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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 112-113页

作者： Yuko Okamoto Kazuaki Taguchi keishi Yamasaki Mina Sakuragi Shun’ichi Kuroda Masaki Otagiri Faculty of Pharmaceutical Sciences Sojo UniversityKumamoto 860-0082Japan Department of Nanoscience Sojo UniversityKumamoto 860-0082Japan The Institute of Scientific and Industrial Research Osaka UniversityOsaka 567-0047Japan Graduate School of Bioagricultural Sciences Nagoya UniversityNagoya 464-8601Japan

There is now little doubt that PEGylation is useful and is in widespread use because it provides a prolonged half-life,a higher stability and a lowerimmunogenicity[1].However,it is of concern that PEGylation may affect the physicochemical and pharmacokinetic characteristics of protein-encapsulated ***,we prepared the bovine serum albumin(BSA)-encapsulated liposome(BSA-liposome)with or without PEG and then compared their physicochemical and pharmacokinetic characteristics(Fig.1).BSA-liposomes were prepared by the thin-film hydration method.

关键词： Liposome PEGylation Bovine serum albumin

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用一氧化碳作气体放电媒质的VUV光源

用一氧化碳作气体放电媒质的VUV光源

Cancer immunity and therapy using hyperthermia with immunotherapy, radiotherapy, chemotherapy, and surgery

走近CIE 26th——中国照明学会（2005）学术年会

作者： Akimitsu Hatta keishi Yanai 高知工科大学电子光学系统工程系

介绍本文作者致力于用等离子体增强化学蒸气沉积达到金刚石合成的研究。一氧化碳气体也可以作为金刚石的原始材料,在将一氧化碳高度浓缩制成金刚石的试验中,在石英窗口旁(view window of quartz)能闻到强烈的臭氧。根据这一事实,一氧化... 详细信息

介绍本文作者致力于用等离子体增强化学蒸气沉积达到金刚石合成的研究。一氧化碳气体也可以作为金刚石的原始材料,在将一氧化碳高度浓缩制成金刚石的试验中,在石英窗口旁(view window of quartz)能闻到强烈的臭氧。根据这一事实,一氧化碳气体放电可以作为剧烈的紫外发射源。在这一研究中,利用一氧化碳气体放电制成了新颖的VUV光源。试验

关键词：紫外发射源一氧化碳气体放电 VUV光源

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Journal of Cancer Metastasis and Treatment 2017年第1期3卷 218-230页

作者： Yohsuke Yagawa keishi Tanigawa Yasunobu Kobayashi Masakazu Yamamoto Bio-Thera Clinic Tokyo 1600022Japan Department of Surgery Institute of GastroenterologyTokyo Women’s Medical UniversityTokyo 1628666Japan.

Hyperthermia is a type of medical modality for cancer treatment using the biological effect of artificially induced *** though the intrinsic effects of elevated body temperature in cancer tissues are poorly understood,increasing the temperature of the body has been recognized as a popular therapeutic method for tumorous lesions as well as infectious diseases since ancient *** accumulated evidence has shown that hyperthermia amplifies immune responses in the body against cancer while decreasing the immune suppression and immune escape of *** also shows that hyperthermia inhibits the repair of damaged cancer cells after chemotherapy or *** perceptions indicate that hyperthermia has potential for cancer therapy in conjunction with immunotherapy,chemotherapy,radiotherapy,and ***,the anticancer effect of hyperthermia alone has not yet been adequately exploited because deep heating techniques and devices to aggregate heat effects only in cancer tissues are difficult in practical *** review article focuses on the current understanding concerning cancer immunity and involvement of hyperthermia and the innate and adoptive immune *** potential for combination therapy with hyperthermia and chemotherapy,radiotherapy,and surgery is also discussed.

关键词： Hyperthermia cancer immunity chemosensitizer radiosensitizer combination cancer therapy hyperthermic intraoperative peritoneal chemotherapy

Stable Vibration-Based Communication Scheme Using Multi-Step ASK and PPM Techniques

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Journal of Computer and Communications 2018年第1期6卷 284-300页

作者： keishi Usa Eiji Kamioka Khaironi Yatim Bin Sharif Graduate School of Engineering and Science Shibaura Institute of Technology Tokyo Japan Department of Software Engineering and Information System University Putra Malaysia Selangor Malaysia

In the information-oriented society, there are increasing needs to conduct data communication with nearby devices/people. In this light, vibration-based communication method was proposed as one of possible communication means between adjacent devices. This method has been expected to provide an intuitive and safe communication by propagating vibration to a receiver device. This study proposes two types of techniques, which are multi-step ASK (Amplitude Shift Keying) with pseudo clock and PPM (Pulse Position Modulation), to achieve a stable vibration-based communication simply using smart device functions. These proposed techniques are then evaluated through some experiments using several types of smart devices. In addition, the effectiveness of the proposed methods is discussed based on the experimental results.

关键词： Smartphone Communication Method Vibration Motor Acceleration Sensor

Myofiber Permeability and Force Production of Rat Muscles Following Eccentric Contractions: The Repeated Bout Effect Depends on the Interval

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Journal of Biomedical Science and Engineering 2020年第12期13卷 275-289页

作者： keishi Hayao Hiroyuki Tamaki Keigo Tamakoshi Hideaki Takahashi Hideaki Onishi Institute for Human Movement and Medical Sciences Niigata University of Health and Welfare Niigata Japan Southern Tohoku General Hospital Fukushima Japan National Institute of Fitness and Sports in Kanoya Kagoshima Japan

Past eccentric contraction (ECC)-induced muscle injury reduces the severity of symptoms of subsequent muscle injury;this phenomenon is known as a repeated bout effect (RBE). It has been reported that increases in the duration of the interval between the first and second bouts are linked to weakening of the RBE. However, the histology following the attenuation of the RBE remains unclear. We examined the sustained effects of the second bout with regard to myofiber permeability and muscle force. Sixty-four male rats were randomly assigned to eight groups that varied in the number of exercise sessions and the duration of the interval between the first and second bouts: the non-ECC (Control);the single-injury (Post 1st bout);groups that were allowed to recover for 1, 2, and 4 weeks after a single injury (Pre 2nd bout_1w, Pre 2nd bout_2w, and Pre 2nd bout_4w);and groups that were subjected to second injuries 1, 2, and 4 weeks after the first (Post 2nd bout_1w, Post 2nd bout_2w, and Post 2nd bout_4w). The tibialis anterior was electrically stimulated in each ECC group. Twenty-four hours before muscle sampling, Evans blue dye (EBD) (a marker of myofiber damage) was administered. The maximal isometric contraction tension was measured immediately before sampling. The number of EBD-positive (+) fibers was determined via histological analysis. An RBE was revealed by functional examination at the 1- and 2-week and histological examination at the 1-, 2-, and 4-week time points (P < 0.05). In terms of myofiber permeability, prolongation of the interval before the second bout weakened this effect (P < 0.05). Experiments with 1-, 2-, and 4-week intervals indicated that prolongation of the interval before the second bout weakened the RBE with regard to myofiber permeability.

关键词： Eccentric Contraction Muscle Injury Repeated Bout Effect Myofiber Membrane Permeability Maximal Isometric Contraction Tension

Rocket Propulsion Powered Using a Gyrotron

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Journal of Energy and Power Engineering 2017年第6期11卷 363-371页

作者： Masafumi Fukunari Kimiya Komurasaki Yusuke Nakamura Yasuhisa Oda keishi Sakamoto Research Center for Development of Far-Infrared Region University of Fukui Fukui 910-8507 Japan Department of Aeronautics & Astronautics University of Tokyo Bunkyo Tokyo 113-8656 Japan Graduate School of Frontier Sciences University of Tokyo Kashiwa Chiba 277-8561 Japan National Institutes for Quantum and Radiological Science and Technology Naka Ibaraki 311-0193 Japan

The Concept Study of Recombinant Human Soluble Thrombomodulin in Patients with Acute Respiratory Distress Syndrome

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International Journal of Clinical Medicine 2013年第11期4卷 488-495页

作者： Kenji Tsushima Toshiki Yokoyama Tomonobu Koizumi keishi Kubo Koichiro Tatsumi Department of Pulmonary Medicine Shinonoi General Hospital Nagano Japan Department of Respirology Graduate School of Medicine Chiba Uni-versity Chiba Japan Department of Respirology Graduate School of Medicine Chiba Uni-versity Chiba Japan First Department of Internal Medicine Shinshu University School of Medicine Nagano Japan

Background: Recombinant human soluble thrombomodulin (rhTM) was approved for the treatment of disseminated intravascular coagulation in Japan, and rhTM has anti-inflammatory effects. Disordered coagulation is a part of the acute respiratory distress syndrome (ARDS) pathophysiology and thus we hypothesize that anticoagulant therapy may help. This preliminary study was to observe the safety of rhTM administration and the improvement on biomarker levels after the therapy for ARDS-patients. Objectives: Case series of ARDS-patients. Methods: Seventeen ARDS-patients that required ventilatory management were treated with rhTM and clinical and laboratory data were collected including platelets, thrombin-antithrombin complex (TAT), fibrinogen degradation products, oxygen saturation/the fraction of inspired oxygen (SpO2/FIO2), and high-mobility group-1 (HMG-1). The administration of rhTM was started during 6 days at a bolus dose of 0.06 mg/kg/day immediately after the diagnosis of ARDS. Results: Eleven of the 17 ARDS-patients were alive at 28 days after the beginning of the administration of rhTM. The serial pattern of the SpO2/FIO2 showed remarkable differences between the survivors and nonsurvivors from day 5 to day 7. The TAT in the survivors significantly decreased after treatment, and there were significantly lower levels in the TAT on day 7 in comparison to that of the nonsurvivors. The serial changes of HMG-1 showed increased levels in the nonsurvivors until day 5 after the administration of rhTM. Conclusions: Additional rhTM administration can safely improve the parameters in survival ARDS-patients, as demonstrated by significant improvements in the SpO2/FIO2, HMG-1 and TAT.

关键词： Acute Respiratory Distress Syndrome Recombinant Human Soluble Thrombomodulin Thrombin-Antithrombin Complex SpO2/FIO2 High-Mobility Group-1

Bone Quality in Female Ballet Dancers: A Possible Determinant of Bone Health

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Open Journal of Orthopedics 2017年第9期7卷 284-293页

作者： Hiroki Funasaki Mitsuru Saito Mayumi Kuno-Mizumura Hiroteru Hayashi keishi Marumo Department of Sports and Wellness Clinic Jikei University School of Medicine Tokyo Japan Department of Orthopaedic Surgery Jikei University School of Medicine Tokyo Japan Graduate School of Humanities and Sciences Ochanomizu University Tokyo Japan

Hypotheses:Values of serum markers related to bone quality are abnormal in young female ballet dancers. Methods: In 13 elite Japanese female ballet dancers (average age, 22 years), markers related to bone quality were investigated. These included: serum homocystein (HC), a marker of increased oxidative stress;pentosidine (Pent), a marker of glycation- or oxidation-induced non-enzymatic cross-links;markers of bone metabolism (bone alkaline phosphatase, BAP;tartrate-resistant acid phosphatase 5b, TRAP5b) and bone mineral density (BMD). It was determined whether there is a relationship between bone quality markers’ levels are related to amenorrhea and/or fatigue fractures. Results: Two dancers had fatigue fractures and 3 had a history of secondary amenorrhea. The average BMD was 1.305 ± 0.12 (g/cm2), in all these cases the Z-score was higher than -1.0. Although the serum levels of BAP, TRAP5b, and HC were normal in all examined dancers, in 2 out of 3 dancers with a history of secondary amenorrhea, pentosidine serum levels were increased. No relationship between bone quality markers’ levels and fatigue fractures was found. Conclusion: Latent deterioration of bone quality may occur in female athletes with secondary amenorrhea and otherwise normal BMD and calcium metabolism markers.

关键词： Bone Quality Bone Mineral Density Female Athletes Ballet Dancer

Myasthenia gravis in a professional cyclist—A case report

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Open Journal of Therapy and Rehabilitation 2013年第2期1卷 5-9页

作者： Hiroteru Hayashi Hiroki Funasaki Kentaro Kawai Sakiko Ito keishi Marumo Department of Sports and Wellness Clinic Jikei University School of Medicine Tokyo Japan

Since myasthenia gravis affects the muscular system, athletes suffering from the disease often have difficulty in performing or returning to their sports activity, in which exertion of continuous muscular power is required. In this paper, we present a case of a professional bicycle rider with symptomatic MG who successfully return to his sport activity after thymectomy, steroid pulse therapy and aggressive rehabilitation. He resumed load training, returned to competitive cycling 8 months after leaving hospital while being on 20 mg PSL/day, and won seven victories in the top class cycling competitions. This is the first report on a professional athlete suffering from MG who successfully returned to competitive sports after aggressive steroid treatment.

关键词： Myasthenia Gravis Aggressive Rehabilitation Return to Sports

Basic peptide protamine exerts antimicrobial activity against periodontopathic bacteria——Growth inhibition of periodontopathic bacteria by protamine

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Journal of Biomedical Science and Engineering 2010年第11期3卷 1069-1072页

作者： Tadashi Miura keishi Iohara Tetsuo Kato Kazuyuki Ishihara Masao Yoshinari 不详

Protamine was investigated for its antibacterial activity against the periodontal pathogens, Porphyromonas gingivalis, Prevotella intermedia and Aggregatibacter actinomycetemcomitans. We determined the minimum inhibitory concentrations of protamine and its hydrolysate and their bactericidal activity. Protamine inhibited the growth of all periodontopathic bacteria tested on agar plates. Protamine, which MIC was 6.3 × 10-7 g L-1, was most effective against P. gingivalis. The antibacterial effect of native protamine was higher than that of its hydrolysate. An ATP bioluminescence assay revealed that protamine showed bactericidal activity against P. gingivalis in a time-dependent manner. These results indicate that protamine could be candidate peptide for prevention of P. gingivalis infection.

关键词： Antimicrobial Peptide Periodontopathic Bacteria Implantitis Protamine