Efficacy of vasopressin, steroid, and epinephrine protocol for in-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis

作     者：Danish Iltaf Satti Yan Hiu Athena Lee Keith Sai Kit Leung Jeremy Man Ho Hui Thompson Ka Ming Kot Arslan Babar Gauranga Mahalwar Abraham KC Wai Tong Liu Leonardo Roever Gary Tse Jeffrey Shi Kai Chan International Health Informatics Study(IHIS)Network Danish Iltaf Satti;Yan Hiu Athena Lee;Keith Sai Kit Leung;Jeremy Man Ho Hui;Thompson Ka Ming Kot;Arslan Babar;Gauranga Mahalwar;Abraham KC Wai;Tong Liu;Leonardo Roever;Gary Tse;Jeffrey Shi Kai Chan;International Health Informatics Study(IHIS)Network

作者机构：Cardiovascular Analytics GroupHong KongChina-UK Collaboration Emergency Medicine UnitLi Ka Shing Fac-ulty of MedicineThe University of Hong KongHong KongChina Aston Medical SchoolFaculty of Health&Life SciencesAston UniversityBirminghamUnited Kingdom Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Department of Anaesthesia and Pain ServicePrincess Margaret HospitalLai Chi KokKowloonHong KongChina Department of MedicineCleveland Clinic FoundationClevelandUSA Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular DiseaseDepartment of CardiologyTianjin Institute of Cardi-ologySecond Hospital of Tianjin Medical UniversityTianjinChina Department of Clinical ResearchFederal Uni-versity of UberlândiaUberlândiaBrazil Kent and Medway Medical SchoolCanterburyKentUnited Kingdom 不详 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2022年第19卷第9期

页      面：705-711页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：resuscitation analysis return 

摘      要：OBJECTIVES To assess the effect of vasopressin,steroid and epinephrine(VSE)combination therapy on return of spontan-eous circulation(ROSC)after in-hospital cardiac arrest(IHCA),and test the conclusiveness of evidence using trial sequential ana-lysis(TSA).METHODS The systematic search included PubMed,EMBASE,Scopus,and Cochrane Central Register of Controlled *** controlled trials(RCTs)that included adult patients with IHCA,with at least one group receiving combined VSE therapy were *** was extracted independently by two *** main outcome of interest was *** out-comes included survival to hospital discharge or survival to 30 and 90 days,with good neurological *** We included a total of three RCTs(n=869).Results showed that VSE combination therapy increased ROSC(risk ra-tio=1.41;95%CI:1.25-1.59)as compared to *** demonstrated that the existing evidence is *** was also validated by the alpha-spending adjusted relative risk(1.32[1.16,1.49],P0.0001).Other outcomes could not be meta-analysed due to differences in timeframe in the included *** VSE combination therapy administered in cardiopulmonary resuscitation led to improved rates of ***-ture trials of VSE therapy should evaluate survival to hospital discharge,neurological function and long-term survival.