *** classification was performed on the discovery dataset and the resulting model was tested on the two independent validation ***:Thirty-three structural connections showed increased FA in ASD compared to TD children and associated with both autistic symptom severity and impaired general cognitive *** majority(29/33)involved the frontal lobe and comprised five different networks with functional relevance to default mode,motor control,social recognition,language and ***,clas-sification achieved very high accuracy of 96.77%in the discovery dataset,and 91.67%and 88.89%in the two independent validation ***:Identified structural connectivity differences primarily involving the frontal cortex can very accurately distinguish novel individual ASD from TD children and may therefore represent a robust early brain biomarker which can address the requirements of precision medicine.

关键词： autism spectrum disorder diffusion tensor imaging fractional anisotropy brain structural connectivity individual diag-nosis early childhood

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Efficacy of vasopressin, steroid, and epinephrine protocol for in-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis

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Journal of Geriatric Cardiology 2022年第9期19卷 705-711页

作者： Danish Iltaf Satti Yan Hiu Athena Lee keith Sai kit Leung Jeremy Man Ho Hui Thompson ka Ming kot Arslan Babar Gauranga Mahalwar Abraham kC Wai Tong Liu Leonardo Roever Gary Tse Jeffrey Shi kai Chan International Health Informatics Study(IHIS)Network Cardiovascular Analytics Group Hong KongChina-UK Collaboration Emergency Medicine Unit Li Ka Shing Fac-ulty of MedicineThe University of Hong KongHong KongChina Aston Medical School Faculty of Health&Life SciencesAston UniversityBirminghamUnited Kingdom Li ka Shing Faculty of Medicine The University of Hong KongHong KongChina Department of Anaesthesia and Pain Service Princess Margaret HospitalLai Chi KokKowloonHong KongChina Department of Medicine Cleveland Clinic FoundationClevelandUSA Tianjin key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of Cardi-ologySecond Hospital of Tianjin Medical UniversityTianjinChina Department of Clinical Research Federal Uni-versity of UberlândiaUberlândiaBrazil kent and Medway Medical School CanterburyKentUnited Kingdom 不详

OBJECTIVES To assess the effect of vasopressin,steroid and epinephrine(VSE)combination therapy on return of spontan-eous circulation(ROSC)after in-hospital cardiac arrest(IHCA),and test the conclusiveness of evidence using trial sequential ana-lysis(TSA).METHODS The systematic search included PubMed,EMBASE,Scopus,and Cochrane Central Register of Controlled *** controlled trials(RCTs)that included adult patients with IHCA,with at least one group receiving combined VSE therapy were *** was extracted independently by two *** main outcome of interest was *** out-comes included survival to hospital discharge or survival to 30 and 90 days,with good neurological *** We included a total of three RCTs(n=869).Results showed that VSE combination therapy increased ROSC(risk ra-tio=1.41;95%CI:1.25-1.59)as compared to *** demonstrated that the existing evidence is *** was also validated by the alpha-spending adjusted relative risk(1.32[1.16,1.49],P<0.0001).Other outcomes could not be meta-analysed due to differences in timeframe in the included *** VSE combination therapy administered in cardiopulmonary resuscitation led to improved rates of ***-ture trials of VSE therapy should evaluate survival to hospital discharge,neurological function and long-term survival.

关键词： resuscitation analysis return

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