Overexpression of p53 predicts colorectal neoplasia risk in patients with inflammatory bowel disease and mucosa changes indefinite for dysplasia

作     者：Bela Horvath Ganglei Liu Xianrui Wu Keith K Lai Bo Shen Xiuli Liu 

作者机构：Department of Anatomic PathologyCleveland ClinicClevelandOHUSA Department of Geriatric Surgerythe Second Xiangya Hospital of Central South UniversityChangshaChina Department of Colorectal SurgeryCleveland ClinicClevelandOHUSA Department of Colorectal Surgerythe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of PathologyUniversity of Arkansas for Medical SciencesLittle RockARUSA Department of Gastroenterology/HepatologyCleveland ClinicClevelandOHUSA 

出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)

年 卷 期：2015年第3卷第4期

页      面：344-349,I0002页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：inflammatory bowel disease ulcerative colitis Crohn’s disease colorectal neoplasia p53 cytokeratin 7 

摘      要：Background and aims:We previously demonstrated a significant colorectal neoplasia risk in inflammatory bowel disease(IBD)patients with mucosal changes indefinite for dysplasia(IND)and the potential diagnostic utility of p53 and cytokeratin 7 immunohistochemistry in IBD-associated *** primary aim of this exploratory study was to determine the predictive value of the two markers for neoplasia risk in the IBD-IND ***:We identified 44 eligible cases with IBD and IND in colon biopsy from our pathology *** semi-quantified the expression of p53 and cytokeratin 7 in the colon biopsies by immunohistochemistry and correlated their expression,demographic information,and clinical features with colorectal neoplasia ***:The mean age of the cohort was 46.6615.1 years,with 25(56.8%)being *** median follow-up was 101 months(range:6–247)after IND *** these 44 patients,11(25%)progressed to neoplasia(low-grade dysplasia¼6;high-grade dysplasia¼2;cancer 3)at a median follow-up of 66 months(range:19–145).Univariate analysis demonstrated that age and p53 overexpression were associated with progression to ***:Twenty-five percent of patients with IBD and IND developed colorectal dysplasia or *** of p53 and age are associated with neoplastic progression.